RCPedia: Rtcs

Summary

Retrocopy Name	WIZP1	Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr11:23403385-23407050 UCSC
Coordinates (T2T)	chr11:23527199-23530864 UCSC
Coordinates (hg19)	chr11:23424931-23428596 UCSC
Strand	+
Parental Sequence	NM_001330395.4
Parental seq. overlap	3227 bp
Parental seq. overlap (%)	54.1%
Genomic Region	Intergenic
Retrocopy Summary	WIZP1, located on chr11:23403385-23407050, is a retrocopy of the parental gene WIZ. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	WIZ
Full Name	WIZ zinc finger
Also known as	ZNF803
Coordinate	chr19:15419978-15449956
Strand	-
Gene summary	Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; histone methyltransferase binding activity; and transcription corepressor binding activity. Involved in positive regulation of nuclear cell cycle DNA replication and protein stabilization. Located in midbody and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	WIZP1
Bonobo	Pan paniscus	WIZP1
Gorilla	Gorilla gorilla	WIZP1
Orangutan	Pongo abelii	WIZP1
Green monkey	Chlorocebus sabaeus	WIZP1
Crab-eating macaque	Macaca fascicularis	WIZP1
Rhesus	Macaca mulatta	WIZP1
Baboon	Papio anubis	WIZP1
Golden snub-nosed monkey	Rhinopithecus roxellana	WIZP1
Gibbon	Nomascus leucogenys	Without Homology
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>WIZP1
GGGAGCCAAGATGGCCGCCTCCACCGCCCAGTTTCGTGACAGAAGCGGAGAGCAAGGCGGCGGCGGGGCCGCGCGCTGGGCGCGACGGGAGCGCGCGCCCGCCTGGCCACCCCAGCCCAGGCTCCCGAGCCCGGGCCCTGCGGCACAGGCCTGGGTTCTGAGGAAAAGGCAATGGTGGCCATGGACCTGGGCTCTCTTCACTCCCTAAGAAAAGCCTGCCTGTCCCTGGGGCCCTGGAGCAGGTGGCCAGTTGGCTGAGCAGCAAAGTGGCTCCAGAGGTTCCTCATGGCAGCAAACAGGAGCTGCAGGACCTCAGATCCCAGAGCCTGCCACCTGCAAGGTCTGTGGCGCCTGCTTTGGGACCGGAAAGGGCCTGTCCATCCACACACGCTCCCACCTGCGGCAGCTGGGAGTGGCAGAGTCAGAGACGAGCGGCGTACCCATCAACCTCCTCTAGGAGCTTGTGAAGCAGAAGAGCATGCCCGACGCCCACCTTGGGCTGCCCCCGGGCCTGGCTAAGAAGTCCAGCTGGCTGAAGGAGGTGGTCGCCCGGGACCCCGGCCCGGCTTGCTTACCCTGGCCAAATCCTTGGATGCCCCTGCTGTCAACAAAACCATCAAGTTGCCTCTCGGCTTCTCGACCAAGGGCCTGGGCCAACTCCCAGCTCTCCGCTCCTTGAAAAGACACCACTGGCCCTGGAGGGCTCCCCTACTCCTAAGAATCCTGAGGACAAGAGCCCCGAGCTATCCCCGAGCCCATGGCCGGCCTCCCAAAAGGCACAGTGGCCTCAGTCAGGCCCTTGAACCTCACCTCAGGCCTAGAGCCAGCACAAGAAATCTGTTGCTGTGAGTTCTCTGGTGAGTTCTTCTAGAACCGCAAGGGCCACTCGAGCCACACGGGCTCCCACCTGCAGCAAATAGGCGTGACCGGGGGGTACGTCAATGGCTCGCCCATCGACAGACTGTGGGAGATCCTGAAGAGACGGACCCAGTTTCGCTCTGGCAGACCTCCCAACCCGCCAGGGCCAAGTCCAAAAGCCCTGGCCAAGATGATGGACGGCACAGGTCCTGGCAGCTCACTGGAAACCCGCAGCCCCTCTGACCTTCACATCTCACCCTTGGCCAAGAAGTTGCCGCCGCCACCAGGCAGACCCCTGGGCCACTCACCAACTGCCTTTCCTCCTCCCGTGCCCGGAAGATGTTCCCAGGTCTGGCTGCACACTCCCTGCCCAAGAAGCTGAAGCCTGAACAAATACGGGTGGAGATCAAGCGGGAGATGCTGCCGGGGGCCCTTCGTGGGGAGCTGCACCCATCTGAGAGTCCCTGGGAGGCACCACGGGAAGACATGATACCCCTGAACCTGTCTTCCCGGGCAGAGCCGGTGCGCAATATCCCCTGTGAGTTCTGCAGCGGGTTCTTTGAGAACCGCAAGGGCCTGTGTAGTCACGCACGCTCCCACTTGCTGCAGATGGGTGTGACCGGGTGGTCCGTCCATGGTTCGCCCATTGACACTGCGAGAGATCCTCAAGAAGTCCAAGCTGTGCCTCATCAAGGAGGAGCCACTGGCTGCAGACCTGGCCCCGGCCTTGGCTGAGGATGGGCCTCCCACTGTGGTCCCTGGGCCCGTTGCCGGTATCTTCTGGCCGGCCAGGCAAACCAGGCTCAGGGCCGGCCCAGGTTTCCTCGCGAGCTCAGCCTGAAGCCCATCACTGGGGCCAAGCCCTCACCCACTGGCTACCTGGGCTCAGTGGCAGCCAAGTGGCCTCTGCAGGAGGACTGCCTCCTCCCAGCAGAGGTCAAGGCCAAGACCTACATCCAGACTGAACCGCCCTTCAAGGCAAAGACCCTTCACGAGAAGACCTCCCATTCCTCCACCGAGACCTGCTGCGAGTTGTGTGGGCTTTACTTTGAAAACCGCAAGGCTCTGGCCAGCCACGCACGGGAACACCTGAGGCAGTTCGACGTGACCGAGTGGTGCGTCAGTGGTTCGCCCATCGAGACACTGAGCGAGTAGATCAAGCACCAGCCCCAGAAGGTGGGCACCTACCACAACTACATCCAGGGCGGCTGCCCCTTCACCAAGAAGTTCCCCAGTGCCATCCATGGCCGTGACAGTGACAAGCGGCCGTCCCTGGGGCTGGCACCTGGGAGCCTGGCCATGGTAGGACGCAGCGCTGGGGGCAGGGCCTGAGGCTGGCGCGGCAGTCGACAGTGGTAAGAGGCCTCTGGCAGCCAGCCCGCCAGGCACCGTGAAGGCTGAGGAGCACCAGCCGCAGAACATCAACAAATTCGAACGCCGACAAGCTCGCCCTGCAGATGCCTCCGCAGCCCGGGGAGGTGAGGAGACCAATGACCTACAGCAGAAGCTGGAGGAGGTGAGGCAACCTCCAACCCGAGTCCGGCCAGTCCCCTCCCTGGTGACCTTGACATCACTTGTCAAGTTCGTGGGCAACATCTACACGTGTCCTCAAATGCAGGTTCTGCGAGGTGGAATTCCAGGGCCCCCTCTCTATCCAGGAAGAGTAGGTGCGGCACTTACAGCGGCACATCCTGGAGATGAACTTCTCCAAAGCGGACCCCCAGCCTAAGGAGTCCCAGGTCCCGCAGGCACAGACAGTGGCGGCAGAGGCTTCCTAACACAAAAGCATTCCAGATCCCCTCTCGTGCCACCTATGTCATAGGAGTAAGCCAAAACCTCAAACCAGCGCCCCCTTGGGGGCTGGGCACACTACAGCCAGGGCGCCGGGAGCCAGCTAGCCGCCCTTCCCCCAGCCCAAAGACTCTGGGACCACAGGGTGTCTTCCTTCAGCCTATGCCCACCTGGTCCAGCAGGGGCAGCAGCCAGGTCTCGGGTGGCAGCCGATCTGGTCACAGGGGAGGACAGCATTCCCCCGTCTAGCAGCCAGGCAGGGCGATGTCTGCCATCGGTGGCCATTTGCAAAGACCCCAAAGACCCCTGTTCTGGTTTCCTCTCGCCCCCATGAATATCCTCTCAAACGCGTCTACATGCGAACACACACGCACCTCGTGAGACCTGGGATCTGCCCCGGACCCCCAGTTCCAGGGTTGAACGACCACATCATGCCACAGTGCTTGCTCAGGGGAAGCCACGCTCCCTCTGTGGGGCCCGCTGGAGCCTGGGAGCCCCCCACTGACCCCACAATGCCACGGAAATCCTTGTTGGCTGCCCCCCAGAGGGGCCTTCCCAACTGGGAAGAGCCTAGAGCTGACAGCTGGCTCCTGCCATGTCAAGACTCCCAAAGAGCGGGGTGGGAtTTTCACTGTTGCTTTCTATGTATGGCTCCCTACATTTTTCACTTTTTTAAAAACGCGTTTTGTGTATAAAATAAAGAACGTGGATCTTTTTATTTTGCAATCCTGGGCCAGCTAGAAGCCAGGAGCTGATTGACCTTTTAGCTTTTTTCAGTGGCCGCATTTTGATTATCGATGTACCTAGAAGTATGTAAATTAGATTAAATTTCTCTTCTGGAAA

>NM_001330395.4
ACTCGGCGCTCAGCTGCTCCCGCCTGGGGCGGCCGCCCCGCGTGCGCCGGAGCCAAGATGGCCGCCTCCACCGCCCAGTGCCGAGTGACAAAAGCGGAGAGCAAGGCGGCGGCGGGGCCGCGCGCGGGGGGCGCCCGGGAGCGCGCGCCCGCGGGGGcgcccccgcccagccccccgagcccgggccccgcggcaccccccgcgccgccgccgccgcccccacccccgccgccgccgccaccaccaccgccaccgccaccgccgccgcGGGACGGGCCCAAGGCCGAGCCGGAGCCGGGGCCCGGGCCCGCGTCCGCTCCCGCGCCCGGCCTGGGTTCTGAGGAAAACGCAATGGTGGCCATGGACTTGGGCTCTCCCTCGCTCCCTAAGAAGAGCCTGCCTGTCCCTGGGGCCCTGGAGCAGGTGGCCAGTCGGCTGAGCAGCAAAGTGGCTGCAGAGGTTCCTCATGGCAGCAAACAGGAGCTGCAGGACCTCAAGGCCCAGAGCCTGACCACCTGCGAGGTCTGCGGTGCCTGCTTTGAGACCCGAAAGGGCCTGTCCAGCCACGCGCGCTCCCACCTGCGGCAGCTGGGAGTGGCAGAGTCGGAAAGCAGCGGCGCACCCATCGACCTCCTCTACGAGCTTGTGAAGCAGAAGGGTCTGCCTGACGCCCACCTTGGGCTGCCCCCAGGCCTGGCTAAGAAGTCCAGCTCACTGAAGGAGGTGGTCGCCGGGGCCCCCCGGCCCGGCTTGCTCAGCCTGGCCAAGCCCTTGGATGCCCCTGCTGTCAACAAAGCCATCAAGTCGCCTCCCGGCTTCTCGGCCAAGGGCCTGGGCCACCCGCCCAGCTCTCCACTCCTCAAAAAGACACCACTGGCCCTGGCGGGCTCCCCTACCCCTAAGAATCCTGAGGACAAGAGCCCCCAGCTGTCCCTGAGCCCCCGGCCGGCCTCCCCAAAGGCACAGTGGCCTCAGTCTGAGGATGAGGGGCCCTTGAACCTCACCTCAGGCCCAGAGCCAGCACGAGACATCCGCTGCGAGTTCTGTGGTGAGTTCTTCGAGAACCGCAAGGGCCTCTCGAGCCACGCGCGCTCCCATCTGCGGCAAATGGGCGTGACCGAGTGGTACGTCAATGGCTCGCCCATCGACACGCTGCGGGAGATCCTGAAGAGACGGACCCAGTCTCGGCCTGGTGGACCTCCCAACCCACCAGGGCCAAGCCCAAAAGCCCTGGCCAAGATGATGGGCGGCGCAGGTCCTGGCAGCTCACTGGAAGCCCGCAGCCCCTCGGACCTTCACATCTCACCCTTGGCCAAGAAGTTGCCACCACCACCGGGCAGCCCCCTGGGCCACTCACCAACTGCCTCTCCTCCTCCTACGGCCCGAAAGATGTTCCCAGGCCTGGCTGCACCCTCCTTGCCCAAGAAGCTGAAGCCTGAACAAATACGGGTGGAGATCAAGCGGGAGATGCTGCCGGGGGCCCTTCATGGGGAACTGCACCCATCTGAGGGTCCCTGGGGGGCACCACGGGAAGACATGACACCCCTGAACCTGTCGTCCCGGGCAGAGCCGGTGCGCGACATCCGCTGTGAGTTCTGCGGCGAGTTCTTCGAGAACCGCAAGGGCCTGTCGAGTCACGCGCGCTCACACCTGCGGCAGATGGGTGTGACCGAGTGGTCCGTCAATGGTTCGCCCATCGACACACTGCGAGAGATCCTCAAGAAGAAGTCCAAGCCGTGCCTCATCAAGAAGGAGCCACCGGCTGGAGACCTGGCCCCTGCCCTGGCTGAGGACGGGCCTCCCACCGTGGCCCCTGGGCCCGTGCAGTCCCCACTGCCGCTGTCGCCCCTGGCTGGCCGGCCAGGCAAACCAGGTGCAGGGCCGGCCCAGGTTCCTCGTGAGCTCAGCCTGACGCCCATCACTGGGGCCAAGCCCTCAGCCACTGGCTACCTGGGCTCAGTGGCAGCCAAGCGGCCCCTGCAGGAGGACCGCCTCCTCCCAGCAGAGGTCAAGGCCAAGACCTACATCCAGACTGAACTGCCCTTCAAGGCAAAGACCCTTCATGAGAAGACCTCCCACTCCTCCACCGAGGCCTGCTGCGAGCTGTGTGGCCTTTACTTTGAAAACCGCAAGGCCCTGGCCAGCCACGCACGGGCACACCTGCGGCAGTTCGGCGTGACCGAGTGGTGCGTCAATGGCTCGCCCATCGAGACACTGAGCGAGTGGATCAAACACCGGCCCCAGAAGGTGGGCGCCTACCGCAGCTACATCCAGGGCGGCCGCCCCTTCACCAAGAAGTTCCGCAGTGCCGGCCATGGCCGTGACAGTGACAAGCGGCCGTCCCTGGGGCTGGCACCCGGGGGCCTGGCCGTGGTCGGCCGCAGTGCCGGAGGGGAGCCAGGGCCCGAGGCTGGCCGGGCAGCCGACGGTGGTGAGCGGCCTCTGGCAGCCAGCCCGCCAGGCACCGTGAAGGCTGAGGAGCACCAGCGGCAGAACATCAACAAATTTGAACGCCGACAAGCCCGCCCTCCAGATGCCTCCGCAGCCCGGGGAGGCGAGGACACCAATGACCTACAGCAGAAGCTGGAGGAGGTGCGGCAACCCCCACCCCGAGTCCGGCCAGTCCCCTCCCTGGTGCCCCGGCCCCCCCAGACATCACTTGTCAAGTTCGTGGGCAACATCTACACCCTCAAATGCAGGTTCTGTGAGGTGGAATTCCAGGGCCCCCTCTCCATCCAGGAAGAGTGGGTGCGGCACTTACAGCGGCACATCCTGGAGATGAACTTCTCCAAAGCGGACCCCCCACCTGAGGAGTCCCAGGCCCCGCAGGCACAGACAGCGGCGGCAGAGGCTCCCTAACACAAAAGCATTCCAGATCCCCTCTCGTGCCAcctctgtctcctcttcttcctcctctgtgtccttgtccctcttcctctttctttccgtttccAAAGGAGCAAGCCAAAACCTCAAACCGGCGCCCCTTGGGGGCCGGGCACACTACAGCCAGGGCGCCGGGAGCCAGCTAGCTGCCCTTCCCCCAGCCCGAGGACTCTGGGGCCACAGGGTGTCTTCCTTCAGCCCATGCCCACCTGGTCCAGCAGGGGCAGCAGCCAGGTCTCTGATGGCAGCCGGTCTGGTCACAGGGGAGGACAGCACTCCCCCGTCTAGCAGCCAGGCAGGGCGATGTCTGCCATCCGTGGCCATTTGCAAAGACCCCAAAGACCCCTGTTCTGGTTCCCTCTCTCCCCCATGAATATCCTCTCACACACATGTACATGCGAACACACACAACACGCACCTCGTGAGACCCGGGACCTGCCCCGGACCCCCAGTTCCTGGGTTGAACGACCACATCATGCCACGGTGCTTGCTCAGGGGAAGCCACGCTCCCTCTGTGGGGCCTGCTGGGGCCTGGGAGCCCCCCACTGAGCCCACAATGCCACGGAAATCCTTGTTGGCTGCCCCCGAGAGGGGCCTTCCCAGCTGGGAAGAGCTCAGAGCTGACAGCTGCCTCCTGCCATGTCAAGGCCCCCCAAAGAGCCTCAGGGGCTCTGGGGCCCTGGAGGGTGGGGTTGGGGGGTGGGACTCTCCTCCCCCACTCCTGCTCCCTCTCCCTTTTCACTGTTGCTTTCTATGTATAGCTCCCTAGACCTTTCACTTTTTTAAAAACGCGTTTTGTGTAGAGAATAAGGAACGTGGATCTTTTTATTTTGCAATCCTGGGCCAGCTAGAAGCCAGGAGCTGATTGACCTTTTAACTTTTTTCAGTGGCCACATTTTGGTTATCGATGTACCTAGAAGTATGTAAATTAGATTAAATTTCTCTTCTGGAAACACCCTGGGGCAGGCGGCCAGCGTGTGTTTTTCTGTCAAGTGGACAGGCTGGCATTGGCTGGCAGCCGGGGCTGGGATCGGGGCCTCCTCTGTCCAGAGCGCCATGGAGGCCCTGGGTTTTCCAGTTGGCCGCCAAGCCGACCAGACGCAGCTGGGGATGAGCCCAAGTTCCCAGCTGTTGGCTCTTTAGGCCATGGCTGGGAGGGGGTCTCTGGCTGGCTGGCAAAGCGGCTCCAGTGAGCAGATGAACCAGGGTTCTGGGCAGCCTGTCTGGGAAGGGAGCCAGGATCAAGAAGCAGTTGAGGCTAGAGGAGCTTATCAAAGGCAGGAGCTACCAGCGAGGGTGTCAGGGACCCGTTGGGAGCATTTGGGTGGGGGCCAGTGGGGTTGTAGAGAGCTGGAACTCACCTGCTTTTAATACATGTGACTTCTAGTGAGACACATGCACCCCTGACCCAAGGAACATGCGGGGAAAAGAGGAGCCACTGGCTCCTTTGCGATGTTATTTATTTTCTCGCTCTGCAAATGTTTATTGAACATTTCTGAGATTTTAAGAGATTTTGTTGGCTGCTCCTTCTTGTTTATTGCATGTGGTTTTTCAGCTCATCGTTTTTACTAAACGGTCAAGTGCTGGAGAGTGGGAACGACCTCATGGCGTGTGGACAGAAGGGGCCACCTCTACCCCCAGCCCTGCTTTCTGGGCCCTCCCACCATACCCCTTCCTGGGAAGGAGGGATTAACAGGCTGCAATAACGCCCACAAGGGTGGTCTTGGCCCACACGTCTGCTCCTGTGGGGTCAGGACGCACATCTCGCCTGGTGGCAGAAGGCCGCAACCACTTCTCTCCATCCTGTGCTGTGGGTGGGTGGATGTATCCAGGACTTAGGAAGCAGGGAGAGCATCTTGTGAGCTGACTCAAAGGTGTTTCTTCCTCTTTCAACTTTTCATAAGTCAGtttttatttttttattttattttttgagacagggtctcattttgttgcccaagctggagtgcagtgtagggacctcggctcgctgcagtctctgcctcctgggttcaagtgattctcctgcctcagccatccaggtagctgggatcacaggcatgcaccaccacccctggcttatatctgtaatttttgtagagacgggggtttcaccatgttgcccgggctggtcttgaactcctgagctcaagtgatcagcctcccaaagtgctgggattacaggcgtgagccactatgcccggccCGTAAGTCAGTTTTTGAAATATAAAAGTGGTATAGGCTAGATGTGACAAAAAACAGTCAAATGATACAAGAGCTTATAAAGTCATATGGCAAGTTCCTCCCCACCAATCATGCAGTGAAGTGAGGGTCATGTGTGTCCTTGGAAGAGTCACCTCCAGTTCTTGCAGGGGGATGTTTTCCTAAAACTTTCTGAGCATTGCTCTTCTCTGCTCAAGCCACTTCAATACACCTCAGGCAGCAAAGTCTCAGCTTTTGAGCCGTGGTCTCTGAGGGTGTTGGATGTGAACGAAATCAAATCGGTACAATGATGACTGTGGCAAGTGCGATGAAGGAACGAACCTGCAGGGCGCAGAAGACGTGTCCTGGGGCCCTGCCTTGGTTTGGAAGACAGGCAGGCATCCCTGAGGCTGATGGGGAGATGAACCCCGAAGCCAGAGTGCTTATCCGTCAGATCTCTGCTTCATGTTTGGAGTTTGCTCACTTAACACATCAGAAGTGGCTTTGTTCCGTATGGCAGCAAGTTCTGCAGAAGCCTCATTTGGGTGGGGGGAGttttattaaaacagtttatcatggagaattccaactatacaaaagtagagcaaacagtaaaatggactctcatctatccatcaccaacccatgaccaatgtcttcagctgtcagagatttatcttatagctccttgcttcctcctcctctctctacctgtctgaattgtgtgaagcacatcctggccataagatcagttaacttcttagtatttcagtatgtttctctcaacgttgtaaatgccactattacacctaaagaaatcaacaataTCAAAAAGAAACAGCATACCTTAAAAAAAGTTTTAAAACACA

>NM_001330395.4 

ACTCGGCGCTCAGCTGCTCCCGCCTGGGGCGGCCGCCCCGCGTGCGCCGGAGCCAAGATGGCCGCCTCCACCGCCCAGTGCCGAGTGACAAAAGCGGAGAGCAAGGCGGCGGCGGGGCCGCGCGCGGGGGGCGCCCGGGAGCGCGCGCCCGCGGGGGcgcccccgcccagccccccgagcccgggccccgcggcaccccccgcgccgccgccgccgcccccacccccgccgccgccgccaccaccaccgccaccgccaccgccgccgcGGGACGGGCCCAAGGCCGAGCCGGAGCCGGGGCCCGGGCCCGCGTCCGCTCCCGCGCCCGGCCTGGGTTCTGAGGAAAACGCAATGGTGGCCATGGACTTGGGCTCTCCCTCGCTCCCTAAGAAGAGCCTGCCTGTCCCTGGGGCCCTGGAGCAGGTGGCCAGTCGGCTGAGCAGCAAAGTGGCTGCAGAGGTTCCTCATGGCAGCAAACAGGAGCTGCAGGACCTCAAGGCCCAGAGCCTGACCACCTGCGAGGTCTGCGGTGCCTGCTTTGAGACCCGAAAGGGCCTGTCCAGCCACGCGCGCTCCCACCTGCGGCAGCTGGGAGTGGCAGAGTCGGAAAGCAGCGGCGCACCCATCGACCTCCTCTACGAGCTTGTGAAGCAGAAGGGTCTGCCTGACGCCCACCTTGGGCTGCCCCCAGGCCTGGCTAAGAAGTCCAGCTCACTGAAGGAGGTGGTCGCCGGGGCCCCCCGGCCCGGCTTGCTCAGCCTGGCCAAGCCCTTGGATGCCCCTGCTGTCAACAAAGCCATCAAGTCGCCTCCCGGCTTCTCGGCCAAGGGCCTGGGCCACCCGCCCAGCTCTCCACTCCTCAAAAAGACACCACTGGCCCTGGCGGGCTCCCCTACCCCTAAGAATCCTGAGGACAAGAGCCCCCAGCTGTCCCTGAGCCCCCGGCCGGCCTCCCCAAAGGCACAGTGGCCTCAGTCTGAGGATGAGGGGCCCTTGAACCTCACCTCAGGCCCAGAGCCAGCACGAGACATCCGCTGCGAGTTCTGTGGTGAGTTCTTCGAGAACCGCAAGGGCCTCTCGAGCCACGCGCGCTCCCATCTGCGGCAAATGGGCGTGACCGAGTGGTACGTCAATGGCTCGCCCATCGACACGCTGCGGGAGATCCTGAAGAGACGGACCCAGTCTCGGCCTGGTGGACCTCCCAACCCACCAGGGCCAAGCCCAAAAGCCCTGGCCAAGATGATGGGCGGCGCAGGTCCTGGCAGCTCACTGGAAGCCCGCAGCCCCTCGGACCTTCACATCTCACCCTTGGCCAAGAAGTTGCCACCACCACCGGGCAGCCCCCTGGGCCACTCACCAACTGCCTCTCCTCCTCCTACGGCCCGAAAGATGTTCCCAGGCCTGGCTGCACCCTCCTTGCCCAAGAAGCTGAAGCCTGAACAAATACGGGTGGAGATCAAGCGGGAGATGCTGCCGGGGGCCCTTCATGGGGAACTGCACCCATCTGAGGGTCCCTGGGGGGCACCACGGGAAGACATGACACCCCTGAACCTGTCGTCCCGGGCAGAGCCGGTGCGCGACATCCGCTGTGAGTTCTGCGGCGAGTTCTTCGAGAACCGCAAGGGCCTGTCGAGTCACGCGCGCTCACACCTGCGGCAGATGGGTGTGACCGAGTGGTCCGTCAATGGTTCGCCCATCGACACACTGCGAGAGATCCTCAAGAAGAAGTCCAAGCCGTGCCTCATCAAGAAGGAGCCACCGGCTGGAGACCTGGCCCCTGCCCTGGCTGAGGACGGGCCTCCCACCGTGGCCCCTGGGCCCGTGCAGTCCCCACTGCCGCTGTCGCCCCTGGCTGGCCGGCCAGGCAAACCAGGTGCAGGGCCGGCCCAGGTTCCTCGTGAGCTCAGCCTGACGCCCATCACTGGGGCCAAGCCCTCAGCCACTGGCTACCTGGGCTCAGTGGCAGCCAAGCGGCCCCTGCAGGAGGACCGCCTCCTCCCAGCAGAGGTCAAGGCCAAGACCTACATCCAGACTGAACTGCCCTTCAAGGCAAAGACCCTTCATGAGAAGACCTCCCACTCCTCCACCGAGGCCTGCTGCGAGCTGTGTGGCCTTTACTTTGAAAACCGCAAGGCCCTGGCCAGCCACGCACGGGCACACCTGCGGCAGTTCGGCGTGACCGAGTGGTGCGTCAATGGCTCGCCCATCGAGACACTGAGCGAGTGGATCAAACACCGGCCCCAGAAGGTGGGCGCCTACCGCAGCTACATCCAGGGCGGCCGCCCCTTCACCAAGAAGTTCCGCAGTGCCGGCCATGGCCGTGACAGTGACAAGCGGCCGTCCCTGGGGCTGGCACCCGGGGGCCTGGCCGTGGTCGGCCGCAGTGCCGGAGGGGAGCCAGGGCCCGAGGCTGGCCGGGCAGCCGACGGTGGTGAGCGGCCTCTGGCAGCCAGCCCGCCAGGCACCGTGAAGGCTGAGGAGCACCAGCGGCAGAACATCAACAAATTTGAACGCCGACAAGCCCGCCCTCCAGATGCCTCCGCAGCCCGGGGAGGCGAGGACACCAATGACCTACAGCAGAAGCTGGAGGAGGTGCGGCAACCCCCACCCCGAGTCCGGCCAGTCCCCTCCCTGGTGCCCCGGCCCCCCCAGACATCACTTGTCAAGTTCGTGGGCAACATCTACACCCTCAAATGCAGGTTCTGTGAGGTGGAATTCCAGGGCCCCCTCTCCATCCAGGAAGAGTGGGTGCGGCACTTACAGCGGCACATCCTGGAGATGAACTTCTCCAAAGCGGACCCCCCACCTGAGGAGTCCCAGGCCCCGCAGGCACAGACAGCGGCGGCAGAGGCTCCCTAACACAAAAGCATTCCAGATCCCCTCTCGTGCCAcctctgtctcctcttcttcctcctctgtgtccttgtccctcttcctctttctttccgtttccAAAGGAGCAAGCCAAAACCTCAAACCGGCGCCCCTTGGGGGCCGGGCACACTACAGCCAGGGCGCCGGGAGCCAGCTAGCTGCCCTTCCCCCAGCCCGAGGACTCTGGGGCCACAGGGTGTCTTCCTTCAGCCCATGCCCACCTGGTCCAGCAGGGGCAGCAGCCAGGTCTCTGATGGCAGCCGGTCTGGTCACAGGGGAGGACAGCACTCCCCCGTCTAGCAGCCAGGCAGGGCGATGTCTGCCATCCGTGGCCATTTGCAAAGACCCCAAAGACCCCTGTTCTGGTTCCCTCTCTCCCCCATGAATATCCTCTCACACACATGTACATGCGAACACACACAACACGCACCTCGTGAGACCCGGGACCTGCCCCGGACCCCCAGTTCCTGGGTTGAACGACCACATCATGCCACGGTGCTTGCTCAGGGGAAGCCACGCTCCCTCTGTGGGGCCTGCTGGGGCCTGGGAGCCCCCCACTGAGCCCACAATGCCACGGAAATCCTTGTTGGCTGCCCCCGAGAGGGGCCTTCCCAGCTGGGAAGAGCTCAGAGCTGACAGCTGCCTCCTGCCATGTCAAGGCCCCCCAAAGAGCCTCAGGGGCTCTGGGGCCCTGGAGGGTGGGGTTGGGGGGTGGGACTCTCCTCCCCCACTCCTGCTCCCTCTCCCTTTTCACTGTTGCTTTCTATGTATAGCTCCCTAGACCTTTCACTTTTTTAAAAACGCGTTTTGTGTAGAGAATAAGGAACGTGGATCTTTTTATTTTGCAATCCTGGGCCAGCTAGAAGCCAGGAGCTGATTGACCTTTTAACTTTTTTCAGTGGCCACATTTTGGTTATCGATGTACCTAGAAGTATGTAAATTAGATTAAATTTCTCTTCTGGAAACACCCTGGGGCAGGCGGCCAGCGTGTGTTTTTCTGTCAAGTGGACAGGCTGGCATTGGCTGGCAGCCGGGGCTGGGATCGGGGCCTCCTCTGTCCAGAGCGCCATGGAGGCCCTGGGTTTTCCAGTTGGCCGCCAAGCCGACCAGACGCAGCTGGGGATGAGCCCAAGTTCCCAGCTGTTGGCTCTTTAGGCCATGGCTGGGAGGGGGTCTCTGGCTGGCTGGCAAAGCGGCTCCAGTGAGCAGATGAACCAGGGTTCTGGGCAGCCTGTCTGGGAAGGGAGCCAGGATCAAGAAGCAGTTGAGGCTAGAGGAGCTTATCAAAGGCAGGAGCTACCAGCGAGGGTGTCAGGGACCCGTTGGGAGCATTTGGGTGGGGGCCAGTGGGGTTGTAGAGAGCTGGAACTCACCTGCTTTTAATACATGTGACTTCTAGTGAGACACATGCACCCCTGACCCAAGGAACATGCGGGGAAAAGAGGAGCCACTGGCTCCTTTGCGATGTTATTTATTTTCTCGCTCTGCAAATGTTTATTGAACATTTCTGAGATTTTAAGAGATTTTGTTGGCTGCTCCTTCTTGTTTATTGCATGTGGTTTTTCAGCTCATCGTTTTTACTAAACGGTCAAGTGCTGGAGAGTGGGAACGACCTCATGGCGTGTGGACAGAAGGGGCCACCTCTACCCCCAGCCCTGCTTTCTGGGCCCTCCCACCATACCCCTTCCTGGGAAGGAGGGATTAACAGGCTGCAATAACGCCCACAAGGGTGGTCTTGGCCCACACGTCTGCTCCTGTGGGGTCAGGACGCACATCTCGCCTGGTGGCAGAAGGCCGCAACCACTTCTCTCCATCCTGTGCTGTGGGTGGGTGGATGTATCCAGGACTTAGGAAGCAGGGAGAGCATCTTGTGAGCTGACTCAAAGGTGTTTCTTCCTCTTTCAACTTTTCATAAGTCAGtttttatttttttattttattttttgagacagggtctcattttgttgcccaagctggagtgcagtgtagggacctcggctcgctgcagtctctgcctcctgggttcaagtgattctcctgcctcagccatccaggtagctgggatcacaggcatgcaccaccacccctggcttatatctgtaatttttgtagagacgggggtttcaccatgttgcccgggctggtcttgaactcctgagctcaagtgatcagcctcccaaagtgctgggattacaggcgtgagccactatgcccggccCGTAAGTCAGTTTTTGAAATATAAAAGTGGTATAGGCTAGATGTGACAAAAAACAGTCAAATGATACAAGAGCTTATAAAGTCATATGGCAAGTTCCTCCCCACCAATCATGCAGTGAAGTGAGGGTCATGTGTGTCCTTGGAAGAGTCACCTCCAGTTCTTGCAGGGGGATGTTTTCCTAAAACTTTCTGAGCATTGCTCTTCTCTGCTCAAGCCACTTCAATACACCTCAGGCAGCAAAGTCTCAGCTTTTGAGCCGTGGTCTCTGAGGGTGTTGGATGTGAACGAAATCAAATCGGTACAATGATGACTGTGGCAAGTGCGATGAAGGAACGAACCTGCAGGGCGCAGAAGACGTGTCCTGGGGCCCTGCCTTGGTTTGGAAGACAGGCAGGCATCCCTGAGGCTGATGGGGAGATGAACCCCGAAGCCAGAGTGCTTATCCGTCAGATCTCTGCTTCATGTTTGGAGTTTGCTCACTTAACACATCAGAAGTGGCTTTGTTCCGTATGGCAGCAAGTTCTGCAGAAGCCTCATTTGGGTGGGGGGAGttttattaaaacagtttatcatggagaattccaactatacaaaagtagagcaaacagtaaaatggactctcatctatccatcaccaacccatgaccaatgtcttcagctgtcagagatttatcttatagctccttgcttcctcctcctctctctacctgtctgaattgtgtgaagcacatcctggccataagatcagttaacttcttagtatttcagtatgtttctctcaacgttgtaaatgccactattacacctaaagaaatcaacaataTCAAAAAGAAACAGCATACCTTAAAAAAAGTTTTAAAACACA

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