Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HNRNPKP3
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:43261656-43263425  UCSC
Coordinates (T2T) chr11:43416879-43418649  UCSC
Coordinates (hg19) chr11:43283206-43284975  UCSC
Strand -
Parental Sequence NM_001318188.2
Parental seq. overlap 1541 bp
Parental seq. overlap (%) 53.7%
Genomic Region Intergenic
Retrocopy Summary HNRNPKP3, located on chr11:43261656-43263425, is a retrocopy of the parental gene HNRNPK. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HNRNPK
Full Name heterogeneous nuclear ribonucleoprotein K
Also known as AUKS|CSBP|HNRPK|TUNP
Coordinate chr9:83968083-83980630
Strand -
Gene summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HNRNPKP4
Bonobo Pan paniscus HNRNPKP4
Gorilla Gorilla gorilla HNRNPKP4
Orangutan Pongo abelii HNRNPKP4
Gibbon Nomascus leucogenys HNRNPKP2
Green monkey Chlorocebus sabaeus HNRNPKP1
Crab-eating macaque Macaca fascicularis HNRNPKP3
Rhesus Macaca mulatta HNRNPKP3
Baboon Papio anubis HNRNPKP4
Marmoset Callithrix jacchus HNRNPKP3
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HNRNPKP3
ATGGAAACTGAACAGCTAGAGAAAACCTTCCCTAGCACTGAAACCAGTGGTGAATTTGGTAAATGCCTTGCAGAATATATGGAAGAAGAACAAGCATTTAAAAGATCTAGAAACACTGATGGTTGAATTATGCGTTGTGTTTCAGAGCAAGAATGCTTGGACAGTGATTGGAAAAGGAGATAAGAATATTAAGGCTTTCTGTATAGACTACAGAGCCAGGGTTCTAGCCCCAGAGGGCAATGGCCCCAAGTGCATGCTGAGTATCAGTGCTGATATTGAAACAGTTGGAGAAACTCTGAAGAAAATCATCCCTACCTTGGAAGAGTACCACCATTATAAAGGAAGCAACTTTGATTGCGAATTGAGGCTGTTGACTCATCAGAGTCTGGCAGGAGGAATTATTGAGGTCAAAGATGCTAAAATCAAAGAGCTTCAAGGGAACACTCAAACAACAATCAAGCTTTTCCGGGAATGCTGTCCTCATTCCACTGACGGAGTTGTTCTTACTGGAGAAAGACTATGGAGTTGTAGAGTGCATAAAATTATCCTTGATCTTATATCTGAGTCTCCTACAGAGGATGTGCACAGACTTATAATCCCAATTTTCATGATGTAACCTATTACATTACATGATGTAACACCATTATATTATGGTGGTTTTACAATGTTGTCTGATGACCACCATGGATGCCTGGTGGGGTTTCCCAGGCAGGGAAGAGGTGGTTTTGACAGAATGTCTACCAGTCAGGGTGGGTGTTCCATGTGGCCATCTGGAAGAGATTATGATGACATGAGTCCTTGTTGAGGACCACCTCCTCCTTCTTTTGGACAAGGTGCCTGGGGTGGTAGCAAAGCTGAGAATCTTCCTCTTTCTCCACTACCACTACAGAGGGTAGGAGACATAAGGGCCTATGACAGAAGAGGAAGACCTGGAGATGGTTACATGGCATGGCTGGCTTCAGTGCTGATGAAACTTGGGACTCTGCAATAGATACATGGAGTGCATCAGAATGGCTGATGGCTTATGAACCACAGAGTGGCTCCAGATATAATTATTCCTATGCAGCGGACAGTGGCTCATATGGTGGACCTATTATTACTACACAAGGAACTATTCCCAAATATTTGGTTGGATCTATTATTGGCAAAGGTGGTCAGTGAATCAAACAAATCCATCATGAGTTGGAGCTTCAACTAAAGTTGATGAGCCTTTAGAAGGAGGTGAAGATCAGATCATTATCATTATAGGAACATAGGACCAGATATAGAATGCACAGTATTTGCTGCAGAACAGTATGAAGCAGTTTTCCGGAAAGTTTTTACTAATGCTAGTGAAGGACTGAAGGAGTCCTGCATCTTTTTTTTTTTTTACATTTGCTTCTGTTTAAAAAGCCATCATGCCTCTGCTTCACAGGTGTTTTGCATCTGAGGTGTAGTGAAACCTTTGCTGTTCACCAGATGTAAGGTTTTAGTTCCTTACAAACAGGGTTGGGGATGTAGGGAAGGGCTTGCAAAAACTAATGTTGAAATTTTGAAACAGCAGTAGAATGAGCGGATTTTTTTTTGTGTTCATTGTTACTGGTTTAAAAAAATGTTCCCCTATGTAATTTTTGTGAACACCTTACTTTGTGGTCACTGTAACATTTGAGGGGTGAGACAGGGAGGAAGAGTAACAATAGGCCACATGTCCCTGGCATCTGTTCAGAGCAGTGTGCAGAATGTAAGGCTCTTTAGTAAGAAATGTTTTACGACTTTTAAGATAAATTTAGA
>NM_001318188.2
GTTTTCTGTCTAGCTCCGACCGGCTGAGGCGGCGCGGCAGCGGAGGGACGGCAGTCTCGCGCGGCTACTGCAGCACTGGGGTGTCAGTTGTTGGTCCGACCCAGAACGCTTCAGTTCTGCTCTGCAAGGATATATAATAACTGATTGGTGTGCCCGTTTAATAAAAGAATATGGAAACTGAACAGCCAGAAGAAACCTTCCCTAACACTGAAACCAATGGTGAATTTGGTAAACGCCCTGCAGAAGATATGGAAGAGGAACAAGCATTTAAAAGATCTAGAAACACTGATGAGATGGTTGAATTACGCATTCTGCTTCAGAGCAAGAATGCTGGGGCAGTGATTGGAAAAGGAGGCAAGAATATTAAGGCTCTCCGTACAGACTACAATGCCAGTGTTTCAGTCCCAGACAGCAGTGGCCCCGAGCGCATATTGAGTATCAGTGCTGATATTGAAACAATTGGAGAAATTCTGAAGAAAATCATCCCTACCTTGGAAGAGGGCCTGCAGTTGCCATCACCCACTGCAACCAGCCAGCTCCCGCTCGAATCTGATGCTGTGGAATGCTTAAATTACCAACACTATAAAGGAAGTGACTTTGACTGCGAGTTGAGGCTGTTGATTCATCAGAGTCTAGCAGGAGGAATTATTGGGGTCAAAGGTGCTAAAATCAAAGAACTTCGAGAGAACACTCAAACCACCATCAAGCTTTTCCAGGAATGCTGTCCTCATTCCACTGACAGAGTTGTTCTTATTGGAGGAAAACCCGATAGGGTTGTAGAGTGCATAAAGATCATCCTTGATCTTATATCTGAGTCTCCCATCAAAGGACGTGCACAGCCTTATGATCCCAATTTTTACGATGAAACCTATGATTATGGTGGTTTTACAATGATGTTTGATGACCGTCGCGGACGCCCAGTGGGATTTCCCATGCGGGGAAGAGGTGGTTTTGACAGAATGCCTCCTGGTCGGGGTGGGCGTCCCATGCCTCCATCTAGAAGAGATTATGATGATATGAGCCCTCGTCGAGGACCACCTCCCCCTCCTCCCGGACGAGGCGGCCGGGGTGGTAGCAGAGCTCGGAATCTTCCTCTTCCTCCACCACCACCACCTAGAGGGGGAGACCTCATGGCCTATGACAGAAGAGGGAGACCTGGAGACCGTTACGACGGCATGGTTGGTTTCAGTGCTGATGAAACTTGGGACTCTGCAATAGATACATGGAGCCCATCAGAATGGCAGATGGCTTATGAACCACAGGGTGGCTCCGGATATGATTATTCCTATGCAGGGGGTCGTGGCTCATATGGTGATCTTGGTGGACCTATTATTACTACACAAGTAACTATTCCCAAAGATTTGGCTGGATCTATTATTGGCAAAGGTGGTCAGCGGATTAAACAAATCCGTCATGAGTCGGGAGCTTCGATCAAAATTGATGAGCCTTTAGAAGGATCCGAAGATCGGATCATTACCATTACAGGAACACAGGACCAGATACAGAATGCACAGTATTTGCTGCAGAACAGTGTGAAGCAGTATTCTGGAAAGTTTTTCTAAGACTAGTGAAGAACTGAAGGAGTCCTGCATCTTTTTTTTTTTATCTGCTTCTGTTTAAAAAGCCAACATTCCTCTGCTTCATAGGTGTTCTGCATTTGAGGTGTAGTGAAATCTTTGCTGTTCACCAGATGTAATGTTTTAGTTCCTTACAAACAGGGTTGGGGGGGGGAAGGGCGTGCAAAAACTAACATTGAAATTTTGAAACAGCAGCAGAGTGAGTGGATTTTATTTTTCGTTATTGTTGGTGGTTTAAAAAATTCCCCCCATGTAATTATTGTGAACACCTTGCTTTGTGGTCACTGTAACATTTGGGGGGTGGGACAGGGAGGAAAAGTAACAATAGTCCACATGTCCCTGGCATCTGTTCAGAGCAGTGTGCAGAATGTAATGCTCTTTTGTAAGAAACGTTTTATGATTTTTAAAATAAATTTAGTGAACCTATTTTTGGTGGTCATTTTTTTTTTAAGACAGTCATTTTAAAATGGTGGCTGAATTTCCCAACCCACCCCCAAACTAAACACTAAGTTTAATTTTCAGCTCCTCTGTTGGACATATAAGTGCATCTCTTGTTGGACATAGGCAAAATAACTTGGCAAACTTAGTTCTGGTGATTTCTTGATGGTTTGGAAGTCTATTGCTGGGAAGAAATTCCATCATACATATTCATGCTTATAATAAGCTGGGGATTTTTTGTTTGTTTTTGCAAATGCTTGCCCCTACTTTTCAACAATTTTCTATGTTAGTTGTGAAGAACTAAGGTGGGGAGCAGTACTACAAGTTGAGTAATGGTATGAGTATATACCAGAATTCTGATTGGCAGCAAGTTTTATTAATCAGAATAACACTTGGTTATGGAAGTGACTAATGCTGAAAAAATTGATTATTTTTATTAGATAATTTCTCACCTATAGACTTAAACTGTCAATTTGCTCTAGTGTCTTATTAGTTAAACTTTGTAAAATATATATATACTTGTTTTTCCATTGTATGCAAATTGAAAGAAAAAGATGTACCATTTCTCTGTTGTATGTTGGATTATGTAGGAAATGTTTGTGTACAATTCAAAAAAAAAAAAGATGAAAAAAGTTCCTGTGGATGTTTTGTGTAGTATCTTGGCATTTGTATTGATAGTTAAAATTCACTTCCAAATAAATAAAACACCCATGATGCTAGATTTGATGTGTGCCCGATTTGAACAAGGGTTGATTGACACCTGTAAAATTTGTTGAAACGTTCCTCTTAAAAGGAAATATAGTAATCTTATGTA

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