Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PLIN2P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:153851627-153853447  UCSC
Coordinates (T2T) chr1:152988882-152990702  UCSC
Coordinates (hg19) chr1:153824103-153825923  UCSC
Strand -
Parental Sequence NM_001122.4
Parental seq. overlap 1682 bp
Parental seq. overlap (%) 87.6%
Genomic Region Intragenic (GATAD2B)
Retrocopy Summary PLIN2P1, located on chr1:153851627-153853447, is a retrocopy of the parental gene PLIN2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PLIN2
Full Name perilipin 2
Also known as ADFP|ADRP
Coordinate chr9:19108391-19127518
Strand -
Gene summary The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PLIN2P1
Bonobo Pan paniscus PLIN2P1
Gorilla Gorilla gorilla PLIN2P1
Orangutan Pongo abelii PLIN2P1
Gibbon Nomascus leucogenys PLIN2P1
Green monkey Chlorocebus sabaeus PLIN2P1
Crab-eating macaque Macaca fascicularis LOC102124370P1
Rhesus Macaca mulatta LOC712661P1
Baboon Papio anubis LOC116268533P1
Golden snub-nosed monkey Rhinopithecus roxellana PLIN2P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PLIN2P1
CTGCCGTCCGTTGATTTATTTCTCCAGGAAGAAAAATGGCATCTGTTGCAGTTGATCCACAACTGAGTGTGATGACTCGGGTGGTCAACCTGCCCTTGATGAGCTCCACATATGACCCCATGTCCTCAGCCCATGTCAGTACAAAGGACCAGTGTCCTACTTGAAGTCTGTGTGTGAGATGGCAGGGAAGGGTGTGAAGACCATCACCTCGGTGGCCATGACCAGTGTGCTCTGCCCATCATCCAGAAGCTAGAGCTGCAAATTGCAGTTGCCAATATCCGTGTCTGTAAGGGGCTAGACAGGATTGAGGAGAGACTGCCTATTCTGAATCAGCCATCAACTCAGGTTGTTGCCAATGCCAAAGGTGCTGTGACTGGGGCAAAAGATGCTGTGACGACTACTGTGACTGGGGCCAAGGATTCATCACAGGGTTGATGGACAAGACCAAAGGGGTAGTGACTGGCACTGTGGAGAAGACCCAAGTCTGTGTCAGTGGCAGCATTAACACAAGCTTAGGAAGTCAGATAATGCAGCTCATGAGCAGTGGCTTGGAACATGCGCTCACCAAATCAGAGCTCTTGGTAGGACAGTACCTCCCTCTCACTGGGGAAGAACTAGAAAAAGAAGCAAAAAAAGTTGAAGGATATGATATGGTTCAGAAGCCAAGTTGTTATGTTAGACTGGGATCCCTGTCTACCAAGCTTCACTCCCTGTCTACCAAGCTTCACTTCGTATGAGCAGGCTCTCAGCAGGGTTAAAGAAGCTAAGCAAAAAAGCCAAGAGACCATTTCTCAGCTCCGTTCTTCTGTTCACTTGATTGAATTTGCCAGGAAGAGTGTGCATAGTGCCAATCAGAAAATTCAGGATGCTCAGGATAAGCTCTAGCTCTCATGGGTGGAGTGGAAAAGGAATATTGGATACGATGATACTGATGAGTCCCACTGTGCAGAGCACATCGAGTCACGTACTCTTGCTATTGCCTGCAACCTGACTTAGCAGCTCCAGACCACATGCCACGGCCTTCTGTCCAACATCCATGATGACCACAGAACATCCAAGGTCAGGCCAAGCATATGAGGGTGATGGCAGGCGACATCTACTCAGTGTTCTGCAATGCTGCCTCCTTTGAGGAAGTGTCTGACAGCCTCCACTTCTAGCAAGGGGCAGCTGCAGAAAATGAAGGAATCTTTAGATGACTTGATGGATTTCTTGTTAACAACATGCCCCTCAACTGGCTGGTAGGTCCCTTTCACCCTCAACTGACTGAGTCTCAGAATGCTTAGGACCAAAGTGCAGAGATGGACAAGAGCAGCCAGGAGGCCCAGCGATCTGAGCACAAAACTCATTAAACTTGCCCCTGTCACCAGTGAATGATGCGGCCAGCCAGTTAACACCTTTCGTTATGTTGAAATTAACCCTGCTAGGCAACCCTAAATTGGGAAGCAAGTAGCTAGTAAAAAGGCCCTCAATTATAGTTATTTCCAGCTGGATTAAGAGCTTTAAAGTTTCTGGCTTTAGCAGATGATTTCTGTTCACCTGGTAAGAAAAGAATGCTAGGCTTGTTAGAGCCTAGCCAGAACTCACAAAAAATTCAAGTGCACTTATGTTCTCATTCTGTGGCCATTGTGTTACCCTCTGTTACTGTTTGTGTTGAATAAAAACATCTTCATGCGGGCTGGGGTAGAAACTGGTGTCTGCTCTGGTATGATCTGAGCAGGCCTCTTTACTGATTTATCTCATGATGATTGCTTGTACAACTTGATTTTAGTTTTTTATTTCTCAAATAGGAATACTACCTTTGAATTCAATATAATTCACTGT
>NM_001122.4
GCTTTGACCGGGTCGTGGCAGCCGGAGTCGTCTTCGGGACGCGCCTGCTCTTCGCCTTTCGCTGCAGTCCGTCGATTTCTTTCtccaggaagaaaaatggcatccgttgcagttgaTCCACAACCGAGTGTGGTGACTCGGGTGGTCAACCTGCCCTTGGTGAGCTCCACGTATGACCTCATGTCCTCAGCCTATCTCAGTACAAAGGACCAGTATCCCTACCTGAAGTCTGTGTGTGAGATGGCAGAGAACGGTGTGAAGACCATCACCTCCGTGGCCATGACCAGTGCTCTGCCCATCATCCAGAAGCTAGAGCCGCAAATTGCAGTTGCCAATACCTATGCCTGTAAGGGGCTAGACAGGATTGAGGAGAGACTGCCTATTCTGAATCAGCCATCAACTCAGATTGTTGCCAATGCCAAAGGCGCTGTGACTGGGGCAAAAGATGCTGTGACGACTACTGTGACTGGGGCCAAGGATTCTGTGGCCAGCACGATCACAGGGGTGATGGACAAGACCAAAGGGGCAGTGACTGGCAGTGTGGAGAAGACCAAGTCTGTGGTCAGTGGCAGCATTAACACAGTCTTGGGGAGTCGGATGATGCAGCTCGTGAGCAGTGGCGTAGAAAATGCACTCACCAAATCAGAGCTGTTGGTAGAACAGTACCTCCCTCTCACTGAGGAAGAACTAGAAAAAGAAGCAAAAAAAGTTGAAGGATTTGATCTGGTTCAGAAGCCAAGTTATTATGTTAGACTGGGATCCCTGTCTACCAAGCTTCACTCCCGTGCCTACCAGCAGGCTCTCAGCAGGGTTAAAGAAGCTAAGCAAAAAAGCCAACAGACCATTTCTCAGCTCCATTCTACTGTTCACCTGATTGAATTTGCCAGGAAGAATGTGTATAGTGCCAATCAGAAAATTCAGGATGCTCAGGATAAGCTCTACCTCTCATGGGTAGAGTGGAAAAGGAGCATTGGATATGATGATACTGATGAGTCCCACTGTGCTGAGCACATTGAGTCACGTACTCTTGCAATTGCCCGCAACCTGACTCAGCAGCTCCAGACCACGTGCCACACCCTCCTGTCCAACATCCAAGGTGTACCACAGAACATCCAAGATCAAGCCAAGCACATGGGGGTGATGGCAGGCGACATCTACTCAGTGTTCCGCAATGCTGCCTCCTTTAAAGAAGTGTCTGACAGCCTCCTCACTTCTAGCAAGGGGCAGCTGCAGAAAATGAAGGAATCTTTAGATGACGTGATGGATTATCTTGTTAACAACACGCCCCTCAACTGGCTGGTAGGTCCCTTTTATCCTCAGCTGACTGAGTCTCAGAATGCTCAGGACCAAGGTGCAGAGATGGACAAGAGCAGCCAGGAGACCCAGCGATCTGAGCATAAAACTCATTAAACCTGCCCCTATCACTAGTGCATGCTGTGGCCAGACAGATGACACCTTTTGTTATGTTGAAATTAACTTGCTAGGCAACCCTAAATTGGGAAGCAAGTAGCTAGTATAAAGGCCCTCAATTGTAGTTGTTTCCAGCTGAATTAAGAGCTTTAAAGTTTCTGGCATTAGCAGATGATTTCTGTTCACCTGGTAAGAAAAGAATGATAGGCTTGTCAGAGCCTATAGCCAGAACTCAGAAAAAATTCAAATGCACTTATGTTCTCATTCTATGGCCATTGTGTTGCCTCTGTTACTGTTTGTATTGAATAAAAACATCTTCATGTGGGCTGGGGTAGAAACTGGTGTCTGCTCTGGTGTGATCTGAAAAGGCGTCTTCACTGCTTTATCTCATGATGCTTGCTTGTAAAACTTGATTTTAGTTTTTCATTTCTCAAATAGGAATACTACCTTTGAATTCAATAAAATTCACTGCAGGATAGACCAGTTA

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