Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MMADHCP2
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:34334783-34336105  UCSC
Coordinates (T2T) chr11:34471515-34472837  UCSC
Coordinates (hg19) chr11:34356330-34357652  UCSC
Strand -
Parental Sequence NM_015702.3
Parental seq. overlap 1242 bp
Parental seq. overlap (%) 89.1%
Genomic Region Intragenic (ABTB2)
Retrocopy Summary MMADHCP2, located on chr11:34334783-34336105, is a retrocopy of the parental gene MMADHC. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MMADHC
Full Name metabolism of cobalamin associated D
Also known as C2orf25|CL25022|cblD
Coordinate chr2:149569637-149587775
Strand -
Gene summary This gene encodes a mitochondrial protein that is involved in an early step of vitamin B12 metabolism. Vitamin B12 (cobalamin) is essential for normal development and survival in humans. Mutations in this gene cause methylmalonic aciduria and homocystinuria type cblD (MMADHC), a disorder of cobalamin metabolism that is characterized by decreased levels of the coenzymes adenosylcobalamin and methylcobalamin. Pseudogenes have been identified on chromosomes 11 and X.[provided by RefSeq, Nov 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MMADHCP1
Bonobo Pan paniscus MMADHCP1
Gorilla Gorilla gorilla MMADHCP1
Orangutan Pongo abelii MMADHCP1
Gibbon Nomascus leucogenys MMADHCP1
Green monkey Chlorocebus sabaeus MMADHCP1
Crab-eating macaque Macaca fascicularis MMADHCP1
Rhesus Macaca mulatta MMADHCP1
Baboon Papio anubis MMADHCP1
Golden snub-nosed monkey Rhinopithecus roxellana MMADHCP2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MMADHCP2
GATGGCAGGAACGTCAGGTTCTGGGACAGCTGGAGACAGTGGTGGTGACTGGAATAACTTTACCAAAGGAAAGCTATTTAGTGAACTGTCCCCTCCAGTAGAGTTGGCCAATGTGCTTTGTAACAGAGCCAGACTGTTTTCCTATCTCCCAGGATTTTACTCTTTAGTTAAAACGTTGGCAATCCCAAAGCCTTTTCAACCGCAGGATTGTCAGGTTTAGGTGTCTCATGTGGCCGCTCTACCTCCAGATATATGCTCTCAAAAGGTGTGGCCTGATGAAACTATGGGACCGTTTGGACCTCAAGATCAGAGGTTCAAGCTTCCTGGGATCATAGGTTTTGATTGTCACCTCAATGGGACTGCTTCACAGAAGAAAAGCCTGCTTTATAAAACTTTGCCTGATGTTCTAGCAGAAACTTTATCAAGTGAAAGACACAAGTTTGTGATGACACAATATGTGAATGAATTTCAGGGTAATGATGCACCTGTTGAACAAGAAATTAACAGTGCAGAAACTTAACTTTGAAAGTGCCAGAGTGGAGTGTGCAATACAAACGTGTCCAGAATTGTGGCGAAAAGATTTTGAATCACTGTTTCCAGAAGTAGCTAATAGCAAATTAATCATTCTGACTGTAACACAGAAAACTAAGAATAATATGACTGTTTAGAGTGAAGAAGTAGAAACTGAAAGAGAAGTGCTCTTAGAAAAGTTCATCAATGTTGCTAAGGAAATTTGCTGTACTCTTTGTGCTGAGGGATATTGGGCTGACTTTACTGACCCATCATCTGGTTTGGCATTTTTTTGGACCATATACAAACAACAATCTTTTTGAAACTGATGAATGCTACCGACATTTAGGATTCTCTGTTGATGACCTTCGATGCTTAAAGTGATTCGTCATAGTCTCTGGGGTACCCGTGTAGTTGTAGGAAGCATCTTCACTAATGCAACACCAGACAGCCATATTATGAAGAAATTAAGTGGAAATTAGCGGAAATGTCCATTCATTTGCTGTATTATTTGTATGTAATATTTGGGTTGATCTATAAACACTGTCAGACTAAAGTTTTTAAAATATACTTATTTCTATTTATTTCAGCATTTATGAATTTACAACATTGGTAAGTGATATGGGATTTTAAAATTGCAAATGTTCATTATTCATATCATTGAATACATGTTGAGCACACCCACATTGTATAGGTTGTGGTAATTAGCTTGTAACTAGGGTATTATCTGTTATTGTTATTTCTCCCCTTTATTGGAAAAAGGCCTCAGTTTTAATTACTTTCTTCCAAAAATAAATCACACATTTGGTTACG
>NM_015702.3
CCTTTGCCTGCTCACCGCCAGCGTAGGTGCTACCACCGCTGCCGTCGCCGCCGCCATTTTGATGGCAGGAAGAGTCCGGTTCTGGGACAGCTGGAGACAGTGGTGGTGACTGAAATAACTTTACCAAAGGAAAGCTATTTTGCGAACTATCTTCTCCAGCGGAGATGGCCAATGTGCTTTGTAACAGAGCCAGACTGGTTTCCTATCTCCCAGGATTTTGCTCTTTAGTTAAAAGGGTTGTCAATCCCAAAGCCTTTTCGACTGCAGGATCATCAGGTTCGGATGAGTCTCATGTGGCTGCTGCACCTCCAGATATATGCTCTCGAACAGTGTGGCCTGATGAAACTATGGGACCCTTTGGACCTCAAGATCAGAGGTTCCAGCTTCCTGGGAACATAGGTTTTGATTGTCACCTCAATGGGACTGCTTCACAGAAGAAAAGCCTGGTTCATAAAACTTTGCCTGATGTTCTAGCAGAACCTTTATCAAGTGAAAGACATGAGTTTGTGATGGCACAATATGTGAATGAATTTCAGGGTAATGATGCACCTGTTGAACAAGAAATTAACAGTGCAGAAACTTACTTTGAAAGTGCCAGAGTAGAGTGTGCAATACAGACATGTCCAGAATTGCTGCGAAAAGATTTTGAATCACTGTTTCCAGAAGTAGCTAATGGCAAACTAATGATTCTGACTGTAACACAAAAAACTAAGAATGATATGACTGTTTGGAGTGAAGAAGTAGAAATTGAAAGAGAAGTGCTCTTAGAAAAGTTCATCAATGGTGCTAAGGAAATTTGCTATGCTCTTCGAGCTGAGGGTTATTGGGCTGACTTTATTGACCCATCATCTGGTTTGGCATTTTTTGGACCATATACAAACAACACTCTTTTTGAAACTGATGAACGCTACCGACATTTAGGATTCTCTGTTGATGACCTTGGATGCTGTAAAGTGATTCGTCATAGTCTCTGGGGTACCCATGTAGTTGTAGGGAGTATCTTCACTAATGCAACACCAGACAGCCATATTATGAAGAAATTAAGTGGAAATTAGCAGAAATATCCATTCATTTGCTGTACTATTTGTATGTAATATTTGGGTTGATCTATAAACACTGTCAGACTAAAGTTTTTAAAATATATTTATTTCTAAGTATTTATTTCAGCATTTATGAATTTACAACATTGGCAAGTGATTTGGGATTTTAAAATTGCAAATGTTCATTTATTCATATCATTGAATACACGTTGAACACATCCACATTGTATAGGATGTGGTAATTAGCTTGTAACCAGGGTATGATCTGCTATTGTTATTTCTCCTCTTTATTGGAAAAAGGCCTCAGTTTTAATTATTTTCTTCCCAAAATAAATCACACATTTGGTTACAA

Publications

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