Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name AKR1D1P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:167519785-167520623  UCSC
Coordinates (T2T) chr1:166871236-166872074  UCSC
Coordinates (hg19) chr1:167489022-167489860  UCSC
Strand +
Parental Sequence NM_005989.4
Parental seq. overlap 742 bp
Parental seq. overlap (%) 27.6%
Genomic Region Intergenic
Retrocopy Summary AKR1D1P1, located on chr1:167519785-167520623, is a retrocopy of the parental gene AKR1D1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AKR1D1
Full Name aldo-keto reductase family 1 member D1
Also known as 3o5bred|CBAS2|SRD5B1
Coordinate chr7:138076459-138118305
Strand +
Gene summary The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet. [provided by RefSeq, Jul 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AKR1D1P1
Bonobo Pan paniscus AKR1D1P1
Gorilla Gorilla gorilla AKR1D1P1
Orangutan Pongo abelii AKR1D1P1
Gibbon Nomascus leucogenys AKR1D1P1
Green monkey Chlorocebus sabaeus AKR1D1P1
Crab-eating macaque Macaca fascicularis AKR1D1P1
Rhesus Macaca mulatta AKR1D1P1
Baboon Papio anubis AKR1D1P1
Golden snub-nosed monkey Rhinopithecus roxellana AKR1D1P1
Marmoset Callithrix jacchus AKR1D1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AKR1D1P1
AGCCTACATATACCAAAATGAAGACACAGCTGGGGAGGCCATCAGGGGGAAAATAGCAGAAGGAAAGGTGCAGAGGAAGGATATCTTCTACTGTGGAAAACTGTGGGCTACAAATCACAACCCAGAGCTGGTCTGCCCGAGCCTAGAGAGGATGCTCAAGGTCCTCCAGCTAGATTGTGTGGATCTTTACATCACTGAAATACCCATGGCCGCTAAGCCAGAAGACAAAATCTACCCTATAGGTGAGAATGGCAAATGGTTATATCACAAGTCAAATCTGTGTGCCACTTGGGAGACTTCGGAAGCTTGTAAAGATGCTGGCTTGGTGAAATCCCTCGGAGTATCCAGTTTTAACAGCAGGCCAGCTGGAGCTCATCCAGAACAACCCAGGACTCAAACCCAAGCCAGTCAGCAACGAGGTTGAGTGCCACCCATATTACACCCAACCAAAACTTTTGAAATTTCGCCAACAACATGACATTGTCATGATTGCATATAGCCCTTTGGGGACCACTAGGAATCCAACCTGGACAAATATGTCTTCTCTGCCTTCGTTAAAGGATGCACTTCTAAAAAGGTGCAATAAGATCACAGCTCAAGTTATTTTGCGTTTCAACATCCAGCAAGGGGTGGTTGTCATTCCTAAAAGCTTTAATCCTGAAAAGATCAAGGAAAACCTTCAGGCCTTTGACTTTTCTCTCACTGAATCAAGGACATTGAAGCCTGGAGTGAAAATGTCCGCTTCATAGAAATGCTCATGTGGTGTGATCATCCCAAATACCCATTTCTTGATGAATACTGACTTCAGAGAGTTCCTGAACAGATTCTCCCCTCCCACG
>NM_005989.4
ACCTTTCTAAAAAGACTCCCTGTGGTGTTCAGAATCACTCCTACAGTCAGGTTCTCCACAATGGATCTCAGTGCTGCAAGTCACCGCATACCTCTAAGTGATGGAAACAGCATTCCCATCATCGGACTTGGTACCTACTCAGAACCTAAATCGACCCCTAAGGGAGCCTGTGCAACATCGGTGAAGGTTGCTATTGACACAGGGTACCGACATATTGATGGGGCCTACATCTACCAAAATGAACACGAAGTTGGGGAGGCCATCAGGGAGAAGATAGCAGAAGGAAAGGTGCGGAGGGAAGATATCTTCTACTGTGGAAAGCTATGGGCTACAAATCATGTCCCAGAGATGGTCCGCCCAACCCTGGAGAGGACACTCAGGGTCCTCCAGCTAGATTATGTGGATCTTTACATCATTGAAGTACCCATGGCCTTTAAGCCAGGAGATGAAATATACCCTAGAGATGAGAATGGCAAATGGTTATATCACAAGTCAAATCTGTGTGCCACTTGGGAGGCGATGGAAGCTTGCAAAGACGCTGGCTTGGTGAAATCCCTGGGAGTGTCCAATTTTAACCGCAGGCAGCTGGAGCTCATCCTGAACAAGCCAGGACTCAAACACAAGCCAGTCAGCAACCAGGTTGAGTGCCATCCGTATTTCACCCAGCCAAAACTCTTGAAATTTTGCCAACAACATGACATTGTCATTACTGCATATAGCCCTTTGGGGACCAGTAGGAATCCAATCTGGGTGAATGTTTCTTCTCCACCTTTGTTAAAGGATGCACTTCTAAACTCATTGGGGAAAAGGTACAATAAGACAGCAGCTCAAATTGTTTTGCGTTTCAACATCCAGCGAGGGGTGGTTGTCATTCCTAAAAGCTTTAATCTTGAAAGGATCAAAGAAAATTTTCAGATCTTTGACTTTTCTCTCACTGAAGAAGAAATGAAGGACATTGAAGCCTTGAATAAAAATGTCCGCTTTGTAGAATTGCTCATGTGGCGCGATCATCCTGAATACCCATTTCATGATGAATACTGACTGCAGGGAGTTCCTGAACAGATTTTTCACTCCCACGAGTGCCAAGACGGTGCAATGGGTAGTCCCCTAGATGTGAAAATGAAGAGAGAGGGTTTTACCATCCTGAGAAGAAATAATGATGGAAACATGTTTAATGTTTGTGCAGTGTAAATGACTTTGACTCAGTCACATTGAAGTAAAAATATTAAAATCTGTTGAAATAACTCTTAGGAAATTATCAACTAATTTTTTCAGATCAGTATCTTCTAGATTCCAGACAGAAAAAAATTACACTTCAGAAAAGACATCAAAGGCAACATATGACAACAAGTAATTTATGAATCTGGGTAGTAGCGTTGGTAATCTGAGTTCTTTAAGGGTTAACAGGACAACGAAGTGCATGTGGCAGTGTGCTGGCAGTGGCCTTGAGGCTTTGGACCATTGGTTACAAAACAGACACAGCCAAGATAAGATCCACACACACATTATTAACAAGGAAGTGATTTGCTGCACCTTGAGTTGAGAGGGCTACATGTAGAAAAGTCTTAAAATAGAGCTAAACACCACAGTGGTCAACAAAGCCATCATAATGTTGGTGTTTGTTTCCCTCCAATGTATGTATGTTTAGTTTTTATCCAACCTGAGGAATGAAAACTTAACTGGATCTCTCTTGCATCCTTAAAGGGCCTGAGTCTCAACATGGCTGCTGATCCATACTTACACATCTTACTGTCAATCTTGCCTACATTGATTATAGAACCACTATTACGTGAAAAGGCTTGAAACAACCAACATATACAAATAAAACCCTGCCTTGTAAAATAGTAAAAGAGAAGCCATATATTGGCTTTTCTTCTTAACTTGGGAGATATATTGAAACAAGGTGCTTTATAAGATTATTGTACTTAAGACTTTAATAGTGTTACTTGGATAGCTTATATGAATTTTGAGAATTTTATATGAATTTTGAGAAAGCAAGTTCAAAAGAACTCTGGTAATTTTCCTGTATGTACAATTTAAAGAGTGAATAAGATTATTAGAATTCAGCAATAGAGATATATCTATTTTCAATTCAACTACAGAAATATATTTTATTggccgggtgcggtggctcatgcctataatcccagcactttgggaggccaaggtgggcagatcaggaggtcaggagatcgagaccatcttggctaacaaggtgaaaccccgtctctactaaaaatacaaaaaattagccaggcgcggtggcgggggcctgtaatcccagctactcaggaggctgaggcagaagaatggcatgaacccgggaggaggagcttgcagtgagccgagatagcgccactgcagtccggcctgggtgaaagagcgagactccgtctcaaaaacaaaaaaaaaagaaaagaaaTATATTTTATTCATTCACATTAGGTCACTGTCATACTGTCATAGGATGAGAGAGTTCTTCAAAAATTATGTTTTCCCAAGATCAGTTGCTTATAGATAATGTTCAATGACCTCAAGACATATATTTTTGAGAAATTATCATTTTAAAAAATTTGGTCTATACTGATTGTTTTCACTGATTCCAATATTATTACTTATAACACTGACCTCTGGAAAATATTTTGTTCACAAGAAATAATAAAGTATAATGATTTGTTGCATCA

Publications

PMID - Link Title