Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name EWSR1P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr22). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:166275453-166277630  UCSC
Coordinates (T2T) chr1:165621497-165623674  UCSC
Coordinates (hg19) chr1:166244690-166246867  UCSC
Strand -
Parental Sequence XM_017028661.2
Parental seq. overlap 1987 bp
Parental seq. overlap (%) 31.9%
Genomic Region Intergenic
Retrocopy Summary EWSR1P1, located on chr1:166275453-166277630, is a retrocopy of the parental gene EWSR1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name EWSR1
Full Name EWS RNA binding protein 1
Also known as EWS|EWS-FLI1|bK984G1.4
Coordinate chr22:29268254-29300523
Strand +
Gene summary This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes EWSR1P1
Bonobo Pan paniscus EWSR1P1
Gorilla Gorilla gorilla EWSR1P1
Orangutan Pongo abelii EWSR1P1
Gibbon Nomascus leucogenys EWSR1P1
Pale spear-nosed bat Phyllostomus discolor EWSR1P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>EWSR1P1
GGAAGGAGAGAAAATGGCATCCATGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACAACACCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCATTGATGTCAGCTATACCCAGGCTCAGACCACTGCAATCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTACAGTCACCACCACCCAGGCCTCCTATGCAGCTCAATCTGCATATGGCACTCAGCCTGCTTATCCAGCTTATGGGCAGCAGCCAGTAGCCACTGCACCTACAAGACTGCAGAATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCCCAGCCTAGGATATGGACAGAGTAACTGCAGTTATCCCCAGGTACCTGGGAGCTACTCCATGCAGCCAGTCACCGCACCTCCATCCTACCCTCCTACCAGCTATTCCTCTACACAGCCAACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGAAACCGAGCAGCTATGGACAGCAGAGTAGCTATGGTCAACAAAGCAGCTATGGGCAGCTGCCTCCCACTAGTTACCCACCCCAAACTTGATCCTACAGCCAAGCTCCAAGTCAGTATAGCTAACAGAGCAGCAGCTACGGGCAGCAGAGTTCATTCTGACAGGACCACCCCAGTAGCATGGGTGTTTATGGGCAGGAGTCTGGAGGATTTTCCGGACTAGGAGAGAACCGGAGCATGAGTGGCCCTGATAACTGGGGCAGGGGAAGAGGGGGATTTGATCGTGGAGGCATGAGCAGAGGTGGGCGGGGAGGAGGATGCGGTGGAATGGGCAGCGCTGGAGAGCAAGTTGGCTTCAATAAGCCTGGTGGACCCATGGATGAAGGACCAGATCTTGATCTAGGCCCACCTGTAGATCCAGATGAAGACTCTGACAACAGTGCAATTTATGTACAAGGATTAAATGACAATGTGACTCTAGATGATCTGGTAGACTTCTTTAAGCAGTGTGGGGTTGTTAAGATGAACAAGAGAACTGAGCAACCCATGATCCACACCTACCTGGACAAGGAAACAAGAAAGCCCAAAGGTGATGCCACAGTGTCCTGTGAAGACTCACCTACTGCCAAAGCTGCCGTGGAATGGTTTGATGGGAAAGATTTTCAAGGGAGCAAACTTAAAGTCTCTCTTGCTCGGAAGAGGCCTCCAGTGAACAGTATGCAGGGTGGTATGCCACCCCATGAGGGCAGAGGGATGCCACCACCACTCTGCGGAGGTCCAGGAGGCCCAGGAAGTCCTGGGGGACCCATGGGTCACATGGGAGGCCGTGGAGGAGATAGAGGAGGCCTCCCTCCAAGAGGACCCCAGGGTTCCCGAGGGAACACCTCTGGAGGAGGAAACGTCCAGCACCAAGCTGGAGACAGGCAGTGTCCCAATCCGGGTTGTGGAAACCAGAACTTCGCCTGGAGAACAGAGAGCAACAAGTGTAAGGCTCCAAAGCCTGAAGGCTTCCTCCCGCCACCCTTCCCACCCCCGGGTGGTGATCATGGCAGAGGTGGCCCTGGTGGCATGTGGGGAGGAAGAGGTGGCCTCATGGATCATGGTGGTCCCGGTGGAATGTTCAGAGGTGGCTGTGGTAGAGACAGAAGTGGCTTCTGTGGTGGCTGGGCATGGACCGAGGTGGCTTTGGTGGAGGAAGACAAGGTGGCCCTGGGGGGCCCCCGGACCTTTGATGTAACCAATGGGAGGAAGAAGAGGAGGACGTGAAGGACCTGGAAAAACGGATAAAGGCGAGCACTGTCAGGAGCGCAGAGATCAGCCCTACTAGATGCAGAGAACCCGCAGAGCTGCATTGACTACCAGATTTATTTTTTAAACCAGAAAATGTTTTAAATTTATAATTCCATATTTATAATGTTGGCCACAACATTATGATTATTCTTTCTCTGTACTTTAGTATTTTTCACCATTTGTGAAGAAACATTAAAACAAGTTAAATGGTAA
>XM_017028661.2
AGTGCGGCGCCTagagggaaagcgagagggagacggacgttgagagaacgaggaggaaggagagAAAATGGCGTCCACGGATTACAGTACCTATAGCCAAGCTGCAGCGCAGCAGGGCTACAGTGCTTACACCGCCCAGCCCACTCAAGGATATGCACAGACCACCCAGGCATATGGGCAACAAAGCTATGGAACCTATGGACAGCCCACTGATGTCAGCTATACCCAGGCTCAGACCACTGCAACCTATGGGCAGACCGCCTATGCAACTTCTTATGGACAGCCTCCCACTGTAGAAGGGACCAGTACAGGTTTGACTATCCTGCTCATTCTTGCATGGGAAATGCTTTCCATCTTGTCTAACCCTGTAATGTTAATCCTTTAGGTGTTTTCATTTGTTGAACCCCCAAACTTTCTAACATCACACACAGCAAGGTGCTAATGAAAAACTGCTTCAGGTGCCATTTGCAGATCCATGTCCTATTCTTTATATGATTTTGGGAAAGGTTTTTTTATTTAATATTACTTTGTTTCAAGCCTTAATAATAGTTATTTACCTTCCCAAAGGTATTTCAGGTGATTTCTCCCCAGCTGATTTTCCCCTGTTCCCTGAAGGATAGATTGCATGATGAGATTTATTTAGAGGAGCAGACTGCCACCCTGCATGTATCATGTTTGTCTATTGGTTGGTTTCTAGTCCAGACACATTTTATTTTCTGTTTTAAGTGTTATGAATTATTTTAATCCATGGTATGTCTTGAATATATATAACATTATTCCAAGATACTAAAAAATAAACTATTCTAAGAATTAGAAGAAATTGTATTCCGATACTGAGGTTGGGTGGGATACATGAAAAACCTATGATAATTTTTTTGTGTTCAGTGCTGTGTAATGTTTCAGGCTGTCTCCCCCTGCCCTTTTATTATTGCTGTTATAAAAGACTCTAATAAAGTCTTAAAGATATCAGAGCTCTTATTTTCAAACTGTCTTTAGTTCTCCAAATTATATATAGTCCAGTTAAGGGGAAAAACCTGTCTGTAATTTATCTCATTGAGTACCAGTGTCCTGATTTTGATGGGAAGTAATTCCTAACCTCTTCTAGGGTGTTTCTCAAATAGGATGGGAAATGTTTATCTAAACTTTCTAGTGGTGTTAATTGCAGCTGTGGGAAGAGCTGGAACTAAGGTTATGCAGTTTGGATTTTTTAGCATAGAATTTTGAAATTGTGAGATAAACTTCATGTATTAAAGCCATTACATTTTTTAAAACAAGCATGATGTGAAAGTTAATGTGGCCTAGATCTAGCCTTCCGAATCCTTAGATCATTTTACAGGAATGAGACGGAGTGATTTATAGGCAAATTAATGGTTCTCTAGAGCCATGTATCACATTGTCGTTGGTTGAGAAATCCCCATCATGACTGTGGGCCTAAAAAGTACAGGTCATTCTAGTTTAGAGACTAGTAGCTTTGATGAGCTGGAGATTGCACTtagtaataataatgtttgtataaaattcacagtttatagagtggccttcttgtctcccttaatcctcccaagaacttttggggtaTAAAAACACCAAAATTAAGCCTGATGAGCAAACTGTGTGAACAAAACTTAGCAGGAGCCTAATTGGTAGTGCGTGGGTTCAAGCACACATGCTGCATTTTTCCTTACCTCATACTGCCTTTACACATGAAAGTTATCGGATAGTCATTGGAGGGAATACATAGAAATACACTGTTCTCTTCTAGGATTTTTAAAAATTAAACTTCAGAAGAAAGGGGTTATATAAACCTCAATTCAATGGAATTCTTAAAAACTTCTTAATTTTTACGTTGAACAAAAGTTTTGGTTTGTGTAATATTTCTTACCACCTTTTTCCTTCAAGTTGTCAGCACATAGTAGGTGtgttttctttttttgccactggtcttttgtttttttgtttttttgttttttttttggtcattaaatcattttgctctgttgatttttgttcattttgcttggctgcttttgtgggtactacagattaattaaaaggttatttattaacccagtgtctattgctgtaatctttagcatgacaaggccctaactgttgctgcatagttttatgacatgagttattgccctgatcacttttagttttttgtttttttaattgccctCCTTGTAAATCTTATAGACGTGTCATGTAGTGGGGTGTAATCGGTATATGAACGGTAGGGTAGATGGTATTAGATTCTAATTTAAATAAATGAATGCCTTATGTGGTTGACCTTAGGACTCTGCAAAAACTTAAGCAGTTCAGATGAACAACATGCCAACTCAAAAACTTTTATTGCTTGGGGCTTCCTGTTTTCTGGAACTATGTATACTTTCATACACATTTTAACTCAGCAGTTTTGACAAGGACATTACTATCTCTGTGTATAATTTCAGAATTTCCTTTTAATATTTGAGGTAGAGAAGAAAGAGTATTATTATATTCTGTGCTACAAATGGTGATTGTACAAAAGGAAGCTGATACTTGTTTCTGGCCAGTACATGAGGACACTTTAAGGCCCTAAATCTTAACTAAAATGGGCAGTCTTGATTCAGGATTTATTTTAAATATGGAAGCTTTTTCTTTAGTGAGATGTAGACTTTTTTTTTGGATATAAATGCCAGCACCTAGACCAAAGttttgttttgttttgtttttttaagatagggtctctgttgcctaggctggatcttactgcagccttgacctcccagcctcaagcagtccacccacctcagcctcccaagtagctgggactgaaggctcacgccaccatgcccagctaagtttgtttattttttgtagaggcgaggtctcactatattgcccagggtggtctctaactcctaaactcaagcagtcctcccacctcagcctcccaaagtgTAAACCAAACTTTTTATTGCATGGCTTAATTGTACCCATTGACCATGAGGAAGAAGAGTCCAGCACCAGGAATGGTTGTAACACCTCCTACAGGAAAGGTACTCTAGTTAGGAGCTGCAGACTTTCGTGGTTTTGGTCATGCTCCACGCCGAAGTCCCGAAGGGAAAGGCATGGATCCTGCCTGGTCTGGCAGAGGCAGGAGCTAGGGATAGAATGCATCTTGCTTTGCAGCATACCTGTGAAACCAGGTTTTTTCTGACACCTGGTTAGTGAAATACTGAAGGGGAGGAGAGACTCTAGGGTTTACCTCCAATATTGCTGAGCAGGAAAAAGGCCTTTTGCTTGTGGTAGGTAAGTAAGAGGAATGGAGCTGAGTAACTTGATAACGAGGCAGGAATCTGCTTTATGATGTGAAAACATTACCTTTTAAATGTTTGTTTGGAGCAATATCGAAGTTTAATTTTAAATAATTTACAAAAAAAGGATAAACTGTGTTAAGCAACTATAATTTATAGCTTATTTTTATTAATCATGTGCTCAAGTAATTAAGCTTGTGCTTCACATGATGTTAGTGCTTGGGACCAAAAGAAAGTGATTAAATTAATTACTACCCAAATTACAGGTTTTAGTGCTAGAACTAGTACCTGGATCATTTTCTAATTATTTTAAAATGCTATGTCATTTGCCTTTTACCTTTTCTTCTGGGATGTTTTATTCCTGCTTGAGGGTATTTTGGGGTAAGTTTGTTTACAAACTTGTTAAGACGACCTGCTAGCAAAATCAGTACAGACTTGGCAAAAACAGACTTGTCTCCTATTCACAGCATTCAAGAGGGGGCAGAAGGAACCCTGTTTTCTGTAGCATGACATGCCATTTCTGTTAGGTGTGGTTTTAGAGCAAATGAGACAGTTACTTTACCAAAAACTAGGTACATTCAGAGAACTTAGGCTTTAAATACCAGTTTGTTGCTACTCTTGCGGAAGGGGGAATATTTAAAGGGATTCAATATCCTGATGGTTTAAAGTAAGTGGTTTACAAATTGTTCTGATAATGAGTGTCTAGGCAGATCTCTGAGGGGACCTGAAATCTGATGCAGCTCTCCTTTGTTCTAGGTTATACTACTCCAACTGCCCCCCAGGCATACAGCCAGCCTGTCCAGGGGTATGGCACTGGTGCTTATGATACCACCACTGCTACAGTCACCACCACCCAGGCCTCCTATGCAGCTCAGTCTGCATATGGCACTCAGCCTGCTTATCCAGCCTATGGGCAGCAGCCAGCAGCCACTGCACCTACAAGACCGCAGGATGGAAACAAGCCCACTGAGACTAGTCAACCTCAATCTAGCACAGGGGGTTACAACCAGCCCAGCCTAGGATATGGACAGAGTAACTACAGTTATCCCCAGGTACCTGGGAGCTACCCCATGCAGCCAGTCACTGCACCTCCATCCTACCCTCCTACCAGCTATTCCTCTACACAGCCGACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGGACAGCAGAGTAGCTATGGTCAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTACCCACCCCAAACTGGATCCTACAGCCAAGCTCCAAGTCAATATAGCCAACAGAGCAGCAGCTACGGGCAGCAGAGTTCATTCCGACAGGACCACCCCAGTAGCATGGGTGTTTATGGGCAGGAGTCTGGAGGATTTTCCGGACCAGGAGAGAACCGGAGCATGAGTGGCCCTGATAACCGGGGCAGGGGAAGAGGGGGATTTGATCGTGGAGGCATGAGCAGAGGTGGGCGGGGAGGAGGACGCGGTGGAATGGGCGCTGGAGAGCGAGGTGGCTTCAATAAGCCTGGTGGACCCATGGATGAAGGACCAGATCTTGATCTAGGCCCACCTGTAGATCCAGATGAAGACTCTGACAACAGTGCAATTTATGTACAAGGATTAAATGACAGTGTGACTCTAGATGATCTGGCAGACTTCTTTAAGCAGTGTGGGGTTGTTAAGATGAACAAGAGAACTGGGCAACCCATGATCCACATCTACCTGGACAAGGAAACAGGAAAGCCCAAAGGCGATGCCACAGTGTCCTATGAAGACCCACCCACTGCCAAGGCTGCCGTGGAATGGTTTGATGGGAAAGATTTTCAAGGGAGCAAACTTAAAGTCTCCCTTGCTCGGAAGAAGCCTCCAATGAACAGTATGCGGGGTGGTCTGCCACCCCGTGAGGGCAGAGGCATGCCACCACCACTCCGTGGAGGTCCAGGAGGCCCAGGAGGTCCTGGGGGACCCATGGGTCGCATGGGAGGCCGTGGAGGAGATAGAGGAGGCTTCCCTCCAAGAGGACCCCGGGGTTCCCGAGGGAACCCCTCTGGAGGAGGAAACGTCCAGCACCGAGCTGGAGACTGGCAGTGTCCCAATCCGGGTTGTGGAAACCAGAACTTCGCCTGGAGAACAGAGTGCAACCAGTGTAAGGCCCCAAAGCCTGAAGGCTTCCTCCCGCCACCCTTTCCGCCCCCGGGTGGTGATCGTGGCAGAGGTGGCCCTGGTGGCATGCGGGGAGGAAGAGGTGGCCTCATGGATCGTGGTGGTCCCGGTGGAATGTTCAGAGGTGGCCGTGGTGGAGACAGAGGTGGCTTCCGTGGTGGCCGGGGCATGGACCGAGGTGGCTTTGGTGGAGGAAGACGAGGTGGCCCTGGGGGGCCCCCTGGACCTTTGATGGAACAGATGggaggaagaagaggaggacgtggaggaCCTGGAAAAATGGATAAAGGCGAGCACCGTCAGGAGCGCAGAGATCGGCCCTACTAGATGCAGAGACCCCGCAGAGCTGCATTGACTACCAGATTTATTTTTTAAACCAGAAAATGTTTTAAATTTATAATTCCATATTTATAATGTTGGCCACAACATTATGATTATTCCTTGTCTGTACTTTAGTATTTTTCACCATTTGTGAAGAAACATTAAAACAAGTTAAATGGTAGTGTGCGGAGTTTTTTTTTCTTCCTTCTTTTAAAAATGGTTGTTTAAGACTTTAACAATGGGAACCCCTTGTGAGCATGCTCAGTATCATTGTGGAGAACCAAGAGGGCCTCTTAACTGTAACAATGTTCATGGTTGTGATGTTTTTTTTTTTTTTTTAAATAAAATTCCAAATGTTTATAAAGAG

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