Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name HNRNPABP1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:10111740-10112985  UCSC
Coordinates (T2T) chr12:9998418-9999663  UCSC
Coordinates (hg19) chr12:10264339-10265584  UCSC
Strand +
Parental Sequence NM_004499.4
Parental seq. overlap 1125 bp
Parental seq. overlap (%) 68.8%
Genomic Region Intergenic
Retrocopy Summary HNRNPABP1, located on chr12:10111740-10112985, is a retrocopy of the parental gene HNRNPAB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HNRNPAB
Full Name heterogeneous nuclear ribonucleoprotein A/B
Also known as ABBP1|HNRPAB
Coordinate chr5:178204533-178211163
Strand +
Gene summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HNRNPABP1
Bonobo Pan paniscus HNRNPABP1
Gorilla Gorilla gorilla HNRNPABP1
Orangutan Pongo abelii HNRNPABP1
Gibbon Nomascus leucogenys HNRNPABP1
Green monkey Chlorocebus sabaeus LOC103245077P2
Crab-eating macaque Macaca fascicularis HNRNPABP1
Rhesus Macaca mulatta HNRNPABP1
Baboon Papio anubis HNRNPABP1
Golden snub-nosed monkey Rhinopithecus roxellana HNRNPABP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HNRNPABP1
AGCGACCGCAGCGCCCTCGAGCGGGAATCAAAATCAAAAATCGCCGAGGACGAACAGATCAACGCCAGCAAGAACGAGGAGGACGCAGCAAAAATGCTCGTTGGTGGCCTGAGCTGGGATACCAGCAAAAAAGATTTAAAAGACTATTTCCCTAAATTTGGAGAGGTCATTGACTGTACAATAAAAATGGATCCCAACATTGGACGGGCAAGAGGGTTTGGGTTTATCCTGTTCAAAGATGCAACCAATGTGGAGAAGGTCCTAGACCAGAAGGAGTACAGGCTGGATGTCCGTGTCATTGACCCTAAAAAGGCCATGGCTATGAAGAAGGACCCGGTGAAGAAAATCTTCGCCGAGGGTCTGAATCCTGAAGCCACTGAGGAAAAGATCAGGGAGTACTTTGGCGAGTTTGGGGAGATCGAGGCCATTGAAATTCCAGTGGATCCAAAGTTGAACAAAAGACAAGGTTTTGTGTTTATCACCTTTAAAAAAGAACCTGTGAAGAAAGTTCTGGAGAAAAAGTTCCATACTATCAGTGGAAGTAAGCGTGAGATCACGGTGGCCTAGCCCAAAGAAGTTTATTGGCAGCAGCGGTATGGTTCTGGGGACCGTGGAAACCACAACCGAGGGAACCGAGGCAGCtCAGGGCAGTACAAACTACAGCAAGAGCCAGTGACATGGTGGCCATCAGAATACCTACAAGCCATACTGAAGCAGCAGCAGGAGAGACCAACCGACCGCACACATGTTGTGTTTGGATATGGAGTGAACACAATTATGTACCAAATTTAACCTGACAAACTTTCTATGGCTTGCCCCATGTGCATCTTACTTAAAATTTCCCCCATGGAAATCACTCTCTTGTTTACTATTTCCAGAACTCTAGTTATTTAGGCAGCGTGTGGTGTCTGAGAGGCCAGAGGGGCATTATGGGCTGACTTTTAGTACCAGGTCCCCCAGAACAAAATGGCAGTCTCTGCTTCCTGCTGCCGCACTCTGCAGCCTGGTCCTGTGGACCCTGGTTGTAAAGAGTAAATTGTATCTCAGGAAACCAGTGTCAGCTTTTCATTTTATATTATTTATGTCATACATTTCCTGTAATGGAAGTGTTAATTTTACTGTACTTTTTGGTACCTTTGGGGAATCTAATGTAAGGTATTTTACATGTGTCCTGATTTTGCCACAACCTGGATATTGAAGCTATCCAAGCATTTAAAATAAAA
>NM_004499.4
AGGCGGCGGCACCGCGCGGGACGGAGCTTGGCTGTTGGTCGGTGGGTTCCCGTGCGGCGGCGGCCAAGGAGGAGGAGACACAGTTGGAGCAGCTCCGTGGGCTGACTGGGGCGAGGCCTCAGCAGCGCGAGCTTGAGTGCGGCCGAGCCTGCGGCGCCTTCCCCTGCGGGTGGGGACGAGCGGGCCCCGCGGCGTCATCGGCGGCGAGGAGCCGCCGCGCCTCGGCCTAGCATGTCGGAAGCGGGCGAGGAGCAGCCCATGGAGACGACGGGCGCCACCGAGAACGGACATGAGGCCGTCCCCGAAGGCGAGTCGCCggccggggctggcacgggcgccgcggcgggggctggaggcgcgaccgcggcGCCCCCGAGCGGGAATCAGAACGGCGCCGAGGGCGACCAGATCAACGCCAGCAAGAACGAGGAGGACGCGGGAAAAATGTTCGTTGGTGGCCTGAGCTGGGATACTAGCAAAAAAGATTTAAAAGACTATTTTACTAAATTTGGAGAGGTCGTTGACTGTACAATAAAAATGGATCCCAACACTGGACGGTCAAGAGGGTTTGGGTTTATCCTGTTCAAAGATGCAGCCAGTGTGGAGAAGGTCCTAGACCAGAAGGAGCACAGGCTGGATGGCCGTGTCATTGACCCTAAAAAGGCCATGGCTATGAAGAAGGACCCGGTGAAGAAAATCTTCGTTGGGGGTCTGAATCCTGAAGCCACTGAGGAAAAGATCAGGGAGTACTTTGGCGAGTTTGGGGAGATTGAGGCCATTGAATTGCCAATGGATCCAAAGTTGAACAAAAGACGAGGTTTTGTGTTTATCACCTTTAAAGAAGAAGAACCCGTGAAGAAGGTTCTGGAGAAAAAGTTCCATACTGTCAGTGGAAGCAAGTGTGAGATCAAGGTGGCCCAGCCCAAAGAAGTCTATCAGCAGCAGCAGTATGGCTCTGGGGGCCGTGGAAACCGCAACCGAGGGAACCGAGGCAGCggaggtggtggtggaggtggagGTCAGGGTAGTACAAACTACGGCAAGAGCCAGCGACGTGGTGGCCATCAGAATAACTACAAGCCATACTGAGGCGGCAGCAGGAGCGACCAACTGATCGCACACATGCTTTGTTTGGATATGGAGTGAACACAATTATGTACCAAATTTAACTTGGCAAACTTTCTATTGCCTGTCCCATGTGCATCTTATTTAAAATTTCCCCCATGGAAATCACTCTCCTGTTGACTATTTCCAGAGCTCTAGGTGTTTAGGCAGCGTGTGGTGTCTGAGAGGCCATAGCGCCATCATGGGCTGATTTTTATTACCAGGTCCCCCAGAAGCAGGTGGGAGGCTCTGCTTCCTGCTGCCGCTCTGCAGCCTGGACCTGTGGACCCTGGTTGTAAAGAGTAAATTGTATCTTAGGAAACCAGTGTCACCTTTTTTTCACCTTTTAATTTTATATTATTTGCGTCATACATTTCCTGTAACGGAAGTGTTAATTTTACTGTACTTTTTGGTACCTTTTGGGAATCTAATGTATTGTAAGGTATTTTACACGTGTCCTGATTTTGCCACAACCTGGATATTGAAGCTATCCAAGCTTTTGAAATAAAATTTAAAAACCCCCAA

Publications

PMID - Link Title