Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TROP1
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:38448109-38448321  UCSC
Coordinates (T2T) chr11:38592601-38592813  UCSC
Coordinates (hg19) chr11:38469659-38469871  UCSC
Strand -
Parental Sequence NM_001039705.3
Parental seq. overlap 186 bp
Parental seq. overlap (%) 4%
Genomic Region Intergenic
Retrocopy Summary TROP1, located on chr11:38448109-38448321, is a retrocopy of the parental gene TRO. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TRO
Full Name trophinin
Also known as MAGE-d3|MAGED3
Coordinate chrX:54920796-54931436
Strand +
Gene summary This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TROP1
Bonobo Pan paniscus TROP1
Gorilla Gorilla gorilla LOC101139594P1
Orangutan Pongo abelii LOC100433749P1
Green monkey Chlorocebus sabaeus TROP1
Crab-eating macaque Macaca fascicularis LOC102136335P1
Rhesus Macaca mulatta LOC704512P1
Baboon Papio anubis TROP1
Marmoset Callithrix jacchus LOC100409482P1
Gibbon Nomascus leucogenys Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TROP1
CACTGGTGTTAGGTTTGGTGGTGAACTGGGCACCAGTACTGGCTTTGGCAGTGGAGCCACCAGCCTTGGTGCTTGTGGCTTCACCTATGGCTAGCGAGATTTCAGGTTTATTCCCTATATTTACAGATACCACCAATAGATTGGATCAGTCCTTCCCATGGAGCCAAAGTACATTCTTGGAATCTTTGTCCACACAGCAGTCTAAGCAGTTAC
>NM_001039705.3
AGACACAAGGAGAGGCTTGGAGAGAGCAGACGCCTTCTGGATTCAAGAAGACGAGGCCCATTCCCCTCAGGCTCACCTGTTACTCGGCCTCCCAGAAAGATGGATAGGAGAAATGACTACGGATATAGGGTGCCTCTATTTCAGGGCCCTCTGCCTCCCCCGGGGAGCCTGGGGCTTCCCTTCCCTCCAGATATACAGACTGAGACCACAGAAGAGGACAGTGTCCTGCTGATGCATACCCTGTTGGCGGCAACCAAGGACTCCCTGGCCATGGACCCACCAGTTGTCAACCGGCCTAAGAAAAGCAAGACCAAGAAGGCCCCTATAAAGACTATTACTAAGGCTGCACCTGCTGCCCCTCCAGTCCCAGCTGCCAATGAGATTGCCACCAACAAGCCCAAAATAACTTGGCAGGCTTTAAACCTGCCAGTCATTACCCAGATCAGCCAGGCTTTACCTACCACTGAGGTAACCAATACTCAGGCTTCTTCAGTCACTGCTCAGCCTAAGAAAGCCAACAAGATGAAGAGAGTTACTGCCAAGGCAGCCCAAGGCTCCCAATCCCCAACTGGCCATGAGGGTGGCACTATACAGCTGAAGTCACCCTTGCAGGTCCTAAAGCTACCAGTCATCTCACAGAATATTCACGCTCCAATTGCCAATGAGTCAGCCAGTTCCCAAGCCTTGATAACCTCTATCAAGCCTAAGAAAGCTTCCAAGGCTAAGAAGGCTGCAAATAAGGCCATAGCTAGTGCCACCGAGGTCTCGCTGGCTGCAACTGCCACCCATACAGCTACCACCCAAGGCCAAATTACCAATGAGACAGCCAGTATCCACACCACAGCAGCCTCCATCCGAACCAAGAAAGCCTCCAAAGCCAGGAAGACAATTGCTAAGGTCATAAATACTGACACTGAGCATATAGAGGCTCTAAATGTCACTGACGCAGCTACCAGGCAGATTGAGGCCTCAGTAGTGGCTATCAGGCCCAAAAAATCCAAGGGCAAGAAGGCTGCCAGCAGGGGCCCAAATTCTGTCTCTGAGATCTCTGAGGCCCCACTTGCCACTCAGATAGTCACAAACCAAGCCCTGGCAGCCACCCTGCGGGTCAAGAGAGGGTCTAGGGCTCGGAAGGCTGCCACTAAGGCTCGGGCAACTGAAAGCCAGACTCCAAATGCTGACCAAGGGGCCCAGGCCAAGATAGCCTCTGCTCAGACCAACGTAAGTGCCCTTGAGACTCAGGTTGCTGCTGCTGTCCAGGCCCTGGCAGATGACTATCTGGCTCAGTTGAGCCTGGAGCCCACAACCAGGACCCGGGGCAAAAGAAACCGAAAGTCCAAGCATCTGAATGGGGATGAGAGAAGTGGCAGTAATTACAGGCGGATCCCATGGGGCCGGAGGCCTGCACCACCGCGAGATGTGGCCATTTTACAAGAAAGGGCTAATAAGTTGGTGAAATACCTGTTGGTTAAGGACCAGACAAAGATCCCCATCAAACGCTCAGACATGCTGAGGGATGTCATCCAAGAATATGATGAATATTTCCCAGAAATCATTGAACGAGCAAGCTACACTCTGGAGAAGATGTTTCGAGTCAATCTGAAAGAAATTGATAAGCAAAGTAGCTTGTATATTCTCATCAGCACTCAGGAATCCTCTGCAGGCATACTGGGAACGACCAAGGACACACCCAAGCTGGGTCTCCTCATGGTGATTCTGAGTGTCATTTTTATGAATGGCAACAAGGCCAGTGAGGCTGTCATCTGGGAGGTGCTGCGCAAGTTGGGGCTGCGCCCTGGGGTGAGGCATTCACTCTTTGGGGAAGTGAGGAAGCTCATCACAGACGAGTTTGTGAAGCAGAAGTACCTGGAGTACAAGAGGGTCCCTAACAGCAGACCACCTGAATATGAGTTCTTCTGGGGCTTGCGCTCCTACCACGAGACTAGCAAGATGAAAGTCCTCAAGTTTGCATGCAGGGTGCAGAAGAAAGACCCCAAGGACTGGGCTGTGCAGTACCGCGAGGCAGTGGAGATGGAAGTCCAAgctgcagctgtggctgtggctgaggctgaagccagggctgaggcAAGAGCCCAAATGGGGATTGGAGAGGAAGCTGTGGCTGGGCCCTGGAATTGGGATGACATGGATATCGACTGCCTAACAAGGGAAGAGTTAGGCGATGATGCTCAGGCCTGGAGCAGATTTTCATTTGAAATTGAGGCCAGAGCCCAAGAAAATGCAGATGCCAGCACCAACGTCAACTTCAGCAGAGGAGCTAGTACCAGGGCTGGCTTCAGCGATGGTGCTAGTATTAGCTTCAATGGTGCACCCAGCTCCAGTGGTGGCTTCAGTGGTGGACCTGGCATTACCTTTGGTGTTGCACCCAGCACCAGTGCCAGCTTCAGCAATACAGCCAGCATTAGCTTTGGTGGTACACTGAGCACTAGCTCCAGCTTCAGCAGCGCAGCCAGCATTAGCTTTGGTTGTGCACACAGCACCAGCACTAGTTTCAGCAGTGAAGCCAGCATTAGCTTTGGTGGCATGCCTTGTACCAGTGCCAGCTTTAGTGGTGGAGTCAGCTCTAGTTTTAGTGGCCCACTCAGCACCAGTGCCACTTTCAGTGGTGGAGCCAGCTCTGGCTTTGGAGGCACACTCAGCACCACGGCTGGCTTTAGTGGTGTACTCAGCACTAGCACCAGCTTTGGCAGTGCACCCACAACGAGCACAGTCTTCAGTAGTGCGCTTAGCACCAGCACTGGCTTTGGAGGCATACTCAGCACCAGTGTCTGTTTTGGTGGCTCTCCCAGCTCCAGTGGTAGCTTTGGTGGTACACTCAGTACCAGTATCTGCTTCGGTGGCTCTCCCTGCACCAGCACTGGCTTTGGAGGCACACTTAGCACCAGTGTCTCCTTTGGTGGCTCTTCCAGCACCAGTGCCAATTTTGGTGGTACACTAAGTACCAGCATCTGCTTTGATGGCTCTCCCAGCACTGGTGCTGGCTTTGGTGGTGCTCTCAACACCAGTGCCAGCTTTGGCAGTGTGCTCAACACCAGTACTGGTTTTGGTGGTGCTATGAGCACCAGTGCTGACTTTGGCGGTACACTAAGCACCAGTGTCTGCTTTGGTGGCTCTCCTGGCACCAGTGTCAGCTTTGGCAGTGCACTCAACACCAATGCTGGTTATGGTGGTGCTGTCAGCACCAACACTGACTTTGGTGGTACACTAAGCACCAGCGTCTGTTTTGGTGGCTCTCCCAGCACCAGTGCTGGCTTTGGTGGTGCACTCAACACCAATGCCAGCTTTGGCTGTGCCGTCAGCACCAGTGCCAGCTTCAGTGGTGCTGTCAGCACCAGTGCTTGCTTCAGTGGTGCACCAATCACCAACCCTGGCTTTGGCGGTGCATTTAGCACCAGTGCTGGCTTCGGTGGGGCACTTAGTACCGCTGCTGACTTCGGTGGTACTCCCAGCAACAGCATTGGCTTTGGTGCTGCTCCCAGCACCAGTGTCAGCTTTGGTGGTGCTCATGGCACCAGCCTCTGTTTTGGTGGAGCTCCCAGCACCAGCCTCTGCTTTGGCAGTGCATCTAATACTAACCTATGCTTTGGTGGCCCTCCTAGCACCAGTGCCTGCTTTAGTGGTGCTACCAGCCCTAGTTTTTGTGATGGACCCAGCACCAGTACCGGTTTCAGCTTTGGCAATGGGTTAAGCACCAATGCTGGATTTGGTGGTGGACTGAACACCAGTGCTGGCTTTGGTGGTGGCCTAGGCACCAGTGCTGGCTTCAGTGGTGGCCTAAGCACAAGTTCTGGCTTTGATGGTGGGCTAGGTACCAGCGCTGGCTTCGGTGGAGGACCAGGCACCAGCACTGGTTTTGGTGGTGGACTGGGCACCAGTGCTGGCTTCAGTGGCGGACTGGGCACCAGTGCTGGCTTTGGTGGTGGACTGGTCACTAGTGATGGCTTTGGTGGTGGACTGGGCACCAATGCTAGTTTCGGCAGCACACTTGGCACCAGTGCTGGCTTTAGTGGTGGCCTCAGCACCAGCGATGGCTTTGGCAGTAGGCCTAATGCCAGCTTCGACAGAGGACTGAGTACCATCATTGGCTTTGGCAGTGGTTCCAACACCAGCACTGGCTTTACTGGCGAACCCAGCACCAGCACGGGCTTCAGTAGTGGACCCAGTTCTATTGTTGGCTTCAGCGGTGGACCAAGCACTGGTGTTGGCTTCTGCAGTGGACCAAGCACCAGTGGCTTCAGCGGTGGACCGAGCACAGGAGCTGGCTTCGGCGGTGGACCAAACACTGGTGCTGGCTTTGGTGGTGGACCGAGCACCAGTGCTGGCTTTGGCAGTGGAGCCGCCAGTCTTGGTGCCTGTGGCTTCTCGTATGGCTAGTGAGGTTTCAGATTTATTCCCCATGTTTACAGATACCGCTAATAAATTGCAGTAGTCCTTCCCATGGAGCCAAAGTACATCCTTGGAATCTTTGTCCACACAGCAGTCAAGGCAGTTATGGCCAATCAGCTGAGGGTGTCATGTGATGGAAAAATctgtttgctgttcctgctttattgtttgctttctgtgtgctgtCATATTTTGGTATCAGAGTTACATTAAATTTGCAAAATGAA

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