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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPL26P42
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:173351700-173352047  UCSC
Coordinates (T2T) chr1:172709826-172710173  UCSC
Coordinates (hg19) chr1:173320839-173321186  UCSC
Strand +
Parental Sequence NM_001315530.2
Parental seq. overlap 318 bp
Parental seq. overlap (%) 34.9%
Genomic Region Intragenic (TNFSF4)
Retrocopy Summary RPL26P42, located on chr1:173351700-173352047, is a retrocopy of the parental gene RPL26. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPL26
Full Name ribosomal protein L26
Also known as DBA11|L26
Coordinate chr17:8377516-8383193
Strand -
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPL26P3
Bonobo Pan paniscus RPL26P3
Gorilla Gorilla gorilla RPL26P3
Orangutan Pongo abelii RPL26P5
Gibbon Nomascus leucogenys RPL26P11
Baboon Papio anubis RPL26P3
Golden snub-nosed monkey Rhinopithecus roxellana RPL26P19
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPL26P42
AATCCATGCCTAACCGAAAGGATAATGAAGTTCAGGTTGTACGAGTACGAGGACACTATAAAGGTCAGCAAATTGGTACAGTAGTCCAGGTTTACAGGAAGAAATATGTCATCTACATTGAATGGGTGCAGCAGGAAAAGGCCAATGGCACAACTGTCCATGTAGGCATTCACCCCAGCAAGGCGGTTATCACTAGGCTAAAACTGGACAAAGACCGCAAAAAGATCCCTGAACAGAAAGCCAAATCTCACCAGGCAGGAAAGGAAAAGGGCAAATACAAGGAAGAAAAAATTGAGGAGATGCAGGAATAAAGTAATCTTATATACAAGTTTTGATTAAAATTTGAAA
>NM_001315530.2
CTCTTCCCTTTTGCGGCCATCACCGAAGCGGGAGCGGGTAAGGATTCGGCGGGCAAGCGGGTGTAATCAGCAGCCATCCGTTCTTGGGCATGGTGGCTTCCGACCGCGGGGACCCCGAGAGTCTCTTGTCGGCCGAGTAGCAGCCAGGAAGGAGAGACTGGGATGGTTTTTTATCTGTTGCTTTCTTAAATCAAGGGCCGCCGGGCCGGAGATGGATGGAGGGACCGGGGATTTGGGAACTCGAAAACGAGCTGAGGGAAGGGAGCCTGTGGAAATAGACTGGAGTCTGGGTAGTGTCGTTTCCTAGAGAATGGTCTCGAAGTAACTTCTCGGTAAAGTCTTCACGGAATTTCCAGACCACACTTGCCCACTGGGAGGCTTTTAGGACCCGAGACGTGTGCAGGCTTTTCCAGCCAAAATGAAGTTTAATCCCTTTGTGACTTCCGACCGAAGCAAGAATCGCAAAAGGCATTTCAATGCACCTTCCCACATTCGAAGGAAGATTATGTCTTCCCCTCTTTCCAAAGAGCTGAGACAGAAGTACAACGTGCGATCCATGCCCATCCGAAAGGATGATGAAGTTCAGGTTGTACGTGGACACTATAAAGGTCAGCAAATTGGCAAAGTAGTCCAGGTTTACAGGAAGAAATATGTTATCTACATTGAACGGGTGCAGCGGGAAAAGGCTAATGGCACAACTGTCCACGTAGGCATTCACCCCAGCAAGGTGGTTATCACTAGGCTAAAACTGGACAAAGACCGCAAAAAGATCCTCGAACGGAAAGCCAAATCTCGCCAAGTAGGAAAGGAAAAGGGCAAATACAAGGAAGAAACCATTGAGAAGATGCAGGAATAAAGTAATCTTATATACAAGCTTTGATTAAAACTTGAAACAAAGAGCCTG

Publications

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