Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FBLIM1P2
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:46142721-46144310  UCSC
Coordinates (T2T) chr11:46298722-46300311  UCSC
Coordinates (hg19) chr11:46164272-46165861  UCSC
Strand +
Parental Sequence NM_017556.4
Parental seq. overlap 1153 bp
Parental seq. overlap (%) 34.4%
Genomic Region Intergenic
Retrocopy Summary FBLIM1P2, located on chr11:46142721-46144310, is a retrocopy of the parental gene FBLIM1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FBLIM1
Full Name filamin binding LIM protein 1
Also known as CAL|FBLP-1|FBLP1
Coordinate chr1:15756170-15786590
Strand +
Gene summary This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FBLIM1P1
Bonobo Pan paniscus FBLIM1P1
Gorilla Gorilla gorilla FBLIM1P1
Orangutan Pongo abelii FBLIM1P1
Gibbon Nomascus leucogenys FBLIM1P1
Green monkey Chlorocebus sabaeus FBLIM1P1
Crab-eating macaque Macaca fascicularis FBLIM1P1
Rhesus Macaca mulatta FBLIM1P1
Baboon Papio anubis FBLIM1P1
Golden snub-nosed monkey Rhinopithecus roxellana FBLIM1P2
Marmoset Callithrix jacchus FBLIM1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FBLIM1P2
TCCACCCCCTCCTCCTGTCCTGGATGGTTAGGACGTGCTTCCCCACCTGGACCTCCTCCCACCCGCTTCACCGCCCCCGCCGGTGCTCCTGCCTTGTGAAGACGAGGCTCCTGCTCCAATGGGGGCCTCACTTATTGCGGACTTAGAGCAGCTGCACCTGCCCCCGTCCCCACCCCCACCACAGGCCCCTGCGGAGAGACCTTCAGTCCAGCCTGGGCCGGATCCCCTCTGGCCCGTGGAAAAAGAGCTGCCGCCTCCCCCAGCAGAGCCTGTTGAGAGAGAGGCGTCCACAGACATCCGTGCCTTCTGCCATAAGACTGTGTCCCCCCAGGAGCTGGCTGTGGAGGCCATGAAGAGGCAGTACCATGTCCAGTTCTTCACGTGCCGTACCTGCCGCCGCCAGCTGGCTGGGCAGAGCTTCTATCAGAAGGATATGCGACCCCTCTGCGAACCCTGCTGCCAGGACACGCTGCAGAAGTGCAGCAAGTGTGGCGAGGTGGTCCGGGACCACATCATCAGGGCCCCGGGCCAGGCCTTCCACCCCGCCTGCTTCACGTGTGTGACCTGCGCCCGGTGCAGCGGGGATGAGAGCTTTGCCCCGGGCAGCCAGAAGGAGGTGTACTGCCTGGACGACTTCTACAGGAAATTTGCCCCCGTCTGCAGCATCTGTGAGAATCCCATCATTCCTCGGGATGGGAAAGATGCCTTCAAAATCGAGTGCACTGGAAGAAACTTCCATGAAAATTGCTACAGGTATGAGGACTGCAGGATCCTCCTGTCTATTGAGCCCACGGACCAAGGCTGCTACCCGCTCAACAACCATCTCTTCTGCAAGGCGTGCCACCTGAAGCAGAGTGCTGCGGGGTGCTGCTGAGAGTGCCCGCCGGGTGTCAGGCAGTGAGCGGACTACTAGTCCCGGCTGGGGCCCTTTCCTGACTTGGTTTCCCTTCCTGACCTGCTCTTGCACACTTTCCTTCTGAGCCTCCATGGGGACCAGCCTGCAAGTCGGCCCAGCCTTTCCAGGACACAGTGGGGCTGAGCGCCGTCAGAACTTCCACTCCTCCTTTACCCTCTGGGCACCAGAAGGTTCCTGGACCATGAGCGTCGCCCCCAGAATTCCTTGCTGGCCCCACCCCACTTCCAGGGGAAAGCTGGGGGGAGTCTGCCGGGGACAATTGGACCCCTAGTGCTGACTGTAGCTGTCTGGTCGGGGTGCTGAGACCAGCATGGCTTTGCACGGTTGAGCTGTTTGAGGAAAAACTCCAAAGTCCCTTAAAAAGTGCTTTTTAaGTGC
>NM_017556.4
GGGCTCCGCTGGCTCGGGCGTCGGATCGGAGCCGCCGGGGCGCGGGCGGCCCAGAGCTGGCCTGAACCTCCAGGACTTCAGCCCTTCTAGGAGAATCTGATCCCAGGTGAGGGAGGTCACTTGGGGTGTGGCCCAGCAGGCAGGCGGGACTCCAGACTGGGAACGGAAGTCAGCCCTGCTGGGGCTGGGAGCTGAAGCATCTGTTCCTTCCTCGCGGGTGTGAGACAAGGAAGAGTGATCATTGCCACACCAGGAGCTGAAGCCATGGCCTCAAAGCCTGAGAAGAGGGTGGCATCGTCTGTCTTTATCACCCTGGCACCCCCGCGCCGCGATGTGGCCGTGGCGGAGGAAGTGAGGCAGGCAGTTTGTGAGGCCCGGCGTGGCCGCCCCTGGGAGGCTCCTGCCCCCATGAAGACACCCGAGGCTGGCTTGGCGGGGAGGCCCAGCCCCTGGACAACCCCTGGCAGAGCTGCAGCCACAGTGCCGGCTGCACCTATGCAGCTCTTCAATGGAGGATGCCCACCCCCTCCTCCTGTCCTGGATGGTGAGGACGTGCTTCCTGACCTGGACCTCCTCCCACCCCCTCCACCGCCCCCTCCAGTGCTTCTGCCTTCTGAAGAGGAGGCTCCTGCTCCAATGGGGGCCTCACTCATTGCAGACTTAGAGCAGCTgcacctgtccccgcccccgcccccaccacagGCCCCAGCGGAGGGACCTTCAGTCCAGCCCGGTCCCCTCAGGCCCATGGAGGAAGAGCTGCCACCTCCCCCGGCAGAACCTGTTGAGAAAGGGGCATCCACAGACATCTGTGCCTTCTGCCACAAGACCGTGTCCCCCCGAGAGCTGGCTGTGGAGGCCATGAAGAGGCAGTACCATGCCCAGTGCTTCACGTGCCGCACCTGCCGCCGCCAGCTGGCTGGGCAGAGCTTCTACCAGAAGGATGGGCGACCCCTCTGCGAACCCTGCTACCAGGACACACTGGAGAGGTGCGGCAAGTGTGGCGAGGTGGTCCGGGACCACATCATCAGGGCCCTGGGCCAGGCCTTCCACCCCTCCTGCTTCACGTGTGTGACCTGCGCCCGGTGCATTGGGGATGAGAGCTTTGCCCTGGGCAGCCAGAACGAGGTGTACTGCCTGGACGACTTCTACAGGAAATTCGCCCCCGTCTGCAGCATCTGTGAAAATCCCATCATCCCTCGGGATGGGAAAGATGCCTTCAAAATCGAATGCATGGGAAGAAACTTCCATGAAAATTGCTACAGGTGTGAGGACTGCAGGATCCTCCTGTCTGTCGAGCCCACGGACCAAGGCTGCTACCCCCTGAACAACCATCTCTTCTGCAAGCCATGCCATGTGAAGCGGAGTGCTGCGGGGTGCTGCTGAGAGTGCCCGCTGGGCAGTGAACAGACCACTAGCCCCGGCTGGGGCCCTTCCCTGACTTGGTTTCCCTTCCTAACCTGCTCTTGCACACTTTCCTTCTGAGCCTCCATGGAGACCAGCCTGCAAGCCGGCCCAGCCTGTCCAGGATACAGTGGGGCTGAGCACCCCCAGGCCTTCCACTCCTCTACCCTCTGGGCACCAGAAGGCTCCTGGACCATGAGCTTCACCCCCAGAATTCCCTGCTGACCCTGCCCCACTTCCAGGGAAAAGCTGGGGGAGGTTGGACCCCTCTCACTGACTAGCTGTCTGGTAGGGGTGCTAGGACCAGCCTCGCCTGTGGGGTTGAGCTGTTTGAGGACAAACTCCAAGGTCCCTTAAAAAGTGCCTTTTAGAggctgggcatggtggctcacgcttgtaatcccagcactttgggaggccaaggtgggtggatcacctgaggtcaggagttcaagaccagcctggccaacatggtgaaaccctgtctctactaaaaatacaaaaattagccaggcatggtagcaggtgcctgtaatcccagctactggggaaagctgaggcaggagaattgcttcaatctggaaggcagaggttgcagtgagattgcaccattgcattccagcctgggcaacaagagggaaactccgtctcaaaaaaaaaaaaGTGCCTTTTAggccggatgtggtggctcatgcctgtaatcccagcactttgggaggccaaggcaggcagatcacttgaggtcaggagtttgagaccagcctggccaacacggcaaaaccccgtttctactaaaaatacaaaaattagctgggtgtggtggcgtgcgcctgtaatcccagctactcaggaggctgaggcaggagcattgcttgaacccgggaggcagaggttgcagtgagctgagatggcaccactgcactccagcctgggagacacagcgagactctgtctccaaaaaaaaaaGTGCTTTTTGAAAATGTTGAGGTTGAAATGATGGGAACCAACATTCTTTGGATTTAGTGGGGAGCATAATAGCAAACACCCCCTTGGTTCGCACATGTACAGGAATGGGACCCAGTTGGGGCACAGCCATGGACTTCCCCGCCCTGGAATGTGTGGTGCAAAGTGGGGCCAGGGCCCAGACCCAAGAGGAGAGGGTGGTCCGCAGACACCCCGGGATGTCAGCATCCCCCGACCTGCCTTCTGGCGGCACCTCCCGGGTGCTGTGTTGAGTCAGCAGGCATGGGGTGAGAGCCTGGTATATGCTGGGAACAGGGTGCAGGGGCCAAGCGTTCCTCCTTCAGCCTTGACTTGGGCCATGCACCCCCTCTCCCCCAAACACAAACAAGCACTTCTCCAGTATGGTGCCAGGACAGGTGTCCCTTCAGTCCTCTGGTTATGACCTCAAGTCCTACTTGGGCCCTGCAGCCCAGCCTGTGTTGTAACCTCTGCGTCCTCAAGACCACACCTGGAAGATTCTTCTTCCCTTTGAAGGAGAATCATCATTGTTGCTTTATCACTTCTAAGACATTTTGTACGGCACGGACAAGTTAAACAGAATGTGCTTCCCTCCCTGGGGTCTCACACGCTCCCACGAGAATGCCACAGGGGCCGTGCACTGGGCAGGCTTCTCTGTAGAACCCCAGGGGCTTCGGCCCAGACCACAGCGTCTTGCCCTGAGCCTAGAGCAGGGAGtcccgaacttctgcattcacagaccacctccacaattgttataaccaaaggcctcctgttctgttatttcacttaaatcaacatgctattttgttttcactcacttctgactttagcctcgtgctgagccgtgtatccatgcagtcatgttcacgtgctagttacgtttttcttcttacacatgaaaataaatgcataagtgttagaaGCTC

Publications

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