Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CLNS1AP2
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:151777905-151778626  UCSC
Coordinates (T2T) chr1:150901392-150902113  UCSC
Coordinates (hg19) chr1:151750381-151751102  UCSC
Strand -
Parental Sequence NM_001311200.2
Parental seq. overlap 661 bp
Parental seq. overlap (%) 22.9%
Genomic Region Intragenic (TDRKH)
Retrocopy Summary CLNS1AP2, located on chr1:151777905-151778626, is a retrocopy of the parental gene CLNS1A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CLNS1A
Full Name chloride nucleotide-sensitive channel 1A
Also known as CLCI|CLNS1B|ICln
Coordinate chr11:77614530-77637794
Strand -
Gene summary This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CLNS1AP1
Bonobo Pan paniscus CLNS1AP1
Gorilla Gorilla gorilla CLNS1AP1
Orangutan Pongo abelii CLNS1AP1
Gibbon Nomascus leucogenys CLNS1AP2
Green monkey Chlorocebus sabaeus CLNS1AP2
Crab-eating macaque Macaca fascicularis CLNS1AP1
Rhesus Macaca mulatta CLNS1AP1
Baboon Papio anubis CLNS1AP1
Golden snub-nosed monkey Rhinopithecus roxellana CLNS1AP3
Marmoset Callithrix jacchus CLNS1AP2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CLNS1AP2
TGGAGAGATTAGAAGGAATGCCTTCTCAGTCTGAGCAGCCAGTATAATATGGCTGGGGTCAGGACAGAAGATTCGGTAAGATATTTTGAAGATGGGATGGAGGTAGAATCCACACCAACAGTTGCTGGACAGTTTGAGGGTGCAGATGTTGATCACTGAAAATGATTTATGCAGGTATAAGATTCTGCTCCTAATTGTAGGAGAGAACTTGGTGCCTCTTCCACTCTGAAGCAAAGTTGATGAAAGTCTTCTTCCTTTTCCAAAACCCAACCTGAACTACTTCTTTCTTGAGACAGACTATATTGAGACAAGTTGTTACCAGCAAAAGATAGATACATGACCTTTATTAACAAAAATGAATTAACCAAGAGGATATTTGTAGTTTATTATTTACCCCAAACTTTCTGTGTCTGGGTACCCTCTGAGTAGGCCTATAATTCCTGCCTTCACTGTATGCATTTTATGTAAGCTAGCAGACCTATGTGGTGAGAATGCACAGGAGCTTGGAGGTATAAATAGACAGGGTGGGAAAGAGAGAGCTCCTTTCGCCATGTTTTACCAGCCCGCTCTGTTATAACCTCTTAGGTTATATTCTTTAATTTCCAACCTTTTAGGTTAGTTTCTGTAACAGAACAAATGAGTCTGGGATAAAGTCCTCAAAGTACTTCAAATGGTAATTGTTTTGTTTTTGTAACGGCTTAACAAATAACCTAGGTTTTCTG
>NM_001311200.2
CTCTTCCAGGGCGGGCGGTGTGGTGCACGCATTGCTGTGCTCCAACTCCCTCAGGGCCTGTGTTGCCGCACTCTGCTGCTATGAGCTTCCTCAAAAGTTTCCCGCCGCCTGGGCCAGCGGAGGGGCTCCTGCGGCAGCAGCCAGACACTGAGGCTGTGCTGAACGGGAAGGGCCTCGGCACTGGTACCCTTTACATCGCTGAGAGCCGCCTGTCTTGGTTAGATGGCTCTGGATTAGGATTCTCACTGGAATACCCCACCATTAGTTTACATGCATTATCCAGGGACCGAAGTGACTGTCTAGGAGAGCATTTGTATGTTATGGTGAATGCCAAATTTGAAGTGGAGGCAATGTTCACTGCAATGTGCGAATGCCAGGCCTTGCATCCAGATCCTGAGGATGAGGATTCAGATGACTACGATGGAGAAGAATATGATGTGGAAGCACATGAACAAGGACAGGGGGACATCCCTACATTTTACACCTATGAAGAAGGATTATCCCATCTAACAGCAGAAGGCCAAGCCACACTGGAGAGATTAGAAGGAATGCTTTCTCAGTCTGTGAGCAGCCAGTATAATATGGCTGGGGTCAGGACAGAAGATTCAATAAGAGATTATGAAGATGGGATGGAGGTGGATACCACACCAACAGTTGCTGGACAGTTTGAGGATGCAGATGTTGATCACTGAAAATGATTTATGCAAGTTTAAGATTCTGCTCCTAAGTGTAGGAGAGAACTTGGTGCCTCTTCCACTCTGGAGTGAAGTTAATGAAAGTCTTTTTCCTTTTCCAAAACCCAACCTGAACCAGTTCTTTCTTGAGACAGACTATACTGAGACAACAAGTTGTCACCAGCAGAAGATAGATAATATGACCTTTATTAACTTGATGAATTAACTTAACCAAGAGGGTATTTGTAGTTTACTATTTACCCTAAAACTTTCTGTGTCTGGGTACCCTCTGAGTAGGCCTATAATTCCTACCTTGACTGTGTGCATCATTTGTAAGCTAGCAGATCTATGTGGTGAAAATGCACAGGAGCTTGGTAGACTGCGGGGGAAAGAGAGAGCTCCTTTCGCCATGTTTTACCAGTCTGCTGTTATAACCTCTTAGGTTGTATCCTTTAATTTCCAGCCTTTTAGGTTAGTTTCTGTAACAGAACAAGTGAGTCTGGGATGAAGTCCTCAAAGTACTTCAAATGGTAATTGTTTTGTTTTTGTAATAGCTTAACAAATAAACCTAGGTTTTCTATATTACTTTGCTCTCATTCTTGACTAAAACCATTAATGAGAAATGTTTTTTAAAAAATAATGCTGGCAAATATGAGAATTTTGTTGGCTTTATTTTTGTTTACTTGTTGAGAAGATGAACATGAAATTAATAAGAAAATATAGTTATAGCTTCTGGCAAGTATTTAGTAAGGCAAAGATTTAACACATTTCAGGGGATTTCTGCCACTTCCTTTTAGATCAGCAGTAATTTCTTATATTTATCAACTCTCAATTTTTAGTTTTCATAGATACCTGGGTATTATAAGGCTGATTTGTAATTACTGATTTATACTTGGACTTTTGAAATCATTATGTGTCCTTAAAAATAAGGTTATACAAGCTAACCTTCTTAACAGGATCACATGGCTAATTAGTGACTAAACTGATGTTTGGTACCACTCAGCCCAGTGTTCATTTCAGCACTGTCACTTGGTTTCCCTTATCTTGCAAGGTAGACTGAAAAAAAACGAATTTTCCTTTTTCTAACCAGACTCTCAGAATTTCTGAGTCTGTTAACAATAGGCAAGTAAAACAGCCACTTGAAATGGAaactaaaatttactgagacctctgtactagccactgtcctgagttctttattatgtattataatattcttaattatcttatgagatacgcttttatcccactttatagttgaggaaactgagttatagagagaggtaaaataacttgcttaaggtcatgtagatagtgaatTGTGATTTTTGAGCCTGTGCTTTAAAACATCATACAGCCTTACCACCTACCAGCAGCAGAAAGCATGCACACTCTCCCCACTGCTGCAGGGTTTCAGTGTTAACATTTCAATGGCCAGTACAAGAGCTTCCCCAGTTTCTCTGCTACCCATCTGAGCAACACCCATAATTCTATCCTAGAAGTTTGTCCATTCTTCAGTAATCAGTCAGGACATTCTCACAGGCTAATATTAGAAATTCCATTTGAGTTCCTTTTAAAAGGAACAAATTTATAATTGTGACTTTCCATGAACATAAATTGCTCTGATAGCAAAATGTCGAGAAGATTCAGAGTGTACTTGGTTTCTTGTTGGTGTTGCTGTGGTCAATGCAATATGCAAAAAGGCAGGAGACCAAAGCATGTGGGCACCTCTCTGGGCTTATTTCCTCATTAGACTAAGTGACTTTCAAAGATTGAGCTGTAACATTCACTAGATAGTTAGAACCGTAGCATTGAGAAAATAGAAGCTGAGAAAAAAGAGCAGGTCAGGCTTTTAAAAGATAAAATTTATAATGATCAGCCAGACAATATTTATTGATTTCATTTGAGCCTAATTTTAGGGTTGCTGGAATTGTTTTCTTTGTGTGTTCCTGATGTAGAGACACTTTAAAGGTACATAGACATTTCCCCTCCAAAATGTAAGTCATCTAAATGTTCCTAAAAGCTAGGGTTAATGGTTCTCTGTTCTAGGTTCTTCATTTAAAAAATGTATTCATTAAGATATGGTCCCAgccggacgtggtggctcacacctgtaatcccagcactttgggaggctcaggtgggcagatcacttgaggtcaggagtttgagaccagcctggccaatacggtgaaaacccatctct

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