Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name KRT8P49
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:4722490-4724198  UCSC
Coordinates (T2T) chr11:4787999-4789705  UCSC
Coordinates (hg19) chr11:4743720-4745428  UCSC
Strand -
Parental Sequence NM_001256293.2
Parental seq. overlap 1344 bp
Parental seq. overlap (%) 65.1%
Genomic Region Intragenic (MMP26)
Retrocopy Summary KRT8P49, located on chr11:4722490-4724198, is a retrocopy of the parental gene KRT8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name KRT8
Full Name keratin 8
Also known as CARD2|CK-8|CK8|CYK8|K2C8|K8|KO
Coordinate chr12:52897191-52949860
Strand -
Gene summary This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes KRT8P31
Bonobo Pan paniscus KRT8P32
Orangutan Pongo abelii KRT8P34
Gibbon Nomascus leucogenys KRT8P34
Green monkey Chlorocebus sabaeus KRT8P5
Baboon Papio anubis KRT8P41
Golden snub-nosed monkey Rhinopithecus roxellana KRT8P52
Gorilla Gorilla gorilla Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>KRT8P49
CCAGGGCCGTGGTTGTGAAGAATATCGAGACCCACGAAGGGAAGCTGGTGTCCGAGTCCTCTGACGTCCTGCCCAAGTGAACAGCTGTGGCAGCCCCTCCCAGCCTGCCCCTCCTGCGGCTGCGGGAAAGCACAGGAGGGAGGCCACTGTGCAGGGTAGCACAGGGAACAGGGGACCCACCTGAGGCTCAGCCCTAGCCCTCAGCCCACCCACGGGGGAGTTTAGTGCCTGAGGACACCCCTTGCCCGTGCCTCCAGCTACAAAACAATTCAATTGCTTTTTTTTTTTTCCTGTCCTAAATAAATCCTCAGCTAACCCTGCCCGCCTGCCTCCACTCCTGCCTCTACCATGTCCATCAGGGTAACCCAGAAGTCCTACGAGGTGTCCACCTCTAGCCCCCCAGGACTTCAGCAGCCGCTCCTACACGAGTGGACCTGGTGCCTGCATCAGCTCCTCAAGCTTTTCCCCAGTGGTACCAGCAGCTTCCGGGGTAGCCTGGGTGGAGGTTATGGTGGGTCCAGCGGCATGGGAGGCATCACCACTGACACAGTCAACCAGAACCTGCTGAGTCCCCTTAACCTGGAGGTAGATCCCAACATCCAGGCCATGCGCACCCAGGAGAAGGAGCAGATCAAGACCCTCAACAGCTAGTTTGCCTCCTTCATAGACAAGGTACGGTTCCTGGAGCAGCATAACAAGATGCTGGAGACCAAGTGGAGCCTCCTGCAGCAGCAGAAGACAGCTCGGAGCAACATGGACAACATGTTCGAGAGCTACATCAACAACCTTAGGCGGCAACTGGACACTCTGGGCCAGGAGAAGCTGAAGCTTGGCAACATGCAAGGGCTGATGGAGAACTGCAAGAACAAGTATGAGGATGAGATCAATAAGTGTGCAGAGCTGGAGAATGAATTTGTCCTCATCAAGAAGGATGTGGATGAAGCTAACATGAACAAGGTAGAGCTGGAGTCTCTCCTGGAAGGGCTGACTGACGAGATCAACTTCCTCAGGCAGCTGTATGAAGAGGAGATCCCAGAGCTGCAGTCCCAGATTTCGGACACATCTGTGGTGCTGTCCATGGACAGCAGCCGCTCCCTGGACATGGACAACACTATCGCTGAGGTCAAGGCGCAGTACAAGGTGATCTCCAACCGCAGCCGGGCGGAGGCTGAGAGCATGCACCAGATCAAGTATGAGGAGCTGCAGATGCTGGCTGGGAAGCAGGAGGATGACCCGCAGCGCACAAGACTGAGATCTGCAAGATGAACTGGAACATCAGCCGGCTCCAGGCTGAGATTGAGGGCCTCAAAGGCCAGAGGGCTTCCCTGGAGGCCGCCATCGCAGATGCCGAGCAGCGTGGGGAGCTGGCCATTAAGGATGCCAACTCCAAGCTGTCCGAGCTGGAGGCCGCCCTGCAGCGGGCCAAGCAGAACATGCCGTGACAGCTGCATGGGTACCAGGAGCTGATGAAAGTCAAACTGGCCCTGGATATCGAGATCGCCACCTACAGGAAGCTGCTGGATGGCGAGGAGAGCCGGCTGGAGTCTGGGATGCAGAACATGAGTATCCATACAAAGACCACCAGTGTCTATGCAGGTGGTCTAAGCTCGGCCTATGGGGGCCTCACAAGCCCTGGCCTCAGCTATGGCCTGGg
>NM_001256293.2
CTTTCCTTACCTCCCTCCATGCTGTCCACTTCCTCTGTAAAGCTCTCAACCCTGTCCCCTTCCCCCTCTCTCCTGGGAAAGAGCCCTCCCATGCCTAGCTGCTGCTCTTAGGGACCCTGTGGCTAGGTGCGCGGATGGAAATCCAGGATCTCCGCCTGGTTCGGCCCGCCTGCCTCCACTCCTGCCTCTACCATGTCCATCAGGGTGACCCAGAAGTCCTACAAGGTGTCCACCTCTGGCCCCCGGGCCTTCAGCAGCCGCTCCTACACGAGTGGGCCCGGTTCCCGCATCAGCTCCTCGAGCTTCTCCCGAGTGGGCAGCAGCAACTTTCGCGGTGGCCTGGGCGGCGGCTATGGTGGGGCCAGCGGCATGGGAGGCATCACCGCAGTTACGGTCAACCAGAGCCTGCTGAGCCCCCTTGTCCTGGAGGTGGACCCCAACATCCAGGCCGTGCGCACCCAGGAGAAGGAGCAGATCAAGACCCTCAACAACAAGTTTGCCTCCTTCATAGACAAGGTACGGTTCCTGGAGCAGCAGAACAAGATGCTGGAGACCAAGTGGAGCCTCCTGCAGCAGCAGAAGACGGCTCGAAGCAACATGGACAACATGTTCGAGAGCTACATCAACAACCTTAGGCGGCAGCTGGAGACTCTGGGCCAGGAGAAGCTGAAGCTGGAGGCGGAGCTTGGCAACATGCAGGGGCTGGTGGAGGACTTCAAGAACAAGTATGAGGATGAGATCAATAAGCGTACAGAGATGGAGAACGAATTTGTCCTCATCAAGAAGGATGTGGATGAAGCTTACATGAACAAGGTAGAGCTGGAGTCTCGCCTGGAAGGGCTGACCGACGAGATCAACTTCCTCAGGCAGCTATATGAAGAGGAGATCCGGGAGCTGCAGTCCCAGATCTCGGACACATCTGTGGTGCTGTCCATGGACAACAGCCGCTCCCTGGACATGGACAGCATCATTGCTGAGGTCAAGGCACAGTACGAGGATATTGCCAACCGCAGCCGGGCTGAGGCTGAGAGCATGTACCAGATCAAGTATGAGGAGCTGCAGAGCCTGGCTGGGAAGCACGGGGATGACCTGCGGCGCACAAAGACTGAGATCTCTGAGATGAACCGGAACATCAGCCGGCTCCAGGCTGAGATTGAGGGCCTCAAAGGCCAGAGGGCTTCCCTGGAGGCCGCCATTGCAGATGCCGAGCAGCGTGGAGAGCTGGCCATTAAGGATGCCAACGCCAAGTTGTCCGAGCTGGAGGCCGCCCTGCAGCGGGCCAAGCAGGACATGGCGCGGCAGCTGCGTGAGTACCAGGAGCTGATGAACGTCAAGCTGGCCCTGGACATCGAGATCGCCACCTACAGGAAGCTGCTGGAGGGCGAGGAGAGCCGGCTGGAGTCTGGGATGCAGAACATGAGTATTCATACGAAGACCACCAGCGGCTATGCAGGTGGTCTGAGCTCGGCCTATGGGGGCCTCACAAgccccggcctcagctacagcctgggctccagctttggctctggcgcgggctccagctccttcagccgcaccagctccTCCAGGGCCGTGGTTGTGAAGAAGATCGAGACACGTGATGGGAAGCTGGTGTCTGAGTCCTCTGACGTCCTGCCCAAGTGAACAGCTGCGGCAGCCCCTCCCAGCCTACCCCTCCTGCGCTGCCCCAGAGCCTGGGAAGGAGGCCGCTATGCAGGGTAGCACTGGGAACAGGAGACCCACCTGAGGCTCAGCCCTAGCCCTCAGCCCACCTGGGGAGTTTACTACCTGGGGACCCCCCTTGCCCATGCCTCCAGCTACAAAACAATTCAATTGCTTTTTTTTTTTGGTCCAAAATAAAACCTCAGCTAGCTCTGCCAA

Publications

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