Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RAD1P2
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:159080980-159081691  UCSC
Coordinates (T2T) chr1:158218015-158218726  UCSC
Coordinates (hg19) chr1:159050770-159051481  UCSC
Strand -
Parental Sequence NM_002853.4
Parental seq. overlap 613 bp
Parental seq. overlap (%) 13.6%
Genomic Region Intragenic (AIM2)
Retrocopy Summary RAD1P2, located on chr1:159080980-159081691, is a retrocopy of the parental gene RAD1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RAD1
Full Name RAD1 checkpoint DNA exonuclease
Also known as HRAD1|REC1
Coordinate chr5:34905260-34915504
Strand -
Gene summary This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RAD1P1
Bonobo Pan paniscus RAD1P1
Gorilla Gorilla gorilla RAD1P1
Orangutan Pongo abelii RAD1P1
Gibbon Nomascus leucogenys RAD1P2
Green monkey Chlorocebus sabaeus RAD1P3
Crab-eating macaque Macaca fascicularis RAD1P1
Rhesus Macaca mulatta RAD1P1
Baboon Papio anubis RAD1P1
Golden snub-nosed monkey Rhinopithecus roxellana RAD1P1
Marmoset Callithrix jacchus RAD1P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RAD1P2
TATTTTTGGATCAAGTCCTATGCCAGGGATTTTAACTGCACTTTGAATGTGTTACCAAGGTTATGGTGACCCTTGGATGCTATTTTTGGAAGAAAGACGAATGGTGACAGACTGCAAAATCAATACTCAAGAGCCTGAGGAGCCTCTGGATTTTGACTTCTGCAGCACCAATGTTATTAATAAAATTATTCTGCAGTCAGAGGGGCTCTGAAGCATTTCCCAGATTGGATGTGACGACTGAGGTCCTACAGATTATCATGTCTCCTGACAAGCATTATTTCAGGTTATCTACTTTTGAAAATTTAGAAAGTTTGCAATTTGACTTCCAAAGATTTTTATGTGGTGCAAGCATTTCATTGTAATCAGACCCAGGTCAACAGATTTTATTTCTTTGCTAATCCCCTTTACAAAAACGTTAGTCCTATCTTGTAAGGTATTTTATTCACACAAATAACAGGATTTCTTTCATTATGGTATATTTTTAGAATGAAGGGGGGCAAATATCTTTTGTGGAATATTACTGTTGCCCTGATGATGAAGTTCCTGAATCTGAGTCTTGAGTATGATGATTCACTGTGATATTTATGTGTACATTCATGATAAGTTGAGTTATCATTATGAGTATAAAAATCTTCATAATTTCTTATTGAATTTTCTGTAGAGAAGATGCATGGAGAAGATAAAAGCAAGGTCCCTGTACCCTAATAGTTAT
>NM_002853.4
ACTTCCTCCGCGGTTCCTCGGAGCCGCCTCGCTCCTCTTCAGGGACTTTGCTGAGAAGGGCTCTCGGGCGTCCAGACCCCACCGCAAAGGTGTTTGGCGATCCGCCGAGAAGTTGTTGGCCCCAGGAGCATCCCTCGGGGCCGAATGCGCAGTGGACGATGCCCCTTCTGACCCAACAGATCCAAGACGAGGATGATCAGTACAGCCTTGTGGCCAGCCTTGACAACGTTAGGAATCTCTCCACTATCTTGAAAGCTATTCATTTCCGAGAACATGCCACGTGTTTCGCAACTAAAAATGGTATCAAAGTAACAGTGGAAAATGCAAAGTGTGTGCAAGCAAATGCTTTTATTCAGGCTGGAATATTTCAGGAGTTTAAAGTTCAGGAAGAGTCTGTTACTTTTCGAATTAATTTAACTGTCCTTTTAGACTGTTTATCTATTTTTGGATCAAGTCCTATGCCAGGGACTTTAACTGCACTTCGAATGTGTTACCAAGGTTATGGTTACCCTTTGATGCTGTTCCTGGAAGAAGGAGGAGTGGTGACAGTCTGCAAAATCAATACACAGGAACCTGAGGAGACCCTGGACTTTGATTTCTGCAGCACCAATGTTATTAATAAAATTATTCTGCAGTCAGAGGGGCTCCGTGAAGCATTTTCTGAATTGGATATGACGAGTGAAGTCCTACAAATTACCATGTCTCCTGACAAGCCTTATTTCAGGTTATCTACTTTTGGAAATGCAGGAAGTTCCCACCTTGACTATCCCAAAGATTCTGATTTGATGGAAGCATTTCATTGTAATCAGACCCAAGTCAACAGATACAAGATTTCCTTACTGAAACCCTCTACAAAGGCATTAGTCCTATCTTGTAAGGTATCTATTCGGACAGATAACAGAGGCTTCCTTTCATTACAGTATATGATTAGAAATGAAGATGGACAAATATGTTTTGTGGAATATTACTGCTGCCCTGATGAAGAAGTTCCTGAATCTGAGTCTTGAGTATGACAATTCACTGATATTTATGTGTACATTTATGATAGATGAAGTTCTTATTCTGAGTACAGTACTCTTTGTCATTTCATATTGGATTTTCTATAGAGAAGAAGCACAATGGGGAAGATAGGAGCAAGGTCATGTACCCTAATAGTTACTATGTTTTGTAAATCCATTTTGTAGAGGGCATGTAAATAAATGTTTTCCTGTAGTCATAGATTATTCAGGACTGTCCTTTAGTTCTGTCTTTTGAACTCATGGGAATAATTGTGAGTCAGCGTAACATTTCAAGAGTCTAAAGGTggccgggtgtggtggctttaatcccagcactttgggaagccgaggtgggcggatcacctgaggtcaggagttcgagaccagcctgaccaacgtggagaaaccccatctctactaaaaatacaaaaaattagccggacgtggtggcacatgcctgtaatgccagctactcgggaggctgaggcaggagaattgcttgaacccgggaggcggaggttgtggtgagctgagatgacgccattgcactccagcctaggcaataagagcaaaactctgcctcaaaaaaaaaaaaaaaaaaaGTCTAAAGGCTTAAAGTTTGATGCAGCTACCTGAAATGATCTTTTATTTATTTATTATTAGAAAAAGCAAAGGCATATGGGCATTGCTTATTAGTTTGAATTCTAGAGACTAGATCTTAAAGTagtggttctcaaagtgttgtgcccgcaccaacatcagaatggcctgcaaacttgtagcaaactctggggaggaggccagcattctgtattttaacaagcttccctcaggagattctgatgcctgctaaattttgggaaccactgTTTTAAAGGAAACTTTTTTTTTCTTTAATAGCATTTAATTGTATGAGATGATTGCTTTTACATGTGATTTCCTTGCAAATGTTCTGAAGTTGAGGCATCACCAAACAAGTCTGAACAATTCTTTATGTGATTTATTTTTAAAGTAGACCTTTTGAAGAGATCTATGAATGGGATATAAAGCAATTTTCAGTGTTACAGGTTTTCTTCTTCTTCTCAAAACTGTTTGCTGTAAGTAACTGCAATCAGTACTTACTACTTTCCATTTGCTTATGAGTTTCTTGACAAATCAAGGTGTAGAAAACCAGTTATTAAGTGATTTTGTACTTTCCTGGTAGTTGTCACTAAAATAATTTTTGTGGCATATAAATATATTTAATAAAATGCAAAAATTATCTTCCTGTCTAGTAGAAAAAATTACATGAGTAAAGTGAAGCTTCTGTCTTTGTTACTGTACCAGGTGACAACAGCTGAGTGTCCCTCCATGGACAGTCACTATTGGCCTTTTGAGTGAGACAGTTCTTTAGGATAAAAACCTGTCATCCCATTGCAGGATTCATTTAGCCTTTCTGGCCCTTACCCACTGATGCTAGTCATTGTGACCACCCCACCTCCCCCAAATAAAAGTGTGCCAAACTATTCATTGTTGAGAACCATTCAATTGTAttcaccaaaattggaggatatattggaatgccctaccttaatataggtcacatagcatTAGAGAAAATTGGTTTGGAGAGTATTACAGCAAAGTGTGCTGCAAGGAGGCTACTCCAGCACAATGGCAGGCACTGCTTCCCAGGCATATGGACAATTCTGGGAGGTGGCCAGGGTCAGCACCTGATAACTAGTAAGTGTCTCAATCTCAGCATACAAAATTTAGCAGTGACTACAAAAGAAGTTGGAATTTTCTAAAATGTTTGTATTCAAGAAGGAAACAAATGAATTTACTAAATGTTGTCAGAGTATTTTTTGTTTAGATAACCACCAAGAACAGAACAAACCTAAAAGATACTTGGGAAAATATCTAATCAGTCAACATTCTAAGGACTGTTAAATGTGAAATAGCATAGTTATTttttgtcttttgttactagtgtgaacaaagaacggcgcctaacatataatgggcatttagtaactctgttagatgaaagaCTCTCCAATTTCAGATTTTCTTTTAGCATCTTATTAGTCACTACTTAATTCTGATGATTTAGCTCTAAATTTATTTTGATCTCAGtttttttatttttatttttggagacaagatcttgctctgttgcccaggctggagtacagttgtaggattacagttcactccagcctcaatctcctaggctcaagcaatcctcccatctcagcttcccaaatagctacgactacaggtgcatgcctccatgccctgctaatttttgtattttttgtagagatggggttttactatgttccctaggctaatcttgaactcctgagctcaagcaatccacccgcctcggcctcccaaagggctgggattacaggcgtgagctatcatgcctggccTAATGTATTTTTTAAAAGTTGAATCTAAAAAGAATTTAAAACAAATATAAATCAGCTCAGTAAGGATGGATATTTTTGTACATTTAAAACTATTATTTTAggccgggagtggtggctcacacctgtaatcccagcattttgggaagccgaggcagggggatcatctgaggtcaggaagttcgagatcagcctggccaacatggtgaaacccctacctctactaaaaatacaaaaattagctgggtgtggtggtgggtgtctgtaatcccagctacttgagaggctgaggcaagagaatcacttgaaactggaaggcgggggttgcagtgagccgagattgcaccattgcactccagcctgggtgacagagcaagactccgtctcaaaaacaaaaaaaattaaaataaaaaTTATTGTTTTAGCTGCATGTCTTCAGCTATTTAGAATTCAAAGACTAATGAATTGTTTCTAAGTCACCCTAACATCAAGGTACTTATTTTATAAAGAATTTCCTCCTTATTTGTGTTCTAATTGACCCAGGAATTTTTACTTTAATAAAAGTTTAACTTTATTTCCTATGGAAAATCACTAGGGGGAGTGCTCCCTCAGGCAGAGCAGGCGACACTTTGGTGCCACTACAAATTGATGTGTAGTATATAGAAGAATACAGTCTTATATTTAAAGACTTTTAGTTCTGTCTTTTTGAAGTTTATCTCTCTTTCTAGTAAAATGGTGCTTACTGTGAATGGATAATCTTTTTTTTCATTTTTCATTTGTTGATTTCCCATTCGATGATGTAGTGCTTCCACCGAGAATTGATGAAATGCTTCAAAATAATAAAAGTATTTGTTAAATTCCACTTTAATAAAAATAAGGCATGTAACACAGTCATTTTAACAGGAAGCCACAGGGTTTCTGTGGTGTTACCAAAGTCCTAGTAAAAATTAATTAAAATTGCTAAAAGGGCAGAATGTGGCACTCTCAACAGTGGGGTAGGCAGTCCTTCAGAACATAGAGACTTCCTTCTTTCCTTCCCTGTCTTCACATTGCTTGTCCCTTATCCCCACCTGAAATAAAATCTATTGGGTCCTGAGAAA

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