Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HNRNPA1P43
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:115856004-115857878  UCSC
Coordinates (T2T) chr1:115864000-115865875  UCSC
Coordinates (hg19) chr1:116398625-116400499  UCSC
Strand -
Parental Sequence NM_002136.4
Parental seq. overlap 1171 bp
Parental seq. overlap (%) 29.9%
Genomic Region Intergenic
Retrocopy Summary HNRNPA1P43, located on chr1:115856004-115857878, is a retrocopy of the parental gene HNRNPA1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HNRNPA1
Full Name heterogeneous nuclear ribonucleoprotein A1
Also known as ALS19|ALS20|HNRPA1|HNRPA1L3|IBMPFD3|UP 1|hnRNP A1|hnRNP-A1
Coordinate chr12:54280726-54287087
Strand +
Gene summary This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HNRNPA1P1
Bonobo Pan paniscus HNRNPA1P10
Gorilla Gorilla gorilla HNRNPA1P1
Orangutan Pongo abelii HNRNPA1P1
Gibbon Nomascus leucogenys HNRNPA1P31
Rat Rattus norvegicus Hnrnpa1P31
Velvety free-tailed bat Molossus molossus HNRNPA1P3
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HNRNPA1P43
AGTTTTTTTTTTTTTCTTTTCCACCCATGCTGTTGATTGCTAAATATAATGGTCTGATTGTGATGCTGAATAAATGTGTCTTTTAAAAAAACATGCTAAGTTAGTCTACTCTGAAGCCATCTTGGTAAATTTCCCCAACAGTGTGAAGTTAGAATTCCTTCAGGGTGATACCAGGTTCTATTTGGAATTTATATACAACCTGCTTGGGTGAAGAAGCCACTGTCTTCAGAAACCTTGGTGTAGTTGAACTGACAGTTACTGTTGTGACCTGAAGTTCACCATTAAAAGGGATTGCCCAAGCAAAATCATGGAATTATTGGTTATAAAAATGATTGTTGGGCTTTCTGCCCATGGATGCCGCCGAGGAAGCATTGTAAAGTCTCTCATCCCCCTGCCGTCATGTCTAAGTCAGAATCTCCTAAAGAGCCCTAACAGCTGAGGAAGCTCTTCATTGGAGGATTGAGTTTTGAAACAACCAACGAGAGCCTGAGGAGCCATTTTGAGCAATGGGGAATTCACGGGCTGAGTGTTAATGAGAGATCCAAACACCAAGCTCTCCAGGGGCTTTGGGTTTGTCACATATACCACTGTGGAGGAGGTGGATGCAGCCATGAATGCGAGGCCACACGAGGTCGACGGAAGAGTTGTGGAACCAAAGAGAGCTGTCTCAAGAGAAGATTCTCAAAGACCAGGTGCCCACTTAACTGTGAAAAAGATATTTGTTGGTGGTATTAAAGAAGACACTGAAGAACATCACCTAAGAGATTATTTTGAACTGTGTGGAAAAATGGAACTGATTGAAATAATAACTGACCGAGGCAGTGGCAAGAAGAGGGGCTTTGCCTTTGTAACCTTTGACGACTATGACTCCATGGATAAGACTGTCATTCAGAAATGCTATACTGTGAATGGCCACAACTGTGAAGTTAGGAAAGCCCTGTCAAAGCAAGAGATGTCTAGTGCTTCATCCAGCCAAAGAGGTCGAAGTGGTTCTGGAAACTTTGGTGGTGGTCATGGAGGTAGTTTTTGGAATGACAACTTTGGTCATGGAGGAAACTTCAATGGTTGTGGAGATGGCTATAATGGATTTGGTAATGATGGAAGCAATTTTGGAAGTGGTAGAAGCTGTAATGATTTTGGCAGTTACAACAATCAGTCTTCAAATTTTGGACCCATGAAGGCAGGAGACTTTGGAGGCAGAAACTCTGGCCCCTATGGTGGTGGAGGCCAATACTTTGCCAAACCATGAAACCAAGGTGGCTACGGTGGTTCCAGTAGCAGCAGAGCTATGGCAGTGGCGGAAGATTTTAATTACTGCCAGGAAACAAATCTTAGCAGGAGAGGAGAGCCAGGGAAGTGACAGGGAAGCTACAGGTTACAAAAGATTTGTGAACTCAGCCAAGCACAGTGGTGGCAGGGCCTAGCTACTATAAAGAAGACATGTTTGAGACAAATACTCATGTGTATGGGCAAAAAAACTTGAGGAGGACTGTATTTGTGACTAATTGTATAACAGGTTATTTTAGTTTCTGTTCTGCGGAAAGTGTAAAGCATTCCAACAAAGGGTTTTAATGTAGt
>NM_002136.4
AGATACGTTCGTCAGCTTGCTCCTTTCTGCCCGTGGACGCCGCCGAAGAAGCATCGTTAAAGTCTCTCTTCACCCTGCCGTCATGTCTAAGTCAGAGTCTCCTAAAGAGCCCGAACAGCTGAGGAAGCTCTTCATTGGAGGGTTGAGCTTTGAAACAACTGATGAGAGCCTGAGGAGCCATTTTGAGCAATGGGGAACGCTCACGGACTGTGTGGTAATGAGAGATCCAAACACCAAGCGCTCCAGGGGCTTTGGGTTTGTCACATATGCCACTGTGGAGGAGGTGGATGCAGCTATGAATGCAAGGCCACACAAGGTGGATGGAAGAGTTGTGGAACCAAAGAGAGCTGTCTCCAGAGAAGATTCTCAAAGACCAGGTGCCCACTTAACTGTGAAAAAGATATTTGTTGGTGGCATTAAAGAAGACACTGAAGAACATCACCTAAGAGATTATTTTGAACAGTATGGAAAAATTGAAGTGATTGAAATCATGACTGACCGAGGCAGTGGCAAGAAAAGGGGCTTTGCCTTTGTAACCTTTGACGACCATGACTCCGTGGATAAGATTGTCATTCAGAAATACCATACTGTGAATGGCCACAACTGTGAAGTTAGAAAAGCCCTGTCAAAGCAAGAGATGGCTAGTGCTTCATCCAGCCAAAGAGGTCGAAGTGGTTCTGGAAACTTtggtggtggtcgtggaggtggtttcggtggGAATGACAACTTCGGTCGTGGAGGAAACTTCAGTGGTCGTGGTGGCTTTGGTGGCAGCCGTGGTGGTGGTGGATATGGTGGCAGTGGGGATGGCTATAATGGATTTGGTAATGATGGAAGCAATTTTGGAGGTGGTGGAAGCTACAATGATTTTGGGAATTACAACAATCAGTCTTCAAATTTTGGACCCATGAAGGGAGGAAATTTTGGAGGCAGAAGCTCTGGCCCCTATGGCGGTGGAGGCCAATACTTTGCAAAACCACGAAACCAAGGTGGCTATGGCGGTTCCagcagcagcagtagctatggcagtggcagaagATTTTAATTAGGAAACAAAGCTTAGCAGGAGAGGAGAGCCAGAGAAGTGACAGGGAAGCTACAGGTTACAACAGATTTGTGAACTCAGCCAAGCACAGTGGTGGCAGGGCCTAGCTGCTACAAAGAAGACATGTTTTAGACAAATACTCATGTGTATGGGCAAAAAACTCGAGGACTGTATTTGTGACTAATTGTATAACAGGTTATTTTAGTTTCTGTTCTGTGGAAAGTGTAAAGCATTCCAACAAAGGGTTTTAATGTAGATTTTTTTTTTTGCACCCCATGCTGTTGATTGCTAAATGTAACAGTCTGATCGTGACGCTGAATAAATGTCTTTTTTTTAATGTGCTGTGTAAAGTTAGTCTACTCTTAAGCCATCTTGGTAAATTTCCCCAACAGTGTGAAGTTAGAATTCCTTCAGGGTGATGCCAGGTTCTATTTGGAATTTATATACAACCTGCTTGGGTGGAGAAGCCATTGTCTTCGGAAACCTTGGTGTAGTTGAACTGATAGTTACTGTTGTGACCTGAAGTTCACCATTAAAAGGGATTACCCAAGCAAAATCATGGAATGGTTATAAAAGTGATTGTTGGCACATCCTATGCAATATATCTAAATTGAATAATGGTACCAGATAAAATTATAGATGGGAATGAAGCTTGTGTATCCATTATCATGTGTAATCAATAAACGATTTAATTCTCTTGAATGAAATGACAACTGTATGGATTTGGGACTGGCAGAGATTTGGACTTTCCCTACCCACTCCCCCTGATAATAATGTTGAATGCTTCTATCACAATTCAAGTTCAAAGCTCTGCCAGGGAATAGAAACTAGCTGCTGGCTAATGCCGCTCCATAAATCCGCAGATTTGAAGTGTCTGGGAGGCCTTTTAAAAATAACTAATATCAGAAAGCATTTTAATGAACGTAAAGATAGGCTTACATTAAAGGAAAACTGCAGTTTGACTGGGTTCTGGTTGGGTGGGCCTTCAGAGGTTCTATCAGTTAACTATACTAATTAATTTGGAGATTCAAACCATACCAATAGAAACTAAATTTTTCTACATAATTTCATGTTAACTGCAGTTTCCCTTTATGGCACAAGGGGTCACACAACCTACCTAAAATGTTAATTGTATAGAAAATGATTTCTAAACCTTTAACAGTTAATATCCAATAATGTGTTATTTGTACATAGATTCTTTTGAGCCTTACCTTTGGTGCTCTCTCAATTTCAGTGCTATTGTACCTAGTAGCATAGAGATTTGTCTATCAATAGGACTGTATATTCCATCCCATGGGTGTGTTGGAAGTTTGGGGAggaggagggtggtgggaggtgggtgggaggtggtggtgggtgggaAAGCATGGGTGATAGTTCCATGATACTGGCTGAGTTTGCAATAGCAGGTGGAACCCTAACTATTGAGGGAGTTTGCAGATACCTCAGGATTCGTGACAATGCCTTTAAAGATCCAGGAGAGATGTTCAGCTACTAGGAACTGCTAGCAAGTATAGCGCGAATGGCTCCGAGCTCAGACACTCTACAGCTGAGAGTAGACACTTGTGGTATGTGGAGTACAGATAAGCCAGGGGCAGGCCACGGCACGCTCCATGAAAGCTAGGAGGGAGTGAAATATCAGTGATCATCGCAAGGAAGGAGGCAGACAAGAGTAAGGCACACCTGACTCTTAGGACTAGCAGTCAGAACCAGGAGGAAAGGTTTTATTGCTATGCGGGTAGGTAAGAACAGATTTTACTTACATCCATATAGTTACTTAAAGTCCAGTTTTCTGTTAAACATTTTTCTTAATATATTGAGCCAAAACTAGTCCAGTTAAGCTGAACTTGGTTTTTCTGGAGATGAATTGTTTTAAATTGACACCCTATTGATGGCTCCCAGTTGAAGGAAGTGAGCACATTATTTGTACTGTGAATATAAATTTTTGCCCTTTTATTTATCTTCCTTTGACCCATTTCCTTAAAATAATGGCTCAAAGTAATAGACTTCCCCAAATGGTGGGGGGATGGGTGGGTTATTAATGGGAGGTATGGGGGGTTTAGCTTGAGATGGGACTTGGTCTTAGAGCTAGTTCTAAAGGTTGTTTACTTTTCTAGGGAGGAGTCTGCTACTAGTCTTATCAGCTCTTAAAAACAGAAACTCATCTGTCCAAGTTCGTGGCAGAAAGGTAAGTTTTTACAAATTAGTGCTCAGCAAAAGAATGCCCTGCGTTCCCAAAGTAAAAGAATGACAAGCTGTACCTTAAACCAAAACACTTCGTAATCTCATCCAATTGCAAAAAGAGTTATTAGCCAACCAGGTATTCCCAGTAGTGACAGTGGATATAACTGTGTAGTCATTCACCTCTGCTTATATGAATACTTTACAACCTCTTTTGCCTTTTGCAGGAACGTCCTTGTGAAGACCTTTATCTGAGCCACTGTACTTCGTTATCACTGCCATGCAGTTTACATGAGCTGTTCTGCAGCTCAAATTCCATTTTGTGAATGGGTTTTTTTTTTTAATAAACTGTATTTAACTTA

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