Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name GCDHP1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:103504293-103505237  UCSC
Coordinates (hg19) chr12:103898071-103899015  UCSC
Strand +
Parental Sequence NM_000159.4
Parental seq. overlap 781 bp
Parental seq. overlap (%) 42.1%
Genomic Region Intragenic (C12orf42)
Retrocopy Summary GCDHP1, located on chr12:103504293-103505237, is a retrocopy of the parental gene GCDH. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GCDH
Full Name glutaryl-CoA dehydrogenase
Also known as ACAD5|GCD
Coordinate chr19:12891160-12899999
Strand +
Gene summary The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GCDHP1
Bonobo Pan paniscus GCDHP1
Gorilla Gorilla gorilla GCDHP1
Orangutan Pongo abelii GCDHP1
Gibbon Nomascus leucogenys GCDHP1
Green monkey Chlorocebus sabaeus GCDHP1
Crab-eating macaque Macaca fascicularis GCDHP1
Rhesus Macaca mulatta GCDHP1
Baboon Papio anubis LOC101006750P1
Golden snub-nosed monkey Rhinopithecus roxellana GCDHP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GCDHP1
CCTGTTTGTAGCGTGGGCTGGAAGATGGCTACCTTCAGGGCTTCCTGTCGGAGAAGGGTATGTTGGGTCTCTTGGCCTCCAAGATTGAGGGCAAGTTCTCCCTGCGGGCCTCTGCCATGGGCATGATCATCGTGGACAGCGTGGAGGTGGAGGACGTGCTGCTCAGTGCAGGCAGCCTGGAGGGTCCCTTTGGCTGCCTGAACAACGCCAGATCTGGTATCATGTGGGGAGTGCTTGGAGCTGCCGAGTTTTGTCTGCTCGTGGCCAGGCAGTACACCCCACACAGGATCCAGTTTGGCATCCTGTTGGTCAGGCACCAGCTGATTCAGAAGTTGGAGGACATGCTCACTGAGGTCACGCTGGGCCTTCATGCCTGTCTGCAGCACAGCCACTTGAAGAATCAGGGCAAGGCAGCCCCCGGACAGGTCTCTCTGCTAAAGACGAATAACTATGAAAAAAGCCTGGACATTGCCTGCCAGGCCTGAGACATGCTGGGGGGTACTGGGGTTTCTGATGACTATCATATGGTCCGGAACATCAGGAACTCAGAGGCCATGAAAACCTCTGAGGGTACACATGACATGCGCACCCTGATCCTGGAAAGACCTGTCACGGGAATCCACAAATTCACGGCTGGCAAGTGAGCCCATCCAGCCAGTGGCCCAAAGCTCTCAAACCCCTTCCCAGAGACAGGCCTGGCTGGACCATGGGAATGCTGTGTTCTGAGCTTAGGAAGGAAGCTAGCGGATGGAGTGGGAAGTGAGAGACACTGATTTTTAAATATCAGAATTTCCCTTCTGAAGTTGTTCAGATGTGTTCCTTAAAAAGAAGATGGAATTCTCTGTAGAGTTTCTCAGTCCACTTTTAACAATGGATGAGAACAGACTCCATTTACCTTGAAATAGAAACATCTATTGAGAGAAGGAGTGTGACATTGAAGCAACT
>NM_000159.4
AGTTGCACTGTAGCCTCGGCAGTGAACCGGGAGGTACTACCAGGTCGCCGTCGTTGCTCCGCTCGCTCTGAGAGAGCATGGCCCTGAGAGGCGTCTCCGTGCGGCTGCTGAGCCGCGGACCCGGCCTGCACGTCCTTCGCACGTGGGTCTCGTCGGCGGCGCAGACCGAGAAAGGCGGGAGAACACAGAGCCAACTGGCTAAGTCCTCGCGTCCCGAGTTTGACTGGCAGGACCCGCTGGTGCTGGAGGAGCAGCTGACCACAGATGAGATCCTCATCAGGGACACCTTCCGCACCTACTGCCAGGAGAGACTCATGCCTCGCATCCTGTTGGCCAATCGCAACGAAGTTTTTCATCGGGAGATCATTTCGGAGATGGGGGAGTTGGGTGTGCTGGGCCCCACCATCAAAGGATATGGCTGTGCTGGGGTTTCGTCTGTGGCCTATGGGCTCCTGGCCCGAGAGCTGGAGCGGGTGGACAGTGGCTACAGGTCGGCGATGAGTGTCCAGTCCTCCCTCGTCATGCACCCTATCTATGCCTATGGCAGCGAGGAACAGCGGCAGAAGTACCTGCCCCAGCTGGCCAAGGGGGAGCTCCTGGGCTGCTTCGGGCTCACAGAGCCCAACAGCGGAAGTGACCCCAGCAGCATGGAGACCAGAGCCCACTACAACTCATCCAACAAGAGCTACACCCTCAATGGGACCAAGACCTGGATCACGAACTCGCCTATGGCCGATCTGTTTGTAGTGTGGGCTCGGTGTGAAGATGGCTGCATTCGGGGCTTCCTGCTGGAGAAGGGGATGCGGGGTCTCTCGGCCCCCAGGATCCAGGGCAAGTTCTCGCTGCGGGCCTCAGCCACAGGCATGATCATCATGGACGGTGTGGAGGTGCCAGAGGAGAATGTGCTCCCTGGTGCATCCAGCCTGGGGGGTCCCTTCGGCTGCCTGAACAACGCCCGGTACGGCATCGCGTGGGGCGTGCTTGGAGCTTCGGAGTTCTGCTTGCACACAGCCCGGCAGTACGCCCTCGACAGGATGCAGTTTGGTGTCCCACTGGCCAGGAACCAGCTGATTCAGAAGAAGCTGGCAGACATGCTCACTGAGATTACCCTGGGCCTTCACGCCTGCCTGCAGCTCGGCCGCTTGAAGGACCAGGACAAGGCTGCCCCCGAGATGGTTTCTCTGCTGAAGAGGAATAACTGTGGGAAAGCCCTGGACATCGCCCGCCAGGCCCGAGACATGCTGGGGGGGAATGGGATTTCTGACGAGTATCACGTGATCCGGCACGCCATGAACCTGGAGGCCGTGAACACCTACGAAGGTACACATGACATTCACGCCCTGATCCTTGGGAGAGCTATCACGGGAATCCAGGCGTTCACGGCCAGCAAGTGAGCCGCTCCATCAGGGGCCCGAAACTCTCAAGCCCCTTTCTGGAGAGATGCCTGGCTGGACCGTAGGAGCGCTGTGCTCTGAGCTTAGAAAGGGAGGTGGCGGATGGAGTGGGAAGTGAGAGACACTGATTTTTAAATATCAAAATTTCCCTTCTGAAGTCGTTCAGATGTGTTCCTTAAAAAGAAGATGGAATTCTCTGTAGAGCGTCTCAATCCACTTTTAACCATGGATGAGAGCAGACTCCATTTACCCTGAAATAGCAGCTTCTCTTGAGAGGAGAGTGACATGGAAGCAACTCCGTCTGCTGCAGCTGACCCCCTCACACTGAGTTCACAGTGCGCCCTCCCTCCCTCCCATCTGGGGGTAGTGCCTTATGCTGGGTGTTGGAGCAGAGTGAGGGAGAGGAAAATAAAGACCTGCACATCTGACCCCAAGGTGTCAGGCCGGTTTACTGGTAA

Publications

PMID - Link Title