Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GABARAPP1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:205625426-205626573  UCSC
Coordinates (T2T) chr1:204890062-204891209  UCSC
Coordinates (hg19) chr1:205594554-205595701  UCSC
Strand +
Parental Sequence NM_007278.2
Parental seq. overlap 700 bp
Parental seq. overlap (%) 52.2%
Genomic Region Intragenic (ELK4)
Retrocopy Summary GABARAPP1, located on chr1:205625426-205626573, is a retrocopy of the parental gene GABARAP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GABARAP
Full Name GABA type A receptor-associated protein
Also known as ATG8A|GABARAP-a|MM46
Coordinate chr17:7240008-7242449
Strand -
Gene summary Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GABARAPP1
Bonobo Pan paniscus GABARAPP1
Gorilla Gorilla gorilla GABARAPP1
Orangutan Pongo abelii GABARAPP1
Gibbon Nomascus leucogenys GABARAPP1
Green monkey Chlorocebus sabaeus GABARAPP1
Crab-eating macaque Macaca fascicularis GABARAPP1
Rhesus Macaca mulatta GABARAPP1
Baboon Papio anubis GABARAPP1
Golden snub-nosed monkey Rhinopithecus roxellana GABARAPP2
Marmoset Callithrix jacchus GABARAPP4
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GABARAPP1
CTCCCGGCTCCCCCAGGTTCCTTCAGCCCAGCCTAGTTCAGCCGGGTTCCCAACAGGATGAAATTCGTGTACAAAGAAGAGCATCCGTTCAAGAAACGGGCGGCTCCGAGAGCAAGAAGACTGGAAAGAAATACCCGGACCGGGTGCCGGTGATAGTAGAAAAGGCTCCCAAAGCTCGGATAGGAGACCTGGACCAAAAGAAATACCTGGTGCCTTCTGATCTCACAGCTGGTCAGTTCTGCTGCTGCTGCCAGTTCTACTTCTTGATCCAGAAGCGAATTCATCTCCGAGCTGAGGATGCCTTGTTTTTCTTTGTCAACAATGTCATTCTGCCCACCAGTGCCACAATGGGTCAGCTCTACCAGGAACACCATGAAGACTTCTTTCTCTACGTTGCCTACAGTGACCAAAGTGTCTACAGTCTGTGATGCTGCTACCCCTGAGCTGGAAGGGGGGTCTCATTCTACAGAGAGGTGGCCTCCCTTTCTTGACCTCCTCCTCCAAGCTCAAACACCACCTCCCTTATTCAGGACCGGCACTTCTTAATGTTTGAGGCTTTCTTTCCAGCCTCTCTTAGGAGGGGTAATGGTGGAGTTGGCATCTCGTACCAGACTTCTTGATTGTCAGTCTCTGTCACATCCAGTGATTGTTTCAGTTTCTGTTCCCTTTCTGACTGCCCAAGGGGCTCAGAACCCCAGCAATCCCTTCCTTTTACTACCTTTTTGGGGGGTAGTTGGAAGGGACTGAAATTGCAAGGGGAAGGTAGG
>NM_007278.2
GCAAATTCGTGGATCGCTCCGCTGAATccgcccgcgcgtcgccgccgtcgtcgccgccccccgtcccggcccccCTGGGTTCCCTCAGCCCAGCCCTGTCCAGCCCGGTTCCCGGGAGGATGAAGTTCGTGTACAAAGAAGAGCATCCGTTCGAGAAGCGCCGCTCTGAGGGCGAGAAGATCCGAAAGAAATACCCGGACCGGGTGCCGGTGATAGTAGAAAAGGCTCCCAAAGCTCGGATAGGAGACCTGGACAAAAAGAAATACCTGGTGCCTTCTGATCTCACAGTTGGTCAGTTCTACTTCTTGATCCGGAAGCGAATTCATCTCCGAGCTGAGGATGCCTTGTTTTTCTTTGTCAACAATGTCATTCCACCCACCAGTGCCACAATGGGTCAGCTGTACCAGGAACACCATGAAGAAGACTTCTTTCTCTACATTGCCTACAGTGACGAAAGTGTCTACGGTCTGTGAAGCTGCTGCCCCTGAGCTGGAGGGGGGTCTCATTCTACAAAGAGAGAGGTGGCCCCCCTTTCTTGACCTCCTCCTCCTTCAAGCTCAAACACCACCTCCCTTATTCAGGACCGGCACTTCTTAATGTTTGTGGCTTTCTCTCCAGCCTCTCTTAGGAGGGGTAATGGTGGAGTTGGCATCTTGTAACTCTCCTTTCTCCTTTCTTCCCCTTTCTCTGCCCGCCTTTCCCATCCTGCTGTAGACTTCTTGATTGTCAGTCTGTGTCACATCCAGTGATTGTTTTGGTTTCTGTTCCCTTTCTGACTGCCCAAGGGGCTCAGAACCCCAGCAATCCCTTCCTTTCACTACCTTCTTTTTTGGGGGTAGTTGGAAGGGACTGAAATTGTGGGGGGAAGGTAGGAGGCACATCAATAAAGAGGAAACCACCAAGCTGAACTGAATTTTGCCTTGTGTTGCTCCCCTCGTCCCGCTGATTTTAAGTCTTTCCAAGGTGTCAGTGGGTTTCAGTGGTGGGGAAAGAAGAGTACTGGGTACAAGCTGGAGGGATAGAAGTATATTTTGGTTTATTCTGTTCATGTTGGGCTTTTCCCTGTCTGCAAAAAGAGGGTGCTTTTGTTGTGATGGAATGGAATACTGAGGATTATTTCTTGAAACTTTAGTTTTATAACACGCATGTGAAACTAAATGTTAAAAATGCTCATGTAAAAAAAAATTTTTTTTTACTGTGGGTTCCTGTGGAGAAAGTTCCGAAGTACCTGCTTTAGGTGAACATCCACATTTGCTAGAACATTCTAACTAAGATATTTTCATGTGTGCAAGCTAGTAAAACGGCTGTTCTCAGTTGCA

Publications

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