Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PTP4A1P6
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:86431592-86434248  UCSC
Coordinates (T2T) chr11:86374105-86376760  UCSC
Coordinates (hg19) chr11:86142634-86145290  UCSC
Strand +
Parental Sequence NM_003463.5
Parental seq. overlap 967 bp
Parental seq. overlap (%) 20.8%
Genomic Region Intergenic
Retrocopy Summary PTP4A1P6, located on chr11:86431592-86434248, is a retrocopy of the parental gene PTP4A1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PTP4A1
Full Name protein tyrosine phosphatase 4A1
Also known as HH72|PRL-1|PRL1|PTP(CAAX1)|PTPCAAX1
Coordinate chr6:63516440-63583588
Strand +
Gene summary This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PTP4A1P4
Bonobo Pan paniscus PTP4A1P4
Gorilla Gorilla gorilla PTP4A1P4
Gibbon Nomascus leucogenys PTP4A1P4
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PTP4A1P6
GGGCCCAGCTGTATGGTTAGGCCACCATCGTTCGTGAGTAAACATATTCCTTTCTGTGGTGTTCTTGATAATGCATTTATAGAGTTTCTAAAGGGCCCTGGAGATTACTGCCAGGTTCAGCACGAACTTTATGAGGACAAGTGAATGGTGGAAAGTCATTACTGCCCCACCAAGAAGCCCCCACAGAGCGGGTCACCTGGACACAGAAGTGTAGAATTGAGATCATTAGAGCATTTTACAAGAGTTCTGACCTAGATGGGGTAACCCTTGGTGCACTTCCTTTCCATTGGCCCAGAATTACTGAATTGAAGAACCGCAGCTTCTTGTTGGTAGGTTCATTTCATTTCCTGTCACTACCAACTTCATATTCAAAGCTCTGTGAATTTCAAGTGGAGTATATTGGCGTAGACTTCAGTTTCTTGACATCATTTCTGTATTCAAAAATTTTTAATTTTTTTCGTAACCATATCAGTTTTTTTTTTTTTTAACTAAATTAACATGGCTCCAATGAATCACCCAGCTCCAGTGGAAGTCACATACGGGAACATGAGATTTCTTATTATACACAACCCAACCAATTCGACCTTAAACAGATTTTTAGAAGAACTTAAGAAATACGGGGTTACCACAATAGTAAGAGTATGTGAAGCAACTGATGACCCTGCTCTTGTGGAGAAAGAAGGCCAATCCAGTTTCTGGATTGGGCTTTTGATGATGGTTCATCACCATCCAACCAGATTGTTGATCACTGCTTAAGTCTTCTAGACGTTAAGTTTCGTGAAGAACCTGGTTGTTGTATTGCCTTCACTGTGTTGCAGGTCTTGGGAGGACTCCAGTGCTTGTTGCCCTAGCATTAATTGAAAGTGGAATGAAAAACGAAGATGCAGTACGGTTTATTAGAGATAAACGGCACGGCGCTTTTAACAGCAAGCAACTTTTGTATTTGGAGAAATATCATTCTCAAATGCGGCTTCGCTTaGCTTCAAAGACTCCAGTGGTCACAGAAACAACTGTTGTATTCAATAAACCTGGCTGCCTGATGCTATTGCCTTGAAAGTGGGACTTGAGAAAAGACCTAATTTATTGTACATTTTAGCCAACATATGGGCTTAGTGAATAAGTCTGATGAAGCTTCCATAGG
>NM_003463.5
gcctcggcgcgtgtattggctccttcggctgcgggccggctcggctacgcgctctgctcCGAGCCGCTCACTGCATGGTAGAGTCTGGTgcccccgccgccgcctgcatcgccgccaccgccgctccgccacgaccaccgccgcctcctgccctgcagccaccgccaccgcctgtgtcgccgccgccTCGGGACCGGCTGTATGATTAGGCCACAATCTTCAATGAGTAAACATATTCCTCAATTCTGTGGTGTTCTTGGTCACACATTTATGGAGTTTCTGAAGGGCAGTGGAGATTACTGCCAGGCACAGCACGACCTCTATGCAGACAAGTGAACTGTAGAAACTGATTACTGCTCCACCAAGAAGCCCCCATAAGAGTGGTTATCCTGGACACAGAAGTGTTGAATTGAAATCCACAGAGCATTTTACAAGAGTTCTGACCTGGATGGGGTAAACCTCAGTGCACTTCTTTTCTGTTGGCCTCAGTATTACTGGATTGAAGAATTGCTGCTTCTTGTTAGGAGGTTCATTTCACTTATCATTACTTACAACTTCATACTCAAAGCACTGAGAATTTCAAGTGGAGTATATTGAAGTAGACTTCAGTTTCTTTGCATCATTTCTGTATTCAATTTTTTTAATTATTTCATAACCCTATTGAGTGTTTTTTAACTAAATTAACATGGCTCGAATGAACCGCCCAGCTCCTGTGGAAGTCACATACAAGAACATGAGATTTCTTATTACACACAATCCAACCAATGCGACCTTAAACAAATTTATAGAGGAACTTAAGAAGTATGGAGTTACCACAATAGTAAGAGTATGTGAAGCAACTTATGACACTACTCTTGTGGAGAAAGAAGGTATCCATGTTCTTGATTGGCCTTTTGATGATGGTGCACCACCATCCAACCAGATTGTTGATGACTGGTTAAGTCTTGTGAAAATTAAGTTTCGTGAAGAACCTGGTTGTTGTATTGCTGTTCATTGCGTTGCAGGCCTTGGGAGAGCTCCAGTACTTGTTGCCCTAGCATTAATTGAAGGTGGAATGAAATACGAAGATGCAGTACAATTCATAAGACAAAAGCGGCGTGGAGCTTTTAACAGCAAGCAACTTCTGTATTTGGAGAAGTATCGTCCTAAAATGCGGCTGCGTTTCAAAGATTCCAACGGTCATAGAAACAACTGTTGCATTCAATAAAATTGGGGTGCCTAATGCTACTGGAAGTGGAACTTGAGATAGGGCCTAATTTGTTATACATATTAGCCAACATGTTGGCTTAGTAAGTCTAATGAAGCTTCCATAGGAGTATTGAAAGGCAGTTTTACCAGGCCTCAAGCTAGACAGATTTGGCAACCTCTGTATTTGGGTTACAGTCAACCTATTTGGATACTTGGCAAAAGATTCTTGCTGTCAGCATATAAAATGTGCTTGTCATTTGTATCAATTGACCTTTCCCCAAATCATGCAGTATTGAGTTATGACTTGTTAAATCTATTCCCATGCCAGAATCTTATCAATACATAAGAAATTTAGGAAGATTAGGTGCCAAAATACCCAGCACAATACTTGTATATTTTTAGTACCATACAGAAGTAAAATCCCAGGAACTATGAACACTAGACCTTATGTGGTTTATTCCTTCAATCATTTCAAACATTGAAAGTAGGGCCTACATGGTTATTTGCCTGCTCACTTTATGTTTACATCTCCCACATTCATACCAATATACGTCAGGTTTGCTTAACCATTGATTTTTTTTTTTTTTTACCAAGTCTTACAGTGATTATTTTACGTGTTTCCATGTATCTCACTTTGTGCTGTATTAAAAAAACCTCCATTTTGAAAATCTACGTTGTACAGAAGCACATGTCTTTAATGTCTTCAGACAAAAAAGCCTTACATTAATTTAATGTTTGCACTCTGAGGTGCAACTTAACAGGGAGGGCCTGAGAAAAGAATGGGAGGGGGCTATTAATTATTTTTAGCAAAATGTTGCCTTTGTCTTGTGCAAACATGTAGAATATGCTCTTTAATTTAGTAAAATATTTTTTTAAAAGGTAGAGATGCTTTGTTATTGTAATCATAAACTTCCTGAAATTCTTGTAATTTTTTTCCCATACTTATCAGAAGTGTGTTTACCAACTTATTTTTGTTTGAAAGTGTGATTTTTTTTTTCCTTCCCAACCTCTCTTGCAAAAAAAGAAATGGGTTTCTGCTAATGAATTGAGCAGACATCTAATATTTTATATGCCTTTTGAGCTGTGTAACTTAATATTTGGATACTTGACAATTTGTTTTATTATGTAATTGATAAAATGGTGATGTGTATTAATGTTAGTTCAACCATATATTTATACTGTCTGGGGATGTGTGGTTATAGTTCTGTGGGAGAAATAATTTTGTCAGTGTTCACCAGCTTGTAAAAACTTAGTGCGAGAGCTGAAACATCTAAATAAATAATGACATGCATTTATCATCATTGAGATTGGTTTGCTTAAAATTAACTTATTTTGTAGAAGACAAAATGAATTGCACTTCACTTAATGTGTGTCCTCATCTTTTTACAAATAAATGAAGGATTATAAATGATGTCAGCATTTTAGTAAACTTTTAGACAAAATTTGTTAGGGTCATTCATGAAAACTTTAATACTAAAAGCACTTTCCATTATATACTTTTTAAAGGTCTAGATAATTTTGAACCAATTTATTATTGTGTACTGAGGAGAAATAATGTATAGTAGAGgacagccttggtttgtaaagctcagttccactagttcatggttttgtgcaacttctgagcctcagttttctcctttgcaaattaataattacatacctTTATAGATTTTGAAATTAATTTAAATATTAGTATTTGGTACATGAAGGCTTAATGTTAAGTTTCCTTTAATGATCCACAATAATCCCTTTGATCACGTTAATCTAAATCTAGATGTCTTTGTCTAATTTTTTTTGAATAGCAGTTATAAATGTAAAGGACTCAAAGTTTAAGTAAAAAGTGATACTCCACCTTGTGTTTCAAAGAATTTAGTTCCACCTCTTCATACCAGTTTAACACTTAATATATTTCATTGGATTTTAGACAGGGCAAAAGGAAGAACAGGGGCCTCTGGAGGCCCTTGGTTATTTAAATCTTGGATTATTTGTGATAGTAATCACAAATTTTTGGCTAATTTTTAACCTGAGGTTTTGTTTTTTTTTTAAAGGAAATGCAGCCTAGTCTTGAGAACATAATTTTATATAATCAATTACTAAATGTTAAACTATTACCACACAGCCCATAAAACAGCATTTGCGTTTATTGAGAGAGAGGATGTGCCATCATGATTAATGAAAACTATCTTTTGAGTTTGAAAAGAAATTAATTTGCAGTGTTTGGATTGTATATATGGTGCTAAAAATAAATTAATTTACTTTATAAACCTTATCTGTACATTATACGATGTGATGAAATTTGCTTTTTATCCAAATATTTTGTATCTTGTAAATATGGCTAATTATAGGAATGCCTATAATACATCTTAGATTCCTTATATCTAATAAGAGTTCAAAGAGTTATGAGTTGAAGTCTTGAATGCAGGAAACTATCTGATAGTGTTCTAAAATTTGGTTACTTGGGTTTGGATACCCTTAGTGGGATGATGTAAATAGAGGCTAGCTACCTAGGCTTGTCTATAGCAACCATAATGTTGATGTAAGTAATGCGGTTACTGAATCATAAGAAAATGCCATCTCTTTTTAGTTGAAGGAAAACTCTGGAAGTAGGTGCCATTGGTCATTCTGCAGTGCACTGCAACCATTGTTTCCCCTAGTGCCCTCTTTTCCCTAGGGCATTGCTCTCCTATTCCCACGCCTTAACACAGCTCTATACCTAGAAGCAGCCAGCCCAGGCATGCAGTCACATTTAATCACATCCCCCTTCTAGAGTGCTTCAAAATGATGTAGTCCCTCAACTTGGCTAAAGAATCTCAATCTCTTGAAATTTATTTTTTTAATGTCATATTCATCTGGTAAATATCTACTGTTTGCCAGGCATTTAAGAATATGGCAAAGAACATAAAAGATGGTGTCACCAGATTTTGGTCACCAATGAGTACCCGACCCGTTGCCATGATTAAGAGAGAATGCTTTCTATTGGAGTTTCAGGAAATATAATTTGAGAATACTTTAAAGGGAAGTGGAAGTATAAGTGAATGATATTTTTCTTTTACATGTAAACAATGAAGTTATTTCAAAGTTAAGTTTTAAACAAAATACATGAAGTAGTGTCTGCCATACATGTTAATATTCTACATTCTTGCTTCCTTAAATTAATATGTTTGTGTGTATATATGTGCCTCACACCTGAATTGAAAATTAAAGACTGGTTTAAAAGTGGTTTAAAAGTGACATTTAATGTTTCTCCATTACGTTTGGGGTAACCAGCCTAAGTGGAATCTTGGAAGGAAAGTAAGGGAAAAACTTGTATTTGCCTTCAATGAATTAAACCAGTGATATGTGTTAACGTATGAATGAAAGGATTGATGGTGATTTTATAATTATATATATTGCCGCAGTAACCAGTTAATAAATTGATAGCTACCATTTA

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