Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ORC3P1
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:79987483-79989977  UCSC
Coordinates (T2T) chr11:79922228-79924722  UCSC
Coordinates (hg19) chr11:79698526-79701020  UCSC
Strand +
Parental Sequence XM_017010634.2
Parental seq. overlap 2252 bp
Parental seq. overlap (%) 89.1%
Genomic Region Intergenic
Retrocopy Summary ORC3P1, located on chr11:79987483-79989977, is a retrocopy of the parental gene ORC3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ORC3
Full Name origin recognition complex subunit 3
Also known as LAT|LATHEO|ORC3L
Coordinate chr6:87590128-87677824
Strand +
Gene summary The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ORC3P1
Bonobo Pan paniscus ORC3P1
Gorilla Gorilla gorilla ORC3P1
Orangutan Pongo abelii ORC3P1
Gibbon Nomascus leucogenys ORC3P2
Green monkey Chlorocebus sabaeus ORC3P1
Crab-eating macaque Macaca fascicularis ORC3P1
Rhesus Macaca mulatta ORC3P1
Baboon Papio anubis ORC3P1
Marmoset Callithrix jacchus ORC3P2
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ORC3P1
TCATCTGGTATCCACAGAGCCAGTAAGACCATGGCCACCTCCTCAGTGTCTAAGGGCTGCTTTGTTTTTAAGCCAAACTCCAAAAAGAGAAAGATCTCTGTGCCAATGGAGGACTATTTTAACAAAGGGAAAAATGAGCCTAAGGACAGTAAGCTTCAATTTGGAACTTAGTTGATATGGCAGCAAATGAAATCTGAAAATGAGCCACTACAAGAGGAATTAAATAAAAACTTGTTTGACAATCTAACTGAATTTCTGCAAAAATCTCATTCTGGATTCCAGAAGAATTCAAGAGACTTGGGCTGTCAAACAAAACTCAGAGAAATTCCAACTGCTGCTCTTGTTCTTGGTGTGAAAGTCACAGATCATGATTTAACATTCAGAAGTCTAACAGAGGCCCTTCAGAATAAAGTCACACCATATGTAGTCTCATCGCAAGCTAAAGACTGTCCAGATATGAAACATTTTTTGCAAAATTTGGTCTCATAATTAATGAACTGCTGTGTACATCTAAAATCCAAAGAGGGGGAAAGCGTTCAGGTCACCCAGAGAAATACACATTATTTAATGGATTCACTTTCCAGTTGGTACATGACTGTCACACAGAAGACAGACCCAAAAATGCCAAGCAAAAAGAGGACTACTTCTAGCCAATGGCAGTCTCCTCCTGTTTTGGCTACCTTAAAGGATATGGAAAGCTTTGCCACAAAAGTACTGCAAGATTTCATAATTATCAGCAGTCAACATCTGCATGAATTTCCACTAATACTCATTGTGGGAATCGCCACATCTATTATCAACCACCGATTGTTTCCTCATGCAGTATCATCTCTGTTGTGTATAGAACTGTTCCAATTTTTGTCTTGCAAGGAGCATCAGACTATGGTACTCAATAAGCTACTTCTTACAACTCAGTTTCCCTTTAAAATAAATGAAAAAGTATTGCAGGTTCTGACCAACATCTTTTTGTATCATGATTTCTCGATTCAAAACTTTATAAAAGTCTTCAACTTTCTTTATTAGAGCATTTCTGTTCCCAGCCCTTAAGTGTCCTGTGCTGTAATCTTCCATAAGTCAAAAGAAGAATAAATTTTTTATCAAATAATCAATGTGAAAACATCTGACGTCTTCCATCTTTTAGGAGATATGTGGAAAAGCAAGCTTCAGAAAAGCAAGTTGCGCTCTTGACCAGTGAGAGATGTTTGAAGAAGGAAACGCAATTATTACTAGAAAACCTGCATGTTTATCATATGAATTACTTTCTGGTTTTGAGATGTGTTCATAAGTTCACCTCTTCTCTTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACCGCATGTTTAGAAAAGAACATCCGGAATTCAGAGGAGTACGCATCAGTCTTGCAGCTGCTGAAGATGTTGGCAAAGGATGAACTGATGACCATACTTGAGAAATGTTTCGAGGTTTTTAAAaAACCAAAGAGGTAGAAGATGCTTCTGGTTCATAGCCAAAGGGGCTTCAGAAGGCAGACCTCTATCATCTTCAGAAGTCTTTACTGGAAATGAAGGAGTTAAGCAGAAGTAAAAAGCAAACCAAATTTGAAGTACTCAGAGAAAAGGTTGTGAACTTCATGACTGTCTAGTGAGAGAATACCTTCTGCCTCCCGAGACACAGCCTCCATGAGGTGGTGTGCTTCAGCGCCGCCCATGCCCTTCGTAGGCATTTAATGCTGCTCCGTGAATTGCCCTCCATACTGCACTCAACAATCCTTACTATTCTCTAAAGAATGAAGCACTGAAAAGGGAAGAAGGGTGCATTCCAAATATCACCCCAGACATCTGCATAGCATACAAATTGTACCTAGAGTGTCGCAGGCTAATCAACCTTGTGGACTATTCACAGGCTTTTGCAACAATTTTGACAGCTGCTGAAAAAATGGATGCAAATTCTACATCCTCAGAAGAAATGAATGAAATTATCTATGCTTGGTGTATTAGAACTGTTTTTGAACTAGAACTTTTAGGATTTATAAAACCTACCAAACAGAAGACTGACCATGTGGCAAGGCTAACATGGGGAGGCTGCTAGAAAGCAAATGAGCAAAGCCAGAACTATCAGATTTAGCTTAAGAGAAAAAGGTGACCAGTCATATTTACATACACTAGAGGAGTGGAGGAGCCTGTTTTGGTGAGAAGATAAATGTGTAATCCTTATGTGATGTTTATCCAGAAAAGTACATTGCTAACTCCAAACAGGCATATATCAAAACAACTGTGGAATACTTTAGAGTCCAACAAATAATATATATAACTAAAACTGCTCACACATTTTACTGTACTTTCCACAAAGTCATTACTAAATTGTGAGTAAATCATTCTTGAACTTATAGTATACAAATGTAATGAATTCCTTTATCCAGGAGTATAAATT
>XM_017010634.2
AAATCCCGAGTGCATCTGGAATACGCAGAGTCAGTAAGACCATGGCTACGTCCTCGATGTCTAAGGGTTGCTTTGTTTTTAAGCCAAACTCCAAAAAGAGAAAGATCTCTCTGCCAATAGAGGACTATTTTAACAAAGGGAAAAATGAGCCTGAGGACAGTAAGCTTCGATTCGAAACTTATCAGTTGATATGGCAGCAGATGAAATCTGAAAATGAGCGACTACAAGAGGAATTAAATAAAAACTTGTTTGACAATCTGATTGAATTTCTGCAAAAATCACATTCTGGATTCCAGAAGAATTCAAGAGACTTGGGCGGTCAAATAAAACTCAGAGAAATTCCAACTGCTGCTCTTGTTCTTGGTGTGAATGTCACAGATCATGATTTGACATTCGGAAGTCTAACAGAGGCCCTTCAGAATAATGTCACACCATATGTAGTCTCATTGCAAGCTAAAGATTGTCCAGATATGAAACATTTTTTGCAAAAGTTGATCTCACAGTTGATGGACTGCTGTGTAGATATAAAATCCAAAGAGGAGGAAAGTGTTCACGTCACCCAAAGAAAGACACATTATTCAATGGATTCACTTTCCAGTTGGTATATGACTGTCACACAGAAGACGGACCCAAAAATGCTAAGCAAAAAAAGGACTACTTCTAGCCAATGGCAGTCTCCTCCTGTTGTCGTTATCTTGAAGGATATGGAAAGCTTTGCCACAAAAGTACTACAAGACTTCATAATTATCAGCAGTCAACATCTCCATGAATTTCCACTAATACTCATTTTTGGAATAGCCACATCTCCTATTATCATCCACCGATTGCTTCCTCATGCAGTATCATCTCTATTGTGCATAGAACTGTTCCAATCTTTGTCTTGTAAGGAGCACCTGACTACGGTACTCGATAAGCTACTTCTTACAACTCAGTTTCCCTTTAAAATAAATGAAAAAGTATTACAGGTTCTGACCAACATCTTTTTGTATCATGATTTCTCAGTTCAAAACTTTATAAAAGGACTTCAGCTTTCTCTATTAGAGCATTTCTATTCCCAGCCCTTAAGTGTCCTGTGCTGTAATCTTCCAGAAGCCAAAAGAAGAATAAATTTTTTATCAAATAATCAATGTGAAAACATCCGACGTCTACCATCTTTTAGGAGGTACGTGGAAAAGCAAGCTTCAGAAAAGCAAGTTGCGCTCTTGACCAATGAGAGATATTTGAAGGAGGAAACACAATTATTACTAGAAAACCTGCATGTTTATCATATGAATTACTTCCTGGTTTTGAGATGTCTTCATAAGTTCACCTCTTCTCTTCCCAAGTATCCACTAGGTCGACAGATCAGAGAGTTGTACTGTACATGTTTAGAAAAGAACATATGGGATTCAGAGGAGTATGCATCAGTCTTGCAGCTGCTGAGGATGTTGGCAAAGGATGAACTGATGACCATACTTGAGAAATGTTTCAAGGTTTTTAAGTCTTATTGTGAAAACCACCTTGGCAGCACAGCTAAGAGAATAGAGGAGTTCCTGGCCCAGTTTCAGAGCCTCGATGAAACCAAAGAGGAAGAAGATGCTTCTGGGTCACAGCCAAAGGGGCTTCAGAAGACAGACCTCTATCATCTTCAGAAGTCCTTATTGGAAATGAAGGAGTTAAGAAGAAGTAAGAAGCAAACCAAATTTGAAGTACTCAGAGAAAATGTTGTGAACTTCATTGACTGTCTAGTGAGAGAATACCTTCTGCCTCCTGAGACACAGCCTCTCCATGAGGTGGTGTACTTCAGTGCTGCCCATGCCCTTCGTGAGCATTTAAATGCTGCTCCGCGAATTGCCCTCCATACTGCACTCAACAATCCTTACTATTATCTCAAGAATGAAGCACTGAAAAGCGAAGAAGGCTGCATTCCGAATATCGCCCCAGACATCTGCATAGCATACAAACTGCACCTAGAGTGTAGCAGGCTCATCAACCTCGTGGACTGGTCAGAGGCTTTTGCAACAGTTGTGACAGCTGCTGAAAAAATGGATGCAAATTCTGCAACCTCAGAAGAAATGAATGAAATTATCCACCTCCAGTGCTCGGTTTATTAGAGCTGTTTCTGAACTAGAACTTTTAGGATTTATAAAACCTACCAAACAGAAGACTGACCATGTGGCAAGACTAACATGGGGAGGCTGCTAGAAAGCAAATAAGCAAAGCCAGAACTATCACATTTAGCTTAAGAGAAAAAGGTGACCAGTCATATTTACATATATTAGAGGAGCCTGTTTTGTTGAGAAGATAAATGTGTAACCCCCATTGATGTTTAACCAGAAAAGTACATTGCTAACCCCAAACAGGCATGTATCAAAACACCTGTGGAGTACTTTAGACTCCAACAAATAATAATGTAACTAAAACTGCTCACACATTTTACTGTACTTTCCAAAGTCATTACTAAATTGTGAGTAAATCATTCTTGAACTTAGAGTATGTAAATGTAATAAATTCCGTTATCCAGGAGTATAAATTA

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