Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SRSF2P1
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:95067919-95069098  UCSC
Coordinates (T2T) chr11:95074963-95076143  UCSC
Coordinates (hg19) chr11:94801082-94802261  UCSC
Strand +
Parental Sequence NM_001195427.2
Parental seq. overlap 984 bp
Parental seq. overlap (%) 51.4%
Genomic Region Intergenic
Retrocopy Summary SRSF2P1, located on chr11:95067919-95069098, is a retrocopy of the parental gene SRSF2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SRSF2
Full Name serine and arginine rich splicing factor 2
Also known as PR264|SC-35|SC35|SFRS2|SFRS2A|SRp30b
Coordinate chr17:76734115-76737411
Strand -
Gene summary The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SRSF2P1
Bonobo Pan paniscus SRSF2P1
Gorilla Gorilla gorilla SRSF2P1
Orangutan Pongo abelii SRSF2P1
Gibbon Nomascus leucogenys SRSF2P1
Crab-eating macaque Macaca fascicularis SRSF2P1
Rhesus Macaca mulatta SRSF2P1
Baboon Papio anubis SRSF2P1
Golden snub-nosed monkey Rhinopithecus roxellana SRSF2P1
Marmoset Callithrix jacchus SRSF2P1
Green monkey Chlorocebus sabaeus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SRSF2P1
ATCCAAGTCCTCtTCATCTATGACCAGGAGTCCTCCCCGGGTATCCAAGAGGAAATCCAAGTCAAGGTCGCGATCCAAGAGGCCCCCCAAGTCTCCTGAAGAGGAAGGACAGATGTCCTCTTAAGAAAATGATGCATCAGGAAGCAACGTGATGGAGGACTTGGGGGAAAAGGATCACATACTCAGTCTATGGAAGCAACGTCCCTGGAAGAAGAGGCTGCCTATTGAAAAGGTTGTGTCACACTTTTCTACCTTTTTGCCAGTTTGAAGCTTTGCATCAGGTGGCAAAATTCATTCTATGTGCCGTTTTGTTGTTATTCACATTTTATTGTAACTTAGGAGGTGAACGACCTAAGATTACGTTATTGGGTTTGGATATTTGAGGCAAAAATTTATTTTTATTTCTATAGTGATGACTGTTTTGGTTTGAAATGAACAGATTGGTAACCTAATTTGTGGCCTCCTGACTTTTAAGGAAACGTGTGCAGCCATTACACACAGCCTAACGCTGTCAAGACATGCTTCAACATTGCCTTCATTCCTTAAAAACCTACAAAAGGTGGTGTAAATTAATATGGATAATTTTATTTACCTCCAGGTCTAAAAGGTAGTGTGACCCAAATTTGTATAAAGATTTTTCATGTGAAAGGACTGGGGTTTTAGCAAACACAGGTCTAATCTCTTTTGTGTTTTTGTGCACCAGGCCCGGCTGCGTAGCAGTTGAGTGATGCTGGTTAGCTATTAAGGTGGCCTGTTGCAGTGCAGAGTGCTGAGCTGCTTCCTGTTTTCTTCTGATTGCTCCTGGGGAAAACACGCCTTGTCCTGAAGAACAAATGGCTGTCCAGTTTATTAAAATGCCTGTCAACTGCACTTCCAGTCACCCAGGCCTTGCAGATAAATAATGGAGCATGCAGTGAGCACATCTAGCTGACGATAATCACACCTTTTCCCCCGTCTTTTCTGAAAAATTGTAAATCTGATCATATCAACATGTATGAACTTAAAATATGGAGAATGTTATGGAAGAAATAGTTTATAAGTTTGTTAAGTACTTATAACATGGTTTATCTTTTTGATTATTAATTTTTTACGCTAACCATTGTTTCTGTAGTTAAAATTGTTTTCTTGGTGTTATCTTTTCTCAGAA
>NM_001195427.2
AGTTGTTACTCAGGTGCGCTAGCCTGCGGAGCCCGTCCGTGCTGTTCTGCGGCAAGGCCTTTCCCAGTGTCCCCACGCGGAAGGCAACTGCCTGAGAGGCGCGGCGTCGCACCGCCCAGAGCTGAGGAAGCCGGCGCCAGTTCGCGGGGCTCCGGGCCGCCACTCAGAGCTATGAGCTACGGCCGCCCCCCTCCCGATGTGGAGGGTATGACCTCCCTCAAGGTGGACAACCTGACCTACCGCACCTCGCCCGACACGCTGAGGCGCGTCTTCGAGAAGTACGGGCGCGTCGGCGACGTGTACATCCCGCGGGACCGCTACACCAAGGAGTCCCGCGGCTTCGCCTTCGTTCGCTTTCACGACAAGCGCGACGCTGAGGACGCTATGGATGCCATGGACGGGGCCGTGCTGGACGGCCGCGAGCTGCGGGTGCAAATGGCGCGCTACGGCCGCCCCCCGGACTCACACCACAGCCGCCGGGGACCGCCACCCCGCAGGTACGGGGGCGGTGGCTACGGACGCCGGAGCCGCAGCCCTAGGCGGCGTCGCCGCAGCCGATCCCGGAGTCGGAGTCGTTCCAGGTCTCGCAGCCGATCTCGCTACAGCCGCTCGAAgtctcggtcccgcactcgttctcgatctcggtcgacctccaagtccagatccgcacgaaggtccaagtccaagtcctcgtcggtctccagatctcgttcgcggtccaggtcccggtctcggtccaggAGTCCTCCCCCAGTGTCCAAGAGGGAATCCAAATCCAGGTCGCGATCGAAGAGTCCCCCCAAGTCTCCTGAAGAGGAAGGAGCGGTGTCCTCTTAAGAAAATGATGTATCGGCAAGCAGTGTAAACGGAGGACTTGGGGAAAAAGGACCACATAGTCCATCGAAGAAGAGTCCTTGGAACAAGCAACTGGCTATTGAAAAGGTTATTTTGTAACATTTGTCTAACTTTTTACTTGTTTAAGCTTTGCCTCAGTTGGCAAACTTCATTTTATGTGCCATTTTGTTGCTGTTATTCAAATTTCTTGTAATTTAGTGAGGTGAACGACTTCAGATTTCATTATTGGATTTGGATATTTGAGGTAAAATTTCATTTTGTTATATAGTGCTGACTTTTTTTGTTTGAAATTAAACAGATTGGTAACCTAATTTGTGGCCTCCTGACTTTTAAGGAAAACGTGTGCAGCCATTACACACAGCCTAAAGCTGTCAAGAGATTGACTCAGCATTGCCTTCATTCCTTAAAATTAAAAACCTACAAAAGTTGGTGTAAATTTGTATATGTTATTTACCTTCAGATCTAAATGGTAATCTGAACCCAAATTTGTATAAAGACTTTTCAGGTGAAAAGACTTGATTTTTTGAAAGGATTGTTTATCAAACACAATTCTAATCTCTTCTCTTATGTATTTTTGTGCACTAGGCGCAGTTGTGTAGCAGTTGAGTAATGCTGGTTAGCTGTTAAGGTGGCGTGTTGCAGTGCAGAGTGCTTGGCTGTTTCCTGTTTTCTCCCGATTGCTCCTGTGTAAAGATGCCTTGTCGTGCAGAAACAAATGGCTGTCCAGTTTATTAAAATGCCTGACAACTGCACTTCCAGTCACCCGGGCCTTGCATATAAATAACGGAGCATACAGTGAGCACATCTAGCTGATGATAAATACACCTTTTTTTCCCTCTTCCCCCTAAAAATGGTAAATCTGATCATATCTACATGTATGAACTTAACATGGAAAATGTTAAGGAAGCAAATGGTTGTAACTTTGTAAGTACTTATAACATGGTGTATCTTTTTGCTTATGAATATTCTGTATTATAACCATTGTTTCTGTAGTTTAATTAAAACATTTTCTTGGTGTTAGCTTTTCTCAGAA

Publications

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