Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GEMIN2P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:153717262-153717821  UCSC
Coordinates (T2T) chr1:152854518-152855077  UCSC
Coordinates (hg19) chr1:153689738-153690297  UCSC
Strand -
Parental Sequence NM_003616.3
Parental seq. overlap 505 bp
Parental seq. overlap (%) 38.1%
Genomic Region Intergenic
Retrocopy Summary GEMIN2P1, located on chr1:153717262-153717821, is a retrocopy of the parental gene GEMIN2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GEMIN2
Full Name gem nuclear organelle associated protein 2
Also known as SIP1|SIP1-delta
Coordinate chr14:39114261-39136973
Strand +
Gene summary This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GEMIN2P1
Bonobo Pan paniscus GEMIN2P1
Gorilla Gorilla gorilla GEMIN2P1
Golden snub-nosed monkey Rhinopithecus roxellana GEMIN2P2
Marmoset Callithrix jacchus GEMIN2P4
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GEMIN2P1
GAAGTTGAAAAGGAAGCAAGGTGTGAAGGTTTCTCTTTTAGGATGCCAACCTGCCCCTGAAGGTTATTCCCCAATACTTCAGTGGCAATAGAAAGTGGCACCGTTTTCAACGTAAGACAGAATGTGCACAAACATAGAAGTCACTGCAAATCACGACAGTTGGATAGTAATGTGACTATGCCAAAATCTAAAGATGAAGAAGGCTAGAAGAAATTTTGTCTGAGTGAAAGTTTATATGCTGGTGTGGTCACTGACAGCTACAAATGAAAGTCCTAGAATTAATTATGTTCAAATTGGTTTTCCTCCCTTGGTTAGTATTGCTAGCAGAATGAATCAGACAACAGTAGCTACTGTCTTGGAATATCTGAGTAATTGGTTTGGAGAAAGAGACTTTACTTTGGATTTGAGAAGATGGCTTTATGTCTTATTGGCTTGCCTTGAAAAACCTTTATTACATGAGGTTCATTCACTGATTCAGCAGCTTGCAAGAAGGTGCTCTGAAGTGTGAGGCTCTTAGTGGATAGCAAAGATGATGAGAGGGTTCCTGCTTTGAATTTATG
>NM_003616.3
GGCTGGTTTGAAAACCATGGCGTGGGTACCAGCGGAGTCCGCAGTGGAAGAGTTGATGCCTCGGCTATTGCCGGTAGAGCCTTGCGACTTGACGGAAGGTTTCGATCCCTCGGTACCCCCGAGGACGCCTCAGGAATACCTGAGGCGGGTCCAGATCGAAGCAGCTCAATGTCCAGATGTTGTGGTAGCTCAAATTGACCCAAAGAAGTTGAAAAGGAAGCAAAGTGTGAATATTTCTCTTTCAGGATGCCAACCCGCCCCTGAAGGTTATTCCCCAACACTTCAATGGCAACAGCAACAAGTGGCACAGTTTTCAACTGTTCGACAGAATGTGAACAAACATAGAAGTCACTGGAAATCACAACAGTTGGATAGTAATGTGACAATGCCAAAATCTGAAGATGAAGAAGGCTGGAAGAAATTTTGTCTGGGTGAAAAGTTATGTGCTGACGGGGCTGTTGGACCAGCCACAAATGAAAGTCCTGGAATAGATTATGTACAAATTGGTTTTCCTCCCTTGCTTAGTATTGTTAGCAGAATGAATCAGGCAACAGTAACTAGTGTCTTGGAATATCTGAGTAATTGGTTTGGAGAAAGAGACTTTACTCCAGAATTGGGAAGATGGCTTTATGCTTTATTGGCTTGTCTTGAAAAGCCTTTGTTACCTGAGGCTCATTCACTGATTCGGCAGCTTGCAAGAAGGTGCTCTGAAGTGAGGCTCTTAGTGGATAGCAAAGATGATGAGAGGGTTCCTGCTTTGAATTTATTAATCTGCTTGGTTAGCAGgtattttGACCAACGTGATTTAGCTGATGAGCCATCTTGATGTAGCTGATCTCTCAGGGATAGAAGATATTTCTCATGAAGGCAGCCTAACTCTGAGGAAAACAATGCCAATTCAAGTACAGATTTCAACACATCTTCAACACTATGTGAAGGGTTCACATCTTAACCTGTGCAATTCAGATTGATACTCAGAATATGGGTTGATTTGAATATCTGAAATATCAATGGAAAATCCCACTCAGTTTTTGATGAACAGTTTGAACAGTTTTCTGTAATCAAGCAGCTTGCATAGAAATTGTATGATGAAATTTTACATAGGTTCTTGGTGCTGttttgttctttttttgttttttgttgttttgttatttACTTATATACATATAAAATTTTATTGAAAATATGTTTTGGTTACTAAAATTTTGTTTGACTCCTAACAAAAGACAATGGATGGCCTTAGCATCAGAATTAAAATAATCTGGATTAAATGGCAATGTGTTCATAGTCAGCAATAAAATTAAACATTTTTCCCTTTAA

Publications

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