Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name UBE2KP1
Wait
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:178017125-178017444  UCSC
Coordinates (T2T) chr1:177371895-177372214  UCSC
Coordinates (hg19) chr1:177986260-177986579  UCSC
Strand +
Parental Sequence NM_005339.5
Parental seq. overlap 269 bp
Parental seq. overlap (%) 5.2%
Genomic Region Intragenic (CRYZL2P-SEC16B)
Retrocopy Summary UBE2KP1, located on chr1:178017125-178017444, is a retrocopy of the parental gene UBE2K. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name UBE2K
Full Name ubiquitin conjugating enzyme E2 K
Also known as E2-25K|HIP2|HYPG|LIG|UBC1
Coordinate chr4:39698136-39782792
Strand +
Gene summary The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes UBE2KP1
Bonobo Pan paniscus UBE2KP1
Gorilla Gorilla gorilla UBE2KP1
Orangutan Pongo abelii UBE2KP1
Gibbon Nomascus leucogenys UBE2KP1
Green monkey Chlorocebus sabaeus UBE2KP1
Crab-eating macaque Macaca fascicularis UBE2KP1
Rhesus Macaca mulatta UBE2KP1
Baboon Papio anubis UBE2KP1
Golden snub-nosed monkey Rhinopithecus roxellana UBE2KP1
Marmoset Callithrix jacchus UBE2KP1
Horse Equus caballus UBE2KP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>UBE2KP1
tGTAGTAGCAAACCAGTGCAAGCAAACTCCCAAAGTGTTGAAACAGAGAGCTCAACTTTGGGCACATTTGTATGCCAGAGCACCAGTTTCTAATCCAGAATACAGCCAAAGAAATGGAAAACCTGTGTGATACGGGCTTTGATAGGAATGTAGTAACAACAGCCTTCTCTTCAAAATCATAGGACATAGAAACCGAAACAGAATTGTTTCTGAATAACTGAGGCATAGAGAAACAGCTGCTGATATAATCGAAGTTGCCTCTTTTTGAAGTGGCATCAACATCTGCTCTTTTTAGAATTCTGCACGGATTTATTTTAAA
>NM_005339.5
GCCATTTTGGTGGCCGGGCGCGGAGGTGATTCCACACTGAGGCGAGCGCGGCGGCCGGGGTGGTAGTGGCAGTGTTCGTGTGCTCAGGTCTGAATCGCCGAGggaggaggcggtggaggaagaggtggcggcggtggcggtggtcgtagcggtggcggaggaggcggGTACGAATCAGCTGCGGGCGGAGACATGGCCAACATCGCGGTGCAGCGAATCAAGCGGGAGTTCAAGGAGGTGCTGAAGAGCGAGGAGACGAGCAAAAATCAAATTAAAGTAGATCTTGTAGATGAGAATTTTACAGAATTAAGAGGAGAAATAGCAGGACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATAAAAATACCAGAAACATACCCATTTAATCCCCCTAAGGTCCGGTTTATCACTAAAATATGGCATCCTAATATTAGTTCCGTCACAGGGGCTATTTGTTTGGATATCCTGAAAGATCAATGGGCAGCTGCAATGACTCTCCGCACGGTATTATTGTCATTGCAAGCACTATTGGCAGCTGCAGAGCCAGATGATCCACAGGATGCTGTAGTAGCAAATCAGTACAAACAAAATCCCGAAATGTTCAAACAGACAGCTCGACTTTGGGCACATGTGTATGCTGGAGCACCAGTTTCTAGTCCAGAATACACCAAAAAAATAGAAAACCTATGTGCTATGGGCTTTGATAGGAATGCAGTAATAGTGGCCTTGTCTTCAAAATCATGGGATGTAGAGACTGCAACAGAATTGCTTCTGAGTAACTGAGGCATAGAGAGCTGCTGATATAGTCAAGCTTGCCTCTTCTTGAGGAGCACCAACATCTGTTATTTTTAGGATTCTGCATAGATTTCTTTTAAACTGGCATTCTTGCCTAATGATGTTATCTAGGCACCATTGGAGACTGAAAAAAAAAAATCCCTGCTCTGTAAATAAAGCTAATTAAACGTCTGTGTAAATTTAAAAAGGGGAAATACTTTAATTTTTTTTCTTAATAGTGTAAAAATTCCCTGAGCTAAGCTAAAACCATGGAAGAAACATGCTACTTTAGTGTTTAGCAGTGTACCAAGACTAGCAAGAGTTTGCTTCAGGATTTTGTTGAATAATTAAGATAATATTTTGAGTGTGTCAGGGCCATTCAAATTGTTGGTGTTGCATCACAGCTACCTTAACTGTTTTTAACATGGATCCTCTGTGCCTGTGAATTTACTTGCATGCTTGTACTTGACTTCTTAGGATGGGTAGCTGAAAAGACCACCATTTTAAGCATTTGAGAATTCTTAAATATGAAATTTATTCAGAATTGAAGATGGTGACCTATTCAGAGCCTTTTTGTCCTTGTCAACAGACTGGGACAGTGTCTGATTCCCCCTTCACCCCCCCCACCCCCGCCTTGCCACACACAGCTAATATTCTAATGGTAAATTTCTCTGTATCAGGTGGGGAAATGTGCTGAAGGACAGTATGTATCCCTTGCTTCATTTTTAGGTCGTAGGTTTGGAATGTCTTGTCCCAGTTCTTCAAACACTCTTAAATTTTTCTTAAGTAATGTAAAAATGGAACTGCCAATTTTATTTCTCTTGCAAAAATAGTAAATACTTGATGTTACATTATTCCCAGGTTTAATGAAAGAACCCAACTTAGTTTTTCAGTGAATTTGACACCTATTTTTTAGTGATGAAATTTTTCTTTGAGAACTGGCAAGGATGCAGTCAGCTGTTTGCAGTTTTTAGCCTGATTTTGGGGTCTATAGAGATTGCTTTATTGGATACTTCAAGTCATTCTTGCTTGCACTTCCCCTATTGACACATGAAAGCTGTGTTGGTGTTTTATTGTACATACTTCAGATGCACATAGGAATAGAAGTGTGTTATAAATCTAGCTTTCTTTATGATGTTTCTGATAATACGAGAATTGAAAACTTTACCTTCTCTTGTACATAGTCAGACTATTTGTATTAAATTTACATTTCATTCTAAGTTCAAAAGTTTGAAAATTATTAGTTTTGCAAGATCACACACTAATGTAACCATTTTATGAAGGTTGAAGTGGATTTATGCAGGCAGTTCTATATATAGAAATACAATTCTTTTTAAATTTTTAGGACCAATACAAAATAACAAAAATGTAATGGAATCAGACTGAATTAAAGTAAGGCTGTATATTGAAAGTCATATTATAAAAGGTTTGCTTTCTTTAAGTGTTATTTATCTTAAATTATAATCGTTAAATGTTTGGAAGATAATTTTTGAATCATAACGTCAGCATAACTTCATTTGACTTCTCAATAATCTTGATACTAGAAGCAATAAAAGAACCATTATTAAATATATTGTAATGTTAAAGATGTGAAGGTTCTTCCAAAAATTTGTAAGGCTTTCCTAATTAACAGTAAACTCTTATAGCTGATATTATTACATACTAAACACAAGTTGCTGTTTTTTCCCCATATGTTTGCTTACGCATGTCTTTATACAATCACCTCTTTTTATTGCTGTAGTTTATTTTCTAAAGATGCCAAAGGAAACAAGATTTTTCTTTATTTATTTTAAATACCTGAAACCTCGTACTTTATATTTTGAAGTAAGGTGGGATTGTGTGAAAATGTGGATGGTTTTTCTCCAGTGTTGGTTAGAACTACTTTTTTTAAGTGGAGGGCAACTTGGTAGTATTAGTAGAATTTGGGTTTAAAAATATCAGACACATCTACCCAGTTTATTTTTTGCCTGTATTATCAGGGTATATTTAATTGTCCTGTGGTTAAACAAAGGTGAGAGAGCTCAGAGGTTTCTAAAGGTCAAGCATTTtacatatatacatacatacatGCTCTTGGAGGCAGCTATATCCTGCTTTGATTTTTATGCACATGAGCCCTATAGGGTTATATACTCATCTAACTACACTTCAGCATCCCCAGTGCCCAAGAAATTGGAAAGTACAATATTTGGTTTGAGACATTCTTCATAAAAGATTCTTTATTATAAAAATTTACCTCATTTACATTTAATGTGATGATCTTTTTTTTCCTTTCTGGTATATTTCCCACTGTACTGTTTGGTTTTTGTTATTCTCTTGTCTGTGGGTAGATTTAGTTACCCAAACATAGAAACTAAAGCAATTGCTTTTTTCCTCTGGTCTTAAATATGTTTGGACAAAAAGACACTAAAAGGTCAGGCCTAGGGGAAAAGTACCCTGGTGGAAATTATTTTTGTAATTCTTAATATTTTTGAGTTGGCTCCGTTTGTCAGTTTTAAAAGCCTCAAAAATTATGTTAAAAAAAAAATCCAGTGAAATCCCATTTAGGGCAGGCCGATTTGTTAGAAGTCACTGATGCTCCAGTAGGCTTTTGTTATAATCAGGCCTGTTTCCTGAGTATGTGCCTCTTTTAAAAGAAGAAATAATTAGCTGTATAGTATTTCAGTACTGatgaatgaatgaatgaatgaatgGCAGTTAGTGGACCCAAATAAGTATTCAGTGGTATATAAATATTTGAGGAACTAGGTACTGAATTAGGTGCTCTGAGTTGGCACCCCGAAATGTTTGGAATCACGACTATGATTTACTTAAACACGTAACACATTCAAGGATATATAAATGGAGTCTAAGTATTTTGCTTTTGAAGAGAATAATCTATGAAATGGAAGACTTGATTTTTTTTTTCATTTTTTAGAAGTAATACACATTTATGATTGTTGGCACATAAAACTATGCAAAATAATTCTTTTTAAGTATCTGTAAGAAAGAATTGGCAGTTTAAACGGATTTTGCTTATTTATGCACTACAGAATGCAGCATACTGTATTACTGTTGAGGCTGCTTAATAAGTTTACCAATGTGAAAAGCAGATCTTGGGTATAAGTGTATGCCTGATTTGAGCTTTTAAAACTGTGCAGTAGGTGTATGGTAATGTTTTACAATCCTATGTAGCAAAATAGGAAATTATGAATTTTTGTTGTTATTGTTTTAAAGATTTAAGATGGATTGGGGTAGGGAACAGCTGGAGCCAGGTATACCTTCTAGTATGTAGAGGGAAACAATGTTTAGATAGGAAAAAGGAAGCCGTCTGTTTACAGTTAACTTTATTTCATGGACTTCTACAAAATGTTGTATTAATCACTTTTTCTAGTTCAAGGAATTTCAATTCCAGGGTACAAACCATTGATTTAAAAATTACGTTTCCATTCTTTTTAGTATCAGTTTAAAGTAAATGCTTACCATCAGCCAGTTGCTGTCACTGGGAAGAAGGCAACTTGAAGTATTTACTGATAAAATAGCCTTTATTCCCAAGTGTGACTTTTCTTCAGTGTCTACATATTATGTCACACGTTCTATTTGCACTGCTGCAATATAGATCAAAGATCTTGTGGCATAGGGGTAGGGGAGTGTTAGTATCTCCCTTGTCCCATTTGTTCTGTTACTGCTTCATTGGACTGATACACCCTCATGAACTTGCAATCACCTAAATGGAAGTCTTGAATGTGTCACCTTTTGCTTGGTTATTTCAACCATGCTGCTATATATAATCAGGTGTGGCACAGTTTGTCAGTTTGATTATAGGTGTGAGTGGATAGAAATCATTACACTGTGCTGTTAACGATCCTTGTCTGCTTGCTGTTACCTACTTTTTACAGGCATCATAATAAAAGCTAGACTATTTCTTTGGGGGGAAAGAGACTTATTTAATGTAATTTAAAAAACTTTTCCAATAGAAAATGAAATATTATTGAAAATAATATCTATTTTTTAGCTTTCAGCAATTGATGGTGCTTTGTTGTGGTGTCTGCTGGAAGTCTACTGCCATTATAGGGAACCTTGCTTGTTAGCTTCTCTAGATCTCTATTCTAAACAATCTGTTAGTGATGATAAATTCTGTAGGAGGGTCTATTCTGAGCCGTTAACTTCCTGTAAGGGGAAAATGGGTGGGTTACCAGAAATACCATTGAAGCAGGGTGGGCTGTGGGGTGGAAGGTTGGGGTATTTGTCTTGAGAATTAAAAACTACGAAACACTTTTGTACACAACTGATTTTTTAAAAAATAAACACATTTTTAAAGATGTTGAATTTTTCCCCCCTTATTGGGAATTCTTAAAAATAAATGCATGCATGTTTTCCCCTGAAAA

Publications

PMID - Link Title
No publications available for this retrocopy