Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SETP9
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:160670138-160671568  UCSC
Coordinates (T2T) chr1:159807250-159808680  UCSC
Coordinates (hg19) chr1:160639928-160641358  UCSC
Strand +
Parental Sequence NM_003011.4
Parental seq. overlap 1159 bp
Parental seq. overlap (%) 39.4%
Genomic Region Intergenic
Retrocopy Summary SETP9, located on chr1:160670138-160671568, is a retrocopy of the parental gene SET. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SET
Full Name SET nuclear proto-oncogene
Also known as 2PP2A|I2PP2A|IGAAD|IPP2A2|MRD58|PHAPII|TAF-I|TAF-IBETA
Coordinate chr9:128683424-128696396
Strand +
Gene summary The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SETP1
Bonobo Pan paniscus SETP1
Gorilla Gorilla gorilla SETP1
Orangutan Pongo abelii SETP3
Gibbon Nomascus leucogenys SETP7
Green monkey Chlorocebus sabaeus SETP11
Crab-eating macaque Macaca fascicularis SETP4
Rhesus Macaca mulatta SETP4
Baboon Papio anubis SETP1
Golden snub-nosed monkey Rhinopithecus roxellana SETP18
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SETP9
AAGCAGCACCAAGTCTGTGCCAACGGCTAAAGTCAGTAGAAAGGAGCTCAACTCCAACCGCAACCGGGCAGACGAGACCTCAGAAAAAGAATAGCAAGCAGCAATTGAACACATTTGTGAAGTACAAAATGAAACAGACTTCATGAACAAGCCAGTGAGGAGAATTTGAAAGTAGAACAGAAATAGAACAAACTCTGCCAATCATTTTTTCAGAAGAGGTCAGAATTGATCATTGATGGCCCAAATCCCACATTTTTGGGTAACATCATTTGTCAACCACCCACGAGTGTCTGCACTGCTTGTGGAGGAGGATGAAGAGGCACTGCATTATATGACCAGAGTTGAAGTGACATAATTTGAAGATACTAAATTAGGTTACAGAATAGATTTTTATTTTGATGAACATCCTTACTTTGAAAATAAACTCCTCTCCAAAGAATTTCATCTAAATGAGAGTGGCGATCCATCTTCAAAGTCCACTGAAATCAAATGGAAATCTTGAAAGGATGTAACGAATCGTTCAAGTCGAACGAAGAATAAAGCCAGTAGGAAGAGGCAGCCTGAGGCACCAGAGAGCTTCTTGACCTGCTTTACTGACCATTCTGATGCAGGTGCTGGTGAGTTATGAGAGGTCATCACAGGTAGTACTTGGCCAAACCCATAACAGTGCTGCTTGGTTCCCAATGTGaCTAACAGAACACTGATGTTCTGAACAATTTTTTTTTTAATTTTCTCCAGTCCCTGGGAGCAAGTTGCAGTCTTTTTTCTTTTTTCCCCTCTTGTGCTCAGTCGCGCTGTTCTTGAGGTCTCTTTTCTCTACACCATGGTTTTCAACTTATTTGGGGGGAAATGCCTTGAGCATAATACAATGGGAAAATATTCTCTACCCCTTTCTCTTCAGAATTCATTCTTATCTCTTCCTGTCTGAACAAAAACTGTATGGAATCAACACCACCAAGTTCTGTGGGAGAAAAGAAAAACCTTCTCCCTTTGCTCTGCTGGAAGCTGGAGAGTGCCAGACCCCTGTGTAGCAGTGCATAGAATTCTAGCTTCTTTTCTCCTTTCTCTGTATATTGGGTTCAGAGAGTACCGTGTGTCTCTGTGTGAATATGGACCATCATTTATCAACATGTATCTGTCTACTTTCTCTTGTTTAAAAAAAGAAAAAAAAACCTGTAAAAAATGAGGTTATAGAAAGTCATCAAAGGGTGAGTATGAGATGTTTGGGTGGGTTAAGTGGGCATTTTAACAACATGGCTTCTCCTTTGGCATGTTTA
>NM_003011.4
CCCTCGCCGTaggaggaggtggaggaggaggcggCTCGGGAGAGCGAGCAGCGAGCTGGCTGGATCGCCGAGCGCGAGTGAGGGAGCCGAgccgcccgccgccgccgcctccgcctcccctccgcGAACAGGAgcccgggccggggcccggcacgccgccccagcccgTCCCTCGGCGTCAGGCCGCGAGGGTAGCgcgcgcgagcgagcgagggggagggagagcgagcgagcgccgggaggaggcggccggaccgagcgggcgcccgcgcgTGTGGCGTGAGGGGAAGCCGCTTGcccgcccccttcgccttcccttctctccccctccccgctccccccccGACCGCGGAGCAGCACCATGTCGGCGCCGGCGGCCAAAGTCAGTAAAAAGGAGCTCAACTCCAACCACGACGGGGCCGACGAGACCTCAGAAAAAGAACAGCAAGAAGCGATTGAACACATTGATGAAGTACAAAATGAAATAGACAGACTTAATGAACAAGCCAGTGAGGAGATTTTGAAAGTAGAACAGAAATATAACAAACTCCGCCAACCATTTTTTCAGAAGAGGTCAGAATTGATCGCCAAAATCCCAAATTTTTGGGTAACAACATTTGTCAACCATCCACAAGTGTCTGCACTGCTTGGGGAGGAAGATGAAGAGGCACTGCATTATTTGACCAGAGTTGAAGTGACAGAATTTGAAGATATTAAATCAGGTTACAGAATAGATTTTTATTTTGATGAAAATCCTTACTTTGAAAATAAAGTTCTCTCCAAAGAATTTCATCTGAATGAGAGTGGTGATCCATCTTCGAAGTCCACCGAAATCAAATGGAAATCTGGAAAGGATTTGACGAAACGTTCGAGTCAAACGCAGAATAAAGCCAGCAGGAAGAGGCAGCATGAGGAACCAGAGAGCTTCTTTACCTGGTTTACTGACCATTCTGATGCAGGTGCTGATGAGTTAGGAGAGGTCATCAAAGATGATATTTGGCCAAACCCATTACAGTACTACTTGGTTCCCGATATGgatgatgaagaaggagaaggagaagaagatgatgatgatgatgaagaggaggaaggattagaagatattgacgaagaaggggatgaggatgaaggtgaagaagatgaagatgatgatgaaggggaggaaggagagGAGGATGAAGGAGAAGATGACTAAATAGAACACTGATGGATTCCAACCTTCCTTTTTTTAAATTTTCTCCAGTCCCTGGGAGCAAGTTGCAGTCttttttttttttttttttttttttCCCTCTTGTGCTCAGTCGCCCTGTTCTTGAGGTCTCTTTTCTCTACTCCATGGTTCTCAATTTATTTGGGGGGAAATACCTTGAGCAGAATACAATGGGAAAAGAGTCTCTACCCCTTTCTGTTCGAAGTTCATTTTTATCCCTTCCTGTCTGAACAAAAACTGTATGGAATCAACACCACCGAGCTCTGTGGGAAAAAAGAAAAACCTGCTCCCTTCGCTCTGCTGGAAGCTGGAGGGTGCTAGGCCCCTGTGTAGTAGTGCATAGAATTCTAGCTTTTTTCCTCCTTTCTCTGTATATTGGGCTCAGAGAGTACACTGTGTCTCTATGTGAATATGGACAGTTAGCATTTACCAACATGTATCTGTCTACTTTCTCTTGTTTaaaaaaagaaaaaaaaacttaaaaaaaTGGGGTTATAGAAGGTCAGCAAAGGGTGGGTTTGAGATGTTTGGGTGGGTTAAGTGGGCATTTTGACAACATGGCTTCTCCTTTGGCATGTTTAATTGTGATATTTGACAGACATCCTTGCAGTTTAAGATGACACTTTTAAAATAAATTCTCTCCTAATGATGACTTGAGCCCTGCCACTCAATGGGAGAATCAGCAGAACCTGTAGGATCTTATTTGGAATTGACATTCTCTATTGTAATTTTGTTCCTGTTTATTTTTAAATTTTCTTTTTGTTTCACTGGAAAGGAAAGATGATGCTCAGTTTTAAACGTTAAAAGTGTACAAGTTGCTTTGTTACAATAAAACTAAATGTGTACACAAAGGATTTGATGCTTTTCTCTCAGCATAGGTATGCTTACTATGACCTTCCAAGTTTGACTTGTATAACATCACTGTCAAACTTTGTCACCCTAACTTCGTATTTTTTGATACGCACTTTGCAGGATGACCTCAGGGCTATGTGGATTGAGTAATGGGATTTGAATCAATGTATTAATATCTCCATAGCTGGGAAACGTGGGTTCAATTTGCCATTGGTTTCTGAAAGTATTCACATCATTTGGGATACCAGATAGCTCAATACTCTCTGAGTACATTGTGCCCTTGATTTTTATCTCCAAGTGGCAGTTTTTAAAATTGGCCTTTTACCTGGATATAAATTAATTGTGCCTGCCACCACCATCCAACAGACCTGGTGCTCTAATGCCAAGTTATACACGGGACAGTTGCTGGCATGTCTTCATTGGCTATATAAAATGTGGCCAAGAAGATAGGCTCTCAGTAAGAAGTCTGATGGTGAGCAGTAACTGTCCCTGCTTTCTGGTATAAAGCTCTCAAATGTGACCATGTGAATCTGGGTGGGATAATGGACTCAGCTCTGTCTGCTCAATGCCATTGTGCAGAGAAGCACCCTAATGCATAAGCTTTTTAATGCTGTAAAATATAGTCGCTGAAATTAAATGCCACTTTTTCAGAGGTGAATTAATGGACAGTCTGGTGAACTTCAAAAGCTTTTTGATGTATAAAACTTGATAAATGGAACTATTCCATCAATAGGCAAAAGTGTAACAACCTATCTAGATGGATAGTATGTAATTTCTGCACAGGTCTCTGTTTAGTAAATACATCACTGTATACCGATCAGGAATCTTGCTCCAATAAAGGAACATAAAGATTTTTTTTGGA

Publications

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