Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name RNF181P2
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:124807728-124808279  UCSC
Coordinates (T2T) chr11:124836393-124836944  UCSC
Coordinates (hg19) chr11:124677624-124678175  UCSC
Strand -
Parental Sequence NM_016494.4
Parental seq. overlap 469 bp
Parental seq. overlap (%) 67.2%
Genomic Region Intergenic
Retrocopy Summary RNF181P2, located on chr11:124807728-124808279, is a retrocopy of the parental gene RNF181. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RNF181
Full Name ring finger protein 181
Also known as HSPC238
Coordinate chr2:85593823-85597708
Strand +
Gene summary RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RNF181P2
Bonobo Pan paniscus RNF181P2
Gorilla Gorilla gorilla RNF181P2
Orangutan Pongo abelii RNF181P2
Gibbon Nomascus leucogenys RNF181P3
Green monkey Chlorocebus sabaeus RNF181P1
Crab-eating macaque Macaca fascicularis RNF181P3
Rhesus Macaca mulatta RNF181P3
Baboon Papio anubis RNF181P3
Golden snub-nosed monkey Rhinopithecus roxellana RNF181P3
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RNF181P2
GCTGAGCAGCCATGACAGCCTATTTCAATGAACAGGACTGCAAGCTCTTGAACCCCAAGCAGGAGACCCTAACCCACATGCTGCTGGAGCTCACCAGATCACTTTTCAATAGGATGGATTTTGAAGACTCGGGGATGGCAGTAAATTGGAATCACCACCTGCCTCCACCAGCTGCCAAGACAGTGTGGTTGGGAACCTCCCCAGGACAGTCATCAGGAGCTCTCAGGCTGAGAGGCACACACAAGTGCCCCATGTGCTTGAGGAGGAGGAGGCTGTTGTTGGGATGCCTTGCCATTAGCTTTTCCATTCTAACTGCATTTTGCCCCGGCTAAGCAAGACAAATCCCTGTCCCTTGTGCTGCCAGGAGCTGCCCGCTGTTAACGACACTTGTGAGGAGCACAGAGGAGATAAGGCTCGAAACAGCAGCAGCAGCACTGTCTGGAGAACCTCTACAGAGCCATGTGCATATGAGGAGGCTGGGGCTAAGCGCTGGCTCTCTACAAGGTCCTCCTCTTACACCTTGAACCCTCATTAAAGGTTTCTTTACCCACA
>NM_016494.4
GTCAGAAGGCTGGGCAGCCATGGCGTCCTATTTCGATGAACACGACTGCGAGCCGTCGGACCCTGAGCAGGAGACGCGAACCAACATGCTGCTGGAGCTCGCAAGGTCACTTTTCAATAGGATGGACTTTGAAGACTTGGGGTTGGTAGTAGATTGGGACCACCACCTGCCTCCACCAGCTGCCAAGACTGTGGTTGAGAACCTCCCCAGGACAGTCATCAGAGGCTCTCAGGCTGAGCTCAAGTGCCCCGTGTGTCTTTTGGAATTTGAGGAGGAGGAGACTGCCATTGAGATGCCTTGCCATCACCTTTTCCATTCCAGCTGCATTCTGCCCTGGCTAAGCAAGACAAATTCCTGTCCCTTGTGCCGCTATGAGCTGCCCACTGATGACGACACTTATGAGGAGCACAGACGAGATAAGGCTCGAAAACAGCAGCAGCAACACCGACTGGAGAACCTCCATGGAGCCATGTACACGTGAGGAGGTTGGGGCTGAGTGCTGGCCCTCTGCGTCTTCCTTATTAACCTTGAATCCTCATTAAAGGTTTCTTTACCCACCCTGAGGCTGTATTGATCACAGACCTGGCCAGGGGCTCTGCATCCTCCATCAGGTCTCTACTTCTGTTGGGGAAGGTGATCCTAAATCGCAGAAGGCACCAGGCTGCGGTTTTCCTCCCTGCTGGCC

Publications

PMID - Link Title