Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DOK1P1
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:72249407-72251308  UCSC
Coordinates (T2T) chr11:72176031-72177932  UCSC
Coordinates (hg19) chr11:71960451-71962352  UCSC
Strand -
Parental Sequence NM_001381.5
Parental seq. overlap 1742 bp
Parental seq. overlap (%) 90.5%
Genomic Region Intergenic
Retrocopy Summary DOK1P1, located on chr11:72249407-72251308, is a retrocopy of the parental gene DOK1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DOK1
Full Name docking protein 1
Also known as P62DOK|pp62
Coordinate chr2:74549105-74557551
Strand +
Gene summary The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DOK1P1
Bonobo Pan paniscus DOK1P1
Gorilla Gorilla gorilla DOK1P1
Orangutan Pongo abelii DOK1P1
Gibbon Nomascus leucogenys DOK1P1
Green monkey Chlorocebus sabaeus DOK1P1
Crab-eating macaque Macaca fascicularis DOK1P1
Rhesus Macaca mulatta DOK1P1
Baboon Papio anubis DOK1P1
Golden snub-nosed monkey Rhinopithecus roxellana DOK1P1
Marmoset Callithrix jacchus DOK1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DOK1P1
GGAAGCAACCGCTGGGGGCCATGGACGGAGCTATGACAGAAGGGCCGCTCTTTTCGCAGAGTCAGCACTTTGGGACCAAGAGGTGGAGGAAGACCTGGGCCATGCTCTACCCGGCCAGTCCCCATGGCTAGCGCGGCTCAAGTTCTTTGACCATAAGGGGTCGAGCTCTGGGAGTGGCCGAGGGAGCTCGTGCTGCCTGGACTGCAAGGTGATCCATCTGGCGAAGTGTGTGAGTTTGGTCCCCGTGGCCGTGGAGAGCCTCCCTGAGCCCAGCGCCACTGCCTTCCGCCTGGACACTGCACAGCACTAGCACCTGCTGGCTGTTGATGTGCCGTCCAGTGCAGCCTGGTTGCAGACGCTGTGCCAAAACCCCCTTCGGAAAGGCAGCTGGACTCTGGAACCTACCAATAACCCACCTGAGCTTTCTGCCCTGGAGATGCTGGAGAACTCCTTGTGCAGCCCCACCTGGGAAGGATCCCAGTTCTGGGTAACGGTGCAGAGGACTGAGGCGGTCGAGCACTGTGGCCTGCATGCCTCCTACGTGCTGAGGGTGGAGGCTGAAAGGCTGACTCTCCTGACCATGGGAGCCCAGAGTCAGGTACCGGAGCTGCTCCTGTCCTGGCCCTACACTCTGTTGCATTGCTATGGCCGGGACAAGGTCATGTTCTCTTTTGAGGCCAGCGCCGCTGCCTCTTGGGCCCTGGAACCTTCCTTTCCAGACGGCACAGGGAAATGACATCTTCCAGGCAGATGAGACTGCCATCCACCGGCAGAAGGCCCAGGGAAAGGCCAGACAGGGGCACAATGCTCTCAGAGCTGATTCCCATGAAAGGAAGGTGGTAGAGGGGAAGTTCTCTTCCCCACCTGGACCCCAAGAGCTCCTTGAAAGCCCCCCAGCCCTGTATGCTGAGCCCTTAGACTCCCTGCACATTGCTTCAGGCCCATCCCAGGGCTCCCTATACTCAGACCTCTTGGACGGCACTCTTGCTCGGGCAGGAGAGGGAGTACAATGGAAGAAACCTCTCTATTGGGACTTGTATGAGCATGAGCAGCAGCAGTTGCTGAAGGCCAAGCTGACGGACCCCAAAGAGGATCCCATCTATGATGAACCCGAGGGCCTGGCCCCAGCCCTTCCCCAGGGCCTTTATGATCTGCCTTAGGAGCCCAAAGATGTGTGGGATGTCAAGCTGAGGTGAAGTAGGAGGGCTACAAGCTCCCCTACAACCCTGCCACTGATGACTACGCTATGCCACCCACCCAGAGAACAAAGACCCTCCCTGCTTCCAAGTCCCAGGGCCCAGCCTTCCCTGAACCTAGTACTGCAACTGGCAGGAGCAGCAAAAGCCACAACTCAGCCCTGTACAGCCAGGTCCAGAAGAGTGGAGCCTCAGGGAGCAGGGACTGTGTGCTTTCTACAGTAGGGACTGACAGGACTGGGGTCAAGTCAGAGGTCTCTACCTGAGAAGGAGGACTAGGCTGAAGTGGCTGAGGAGGACCATGGGGAGGTGGCACTAGGGATCAGAGAAAATGGTTAGAACCAGCAGAAGCCAGAGGGTGAGAGGGGCCATGCCGTGTGAGACCAGGGGACCAGAGGGATGGGGGAGTCAAGGGAAGGACAGTCAATCCCAGGAAGTCCTAAGAAGTGGGGCAGATGGCAGGGCTGAGGACGGGCTCTGCATCCCCCTAAAGCCATTCCTTCCCAACTTCCCCAAAGGAAGGGACAGCTGTGGGACCAGGTCTGTGGAAAGTGGTGCATGGTCAGAGTGGGTGCGGTTTGAGGGGCCTGTGTGGAGGCCTCAGAGAGATGTTGGACTGTGCCTGGATCCTTACCCCTGCATTATTCTTTGCCAGAGATATATTTTAAAATTTTTTAATTGTCATGAAAGTCAGCTTGGGTTTAAA
>NM_001381.5
AGGGCCAGGAAGCGCGGAAGGAACCGCCGGGGGCCATGGACGGAGCAGTGATGGAAGGGCCGCTTTTTTTGCAGAGTCAGCGCTTTGGGACCAAGAGGTGGAGGAAGACCTGGGCCGTGCTCTACCCGGCCAGTCCCCACGGCGTAGCGCGGCTCGAGTTCTTTGACCATAAGGGGTCGAGCTCTGGGGGTGGCCGAGGGAGCTCGCGCCGCCTGGACTGCAAAGTGATCCGTCTGGCTGAGTGTGTGAGTGTGGCCCCCGTCACCGTGGAGACCCCCCCTGAGCCCGGCGCCACTGCCTTCCGCCTGGACACTGCTCAGCGCTCGCACCTGCTGGCGGCCGACGCGCCGTCCAGTGCAGCCTGGGTGCAGACGCTGTGCCGAAACGCCTTTCCGAAAGGCAGCTGGACTCTGGCGCCTACCGATAACCCACCTAAGCTTTCTGCCCTGGAGATGCTGGAGAACTCCTTGTACAGCCCTACCTGGGAAGGATCCCAATTCTGGGTAACGGTGCAGAGGACTGAGGCCGCCGAGCGCTGTGGCCTGCATGGCTCCTACGTGCTGAGGGTGGAGGCTGAAAGGCTGACTCTCCTGACCGTGGGGGCCCAGAGTCAGATACTGGAGCCACTCCTGTCCTGGCCCTACACTCTGTTGCGTCGCTATGGCCGGGACAAGGTCATGTTCTCTTTCGAGGCCGGCCGCCGCTGCCCCTCAGGCCCTGGAACCTTCACCTTCCAGACGGCACAGGGAAATGACATCTTCCAGGCAGTTGAGACTGCCATCCACCGGCAGAAGGCCCAGGGAAAGGCCGGACAGGGGCACGATGTTCTCAGAGCTGACTCCCATGAAGGGGAGGTGGCAGAGGGGAAGTTGCCTTCCCCACCTGGCCCCCAAGAGCTCCTCGACAGTCCCCCAGCCCTGTATGCTGAGCCCTTAGACTCCCTGCGCATTGCTCCATGCCCTTCCCAGGACTCCCTATACTCAGACCCCTTGGACAGCACGTCTGCTCAGGCAGGAGAGGGAGTACAACGGAAGAAACCTCTCTATTGGGACTTGTATGAGCATGCGCAGCAGCAGTTGCTGAAGGCCAAGCTGACAGACCCCAAAGAGGATCCCATCTATGATGAACCTGAGGGCCTGGCCCCAGTCCCTCCCCAGGGCCTTTATGATCTGCCTCGGGAGCCCAAGGATGCATGGTGGTGCCAAGCTCGGGTGAAGGAGGAGGGCTATGAGCTCCCCTACAACCCTGCCACTGATGACTACGCTGTGCCACCCCCTCGGAGCACAAAGCCCCTCCTTGCTCCCAAGCCCCAGGGCCCAGCCTTCCCTGAACCTGGTACTGCAACTGGCAGTGGCATCAAAAGCCACAACTCAGCCCTGTACAGCCAGGTCCAGAAGAGCGGGGCCTCAGGGAGCTGGGACTGTGGGCTCTCTAGAGTAGGGACTGACAAGACTGGGGTCAAGTCAGAGGGCTCTACCTGAGAAGGACGGCAAGGCTGAGGTGGCTAAGGGGGACCATGGGGAGGTGGCACTAGGGATCAAAGAAGATGGTTAGAACCAGCAGAAGCCAGAGGGTGGGAGGGGCCATGCTGTGTGAGACCAGGGGACCAGAGGGATGGGAGAGTCAAGGGAAGGACAATCCCAGGAAGTCCTAAGAAGTGGGGCAGATGGCAGGGCTGAGGATGGGCTCTGCATCCCCCAAAGCCATCCCTTCCCTACTTCCCCAAATGAAGGGACGGCTGTGGGACCAGGTCTGTGGAAAGTGGTGCATGGTCAGAATGGGTGCAGTTTGAGGGGCCTGTGTGGAGGCCTCAGGGAGATGTTGGACTGTGCCTGGATCCTTACTCCTGCATTGTTCTTTGCCAGAGACCTATTTAAAAATTTTAAAATTCTCATTAAAGTCAGCTTGGGTTTAAGAA

Publications

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