Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name EIF2S2P6
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr20). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:82835488-82837500  UCSC
Coordinates (T2T) chr11:82771947-82773959  UCSC
Coordinates (hg19) chr11:82546530-82548542  UCSC
Strand +
Parental Sequence NM_003908.5
Parental seq. overlap 1108 bp
Parental seq. overlap (%) 40.8%
Genomic Region Intragenic (PRCP)
Retrocopy Summary EIF2S2P6, located on chr11:82835488-82837500, is a retrocopy of the parental gene EIF2S2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name EIF2S2
Full Name eukaryotic translation initiation factor 2 subunit beta
Also known as EIF2|EIF2B|EIF2beta|PPP1R67|eIF-2-beta
Coordinate chr20:34088309-34112243
Strand -
Gene summary Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes EIF2S2P5
Bonobo Pan paniscus EIF2S2P5
Gorilla Gorilla gorilla EIF2S2P6
Orangutan Pongo abelii EIF2S2P5
Gibbon Nomascus leucogenys EIF2S2P7
Green monkey Chlorocebus sabaeus EIF2S2P1
Crab-eating macaque Macaca fascicularis EIF2S2P8
Rhesus Macaca mulatta EIF2S2P8
Baboon Papio anubis EIF2S2P8
Golden snub-nosed monkey Rhinopithecus roxellana EIF2S2P7
Marmoset Callithrix jacchus EIF2S2P5
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>EIF2S2P6
AAGCCCACTTGAGCCACAGCCACGTCCGGGGATGAGACAGTTTTTGGTCCTACTATGAGCAAGAAGAAAAAGAAGAATCCCTTTATGTTAGATGAGGAAGGGGATACACAAACAGAGAAAAACCAGCCGAAGAAGTGGAACCAGAACCAGCTGAGGACAACGATGTAGAAGCTGATGAAGACGACGGTAGGAAAAAAGACATTTCTGATGTTCTAGATGACTTGAACTTCTTTAATCAGAAGAAAAAGGAGAAAAAAAAGACATTTGATGCTGATAAAGCTGAAGAAGTTGTAAAGGATCTTAAGATTGAAAGTGATGTTCAAGAACCAGATGAACCAGAGGAGGACCTTGACATTATGCTTGGCAATAAAAAGAAGAATGTCAAGATCCCAGATGAGGATGGAATACTAAAGACACAGCTCTAGACACAGCTCTAGAAGATGAAGACAGCAAAAAAGACGATGCTGTCTCATTCAGCAATCAGATAGGCCCTGATAGGTAGGTCAGAAAGAGACTGCACATATAAGGAGCTACTGGATCATATGTTCAACATTATAAGGGGAAAGAATCCAGACACAGTTGCTTGAAAGAAAAGGAAATTCACCATGAAACCTCTACAGGTCGTCCAAGTAGGAACCAAGAAAACTCCTTTCATCAACTTTATGGATATCTGTAAACTATTACATCAACAGCCCAAATGTCTCCTTGCATTTCTTTCATTTTTTTTTGTTTTGTTTTTATGGTTTTTGGGGAGcTCCTTGCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTACAGACGGTAATAACCAACTTGTAATCAAAGGAAGATTCCCATAGAAACAGAAAATGTCTTGAGGAGATATATCAAGGAATATGTCATTTAAGTTATGGGGCTCCACCCTTATGAACAGAGTAGTGCCTCATAAAAGGGCTGGAGGAAACTAGCCCTTGATACATCAAGGAATTGTCAAGGTGATGTCACACATGCCAATCACCAGACACAATCCTGCAGAAGGGCATCCGACTCTATTTCTTACAGTGTGAAAGTTGTCCTTCTCAATGTTCTGTTGCCAGTATCAACACCAGGCTGTCACGGGCAAATAAGCACAGCTCCATGCCAAAGCTAACCAATTTGCTAATCACTAATTTTGCAAATTGTGTTGTGGAGATTTGGCTGGATAAGTTTGCCATCAGAGTGGATCTACCATTGTATTAAAAACGAGATTAAAAAGCTGCCAAGTTCTTTGGTGAGTAGTTGGTTGGTCTGAAATCCTTGCAAGATGGCAATGCTCAAGCTGGTGATATATCCATTGCCTACTTTAACAACTGTCAGAGAAATGCGACATGGGGTAAGGAGATGCCTTTTAAAAATCATTCATAGACTTCTGTAAAATGCAAGATAAA
>NM_003908.5
GTCGTTTCCTTTCGCTGATGCAAGAGCCTAGTGCGGTGGTGGGAGAGGTATCGGCAGGGGCAGCGCTGCCGCCGGGGCCTGGGGCTGACCCGTCTGACTTCCCGTCCGTGCCGAGCCCACTCGAGCCGCAGCCATGTCTGGGGACGAGATGATTTTTGATCCTACTATGAGCaagaagaaaaagaagaagaagaagCCTTTTATGTTAGATGAGGAAGGGGATACCCAAACAGAGGAAACCCAGCCTTCAGAAACAAAAGAAGTGGAGCCAGAGCCAACTGAGGACAAGGATTTGGAAGCTGATGAAGAGGACACTAGGAAAAAAGATGCTTCTGATGATCTAGATGACTTGAACTTCTTTAATCAAAAGAAAAAGAAGAAAAAAACTAAAAAGATATTTGATATTGATGAAGCTGAAGAAGGTGTAAAGGATCTTAAGATTGAAAGTGATGTTCAAGAACCAACTGAACCAGAGGATGACCTTGACATTATGCTTGGCAATAAAAAGAAGAAAAAGAAGAATGTTAAGTTCCCAGATGAGGATGAAATACTAGAGAAAGATGAAGCTCTAGAAGATGAAGACAACAAAAAAGATGATGGTATCTCATTCAGTAATCAGACAGGCCCTGCTTGGGCAGGCTCAGAAAGAGACTACACATACGAGGAGCTGCTGAATCGAGTGTTCAACATCATGAGGGAAAAGAATCCAGATATGGTTGCTGGGGAGAAAAGGAAATTTGTCATGAAACCTCCACAAGTCGTCCGAGTAGGAACCAAGAAAACTTCTTTTGTCAACTTTACAGATATCTGTAAACTATTACATCGTCAGCCCAAACATCTCCTTGCATTTTTGTTGGCTGAATTGGGTACAAGTGGTTCTATAGATGGTAATAACCAACTTGTAATCAAAGGAAGATTCCAACAGAAACAGATAGAAAATGTCTTGAGAAGATATATCAAGGAATATGTCACTTGTCACACATGCCGATCACCGGACACAATCCTGCAGAAGGACACACGACTCTATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCCAGTATCAAAACCGGCTTCCAGGCTGTCACGGGCAAGCGAGCACAGCTCCGTGCCAAAGCTAACTAATTTGCTAATCACTGATTTTGCAAAGCTTGTTGTGGAGATGTGGCTGGACAGGTTTGCCATCAGAGTGGATATACCGTTGTATTAAAAACAAGATAAAAAAGCTGCCAAGATTTTTGGCGAGTGGTTGGTCTGAAGTCCTTGCAAGACGCTGATGCTCAAGCTGTTGACATACTCATTGCCTACTTTAACACCTGTCAGAGAAACGTGATATGGGGTAAGGAGGTGCTTTTTTAAAATCGTTCATAGACTTCTGTAAAATGCAAGATAAATTAAAGTTATTATAACAGTGATTCTTTCAATTTGGTTTGTCCTTCAGTTTTCTTTTCTATAAATGTGCTTGGTGAAATCAGCAAGAAACCAACCATATAAAACAGTGTGTGCCGGGCTCTGACTGAGAAACTGAACAATGGCAGGCGCTTCATCTGGGCAGCCATTTTTCTTCTCTGCTTCTCTTGAGATACATAGTTAAAGTAGACACGGCCTCCCACGCGAGTGTGGTGGGACCTTGAGACTTAGGAGGATTGCCTGTTTTCAGTGTCCAGGGAATGACTCCATAGATTTGAATTCTTTTCCGTATGTGGGGATGGTTGCTACTACCTCACCGCCAAGTCCTCCCCCAGCTGTTACCACATGAGGGAATACAAGGTGCTAGGTACCCTCCTTCCTCGTTGGCCACTAAGAGGTCTTAGAAACATAGCCTGTAAATGTGTCTTGTAACTGGCACACTAAAAAAGATCCTAGTTGAGCATCTCTCTTGGTGAGGAAGCGATGTGTGTGCGGTTCAGGAAACTCCTCCAAGAGGAGGAGGAGTCCAAACAGGGATGCCAGAGGAAGCTTTCCGTTTTCCTAGCCAACTTGTGTTCTGGGTTTGAAAAAGACCCACCACAAATGCTTTTTCTATTTTCTGATTTAAAAGTCGCTTTTGAATATGACCATGAGAAACCAAGAAATGCTGCTTGTGTGGTGCTCTGCTTCCTGAGGATTTGGCTGGAAGGGGATTCTCCGCTGGCACATGGGAGAAGGCCATCTTCTGTGTCGGTGCTGTGATCTGCCTTGTTCTCACTTGCTGAGGATAAGGGCATACACGCTGCTCCTCGCTTTCTTGTTGCCCGACTTCGTACTAAGCAGCTCAGGAGCAGTCACTCAGACCCAAATGTCTTGACTGTGTTGTTTTTAATCACTGTGACCCTTAAAGTACAGGCCAAGTGTTGTCAAACACCTTGGCTAAAACAGTGGAGGGTGATGGGTAAAGCAGTAGAGGGCCCTCAACCCACACACTGGCTGAAACTGCCACCAACTGCCACGATGAACCCAACTGCTGTTTATGCCCCCATTTTCCTTTTTTTGTATCTACACCCACACGATTCCCAATGTTGGATATTTCTACATGAATAAAGCAAGGATCAGTGCCTCTTATGTAA

Publications

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