Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PDCD2P3
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:107901723-107903988  UCSC
Coordinates (T2T) chr12:107865845-107868110  UCSC
Coordinates (hg19) chr12:108295500-108297765  UCSC
Strand -
Parental Sequence NM_144781.3
Parental seq. overlap 1086 bp
Parental seq. overlap (%) 37%
Genomic Region Intergenic
Retrocopy Summary PDCD2P3, located on chr12:107901723-107903988, is a retrocopy of the parental gene PDCD2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PDCD2
Full Name programmed cell death 2
Also known as RP8|ZMYND7
Coordinate chr6:170575295-170584637
Strand -
Gene summary This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]

Homology

Species Scientific Name Retrocopy
Gibbon Nomascus leucogenys PDCD2P3
Crab-eating macaque Macaca fascicularis PDCD2P1
Rhesus Macaca mulatta PDCD2P1
Baboon Papio anubis PDCD2P1
Golden snub-nosed monkey Rhinopithecus roxellana PDCD2P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PDCD2P3
CCCCAAATAATACTTATGGAAGATAAATTCCATGTAATGACTGATAAGAGTACAATACAGGTGTCATGGGAACATGTGACATTACTGAAGACTGCCTGGAAGGGGACACACATGTGTTCATACCAATAAGATGAAAAGGATAAAGTTTACAATTTGAGCCTTGAGCCATACACAAAGCCACCATAAACATTAGATTTATAGACTCAAAATGAAAACATCAGCTTACTGGTTTGTAGTTCATACCAGCCCAGCTGTGGGCTGCTCCCCACGCCAGCCCGCGCCCCACATGGCTGCCGCCCCCGCCGGACCTGTGTAGCTGGCCATCGCCAAGTCGGCGCCGGCGGGCGAATGCGCAGCGAGCAGTTTCCCAGCAGGCTGGGCGGGCGGCCAAcgtggctgggcgtggctgggcgtggatgggcgCGGCCGGGCTGCCGGGGCTCCGGCCCCCGGCCTGAGAGCTGTGCGACCGTCGCTCTTCTTCCGGCGGCAGGTGTACGCGTCGCTGCCCGGCCGCGAAGACGCCTTCCACCGCGGCATCTTCCTCTTCTGCTGCCACGAGCCGCCGTGCTGTGCCGCCCTGCGAGTTTCTAGGAATCAGCTACCCAGGAAAAATGATTTTTACTCATATGAGCCACCTTCTGAGAATCCTTCCCCAGAAACAGGAGAATCGGTGTATCTCCAACTTAAGTCTGGTGCTCATCTCTGCAGTGTTTGTGGCTGTTTAGGCCCCAAAACTTGCTCCAGATGCCACAAAGCGTATTACTGCAGCAAGGAGCATCAGACCCTAGACTGGAGATTGGGACATAAGCAGGCTTGTGCACAACCAGATCATTTGGACCTTACAACTCCAGACCACAACTTCCTTTTTCCAGAATTTGAAATTGTAATAGAAACAAGATGAGATTATGCCTGAGGTTGCGGAAAAGGAAGATTATTCAGATATTATAGGGAGCATGGTTAAGCAGTTTCAGGACTTCATTCATTAAGTGGTTAAACTTAATGCTTGGAAGAAAGGTCTCAATGTGTCTAGAAGAGAGGTACTGAGAGGAAGACTCACTTTGGAGGCTGGAGCCTACAATTTTCAAGGATTGCCTCAGGTGAAAATATACTTCCTGGACTTTGTTTCCTGACATATATCAGGTGTGTTCTGCTCCCTATAAAGACAAGAGGAGGCGGGTATCCAGATGGTCCCACGAGTAGGGCTACACAAGATGCTGGAGGCTTGGTAAGTTCCTCTGGGTCCCAGATCTTTTTCTCAGGTCGGGATAGTGTGAGTGCCTAGCACAGTGTCGGGCATGCAGAAGGGCCCCTTAAAAGTTTCTCTTTCATCTGGCCAGTTTTAGATACACAATTTTGTCAGTTTATCTGCAGTGCATACTCTTGGGTAGTGCCTGTGCTGACCAAGTATCTTAGAGGCTTATTTTATTa
>NM_144781.3
GATTTCCGCCTTCCGACCCAGCTGTGGGCTGCGCCCCACGCCAGCCCGCGCCCCGCATGGCTGCCGCCGGGGCCAGGCCTGTGGAGCTGGGCTTCGCCGAGTCGGCGCCGGCGTGGCGACTGCGCAGCGAGCAGTTCCCCAGCAAggtgggcgggcggccggcatggctgggcgcggccgggctgccgggGCCCCAGGCCCTGGCCTGCGAGCTGTGCGGCCGCCCGCTCTCCTTCCTGCTGCAGGTGTATGCGCCGCTGCCTGGCCGCCCGGACGCCTTCCACCGCTGCATCTTCCTCTTCTGCTGCCGCGAGCAGCCGTGCTGTGCCGGCCTGCGAGTTTTTAGGAATCAACTACCCAGGAAAAACGATTTTTACTCATATGAGCCACCTTCTGAGAATCCTCCCCCAGAAACAGGAGAATCAGTGTGTCTCCAGCTTAAGTCTGGTGCTCATCTCTGCAGGGTTTGTGGCTGTTTAGGCCCCAAAACGTGCTCCAGATGCCACAAAGCATATTACTGCAGCAAGGAGCATCAGACCCTAGACTGGAGATTGGGACATAAGCAGGCTTGTGCACAACCAGATCATCTGGACCATATAATTCCAGACCACAACTTCCTTTTTCCAGAATTTGAAATTGTAATAGAAACAGAAGATGAGATTATGCCTGAGGTTGTGGAAAAGGAAGATTACTCAGAGATTATAGGGAGCATGGGTAAGCAGTTTCAGGACTTCATTCATTAAGTGGTTAAACATAATACTTGGAAGAAAGGGCTCCATGTGCCTAGAAGAGAGGTACTGAGAGGAAGACTCACTTTGGAGGCTGTAGCATACAATTTTCAGATATTGCCTCAGGTAAAAATATACTTCCTGGACTTTGTTTTCTGACACATAAGAGGTGTGTTCTGCTCCCTGTAAAGACAAGGGTGGGTATCCAGATGGTCCCATGAGTAGGGCTGCACAAGATGCTGGAGGCTTGGTAAGTTCCTCTGGGTCGCAGATCGGTTTCTCGGGTCGGGATAGTGTGagtgcctagcacagtgtcgggcacgcagaagggccccttaaaagtttctctttcatCTGGCCAGTTTTAGATACACAATTTTGTCAGTTTACTTACAGTGCATACTCTTGGGTAGTACTTGTGCTGACCAAGTATCTTAGAGGCTTATTTTATTatagtagccaacatttatccagcacttaccttatataaagggctgtttgtgcatgagctcattaaaatcgtgacagcagaccaatgagtgagaaactgccccattttgaaggtgaggaaattgaggttctgggtataactttctttggtcacataatattaaatTTTACAATTTGAGCCTTGAGCCATACACAAAACCACCACAAAATTAGATTTATAGACTCAAAATGAAAACATCAGCTTACTGGTTTGTAGTTCATACCAGtcatacattccaaaacatgttttgagtcttactctgtgcctgaccttgtgcttgataacagggatataatgggaagcaacactccagtggtcagatgctcacagtcttatggaggagcccaaataatatctggggaagttaaagtccatataatgactgataagagtacaatacaggtgccatgggaacacGTGACATCACTGAAGACTGCCTGGAAGGGGCCGCGCGTGTGTTCATGCCTATACGATAAACATGATACAtaatgaaaatgcttatctttaggagaaaggagagcctagagtagcaggatcaaggatgaaagctggacttcaaatatgccttgttagtgtaaatgtgactgtggaactgtatgagtattttaagattatggagtaaagtaagttttaaaaagcagtccctaatcatcaaaagtaaaaaactcttgatgtagtcatataaccacactaagaactcttccaggtgacttcaaaacataggacagtacatctctagtagaatatgccctgagaatgaaaagaatgtaacagtgttagtattttgaataaacatgttattactagactgttgcttttattttgagatggttgtgtgtgtattggggggaaaggaaacgagtaattatgttggtgttactgagaactgagatgttgggcgtaggaggaagATAATGTTgattgtgtctacgtaccatttctctctaaaaggaactccaggctctttggagaggtggttgattccagaactaggtcaggaaacgttcatataatgtgggaacatggtcatatcaaagattaaggataaggattactagggccatgtcagaactcaagcaacatgaaaaggctcctgcttgcaaaagatggacagtttgaacatccacaaggacgctaactgcatcagatatgtttaatgggttcaaaatgatactttaaaaaaactcagtaatcatctttataggatacttgggaacagactcattttcaaattggtaaataaaaggaaagaGTTTGCCTTCGAGGGGTACATAACTTAAttatgaatgaagtgatatgtgtggaatttacttcagagtaatggaggtggaagtggcagagaaaggaaacactggacttgatagtgttgaaactgattaatgatatgtggcggttcattatagtatttccacttttctgtatgtccaaaattttctaaaataaaaggAGAATTGAATAGAAAAA

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