Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SPTSSAP1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:115916481-115917508  UCSC
Coordinates (hg19) chr1:116459102-116460129  UCSC
Strand +
Parental Sequence NM_138288.4
Parental seq. overlap 641 bp
Parental seq. overlap (%) 24%
Genomic Region Intergenic
Retrocopy Summary SPTSSAP1, located on chr1:115916481-115917508, is a retrocopy of the parental gene SPTSSA. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SPTSSA
Full Name serine palmitoyltransferase small subunit A
Also known as C14orf147|SSSPTA
Coordinate chr14:34432788-34462240
Strand -
Gene summary Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTA is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla SPTSSAP1
Orangutan Pongo abelii SPTSSAP1
Gibbon Nomascus leucogenys SPTSSAP1
Green monkey Chlorocebus sabaeus SPTSSAP1
Crab-eating macaque Macaca fascicularis SPTSSAP1
Rhesus Macaca mulatta SPTSSAP1
Baboon Papio anubis SPTSSAP1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SPTSSAP1
TCATCGCAGGAGGCGCCTGGCAGGGATGGAGCTGGTGCGGGCCTGGAAGTAGATGTCCTGGTTCTACTACCAACACCTGCTGGTCACAATGCTCTACATGCTGGAGCCCGAGGAGCGGAAGGTGCTCAATTCCACGCTGGTTTCCATTGATACGCAGGATACATCTTCATGACCCAGCACATCATGGCGATATTGCACTACTTTGAAATTGTACAATAACCAAGATTAGAGGTTCCTTGGGGAAGACCCACCCTACGAAGTTGGAATGACACCATCAGATGTGATAAGAAACTCTTCTAAATGTCAACCTAACCAACCTAAAATTCATGAGTAGAACAGGAAAATCACCGACTCATGTGTTGTGTTCTATATTTTTCATTTTAAAAGAAGCTCTTGCATAGTAGCTTTTGTCTATTTTAACATTGCAGCCATTTGTACTTTGATATCACTAgGTGACATCACTATTTTCTTAACCTTTGTGACTGTTTCAATATTACCCCCATGAAAGCTTTTTTTTATGTACCTTTGAGTACATTATAATTGTCTTATATTTTAAAGTCATTAGTTGGGCTTTACTGTTCTTGCTATTGTATGACATATACATCTGCCTGGATATATTTTTACTCTTGACCAAAGTTTTATAAGAACAATATAAGATTTAGGGTAGGGGCATGGGGAGGAAGGATATTTTATTAAGAACTACTTAA
>NM_138288.4
AGACTGACGTGTGAGCTGCATCGCGGGAggcgcatggcggggatggcgctggcgcgggcctggAAGCAGATGTCCTGGTTCTACTACCAGTACCTGCTGGTCACGGCGCTCTACATGCTGGAGCCCTGGGAGCGGACGGTGTTCAATTCCATGCTGGTTTCCATTGTGGGGATGGCACTATACACAGGATACGTCTTCATGCCCCAGCACATCATGGCGATATTGCACTACTTTGAAATCGTACAATGACCAAGATGCGACCAGGATCAGAGGTTCCTTGGGGAAGACCCACCCTACGAAGTTGGAATGAGACCATCAGATGTGATAAGAAACTCTTCTAGATGTCAACATAACCAACCTTATAAAGACTAAAATTCATGAGTAGAACAGGAAAATCATCCTGACTCATGTGTTGTGTTCTTTATTTTTAATTTTCAAAGAGGCTCTTGTATAGCAGTTTTTGTCTATTTTAACATTGTAGTCATTTGTACTTTGATATCAGTATTTTCTTAACCTTTGTGACTGTTTCAATATTACCCCCGTGAAAGCTTTTCTTAATGTAACTTTGAGTACATTTTAATTGCCTTCTATTTTTAAAACTCAAAATCATTAGTTGGGCTTTACTGTTCTTGCTATTGTATGGCATATACATCTGCCTGGATATATTTCTACTCTTGACCAAAGTTTTGTAAAGAACAATATAAGATTTCGGGTAGGGGTATGGGGAGGGAAGATATTTTATTGAGAACTACTTAACAAAAGATTTATCTGTAAGCTTGAACTCAGGAGTACAGTTTTAGCTATCTAGACTCTAACAGCTTTTGCTTTAAAATTATTAAAGTGTTTCTTAATGAAAAAGAAAAGATCTTGCTAAAGTTAAAATAAGGAACATTTCACCTTTTAAATATTTAATTCTTATGTGGACTTATTTCCAGAAAACTTTGGTGATAATTCTTGAGACAAAAGGTGGTTAAGTAGCATTATTATGTAATGCTTATATACCATAGAGTTTTTAATAGAAGAGAAATCCATTTCCTCCGAGGGTCACTATTAACAATGTACTTCCTTAAATTTAGTTTAATGATTGTAATGGGTGCTGCATTTGCACATTGCATTAAGTTATGATGAGACGAATTGTTGTTAAAAATTATAGCAAAAAGAAATGTAAACTTGGTTAAAATCCTTTCACTCTTTGTATTGTTTTTTTTAAGGTTTTTATTCCTTAAATGTAAAATGACTACCTAATTTTTTGATGTAAATACATTAAATTCAAAGAGAAAAAAAATCAGCTGATGTAGCAGTATATCTTTTCCTTGATGGTTAAATATTGATCTAGTATTTATATTGCTGAATTATTTTCTGTGGAGGACCAGATAAGCAGTAAGTATGTCTTATCCTATATGTTTTGCAACATAAAAATATTGCTAATTGAAAAGAATTAGGCAATTATGTGTGTTGCTGGGTTGtttttttgtttttttttttttgagacggagtcttgccctgtcgcccaggatggagtgcaacagcatgatctcggttcactgcaacctccatctcctgggatcaagtgattctcctgcctcagcctcctgaatagctgggattacaggcacctgccaccatgcctggctaattttttgtatctgtagtagagacggggtttcactgtgttggccaggatggtctcaaactcctgacctcctgatccacctgcctcggcctcccaaagtgctgggtttacaggcgtgagccaccgcgcccggccAAAATTGAGGTATTTTTTGCCCTACGTTTTAAGGACTAGACTTTTGAAGTATTTTATAGTCTAGAGGTCTCAAGTAATATATATGTGTTTAATATTTTTAGAGCCAATTGATACCACAATTAGATAGGAGTAGTGAGAATAATATGGAATTACTTGGTTTGAAGTAGTTAAAAATTGGATATGGTTATATCTGAGCTGTAGTCATATTATCTCAAGAAAAATAATACGAGGATTTAACATAAGATTTGTTCTATTAATGCCCAAATTTGGCTTTCCTCTACTATCCCCCATAGAGAACCACTAACAAGTGGATGTCTAATATTCCTCTGGTGAGTTGAAGGCAGGAGAAGTTGAGAATCATTAGTTTCAATGAGTATCCAGGTGACCTATCCTGGCCCTCTACTCAGAAACCGGCAATTTGTCTTCACTCTGAGATTCATTAAATTGCTGTTGTATAACTGATGGTTATTATGAACACTGACCTGTGAGACATATGGAAGATAAAGTTTGGTCTTACAGGAAATCTTGAGGAGAGTCAAAAGAGAAATGGGAGATGTCTCTTGAGAGGTGATCAGAGAAGTTTATGCTCACTGTCTGATGCAAATGTCTGGTCTATTTGTTAGTAAATAACAGGGAAATCATTTTCACTTTTTGTTAAAAATAAGGTATTTAcaagcataccttgtagttattgtgggttcagtttcagaccactgcaataaagtgaatatctcaataaagtgagtcacatgaagttttttggttttcccctgcatataaaagttacatttacaccatcctgtagtctattaagtgtgcagtagcattatggctaaaaaaaaaaaacacccaatatacctatcttaattaaagaattatttattgctgaaaaaa

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