Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DDX39BP1
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:119821221-119822296  UCSC
Coordinates (T2T) chr11:119843925-119845000  UCSC
Coordinates (hg19) chr11:119691930-119693005  UCSC
Strand -
Parental Sequence NM_080598.6_5
Parental seq. overlap 984 bp
Parental seq. overlap (%) 63%
Genomic Region Intergenic
Retrocopy Summary DDX39BP1, located on chr11:119821221-119822296, is a retrocopy of the parental gene DDX39B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DDX39B
Full Name DExD-box helicase 39B
Also known as BAT1|D6S81E|UAP56
Coordinate chr6:31530226-31542003
Strand -
Gene summary This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene. [provided by RefSeq, Feb 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DDX39BP1
Bonobo Pan paniscus DDX39BP1
Gorilla Gorilla gorilla DDX39BP1
Orangutan Pongo abelii DDX39BP1
Gibbon Nomascus leucogenys DDX39BP1
Green monkey Chlorocebus sabaeus DDX39BP1
Crab-eating macaque Macaca fascicularis DDX39BP1
Rhesus Macaca mulatta DDX39BP1
Baboon Papio anubis DDX39AP1
Golden snub-nosed monkey Rhinopithecus roxellana DDX39BP1
Marmoset Callithrix jacchus DDX39BP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DDX39BP1
TTCTCTAAATATATGCCCAATGTCAAGGTTGCTGTATTTTTTGGTGGTCTATCAAGAAGGATGAAGAGGTGCTGAAGAAGAACTGCCTGCATATCGTCGTGGGGACTCCAGGCCGTATCCTAGCCCTGGCTGGAAATAAGAGCCTCAACCTCAAACACATAAAACACTTTATTTCAAATGAATGTGATAAGACGTTTGAACAGCTCAACATGTGTCGGGATGTCCAGGGAATTTTTCGCATGACCCCACCGTGAAAAGCCGGTCATGATGTTCAGGGCTACCTTGAGCAAAGAGATCCGTCCAGTCTGCCACAAGTTCATGCAAGATCCAGTGGAGATCTTCATGGATAATGAGATGAAGTTGATGCTGCATGGGTTGCAGCAGTACTACATGAAACTGAAGGACAACCAGAAGAACTGGAAGCGCTATGACCTTCTGAATGTCCTTGAGTTCAACCAGGTGATGATCTTTTTGAAGTCTGTGCAGCGGCGCATTGCCTCAGCCCAGCTACTGGGTGGAGCAGAACATCCCAGCCATTGCCATCCACCGCGGGATGCCCCAGGGCAGAGGCTGTCTCAGTATCAGCAGTTTAAAGATTTTCAATGGTGAATTATTGTGGCTACCAACCTATTTGGCCAAGGAATGGACATTGAGCGGGTGAACATTGCTTTTAATTATGACATGCCTGAGGATTCTGACACCTACCTGCATTGGGTGGCCAGAGCCAGCCGGTTTGGCACCAAGAGCTTGGCTATCACATTTGTGTCTGACGAGAATGATGCCAAGATCCTCAATGACATGCAGGATCGCTTTGAGGTCAATCGTAGTGATCTGCCTGATGAGAGAGACATCTTCTCCTGCTTTGAAAAGACATGGTAAAGGACATGGTAGAGGACACATTGCAGAATATGACCGTCTGTCCTTCAGGAGAGGACACATCAGGGTGGGGGTGAAGGAGACACCAGTGCCCCCACCCCTGACAGCCCCCACCCCATGGCTTCCTTCTTTTGCATCACCACCACTCCTGAACCCCCATTTCTGATTTGTCAGAATGGTTTTTTAACAAAACTAAAAAC
>NM_080598.6_5
AGATTTCCCTCCTTCGTCGCTGTTGCTGCCGCCATACGCGCTCTCCCTGTTTAGTTATGGCAGAGAACGATGTGGACAATGAGCTCTTGGACTATGAAGATGATGAGGTGGAGACAGCAGCTGGGGGAGATGGGGCTGAGGCCCCTGCCAAGAAGGATGTCAAGGGCTCCTATGTCTCCATCCACAGCTCTGGCTTTCGTGACTTCCTGCTCAAGCCAGAGTTGCTCCGGGCCATTGTCGACTGTGGCTTTGAGCATCCGTCAGAAGTCCAGCATGAGTGCATCCCTCAGGCCATTCTGGGAATGGATGTCCTGTGCCAGGCCAAGTCGGGCATGGGAAAGACAGCAGTGTTTGTCTTGGCCACACTGCAACAGCTGGAGCCAGTTACTGGGCAGGTGTCTGTGCTGGTGATGTGTCACACTCGGGAGTTGGCTTTTCAGATCAGCAAGGAATATGAGCGCTTCTCTAAATACATGCCCAATGTCAAGGTTGCTGTTTTTTTTGGTGGTCTGTCTATCAAGAAGGATGAAGAGGTGCTGAAGAAGAACTGCCCGCATATCGTCGTGGGGACTCCAGGCCGTATCCTAGCCCTGGCTCGAAATAAGAGCCTCAACCTCAAACACATTAAACACTTTATTTTGGATGAATGTGATAAGATGCTTGAACAGCTCGACATGCGTCGGGATGTCCAGGAAATTTTTCGCATGACCCCCCACGAGAAGCAGGTCATGATGTTCAGTGCTACCTTGAGCAAAGAGATCCGTCCAGTCTGCCGCAAGTTCATGCAAGATCCAATGGAGATCTTCGTGGATGATGAGACGAAGTTGACGCTGCATGGGTTGCAGCAGTACTACGTGAAACTGAAGGACAACGAGAAGAACCGGAAGCTCTTTGACCTTCTGGATGTCCTTGAGTTCAACCAGGTGGTGATCTTTGTGAAGTCTGTGCAGCGGTGCATTGCCTTGGCCCAGCTACTAGTGGAGCAGAACTTCCCAGCCATTGCCATCCACCGTGGGATGCCCCAGGAGGAGAGGCTTTCTCGGTATCAGCAGTTTAAAGATTTTCAACGACGAATTCTTGTGGCTACCAACCTATTTGGCCGAGGCATGGACATCGAGCGGGTGAACATTGCTTTTAATTATGACATGCCTGAGGATTCTGACACCTACCTGCATCGGGTGGCCAGAGCAGGCCGGTTTGGCACCAAGGGCTTGGCTATCACATTTGTGTCCGATGAGAATGATGCCAAGATCCTCAATGATGTGCAGGATCGCTTTGAGGTCAATATTAGTGAGCTGCCTGATGAGATAGACATCTCCTCCTACATTGAACAGACACGGTAGAAGACTCGCCCATTTTGGAATGTGACCGTCTGTCCTTCAGGAGAGGACACCAGGGTGGGGGTGAAGGAGACACTACTGCCCCCACCCCTGACAGCCCCCACCCCATGGCTTCCATCTTTTGCATCACCACCACTCCTGAACCCCCATTTCTGATTTGTCAGAATTTTTTTTTAACAAAACTAAAAATGAAACACATGTGTCTGTGGTA

Publications

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