Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SDHCP4
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:17435022-17436206  UCSC
Coordinates (T2T) chr11:17532620-17533804  UCSC
Coordinates (hg19) chr11:17456569-17457753  UCSC
Strand -
Parental Sequence NM_003001.5
Parental seq. overlap 1115 bp
Parental seq. overlap (%) 85.1%
Genomic Region Intragenic (ABCC8)
Retrocopy Summary SDHCP4, located on chr11:17435022-17436206, is a retrocopy of the parental gene SDHC. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SDHC
Full Name succinate dehydrogenase complex subunit C
Also known as CYB560|CYBL|PGL3|QPS1|SDH3
Coordinate chr1:161314381-161375340
Strand +
Gene summary This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SDHCP4
Bonobo Pan paniscus SDHCP5
Gorilla Gorilla gorilla SDHCP4
Orangutan Pongo abelii SDHCP4
Gibbon Nomascus leucogenys SDHCP3
Green monkey Chlorocebus sabaeus SDHCP1
Crab-eating macaque Macaca fascicularis SDHCP9
Rhesus Macaca mulatta SDHCP9
Baboon Papio anubis LOC101006239P7
Golden snub-nosed monkey Rhinopithecus roxellana SDHCP8
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SDHCP4
ACTTCCATCCAGACCAGAACCCAAGATGGCTGTGCTCTTGCTGAGACATGTTGGTTGTCATTGCCTCCGAGCCCACTTTAGCCCTCAGCTCTGTACCAGAAATGCTGTTCCTTTGGGAATCACAGCCAAAGAAGAGATGGAGCAGTTCTGGAATAAGAACACAAGTTCAAACTGTCCCATATCTCCCCACATCACTATCTACAGTTGGTCTCTTCCCATGGCGATGTCCATCTGCCACCGTGGCACTGGTATTGCTTTGAGTGCAGGGGTCTCTCTTTTTGGCATGTTGGCCCTGTTACTCCCTGGGAACTTTGAGTCTTATTTGGAATGCGTGAAGTCCCTGTGTCCGGGGCCAGCACTGATCCACACAGCTAAGTTTGCACTCATCTTCCCTCTCATGTATCATATCTGGAATGGGGTCTGACACTTGATGTGGGACCTAGGAAAAGGCCTGAAGATTCCCCAGCTATACCAATCTGGAGTGGTTGTCCCGGTTCTTACTGTACTGTCCTCTGTAGGGCTGGCAGCCATGTGAAGAACAGAGGTTCCCAGCATCATCTTCCTACACATTATTACATTCACCCATCTTTCTGTTTCTCACTTTTATCTCCAGCCTGGGAAAAGTTCTCCTTATTTGTTTAAATCCTTTTGTGCTTTTAGATCCCCTTGGAGCAGTAGAGTACCTTGTAGACCATAAGAGTGGAAAAGGGTCTAGTTTTCTCCTTGTTTCTAAAGATGGGGTGGCTGAAAAAACTCCCCTTTTTTGCCTACAGCTTGCCTCTCTGGGCCTAGAAGTGGTTATTCTGTCTCCATATTGGCCTTTGATTTGTGCTGAGGGTCAGCTTTTGGCTCCTTCTTCCTGAGACAGTGGAAACAATGCCAGCTGTGTGGCTTCTGCCCTGGGGGCTGGGGGTGAGGCTTTGGGTGCCACTGCCTGTGGGTTGCTGGCTTAAAGGACAATTCTGTTCATTGGTGAGAGCCCAGGCCATTAACACCTACGCAGTGTTATTGAAAGAAGAGAGGCGGGGGTGGAGGGGAATTAGTCTATCCCAGCTAGAGGGAGATAAAGAGGGCTAGTTAGTTCTTGGAGCAGCTGCTTTGAGGAGAAAATGTATAGCTTTTGACACAACAGGAAGATCCAGAAAATTATCATTGAACATATTAAAGGTTATTTCTTTTTCTTGC
>NM_003001.5
ACTTCCGTCCAGACCGGAACCCAAGATGGCTGCGCTGTTGCTGAGACACGTTGGTCGTCATTGCCTCCGAGCCCACTTTAGCCCTCAGCTCTGTATCAGAAATGCTGTTCCTTTGGGAACCACGGCCAAAGAAGAGATGGAGCGGTTCTGGAATAAGAATATAGGTTCAAACCGTCCTCTGTCTCCCCACATTACTATCTACAGTTGGTCTCTTCCCATGGCGATGTCCATCTGCCACCGTGGCACTGGTATTGCTTTGAGTGCAGGGGTCTCTCTTTTTGGCATGTCGGCCCTGTTACTCCCTGGGAACTTTGAGTCTTATTTGGAACTTGTGAAGTCCCTGTGTCTGGGGCCAGCACTGATCCACACAGCTAAGTTTGCACTTGTCTTCCCTCTCATGTATCATACCTGGAATGGGATCCGACACTTGATGTGGGACCTAGGAAAAGGCCTGAAGATTCCCCAGCTATACCAGTCTGGAGTGGTTGTCCTGGTTCTTACTGTGTTGTCCTCTATGGGGCTGGCAGCCATGTGAAGAAAGGAGGCTCCCAGCATCATCTTCCTACACATTATTACATTCACCCATCTTTCTGTTTGTCATTCTTATCTCCAGCCTGGGAAAAGTTCTCCTTATTTGTTTAGATCCTTTTGTATTTTCAGATCTCCTTGGAGCAGTAGAGTACCTGGTAGACCATAATAGTGGAAAAGGGTCTAGTTTTCCCCTTGTTTCTAAAGATGAGGTGGCTGCAAAAACTCCCCTTTTTTGCCCACAGCTTGCCTACTCTCGGCCTAGAAGCAGTTATTCTCTCTCCATATTGGGCTTTGATTTGTGCTGAGGGTCAGCTTTTGGCTCCTTCTTCCTGAGACAGTGGAAACAATGCCAGCTCTGTGGCTTCTGCCCTGGGGATGGGCCGGGTTGGGGGGTGGGTTGGTGAGGCTTTGGGTGCCACTGCCTGTGGGTTGCTGGCTTAAAGGACAATTCTCTTCATTGGTGAGAGCCCAGGCCATTAACACCTACACAGTGTTATTGAAAGAAGAGAGGTGGGGGTGGAGGGGAATTAGTCTGTCCCAGCTAGAGGGAGATAAAGAGGGCTAGTTAGTTCTTGGAGCAGCTGCTTTTGAGGAGAAAATATATAGCTTTGGACACGAGGAAGATCTAGAAAATTATCATTGAACATATTAATGGTTATTTCTTTTTCTTGGATTTCCAGAAAAGCCTCTTAATTTTATGCTTTCTCATCGAAGTAATGTACCCTTTTTTTCTGAAACTGAATTAAATACTCATTTTATCTTTGACTCTCCTTGAAA

Publications

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