Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CEP57P1
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Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:173361683-173363733  UCSC
Coordinates (T2T) chr1:172719786-172721836  UCSC
Coordinates (hg19) chr1:173330822-173332872  UCSC
Strand -
Parental Sequence NM_014679.5
Parental seq. overlap 1618 bp
Parental seq. overlap (%) 50.2%
Genomic Region Intragenic (TNFSF4)
Retrocopy Summary CEP57P1, located on chr1:173361683-173363733, is a retrocopy of the parental gene CEP57. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CEP57
Full Name centrosomal protein 57
Also known as MVA2|PIG8|TSP57
Coordinate chr11:95790471-95832693
Strand +
Gene summary This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CEP57P1
Bonobo Pan paniscus CEP57P1
Gorilla Gorilla gorilla CEP57P1
Orangutan Pongo abelii CEP57P1
Gibbon Nomascus leucogenys CEP57P1
Green monkey Chlorocebus sabaeus CEP57P1
Crab-eating macaque Macaca fascicularis CEP57P1
Rhesus Macaca mulatta CEP57P1
Baboon Papio anubis CEP57P1
Golden snub-nosed monkey Rhinopithecus roxellana CEP57P1
Marmoset Callithrix jacchus CEP57P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>CEP57P1
CTCTGGTGACATGGTAAATATGTGTCTCAACCATGTCTCTGCTGCTTCTGGTTCTCAGTTCTCAAACATCTTAACTGAACCATCAGGGCCTTAGGGAAGCCTGTTCAGCATTCTTCATCTCCAAATGTAGTACATCCATCCGATAAGCCTTTCCTTAAGAGTGATCTACGACACTCCCCAAATAAGCCTACACTTGCCTATCCAGAAAGCAACAGCAGAGCTATATTTTGTGCTCTTAAGAATCTTAAAGGTAAGATTTGATGCTTGGAACTTGAAATGATTCTGGCAGAAGAAAGTGTGAAAACCTTGTCTAGAGAAACAATTGAATCCAAGAAGGTACTGGATGGAGAGATATGGGAAAGGGAGAATTCAAAGAATGAAGAATCAAAGCACAATCAAGAACTGATATCTCAGTTGATAGCTGCAGAAAATAAATGTAATCTTTTAGGAAAACAATTGGAATACATGTGAAATATGATAAAGCATGCAGAAAGGGAGAGGACATCTGTCTTAGAGAAACAGGTTTCCCTAGAAAGAGAATGGCGATACAATCAAAGACATGTTTGGAGCCAACTTGAAAAATTGGATCTTTATGAATGGGAGTATAACTTTCCACAGTGCAGGCCCTTGCAGAAAGAAAAATGTAAGAGTTGGTAGCAAAACTCTGAAGAAGAACAGGAAAGGAAACATGTACAAACTAAGGCAGCTAAGTTACAGACTGGTCTAGAAACAAATAGACTTATTATTGAAGATAAGGCAAGTCCGCATTTTCCCAGTGCAAGAAGAATTTTAAAAAAAGTCAAAACCACAAGAAAAACTAAGTTCTAGGAACTATTTTGGTGCACGAGTACATTATAGATTATGCTTGGGTGATGTGCCATTTGTAGCTGGGAAGTCCACAAGTCTTAGCCATGCTGTGGCAGCCAATGTTCAGCTTGTCTTGCATTGCATCTAATGAAGCAACACAGTAAAGCTTTGTGCAGTGATCAGTCATTAGTGTTCCTTTGGCAAAGCAAGTATCTTCAAGATGTGTTGAAAGTAAGAAGTTGTCATTAATACCTCCCTCCTCTGACAGCATTAATGAGGAATTGTCAGAAGTCTTACAGACTTTACAGGATGAATGGACATAGGACCTTTAATCACCAGCAGCATGCAAAACTTACCCAGGAGTTGGCAACTGTTGAACTGAAAGACAACTTAGTGTGAGAATCGGAGGCATTAGTGGGAAGGATGGAGGCAAAAGCCAACCAAATAACTAAAGTTTGAAAATACCAAGCCCAGCTGGAGAAACAGAAGGTAGAGAAGCAGAAGAAGGAATTAAAAGCTACCAAAAAGACTCTGGATGAAGAAGGAAAGAGCAACAGCCATTCTTCTGGACCACAAATAAGAAGGCGTACAGTATGAGTGCAACATGAACTGTATACACAATTGTCATCATGTTGATGTGAATCATAATTTCAACTAGTTGAAGCCATGTTAACCGTTTATAAATTTGCCAATGAAGTCAATAAAGCATTTTTTTAAAAAAGAAAACACTTAAACTTTCCTTAACAGCCTGTTAACCAAGGCTTTCTTTATTATAAACTCTCAAAATTGCATTTCTAAATAGAACATGAATGTATTGATGATAAGAAAAAACTAGTAATTTAGTATTTAACTTATTTGCCATTCTCATGCTTACATAGAAATTAAGCCCAAGAAGACTGATTTTCCTCATGGTATATGATAAGATACTCCAAGAGTGCTAATGGACATGTTAGCCACATATTAGAGGAATTCCTTTATATGGCCCTCTTGGAATTGATGGAGATAGAGTTCTAGGATTGTATCCAGATATCCAGCATGAATTGTCATGGCTACCTAGGCACTAGGCATGTCAAACCTTTCTATAGTTAAAg
>NM_014679.5
CTTTCTGTGTAAGCTGTGAGCGTAGGCGGCCCTGAGGGGGTGTGTTGCAGGGGTTTCCAAGCCCAGCACCAGCACCCTTGCCCTTTTCCATCAGGGGTTCAGCCTAGGGTCCCCGCTGGTGGGCGGCTCCCGAGTCTTGGAGAAGAGCACGAGAACCTAGACCGCCCCCGAAGTGCGGAGACCCCCTGGGCAGGCTGAAAGATGGCGGCGGCGTCTGTCTCTGCGGCTTCTGGTTCTCACTTGTCGAACAGCTTTGCTGAGCCATCAAGGTCTAATGGAAGCATGGTTCGGCATTCTTCATCTCCATATGTAGTATATCCTTCGGATAAGCCTTTCCTTAATAGTGATCTACGACGCTCCCCAAGTAAGCCTACACTTGCCTATCCAGAAAGCAACAGCAGAGCCATATTTTCTGCTCTTAAGAATCTTCAAGATAAGATTCGACGCTTGGAACTTGAGAGGATTCAGGCAGAAGAAAGTGTGAAAACCTTGTCTAGAGAAACAATTGAATATAAGAAAGTACTGGATGAACAGATACAAGAAAGGGAGAATTCAAAGAATGAGGAATCAAAGCACAATCAAGAACTGACATCTCAGTTGTTAGCTGCAGAAAATAAATGCAATCTATTAGAAAAACAATTGGAATACATGCGAAATATGATAAAGCATGCCGAAATGGAGAGGACATCTGTCTTAGAGAAACAAGTTTCCCTAGAAAGAGAACGACAACATGATCAAACACATGTTCAGAGCCAACTTGAAAAATTGGATCTTCTTGAACAGGAGTATAACAAACTTACCACAATGCAGGCCCTTGCAGAAAAAAAAATGCAAGAGTTGGAAGCAAAACTCCATGAAGAAGAACAGGAAAGGAAACGCATGCAAGCTAAGGCAGCTGAGTTGCAGACTGGTCTAGAAACAAATAGACTTATCTTTGAAGATAAGGCAACTCCGTGTGTTCCCAATGCAAGAAGAATTAAAAAAAAGAAGTCAAAACCACCAGAAAAGAAAAGTTCTAGGAACTATTTTGGTGCACAACCACATTATAGATTATGCTTGGGTGATATGCCATTTGTAGCTGGGAAGTCCACAAGCCCTAGCCATGCCGTGGTAGCCAATGTTCAGCTTGTCTTGCATCTAATGAAGCAACACAGTAAAGCTTTGTGCAATGATCGAGTCATCAACAGTATTCCTTTGGCAAAGCAAGTATCTTCACGAGGTGGTAAAAGTAAGAAGTTGTCAGTAACACCTCCCTCCTCCAACGGTATTAATGAGGAGTTGTCAGAAGTCTTACAGACTTTACAGGATGAATTTGGGCAAATGAGCTTTGATCACCAGCAGCTTGCAAAACTTATCCAGGAGTCGCCAACCGTTGAACTGAAAGACAAGTTGGAGTGTGAATTGGAGGCATTAGTGGGAAGGATGGAAGCAAAAGCCAACCAAATAACTAAAGTTCGAAAATACCAAGCCCAGCTGGAGAAACAGAAGTTAGAGAAGCAGAAGAAGGAATTAAAAGCTACCAAAAAGACTCTTGATGAAGAAAGAAACAGCAGCAGCCGTTCTGGAATCACAGGGACCACAAATAAGAAAGATTTTATGAAACTGAGACCTGGAGAAAAAAGGAGAAAAAATCTTCAGTTATTGAAGGACATGCAAAGCATACAGAATTCATTACAAAGCAGTAGTTTGTGTTGGGATTACTGACTCATAACCAGGTCAGAAATTTTATTCAGATAATCTGTACCTCATCAATCAGATGATGACAATTTACTTCCCAGGTCTCATACTCACTTATGTTGGAATTAATTAATAGCAGGTGTTAAAGGACCCAGGCTTCATTACACAGGCTTTTCATGTATGCAGGATGACTCAATGTTAAAGCATTTAAATGGAAACCAGGGGAGTTTTAAAGCCCGAGAAACCACACATAATCTTTTGTTGAGATGAGTTTGCTGTACTGACGCTGCACTTTGTAAACAGATTACCAGTTTTTTACTTGTGGGTGTGATTTTTTAAAATAGTTCTTTATATATAATTAAAATTAGGTTTAAATTTTCAAAATATGAGACTATGCTATAGGCAGTGCTTGCTTGAAAAGTCTCATTTTTAAATCTCCCTGGCATGAGGTGCCCACTTCCCCTTTCCAAAGCAACCATTAAACATACTTTGTTTCTACTATTGGTGGAGTTTTTCTATATTTAAAAATACATATATATTTCAGAGGATTTTTATTTTGCTTTTTGGCATTTCAGACTTTGATCAGTGTTAAGTGCACTTGTATTGCTTTTTAATCTGTTAATTTTTTAAAGACCCAAGCAGTCATTTTGAGTTATATCTATAAAAATTATAAAAGGATTTTTGAAAGTATAAACAAATTGTCAGTGAAATAAATGAGATTTTGGAATAAAGTGAGAATGGGAGAAGGGATATGTTGTGAGCATATACCTTCACAGTTCTTAATACCTGTTTTGTAATCATGATATTCAGTCAAGGCATTATGGTTTTTAATCTTGAAACTTAGAGAACCCTTTGAATATTTGCTTTTACTGGTGTACAGTATGAGTGGAATATAAACTGTACACATAATTATCATGTTGATATAAATCATAATTTCAACTAGATCAAGACATGTTAACCTTTTATAAATTTAAAGTCAATAAAGCACCTTTTTAAAGGAAACACTGCAACTTTCCTTAACAGCCTGTTAATAAAGGCTTTGTGACAAGCTCTCAAAAAATGCATTTCTAAATAGGAGGACATCAATGTATTGATGAAGAGAAAAAACTAGTACTTAGTTGCCACACTCATGCTTACATAGAAAGAGAGCCCAAGAATATTAGATTTCCTCATGATACAAGATACTACAGTAACAGGCTTTAATTTAGGATCCTTAAGATTTTGGGGTATTATTTGTGACTCTCCTGAAATTGTAAACTTGTGCTTCTGTGTCCAGTTTTCTAATGAGTAGGTTCGTAGCTTGATTGAATTAATAATTGTGAGCCCATAGACACAAGGGAAGTGAGAAACAGTGCTCTGGTGACATGATAAATATATGTGTCAACCACCATTTCAGCTATTAAAAACTCCTGTTATCTCCTTGTTTGAATTTCAGGTCATTAAATTGTATAACCATCATTTGAA

Publications

PMID - Link Title
No publications available for this retrocopy