Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PIGAP1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:100578664-100582672  UCSC
Coordinates (T2T) chr12:100540064-100544072  UCSC
Coordinates (hg19) chr12:100972442-100976450  UCSC
Strand +
Parental Sequence NM_002641.4
Parental seq. overlap 3246 bp
Parental seq. overlap (%) 89.4%
Genomic Region Intragenic (GAS2L3)
Retrocopy Summary PIGAP1, located on chr12:100578664-100582672, is a retrocopy of the parental gene PIGA. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PIGA
Full Name phosphatidylinositol glycan anchor biosynthesis class A
Also known as GPI3|MCAHS2|NEDEPH|PIG-A|PNH1
Coordinate chrX:15319451-15335554
Strand -
Gene summary This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PIGAP1
Bonobo Pan paniscus PIGAP1
Gorilla Gorilla gorilla PIGAP1
Orangutan Pongo abelii PIGAP1
Gibbon Nomascus leucogenys PIGAP1
Green monkey Chlorocebus sabaeus PIGAP1
Crab-eating macaque Macaca fascicularis PIGAP1
Rhesus Macaca mulatta PIGAP1
Baboon Papio anubis PIGAP1
Golden snub-nosed monkey Rhinopithecus roxellana PIGAP1
Marmoset Callithrix jacchus PIGAP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PIGAP1
TGGCCATGGAACTCGCTGGTAATAGAGGACACATCTCTTAACTGGGTTGCTCTAAGAACTGATGCCTAAACCATCTCAGCATGGCGTATAAAGGAGAAGGTGGGCATGGCCAGCCTCCCTCAGCTACACTGTCTCAGGTTAGCCCTGGAAGTCTTTACACACGTAGAACCCATACCCATAATATATGTATGGCATCTGACTTTTTCTACCCAAATATGGGAGGTGTGGAAAGCCACATTTACCAGCTCCCTCAGTGCCTGATTGGAAGAGGGGATAAGGTTATAATTGTCATCCATGCTTATGGAAATCGAAAAGGCATCCGTTACCTCACTAATGACCTCAAAGTCTATTACTTGCCTCTGAAAGTCATGTATAACCAGTCTATGGCCATGACCCTCTTTCACAGTCTGCCATTGCTCAAGTACATATTTGTTCAGGAGAGAGTCACAATAATCCATTCACATAGTTCATTTTCTGCCATGGCCCATGATGTTCTCTTCCATGCCAAGACAATGGGGCTTCAAACAGTCTTAACAGACCATCCCCTTTCTGGATTTGCTAAGGTCCATTCAGTGCTTACAAACAAACTTCTAACTGTGTCTCTTTGTGACACAAGCCGTATCATTTGCGTTTCTTATACTAGTAAGGAAAATACCGTACTACGAGCGGCACTGATTACTGAAATAGTGTCTGTCATTCCTAACGCTGTAGATCCTATTGACTTCACTCCAGACCCATTTAGAAGGCATGATAGTATAACTATTGTTGTCAGCAGACTTGTTTACAGAAAGGGAACAAATTTGGTTAGTGGTATTATACCCAAACTCTTGTCAGAAATATTAAGATTTAAATTTCATAATTGGAGGAGAGGGACCAAAGAGAATCATTTTGCAAGAAGTTCCGGAAAGATACCAGTTGCATGACAGGGTGCATCTTTTGGGAGCTTTAGAACACAAGAATGTTAGAAATGTCTTAGTTCAAGGACATATTTTTCTTAATACCTCCCTTACTGAAGCATTCTGCATGGCGATCATGGAAGCAGCCAGCTGTGGTTTACAGGTTGTAAGTACCAGGGTTGGTGGAATTCCTGAGGTGCTTCCGGAAAATCTTACTATTTTATGAGAAACTTCAGTAAAATCTTTGTGTGAGGGATTGGAAAAAGCTATTTTCCAACTGAAGTCAGGGGCATTGCTGGCTCCAGAAAATATCCGTAACATAGTAAAGACTTTCCACACCTGAAGGAATGTTGTGGAGAGAACTGAAAAAGCGTATGACCAAGTATCAGTGGAATCTGTGTTGCCAATGGACAAACAACTGGACAGACTTATTTCTCACAGTGGACCAGTAACAGGCTACATCTTTGCTTTGTTGGCTGTTTTCAACTTCCTCTTCCTCATTTTCTTGAGATGGATGACTCCAGATTCTTATCATTGATACTGGAATAGATGCCACTGGGCCAAGGGGTGCCTGGACTCATAAATGTTCTCACAGTAAAAGAGGGGGTGAGAATATTAAGATATCTAAAACCAGGTAGAAGAGAGCCTACATTGTAAGATTTTAAACATTTGTAATAGTTGTATTAAGACTATGGAAAATAACCTGCTTTTTGGGGGCTTGTGTTTTTTATTAGTTTTTTATAAGTTAATTTAGTAAGTTATGCTACTTCTATATCATTCAATGTTTTCTTTTGAGGAAAGATAAAAACTTAGGCAATTCCTGAGTGTAGAAACCTTGCACTTATTTAAAATTTAGAAGAGAACATTTAAACCATTCAGGTATTAAATTTTTCAGACTACTGAAATCCCTGTAGCAGAGATGTTTTAACATTATATTTTGAGAGCTTTGGGTGCTGAAGGGCCAAACATTTTCTGGGCATTTTTTTGGCCAGTTTTTAATGTTATGCCATTAGTTAGACACTCACTAGATGTTTACAAGTTTTCTTCAGGGAAGTACAACAACTATATGAACTATTTTAAGTCATGTTTATATACATTTATTAGAAATCTAAGTCATGCCTTTAAACATTTATTAGGTTCACTCAGTAGGTGTTAACATAAAATTAACAGGTTCCTTGAGTAAGATAGTCCATCAGTTACCAGCACATTTTGAGCACCTGCTATATGTGGAATGTTGAACTAGATGCTTCCTGCCGTTAAGGACCAGAAATGCATTAACTCTTTATCATTCAAATGGCTTATTTCATCATAGTCATGGTTGATATAAGATATATAGCCTACATGCCAAAAATGCTCATGCCAGTTAATGCCAGGAAAAAAATCACCGACACACTACTAGTACTTCTTTGATCCTGTTCTATGCATTCTCCTAGGTAGAGCCTTCATCTTCCATTGTGTTGATGAAGATATTTTTTGCTTTTTAAATACTAGGGACTGATATCACTGTTGATAGTGCAGAGAAACCCTCCATAATTAAGTTTTCTGTAAAAGCCTTCGTGTTTTCTGAGCAGAATGTACGAGGTGTGCCATCCCAAAACCAGCTGCTACCCTGTCCTTTTAATGTAAGTCACTCTCCTTTGCTGTGGCCTTGCTGATGTCTGATAAGTATTGTCAGTGTGCAAAAGGCTTTATTTCAGAATGTTTTATTTATAGCAAACCAAGTCTGAAAGTTTTAAGAACACAGTCTTTGTGGGTGGATGTTATTAACTGTAATTGTTGTTGCCCAGAGCCATGGGTTTTTTAACCCCAAATTATCCACATGGTGTGTATTATTCTTTGAACTTTTAAGGTTTTTGTGAGAAAAGGACTGTGAAATCAAAATAAGGAGGCACTTGTGGGTGCACTAGATAGATTCCGTCAGTATTGTGATTATGAGATTTTAAAAAATGACAAAATTCACAAAACTTACTACTTTCTAAAAAGTAACATGTCTGTTAACTGGTTGTACTGATATAAAAAGAAATATATTTGGGTTTTGTTTGCACTAAAATGCAAAAGCAAGAGTCCAGTTTTTAATATCTAGAAGTTAGGGAGTTCTTTTGTTGGAGAAAAATGGACTGATCTAAACCATTCATTCTTGTTGAGATTTTTATGTGTAGGAACTCACATATAAACATGAAATAACCACTGCCAATATTCACGGTAAAGTGAGAAACTATAACATTATTTTACTTAACAAGTTTTAAAGGCATACCACCGTTTTTTCCTTATTTTTTGCTTAATTTTTAAAAATTGTCATTTAATTCTTAAATTGTCATTTATTTGAGATGGAAATGAGATTTAAAGTTAGTTGCCTTTGCATGTAAAATATATAACTTGCAAATTAAAATATTTTTATTTTTTTGAACAAGTGGAAGTAAATTTGTTTTACATAAATCTTAATTTTCAACTTTCCTAGATACaGATACCTTAATTGTAACTGTCAGTGTTGCACTGGTCAGTATTTGGAAACACATTGTTCTACCCTGCTACTTACATTGATTTGAAAGTTAATTTACAGTGATGAGGAATTTATGAAAAATATATTTCTTTTGATGTTTCAAAAGGTTGCCCATGACAAACTGATTTGTTAAAACATGCTACATGTTCAAAAATAAAGACCAGAATGACA
>NM_002641.4
ACTGGCGGCCATGGAACTCACCGGTAATAGAGGACACATCTCTTAACTGGGTTGCTCTAAGAACTGATGTCTAAACCGTCTCAGCATGGCCTGTAGAGGAGGAGCTGGGAATGGCCACCGTGCCTCAGCTACACTCTCTCGGGTTAGCCCTGGAAGTCTTTACACATGTAGAACCCGTACCCATAATATATGCATGGTATCTGACTTTTTCTACCCAAATATGGGAGGCGTGGAAAGCCACATTTACCAGCTCTCTCAGTGCCTGATTGAAAGAGGGCATAAGGTTATAATTGTCACCCATGCTTATGGAAATCGAAAAGGCATCCGTTACCTCACCAGTGGCCTCAAAGTCTATTACTTGCCTCTGAAAGTCATGTACAACCAGTCTACAGCCACGACCCTCTTTCACAGTCTGCCATTGCTCAGGTACATATTTGTTCGGGAGAGAGTCACGATAATCCATTCACATAGTTCTTTTTCTGCTATGGCCCATGATGCTCTCTTCCACGCCAAGACAATGGGGCTTCAGACAGTCTTCACGGACCATTCCCTTTTTGGATTTGCTGATGTCAGCTCGGTGCTTACAAACAAGCTTCTAACCGTGTCTCTTTGTGATACAAACCACATCATTTGTGTGTCTTATACTAGTAAGGAAAATACTGTACTAAGAGCAGCACTGAATCCTGAAATAGTGTCCGTCATTCCTAATGCTGTAGATCCTACTGACTTCACTCCAGACCCATTTAGAAGGCATGATAGTATAACTATTGTTGTTGTCAGCAGACTTGTTTACAGAAAAGGGATCGATTTGCTTAGTGGTATAATACCTGAACTCTGTCAGAAATATCCAGATTTAAATTTCATAATTGGAGGAGAGGGACCAAAGAGAATCATTTTGGAAGAAGTTCGGGAAAGATACCAGCTGCATGACAGGGTGCGTCTTTTGGGAGCTTTAGAACACAAGGATGTTAGAAATGTCTTAGTTCAAGGACATATTTTTCTGAATACCTCCCTTACTGAAGCATTCTGCATGGCGATCGTGGAAGCAGCCAGTTGTGGTTTACAGGTTGTAAGTACCAGAGTTGGTGGAATTCCTGAGGTGCTTCCAGAAAACCTTATTATTTTATGTGAGCCTTCAGTAAAATCTTTGTGTGAAGGATTGGAAAAGGCTATTTTCCAACTGAAGTCAGGGACATTGCCAGCTCCAGAAAACATCCATAACATAGTAAAGACTTTCTACACCTGGAGGAATGTTGCAGAAAGAACTGAAAAGGTATATGACCGGGTATCAGTGGAAGCTGTGTTGCCAATGGACAAACGACTGGACAGACTTATTTCTCACTGCGGCCCAGTAACAGGCTACATCTTTGCTTTGTTGGCAGTTTTCAACTTCCTCTTCCTCATTTTCTTGAGATGGATGACTCCAGATTCTATCATTGATGTTGCAATAGATGCCACTGGGCCACGGGGTGCCTGGACTAATAACTATTCTCACAGTAAAAGAGGGGGTGAGAATAATGAGATATCTGAAACCAGGTAGAAGGAAGCCTAGATTGTAAGATTTTAAACATTTGTAATAGTTCTATAAAGACTATGGAAAATAACCTTGCTTTTGGGGGGTTTTTGTTTTTTTAGAGTTAATTTAGTAAGTTATGCTACCTCTATATCATTCAATATTTTCTGTTGAGGAAAGATAAAAATGTATGCAATTCCTGAGTGTAGAAACTTCTTGCACTTATTTAAAATTTAGGAGAGAACATTTAAGCCACTCAGGTATGCAATTTTTCAGACTACTGAAATCCCTGTAGCAGAGATGTTTTAACATTATATTTTGAGAGCTTTGGGTGCTGAAGGGCCAAACGTTTTCTGGGCATTTTTTGGCCAGTTTTTAATGTAACACCATTAGACACTCACCAGATGTTTACAAGTTTTCTTTAGGGGAACTACAACAATTATATGAACTGTTTTATATCATGTTCATATACATTTATTAGGAATCTAAATCATGTCTTTGAACATTTATTAGGTTCACTCAGTAGGTGTTACATGTAATTAACAGGTTCCTTGAGTAAGATAGTCCATCAGTTACCAGCACATTTTGAACCCCTGCTCTGTGTAGAATGTTGAACTAGATGCTTCCCGCCATTAAGGACCAGGGGTGCATTCACTCTTTGTTTACCATTCAAATGGCTTACTTCATCATAATTGTGGTTGATATGAGATCAATATCCAACATGCCAAAAATGCTCATGCCAGTTAATGCCAGGAAAAAAATCACCGACACACTACTAGTACTTTGTTCCTGTTGTATGCATTCTCCTAGGTAGAGCCTCCATCTTCAGTTGTGTTTGTGAAGGTATTTTTTGCTTTTTAAATACTGGGGACCGATATCACTGTTGATAGTGCAGAGAAACCCTCCACATTTTTCAGTGCATAATTGAGTTTTCTATAAATGCCTTCGTGTTTTCTGAGCAGAATGTACGAGGTGTGCCATCCCAAAACCAGCTGCTACCCTGTCCTTTTAATGTAAGTCACTCCCCTTCACTGTGGCCTCGCTGATGTCTGATAAGTATTGTCAGTGTGCAAAAGGCTTTACTTCAGAATGGTTTATTTATAGCAAACTAAGTTGAAAATTTTAGAAACAGTCTTTGTGGGTGGATGTTATTAACTGTCATTGTTGTTGCCCAGAGCCATGGGTTTTTTAACCCCAAATTATCCACATGGTGTGTATTATGAATTCTTTGAACTCTTAAGGTTTTTGTGAGAAAAGGACTGTGAATTCAAAACAATAAGGCACTTGTGGGTGCACTACATAGATTCTGACAGTGTTGTGATTCTGTATAGGATTTTTAAAAATGACAACATTCACAAAATTTATTACTTTTTAAAAAATAACATGCCTATTAACTGGTTGCACTGATATAAAAGAAATATATTTGTGTTTTGTTTGTACTAAAATGCAAAAGCAAGAGTGCAATTTTTAAAATCTAGAAGTTAGGGGTTTTGTTGGAGAAAAATGGACTGATCTTTAAACTATTCAGTCTTACTGGGATTTTTATGCATAGAAACTCACATATAAACATGAAATAAACAGTGCCAGTATTCATAGGAAAGTGAGAAACTGTAATATTTGGCCATTATTCTATTCAACAGGTTTTAGAGGCATGCCACCATTTTTTCCTTATATTTTTGCTTAATTTTTTTAAATTGTCATTTAATTCTTAAACTGTCATTTATTTGAGATGGAAATAAGATCTAAAGTTAGTTGCCTTTGCCTGTAAAACATGTGATTTGCAAATTATTATTTTTCTTTTTTTTAACAAATGGAAGTAAATTTGTTTCACGTAAATCTTAATTTTCAACCTTTCTGGATACCTTAATTGTAACTGTCAGTTTGCACTGGTCGGTATATGGAAACACATTGCTCTACCCTGCTACTTAGTTGATTTTAAAGTGAATTTACAGTGATGAGAAATTTGTGAAAAATATATTGTATTTCTTTTGATGTTTCAAAAGGTTGCCTATGAAAAACTGATTTGTTAAAACATGCTACATGTCCAAAAATAAAGACCAGAATGACATTTTGATAA

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