Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name N6AMT1P1
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr21). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:93606166-93610341  UCSC
Coordinates (T2T) chr11:93522494-93526669  UCSC
Coordinates (hg19) chr11:93339332-93343507  UCSC
Strand -
Parental Sequence NM_182749.5
Parental seq. overlap 652 bp
Parental seq. overlap (%) 13.4%
Genomic Region Intergenic
Retrocopy Summary N6AMT1P1, located on chr11:93606166-93610341, is a retrocopy of the parental gene N6AMT1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name N6AMT1
Full Name N-6 adenine-specific DNA methyltransferase 1
Also known as C21orf127|HEMK2|KMT9|MTQ2|N6AMT|PRED28|PrmC|m.HsaHemK2P
Coordinate chr21:28872191-28885367
Strand -
Gene summary This gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing pf this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes N6AMT1P1
Bonobo Pan paniscus N6AMT1P1
Gorilla Gorilla gorilla N6AMT1P1
Orangutan Pongo abelii N6AMT1P1
Green monkey Chlorocebus sabaeus N6AMT1P1
Rhesus Macaca mulatta N6AMT1P1
Baboon Papio anubis N6AMT1P1
Gibbon Nomascus leucogenys Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>N6AMT1P1
AAGTTATGTATGAAATATTTATTTCAGCATTATTTAGTAAGGCAACAGATTCAGTGATGTGTATGAGCCTGTGGAGGACACGTTTCTGCTTCTGGACGTACTCCAGGTAGCGGCTGCCGAGCTGGCGGGAGTGGAAATATGCCTGGAAATAGGGGCAGGGTCTGGTGTAGTATCTGCATTCCTAGCCTCTGTGATAGGTCCTCAGGCTTTGTACATGTGCACTGATATCAACCCTGAGGCAGCAGCTTGTACCCTAAAGACAGCACGGTGTAACAAAGTCCACATTCAACCAGTTATTACAGATGTGGTCAAATGTTTGCTACCAATATTGAAGGAAAAGTTGATCTTCTGGTGTTTAATCCCCTCTATGTAGTGACTCCACCTGAAGAGGTAGGAAGTCATGGAATAGAGGCAGCTTGGGCTGCTGGCAGAAATGGTCAGGAAGTCATGCACAGGTTTTTCCCCCTTGTTCCAGATCTCCTTTCACCAAAAGGATTATTCTATTTAGTTACCATTAAAGAAAACAACCCAGAAGACATTTGGAAAATAATGAAGACAAAAGGTCTGCAAGGAACCACTGCACTTTCCAGACAAGCAGGCCAAGAAACTTTCAGTCCTCAAGTTCACCAAGTTCTAGCATACAATGTGTGCCCAGTGCTACTGGAAACTGAATGCATTTAGCATATCTTGAAACTGAAGTCATTCATTAGGTAAAAAGGAATTTTATCAGAAATTTGTCATTAAAAAAAAGGTAGAAAGGTGGAACATTCCCTTTCACTCAGGCCTATAGAATTATTTGCACa
>NM_182749.5
gcatgGAACGCAGCGAAGGACTATGGCAGGGGAGAACTTCGCTACGCCGTTCCACGGGCACGTGGGCCGCGGCGCCTTCAGCGACGTGTACGAGCCCGCGGAGGACACGTTTCTGCTTTTGGACGCGCTGGAGGCAGCGGCTGCCGAACTGGCAGGAGTGGAAATATGCCTGGAAGTAGGGTCAGGGTCTGGTGTAGTATCTGCATTCCTAGCCTCTATGATAGGCCCTCAGGCTTTGTACATGTGCACTGATATCAACCCTGAGGCAGCAGCTTGTACCCTAGAGACAGCACGCTGTAACAAAGTTCACATTCAACCAGTTATTACAGATTTGGTAGGAAGTCACGGAATAGAGGCAGCTTGGGCTGGTGGCAGAAATGGTCGGGAAGTCATGGACAGGTTTTTTCCCCTGGTTCCAGATCTCCTTTCACCAAGAGGATTATTCTATTTAGTTACCATTAAAGAAAACAACCCAGAAGAAATTTTGAAAATAATGAAGACAAAAGGTCTGCAAGGAACCACTGCACTTTCCAGACAAGCAGGCCAAGAAACTCTTTCAGTCCTCAAGTTCACCAAGTCTTAGCATACAGTGTGTGCCCAGAACTACTGGAAACTGAATGCATTTAGCATATTTTGAAACTGAAGTCATTCATTAGGTAACAAGGAATTTTATCAGAAATTTGTCATTAAAAAAAGGTAGAAAGGTGGAACATTCCCTTTCAGTCAGGCCTATAGAATTATTTGCACAAGTACAAGTAAATATGTGtattatatttatagtttgcattttaaatataaaaattatgtatgaaatattTATTTCAGCATTATGTGGTAAGGCAATGGAattgatctggcaaatgtcttttttttcataccagtccataaaggcagtttgctttcagatggcagggccagcaacacaccttcattgtcgtatctccggtgtgtatcagctctccaactctatgtcataattcagttcatggggatcttgattacctttcccttccacaaaatattacactgattggttatatcgatgacattatgctgatttgacctagtgagcaagaagtaggaactacattagacttagtggaaagacatttgcatcagagggtaggaaataaatatgactacaattcaagggccttctaccttagtgaaattggtagggatccagtgacatggggcatgttaggatatttcttctacggtgaaggataagtacttgcatcttgctgctcttaaaaccaagaaagaggcacaatacttagtgggcctctttgggttttggaggcaacattttccaatttcattatgttataccagcctgtttaccaattgactcaaaaagctgctagttttgagtagggcccagaacaagaaaagagtctgcaacaggtccaggctgctgtgcaagctgctctgccacttgggtcatatgatccagcagatccagtggtgtttcagtggcagtggcagatagggatgctgtttgaagcttctggcaggtccctataggtgaatcttggtttaggattttagagcaaagccgtgccattaccaacaaataactagtctctttttgagaaacagctcttggcctgctactgggccttagtagagactgatacttaatgagtcaccaagttaccgtgcaacctgagcttcccatcatgaactggatgttatctgagccaccaacgcacaaagttggatatgcacagcaacactctgtcatcagatggaagtggtatacacatgattgggcctgagaggccctgaaggcacaaggaagttacatgaagaagtaggccaaatttccgtagtccccacttctgctacctgccttctctcttccagcctgcatcggtggcttcatggggacttccctgtgatcagctgacagagaaagagaagacttaggcctggtttacagagtgttctgtatgatatgcaggtaccaccctaaagtggatagctgcagcactacatctcacctctgggctaccttgaaggacagtggtgaagggaaatcctcctggtggacacaactttgagcagtccccctgttgactttgcttagaaggaaaaatagccagatattcaattatatgccaattcataggccgtggccagtggtttggctggatggtcagggagttcaatataactggaaaattggtgacaaagaaatttggagatgaagtatgtggatagacactgaatgggcaaaaagggtgaagatatttgtgccccatgtgaatgctcaccaaagggttagcaaaaaaggattttaataaagtggacaagataacctgttctgtggatactagtaggcctctttctccagccacacctgtcatcacccaattgtttcatgagcaaagtagccatggtgacaagaatagaggttatgcatgggctcagcaacgtggacttctactcaccaaggctgacctggccaaggctatctctgagtgcccagtctgccagcaacagagaccaacactgagcccctgatatgacaccattccccagggtcatcagtcagttgcctagtggcaggttcattacattgatccacctctatcattgaagggatagtgttttatccttactgaaatagatcttactctggatacagattcactttcccttcgcgcagggtgtctgctaaaactaccatccgtggacttacagaatgtctcatctatgaccatggtattccacacagcattacaagaaactcagttcacagcaaaagtgtggcagtgggcccatgatcatggaattttcttaccatgttccctactatcttgaatcaactggctacatagagcagtggaatggcattttgaagacagtaataacaccagctatatagcagtgccttgtagggctgggacaaggttctctagaagactgtctatgctctgaatcaacatccagtatatggtgcatttctcttatgactgggattcacaggtccaggaatcaaggggtcagaataggaaggacaccattcgctattagccctggtgacccactagcaaaatttttgcttcctgttcccatgacttatgcactgctggcctagaggtcttacatagggtggaatattttccactgagagacgcaatcatgatttaattgaactggaagtttaagactgctcctcagccatttggggcttcttatgcctctaactcaatagacaaatgagttacagtgctggctgggtgattgttcctgactaccaagtagaaactggactaccccgaatggtggtaaggtaaagtatgttgggaatacacaggattccttagggcatctcttagtgttatcatgccctgtgattaaggtcaatggaaaactacagcctaattcagacaggaccactaatgatccagacctttcaggaatgaaggtttgggtcaccaccaggtaagtaccatgaccagatgaagtgcttgctgaaggcaaagggaatacagaataaatggtggaataaatactagctttgatcatatgaccagttacagaaacacagactgtgattgtcataagtatgtcctccatattttgctataactacattttgtgtgtgtgtagctttgttttcttctcatttccttattctgtaacataagatgcattgattttatagcatagtgtttaaatattgttaatttttttaactggctccagtgttcaaccttgattaattttacatcatagtatttaagttatgggatatcaaggagagagtaaacatcacatgaagactttaccacctcttctgggaaacgggttagagtgtttctggtggaatgctggattgttaatcgtgttagatggaattatgaccttgttgttgtctttatgtggcagttaagtatggtttaaagagatgtttatgggtgccaagttgacaagggTAAACTtgtgatggttaattttatatgtcaacttgaataggccacagggtgccaaatatctgtttaaacattattctgaagtgtcttgagtgtgtttacagacaagatttgcatttgaactgggggactcagtaaaggagatagccatccccaaggtgggtggacatcatccagtttgttgagggcgtaaataaaataaaaggcagaggaaggaagaattccccccccttttttttcctgcctcattgtttgagctgtgacatctcatcttctgtcctcagatggatttacatcactggcttccctggttctcaagcctttggattcagactgaattataccacaggccttcctgggtctccagcttatagatgacagatcatgggacctcttagcctccataatcatgtaagccactttcttgtagtaCTGGTAAAAGATATATTAGACCAATCTATAAAACAGCTAGCTATGAAAGAGAAAGGTGACAGGCACAAGCCTAGGCAAATAGAGAAGGGTTCCTGGAGAGCCTCTGACTTGCCTAGGTCATTGtgcacacgtggcttgcctgaatgaacatgcccactgtgaaagattccatttctcaacacatgtgcagtaagggaaataaatcaatgtggctcagactaagcgcccacacatggggtggagccacgaggagtttgctccttatgcaggggagaagccgtgcctcttcagctcgtgtgtggtggcctggcattcaatttgtgaggtgtaaaacctgcatgaaggacccctctttttgtggagagctttccttttgcctaataaattctgccctcctcgcc

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