Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ITGB1BP1P1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:192800594-192801232  UCSC
Coordinates (T2T) chr1:192147663-192148301  UCSC
Coordinates (hg19) chr1:192769724-192770362  UCSC
Strand +
Parental Sequence NM_001369749.2
Parental seq. overlap 560 bp
Parental seq. overlap (%) 12.8%
Genomic Region Intergenic
Retrocopy Summary ITGB1BP1P1, located on chr1:192800594-192801232, is a retrocopy of the parental gene ITGB1BP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ITGB1BP1
Full Name integrin subunit beta 1 binding protein 1
Also known as ICAP-1A|ICAP-1B|ICAP-1alpha|ICAP1|ICAP1A|ICAP1B
Coordinate chr2:9403475-9423569
Strand -
Gene summary The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ITGB1BP1P1
Bonobo Pan paniscus ITGB1BP1P1
Gorilla Gorilla gorilla ITGB1BP1P1
Orangutan Pongo abelii ITGB1BP1P1
Gibbon Nomascus leucogenys ITGB1BP1P1
Green monkey Chlorocebus sabaeus ITGB1BP1P1
Crab-eating macaque Macaca fascicularis ITGB1BP1P1
Rhesus Macaca mulatta ITGB1BP1P1
Baboon Papio anubis ITGB1BP1P1
Golden snub-nosed monkey Rhinopithecus roxellana ITGB1BP1P1
Marmoset Callithrix jacchus ITGB1BP1P3
Mouse lemur Microcebus murinus HDAC2P2
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ITGB1BP1P1
AAAAAAACAGACACCGTAGTAGCAGTTCCCAAAGTGGTGAAATCAGTACTAAGAGCAAGTCTGTAGATTCTAGCCTTGGGGGCCTTTCATAGTCCAGCCCTGCGGCCAGCCTCAATACAGATTCCACCAAGAGCTCAGAATAAAGCAACAATAATTCAAATACGTGTGCAGAATTTCAAATAAAATATGTTGGTGCCATTAAGACACTGAAACTCTCTGAGAGAAGATGTCTTAAAGGGCCACTAGACCTGATAAATTATATAGATGTTGCCCAGCAAGATGAAAAGTTGCCTCTTGTTCCTCTGGAGGAAAAATTTATAATGGGAGTTTCCAAATATAATACAAGTATCAACATCAGATCAGTATGATATTTTGTATAGGCATGTTCTATATTTAATCATCTGGATGGTGTGTTATGATGATGGTCTGGGGTGGAAAAACACTTATTGGCTCTGAAGAACACAGATGCAAGCAGTGATGAATACAGCCTGTGAGTTCATCAGTGCAACCAGCTGGAACAAACATAAGCAATTTGAAAAGTTCTATCTGCCACTTTCTATCTGTATTAACATCTGAGAAATGTTGAATCCTGCAAACCAAGTGAAAGTCAATTTATCTGAAAGTTCAGCTGTGTTCAAA
>NM_001369749.2
ATAGTCTTGGAGGCGCGGCCCGGCGGACGTGGGCAGGAGGGCTGGAAAAGCCGGCGCTGGAGCGGGAACGGGAGTAGCTGCCTGGGCGCCAAAGGCCGCGGCACTCCCACGCGGACCCCGAAGTCCGCAACCCGGGGATGGGCCCGCGGCTGCGAGGTGAGCGCCCAGCCCTCGTCCCGCTTGGGGCCGAGCTCGCGGAGGCCTGACGGGAACACGGTCCCGAGAGCGGCGCGGACGGCCAGGAAGGATGGGTGCGTAGTTTCTCTGAAAAGCATCACCCAGGTCAGAATGAAAGGAAACTCTCTGTGCAGACCGCTGTATGTGGGACCTTTGAAGACAGTCAAATAGTGTTCAATTCTATAGGGATCTTCTCTGGATCAAGCAATGGTGGTGAAAAATGTTTCGCAAGGGCAAAAAACGACACAGTAGTAGCAGTTCCCAAAGTAGCGAAATCAGTACTAAGAGCAAGTCTGTGGATTCTAGCCTTGGGGGTCTTTCACGATCCAGCACTGTGGCCAGCCTCGACACAGATTCCACCAAAAGCTCAGGACAAAGCAACAATAATTCAGATACCTGTGCAGAATTTCGAATAAAATATGTTGGTGCCATTGAGAAACTGAAACTCTCCGAGGGAAAAGGCCTTGAAGGGCCATTAGACCTGATAAATTATATAGACGTTGCCCAGCAAGATGGAAAGTTGCCTTTTGTTCCTCCGGAGGAAGAATTTATTATGGGAGTTTCCAAGTATGGCATAAAAGTATCAACATCAGATCAATATGATGTTTTGCACAGGCATGCTCTCTACTTAATAATCCGGATGGTGTGTTACGATGACGGTCTGGGGGCGGGAAAAAGCTTACTGGCTCTGAAGACCACAGATGCAAGCAATGAGGAATACAGCCTGTGGGTTTATCAGTGCAACAGCCTGGAACAAGCACAAGCCATTTGCAAGGTTTTATCCACCGCTTTTGACTCTGTATTAACATCTGAGAAACCCTGAATCCTGCAATCAAGTAGAAGTCAACTTCATCTGAAAGTTCAGCTGTTTTCAAACTGCAATGCTGAAATGTTATGCAAATAATGAAGTTATCCCTTGCTCTAGATTTTCTGAAGAAAATGGATTGTGTAAAATGCTGATCATTTGTTTATTAAAATGTGTCCTATTACACAGTGAGTTAACTCTCAATGAAGTCATCTATTTTCTGGGCTAAAAAACTTCATTTGTCTTTTTCAACTTCTAATAAGCTTAACCTAAGTGTCACAGAAGCCTAGGTGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACTAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACAAACACACACTGAAGGCCTGAGGAAGACGAGATGTCACAGAGGTCCACTCAGTGACACACACTGAAGGCCTGAGGAAGACTGAGGACATGGGCTCAGTGGTGGCTTCCCAGTCATGGTATCACTGGCATGGACCTCTGTCCGGCAGAGGTGTGGACTGGAGACCAGGATTCATGCTGGTCTGGAACAGTGACATTGCCAACTTAAGACACACAAAGCAGATTTTCAGAAGTGTCTGGTCAAGATAACATGCTGGCCAACCACAATTCCTAGAGTTAAGAGAACCTTAAAAGATTACCGCTCATGCTAAAAGTATGTAAAGATCCCATGTACAGTATGATAGTGTACTTTTTTTAAAGGACTGTCAATATACAAAACTTTAAAGATTAAAAACATTAAAAATAAAACCATGTCCATTTAAAAGTATTTTATTTTTTTCCAGTCAAATGACTAGTTAACAAGAAGAGTAAACTTATTAAACATGCTCTAATTATAAATCACTGCATTAAGGACAATGAAAATAATCAATTTCGGTTATACAATATATACAGTTGTGCTGCAACCAAAGTAATCAGGTGAATGAACTGAATATCATACATCTCAAAATAGCATCCTAAGCTGCATATTATGTTATCCACCCCTTAACAGATCACACAGTTACTCTTAGTCTGTGTACATGTTCTGAGCCATCATCCCAGATCTGATGGAGAATGGCATGCAAAATGCCAGAATCCTGCAGCTGCAGTTCATGAAACATAAACTTTAAATATAAATAGATATCTACAATGTTTTTCTTTCTCTTAGTTGCTTTTTTAATTTGCAAGGAGCAAATAACTAAGAAAGGATATTAGCAGGGTCGTTAATATAATTTCTCCTCTGGTAAGAGTACTATTAGTTACTGCACAATAGCACCAAATTGTAGACTGGAAAAATATTTCCTAGGTATTTATGTACCAGTGAACCTGACAGATTAGTTTGGGACTGGAGTTCTAATGTTGATATGAATCAACTTTATTCCTTATATAGCTGGCACCAGGTGGTCAAAAGGCTGACTATAAAATACAGATGCAGGAGGATTGTTAAAATAGACATAAGTGCACTGTGCAAAATACATCTGTTTACTTAAATCTATGAGAAAATTAAATGAAGGGTTCAAACAGAAATTAACAATTAGTGAAAACAGATGTAGTGCTTTaaaaaaaaacaaaaacaaaaaaCTACAGATATAACACATTTTTACCCGGAACTTTGAAAGGTAAAAAGCGATTGCTATACAACATCATAAAACATTCCAGTTTGTTCTGTCTTCCTTTATaacaaaaacaaaaagtacaatgccaaaaaaaaaaaaaacTCTACACAGTCTTGCATAATAAAGACAAGCTGCTTCAATCAAATGCACCATCACAACAAATGCAGTTAACAGCATTGCTGCCTCACTTTCCAAGCCTATATGCAAATTTATTCCTTTACTTTTGTTAAAAGTCCAAGTGGGTATCATATGCCTATTTATTCTCAGAGTGCCAAAATTTCCAATATTCCTACTATGAATCTTACCCTCGCAATTACTAAATAGAGGTATGACAGTCAAGTTCATTAAACGAATGAGTTTTGGTTTTATAATAGACAACCTAATCCTCTACTACCACCCCAAGTAGCTTAAGAATGATATGATGGCCTGAAACAGTAAAAAGTGGGATGTTTGGGAGTATTACCTGGGACCTATATATTTCTGATATGTTCTTGATTATAAACAGATGGACAGATTCAATTTCAAGACAGTGTGACTACCATTCCTGTTGGAGTATTATAGAAATACAAGACACTAAACTGAGTAAACATTCTCCTGGGCTAGAAGGGAAGGCAGTGGTACACTCAGTAGGAAACAGCAAGTGATGTGTTAATACAGCATGGTCTGCGCCACAGAATTCTACTGTGTACAGTTGCTTTCTGTGTGACTCAGGAAGTTCAAGAAGGCAAATTCCAAAACACCTAAAGCATATAAACTAATTTAAAAGAACTGTTTTGCAATCCATCATCCTTAGTTTTTAACCAAATTCAGGAAATGCAGTTTTATATAACCTGGAACAGAATGAACTGTAGTTACCCTACGTTGTCATAAACCATCAGTAGTTTTGTTAAGTATGATTGTTCACAACAGGTTATACATACATGCAGAATATAATGATAGCTGCAACCTCACAAATTAGGGCTAGAAAGTACAATGCTAATGTGTAAATTTCCAAGTTGCTTTTTAAACACTGGGTGGATTTCAAAGGAATGTGTGTCTTTAAAGGTGAACTGATGGCATTTTATCGAGAAAGTTCAGAGCTGGGCTATGGACTTCTGAAGCAGCAGTTCACTGGCCGCCTAAAATAATAATTGTGATAAAGGTCACCAACTCCAGAACTGGGCCAAGGAATGCAGGAAGAATTTATTCATTAATGCAAACATTTTTAGGTTTAGCTAATTCCGTAGAGGCAGGATCTTGATTATGTATAATAGTTAAAATAACTTTTCAGTTCACCTGTTGGGAAATTCAGTTTTTCCTAATAAATGCATAGCAATGTTTCATGAAAACCACAAATTATAAAAACAATTACTGATATGTAAAAA

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