Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TMEM123P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:175725429-175725616  UCSC
Coordinates (T2T) chr1:175080280-175080467  UCSC
Coordinates (hg19) chr1:175694565-175694752  UCSC
Strand +
Parental Sequence NM_052932.3
Parental seq. overlap 153 bp
Parental seq. overlap (%) 4.6%
Genomic Region Intragenic (TNR)
Retrocopy Summary TMEM123P1, located on chr1:175725429-175725616, is a retrocopy of the parental gene TMEM123. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TMEM123
Full Name transmembrane protein 123
Also known as KCT3|PORIMIN|PORMIN
Coordinate chr11:102396332-102452765
Strand -
Gene summary This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Green monkey Chlorocebus sabaeus TMEM123P1
Baboon Papio anubis TMEM123P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TMEM123P1
GGGTCTCAACAGATACGACTTCCACCACTTTAAATTCTATAACTAAAATGACAAATGTTCACAAAACACATCCCAGATGTCAACATCCACGATGACCAAAGCTCTCAATAGTTCAGTGACATCTGTTTCTTCATCAATAACAGTCATGGCAACTATTTATTTTAAAGAAAATAAAGGATCACAATTTG
>NM_052932.3
ATTCGGGGGGCAAGCGGCGGGAGGGGAAACGTGCGCGGCCGAAGGGGAAGCGGAGCCGGCGCCGGCTGCGCAGAGGAGCCGCTCTCGCCGCCGCCACCTCGGCTGGGAGCCCACGAGGCTGCCGCATCCTGCCCTCGGAACAATGGGACTCGGCGCGCGAGGTGCTTGGGCCGCGCTGCTCCTGGGGACGCTGCAGGTGCTAGCGCTGCTGGGGGCCGCCCATGAAAGCGCAGCCATGGCGGCATCTGCAAACATAGAGAATTCTGGGCTTCCACACAACTCCAGTGCTAACTCAACAGAGACTCTCCAACATGTGCCTTCTGACCATACAAATGAAACTTCCAACAGTACTGTGAAACCACCAACTTCAGTTGCCTCAGACTCCAGTAATACAACGGTCACCACCATGAAACCTACAGCGGCATCTAATACAACAACACCAGGGATGGTCTCAACAAATATGACTTCTACCACCTTAAAGTCTACACCCAAAACAACAAGTGTTTCACAGAACACATCTCAGATATCAACATCCACAATGACCGTAACCCACAATAGTTCAGTGACATCTGCTGCTTCATCAGTAACAATCACAACAACTATGCATTCTGAAGCAAAGAAAGGATCAAAATTTGATACTGGGAGCTTTGTTGGTGGTATTGTATTAACGCTGGGAGTTTTATCTATTCTTTACATTGGATGCAAAATGTATTACTCAAGAAGAGGCATTCGGTATCGAACCATAGATGAACATGATGCCATCATTTAAGGAAATCCATGGACCAAGGATGGAATACAGATTGATGCTGCCCTATCAATTAATTTTGGTTTATTAATAGTTTAAAACAATATTCTCTTTTTGAAAATAGTATAAACAGGCCATGCATATAATGTACAGTGTATTACGTAAATATGTAAAGATTCTTCAAGGTAACAAGGGTTTGGGTTTTGAAATAAACATCTGGATCCTTATAGACCGTTCATACAATGGTTTTAGCAAGTTCATAGTAAGACAAACAAGTCCTATCTTTTTTTTTTTGGCTGGGGTGGGGGCATTGGTCACATATGACCAGTAATTGAAAGACGTCATCACTGAAAGACAGAATGCCATCTGGGCATACAAATAAGAAGTTTGTCACAGCACTCAGGATTTTGGGTATCTTTTGTAGCTCACATAAAGAACTTCAGTGCTTTTCAGAGCTGGATATATCTTAATTACTAATGCCACACAGAAATTATACAATCAAACTAGATCTGAAGCATAATTTAAGAAAAACATCAACATTTTTTGTGCTTTAAACTGTAGTAGTTGGTCTAGAAACAAAATACTCCAAGAAAAAGAAAATTTTCAAATAAAACCCAAAATAATAGCTTTGCTTAGCCCTGTTAGGGATCCATTGGAGCATTAAGGAGCACATATTTTTATTAACTTCTTTTGAGCTTTCAATGTTGATGTAATTTTTGTTCTCTGTGTAATTTAGGTAAACTGCAGTGTTTAACATAATAATGTTTTAAAGACTTAGTTGTCAGTATTAAATAATCCTGGCATTATAGGGAAAAAACCTCCTAGAAGTTAGATTATTTGCTACTGTGAGAATATTGTCACCACTGGAAGTTACTTTAGTTCATTTAATTTTAATTTTATATTTTGTGAATATTTTAAGAACTGTAGAGCTGCTTTCAATATCTAGAAATTTTTAATTGAGTGTAAACACACCTAACTTTAAGAAAAAGAACCGCTTGTATGATTTTCAAAAGAACATTTAGAATTCTATAGAGTCAAAACTATAGCGTAATGCTGTGTTTATTAAGCCAGGGATTGTGGGACTTCCCCCAggcaactaaacctgcaggatgaaaatgctatattttctttcatgcactgtcgatattactcagatttggggaaatgacatttttatactaaaacaaacaccaaaatattttagaataaattcttagaaagttttgagaGGAATTTTTAGAGAGGACATTTCCTCCTTCCTGATTTGGATATTCCCTCAAATCCCTCCTCTTACTCCATGCTGAAGGAGAAGTACTCTCAGATGCATTATGTTAATGGAGAGAAAAAGCACAGTATTGTAGAGACACCAATATTAGCTAATGTATTTTGGAGTGTTTTCCATTTTACAGTTTATATTCCAGCACTCAAAACTCAGGGTCAAGTTTTAACAAAAGAGGTATGTAGTCACAGTAAATACTAAGATGGCATTTCTATCTCAGAGGGCCAAAGTGAATCACACCAGTTTCTGAAGGTCCTAAAAATAGCTCAGATGTCCTAATGAACATGCACCTACATTTAATAGGAGTACAATAAAACTGTTGTCAGCTTTTGTTTTACAGAGAACGCTAGATATTAAGAATTTTGAAATGGATCATTTCTACTTGCTGTGCATTTTAACCAATAATCTGATGAATATAGAAAAAAATGATCCAAAATATGGATATGATTGGATGTATGTAACACATACATGGAGTATGGAGGAAATTTTCTGAAAAATACATTTAGATTAGTTTAGTTTGAAGGAGAGGTGGGCTGATGGCTGAGTTGTATGTTACTAACTTGGCCCTGACTGGTTGTGCAACCATTGCTTCATTTCTTTGCAAAATGTAGTTAAGATATACTTTATTCTAATGAAGGCCTTTTAAATTTGTCCACTGCATTCTTGGTATTTCACTACTTCAAGTCAGTCAGAACTTCGTAGACCGACCTGAAGTTTCTTTTTGAATACTTGTTTCTTTAGCACTTTGAAGATAGAAAAACCACTTTTTAAGTACTAAGTCATCATTTGCCTTGAAAGTTTCCTCTGCATTGGGTTTGAAGTAGTTTAGTTATGTCTTTTTCTCTGTATGTAAGTAGTATAATTTGTTACTTTCAAATACCCGTACTTTGAATGTAGGTTTTTTTGTTGTTGTTATCTATAAAAATTGAGGGAAATGGTTATGCAAAAAAATATTTTGCTTTGGACCATATTTCTTAAGCATAAAAAAAATGCTCAGTtttgcttgcattccttgagaatgtatttatctgaagatcaaaacaaacaatccagatgtataagtactaggcagaagccaattttaaaatttccttgaataatccatgaaaggaataattcaaatacagataaacagagttggcAGTATATTATAGTGATAATTTTGTATTTTCACAAAAAAAAAGTTAAACTCTTCTTTTCTTTTTATTATAATGACCAGCTTTTGGTATTTCATTGTTACCAAGTTCTATTTTTAGAATAAAATTGTTCTCCTTCTAAAA

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