Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CLDN6P2
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:155589958-155591314  UCSC
Coordinates (T2T) chr1:154728526-154729882  UCSC
Coordinates (hg19) chr1:155559749-155561105  UCSC
Strand -
Parental Sequence NM_021195.5
Parental seq. overlap 1289 bp
Parental seq. overlap (%) 94.3%
Genomic Region Intergenic
Retrocopy Summary CLDN6P2, located on chr1:155589958-155591314, is a retrocopy of the parental gene CLDN6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CLDN6
Full Name claudin 6
Also known as -
Coordinate chr16:3014712-3018183
Strand -
Gene summary Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CLDN6P1
Bonobo Pan paniscus CLDN6P1
Orangutan Pongo abelii CLDN6P1
Gibbon Nomascus leucogenys CLDN6P1
Gorilla Gorilla gorilla Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CLDN6P2
GGCCTAGGAATTTCGCATATCTCCTTCGCAGTGCAGCTCCTTCAATCTCACCATGGCCTCTGCCAGAATGCAGATCCTGGGAGTCGTCCTGACACTGCTGGGCTGGGTGAATGGCCTGGTCTCCTGCGTCCTGCCCATGTGGAAAGTGACCACTTTCATCGGCAACAGCATCGTGGTGGCCAGGTGGTGTGGGAGGGCCTGTGGATGTCCTGAGTGGTGCAGAGCACTAGCCAGATGCAGTGCAAGGTGTACGACTCACTGCTGGCGCTGCCACAGGACCTGCAGGCTGCACGTGCCGTCTGTGTCATCACCCTCCTTGTGGCCCTGTTCGGCTTGCTGGTCTACCTTGCTGGGGCCAAGTGTACCACCTGTGTGGAGGAGAAGGATTCCAAGGCCCGCCTGGTGCTCACCTCTGGGATTGTCTTTGTCACCTCAGGGGTCCTGACACTAATCCCCGTTTGCTGGACGGCGCATGCCATCATCTGGGACTTCTATAACCCCCTGGTGGCTGAGGCCCAAAAGTGGGAGCTGGGGGCCTCCCTCTACTTGGGCTGGGCGGCCTCAGGCCTTTTGTTGCTGGGTGGCAGGCTGCTGTGCTGCACTTGCCCCTCCGGGGGGTCACGGGGCCCCAGCCATTACATGGCCCGCTACTGGACATCTGCCCCTGCCATCTCTCGGGGGACCTCTGAGTACCCTACCAAGAATTACGTCTGACATGGAAGTGAATGGGGGCTCCGCTGGCACTAGAGCCATCCAGAAGTGGCAGTGCCCAACAGCTTTGGGATGGGTTCATATCTTTTGTTTCTGCCTCCTTCTATTTTTCTTTTGACTGAGGGTATTTAAAATTCATTTAAAAACTGAACCAAGAAGATGACTCAGACTCCCACTTAGGTTCTGCTGTTTCTCACCCTTGGATGATGGAGCCAAAGAGGGGATGCTTTGAGATTCTGGATCTTGACATGCCCATTTTAGAAGCCAGTCAAGCTGTGGAACTAATGTGGAGGCTGCTTGCTGTGCTGGCCTTTGCAACAAGACAGACTGTCCCCAAGAGTTCCTGCTGCTGCTGGGGGCTGGGTTTCCCTAGATGTCGCTGGACAGCTGCCCCCCATCGTACTCAGGCCTCTGGAGCTCCTCTCTTCACCCATGGAAAAGCAAGTGATCTGTTAACAAAGGACTGCCTACCTCCGGAACTTCTGACCTCTGGCTCCTCCGTCCTGGATGTCCACCTTGCAGGGTCAGGTCCCAGCTATGTAGACCCCCGCCCCCACCTCCAACACTGCACCCTTCTGTCCTGCCCGCCCCGCCTCACCCCCTTTACACTCACATTTTTACCAAATAAAGCATGTTTTGTTAGTGA
>NM_021195.5
ACTCGGCCTAGGAATTTCCCTTATCTCCTTCGCAGTGCAGCTCCTTCAACCTCGCCATGGCCTCTGCCGGAATGCAGATCCTGGGAGTCGTCCTGACACTGCTGGGCTGGGTGAATGGCCTGGTCTCCTGTGCCCTGCCCATGTGGAAGGTGACCGCTTTCATCGGCAACAGCATCGTGGTGGCCCAGGTGGTGTGGGAGGGCCTGTGGATGTCCTGCGTGGTGCAGAGCACCGGCCAGATGCAGTGCAAGGTGTACGACTCACTGCTGGCGCTGCCACAGGACCTGCAGGCTGCACGTGCCCTCTGTGTCATCGCCCTCCTTGTGGCCCTGTTCGGCTTGCTGGTCTACCTTGCTGGGGCCAAGTGTACCACCTGTGTGGAGGAGAAGGATTCCAAGGCCCGCCTGGTGCTCACCTCTGGGATTGTCTTTGTCATCTCAGGGGTCCTGACGCTAATCCCCGTGTGCTGGACGGCGCATGCCATCATCCGGGACTTCTATAACCCCCTGGTGGCTGAGGCCCAAAAGCGGGAGCTGGGGGCCTCCCTCTACTTGGGCTGGGCGGCCTCAGGCCTTTTGTTGCTGGGTGGGGGGTTGCTGTGCTGCACTTGCCCCTCGGGGGGGTCCCAGGGCCCCAGCCATTACATGGCCCGCTACTCAACATCTGCCCCTGCCATCTCTCGGGGGCCCTCTGAGTACCCTACCAAGAATTACGTCTGACGTGGAGGGGAATGGGGGCTCCGCTGGCGCTAGAGCCATCCAGAAGTGGCAGTGCCCAACAGCTTTGGGATGGGTTCGTACCTTTTGTTTCTGCCTCCTGCTATTTTTCTTTTGACTGAGGATATTTAAAATTCATTTGAAAACTGAGCCAAGGTGTTGACTCAGACTCTCACTTAGGCTCTGCTGTTTCTCACCCTTGGATGATGGAGCCAAAGAGGGGATGCTTTGAGATTCTGGATCTTGACATGCCCATCTTAGAAGCCAGTCAAGCTATGGAACTAATGCGGAGGCTGCTTGCTGTGCTGGCTTTGCAACAAGACAGACTGTCCCCAAGAGTTCCTGCTGCTGCTGGGGGCTGGGCTTCCCTAGATGTCACTGGACAGCTGCCCCCCATCCTACTCAGGTCTCTGGAGCTCCTCTCTTCACCCCTGGAAAAACAAATGATCTGTTAACAAAGGACTGCCCACCTCCGGAACTTCTGACCTCTGTTTCCTCCGTCCTGATAAGACGTCCACCCCCCAGGGCCAGGTCCCAGCTATGTAGACCCCCGCCCCCACCTCCAACACTGCACCCTTCTGCCCTGCCCCCCTCGTCTCACCCCCTTTACACTCACATTTTTATCAAATAAAGCATGTTTTGTTAGTGCA

Publications

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