Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HSPA8P14
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:111381838-111384924  UCSC
Coordinates (T2T) chr12:111362344-111365430  UCSC
Coordinates (hg19) chr12:111819642-111822728  UCSC
Strand +
Parental Sequence NM_006597.6
Parental seq. overlap 1292 bp
Parental seq. overlap (%) 55.6%
Genomic Region Intergenic
Retrocopy Summary HSPA8P14, located on chr12:111381838-111384924, is a retrocopy of the parental gene HSPA8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HSPA8
Full Name heat shock protein family A (Hsp70) member 8
Also known as HEL-33|HEL-S-72p|HSC54|HSC70|HSC71|HSP71|HSP73|HSPA10|LAP-1|LAP1|NIP71
Coordinate chr11:123057489-123062366
Strand -
Gene summary This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HSPA8P10
Bonobo Pan paniscus HSPA8P10
Gorilla Gorilla gorilla HSPA8P10
Orangutan Pongo abelii HSPA8P10
Gibbon Nomascus leucogenys HSPA8P7
Green monkey Chlorocebus sabaeus HSPA8P3
Rhesus Macaca mulatta HSPA8P9
Marmoset Callithrix jacchus HSPA8P7
Crab-eating macaque Macaca fascicularis Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HSPA8P14
TGAGCCAGGCCTGCATGCCAGCAACCGTTTTCTAAGGGAACTGCATTTAGTGTTGATCTTGGTTCCACCAACTCTTGTGTGGGTATTGTCCAGCACAAAAAGGTAAAGTTAATTGTCAATGATTGGGGAAACTGAACCCCTCCAAGCTATGTCACCTTTACGGCTACTGAACGATTGATTGGTGATGCCACAAAGAATCAAGTGGCAATGAACCCCAACAACACAGTTTTTGATGGCCAACATCTTATTGGATGCGGATTTGATCATACTGTTGTCTGGTCTGATAAGAAGCACTGGCCCTTCATGGTGGTGAGTGATGCTGGCAGACCCAAGGTCCAAGGAGAGAACAAGGGAAAAACAAAAAGCTTCACTTCTATCCAGAGATGTCCCCTATGGTTGTGACAAAGATGAAGGAAATTGCAGAAGCCTACCTTGGGAAGACTGTTACCAATGCTGTGCTCACAGTGCCAGCCTACTTTAATGACTCAGCATCAGGCTACCAAAAAGATGCTAGAACTATTGCTGGTCTCAATGGACTTAGAATTAGCAATGAGCCAACTGCTGCTGCTATTGCTTATGGCTTAAACCAAAAGGTTGGAACTGAAAGAAATGTGTTGATCTTTGACCTGGGAGGTAGCACTTTTTAAAACGGGATGTGGCACTTTTGATGTGTCAGTCCTCACTATTGAGGATGAAATTTTTGAAGTCAAATCTACAGCTGGAGAAGGTGGAGAAGACTTTGCAACCAAATGGACAGCCGTTGCATTGCTGAGCTCAAGTGCAAGCATAAGAAGGACCTCAGTGAGAACAGGAGAGCTGCTGCCCGCACGCCTTCATGCGGCTTGTGAACATGCAAAACATACTCTCTCTTCCAACACCCAGGCCAGTATTGAGATTGATTCTCTCTAGGCAGGAATTGACATCTATACCTCCATTACCATGCCCGATTTGAAGAATTGAATGCTGACCTGTTCCATAGCATCCTGGACCCCGTAGAAGAAGCCCTTTGAGACACCAAACTAGACAAGTCACAGATTCATGACATCACCCTGGTTGCTGGTTCGGCTTCTAACTGCAAGATTCAGAGCTTGCCCAAGACTTCTTCAATAGAAAAGAACTGAAGaCTGCATAGGAGCATTGACCCTGATGAAGCTGTTTCTTACGATCCAGCTACCCAGGCAGCCATCTGATCTGGAGACAAACAGATCAGAAAATCAGAAAATGTTCAAGACTCATTGCTCCTGGATGTCACTCCTCTTTCCCTTCCATTGAAACTGCTGGCAGAGTCACAACAGTCCTTGTTAAGCATAATACTACCATTCCTACCAAGCAGACACAGACCTTCACTACCTGCTCTGGCAACCAGCCTGCTGTGCTTACTCAGGTTTATGAAGGCGAGCGTGCCGTGAGCAAGGATAACAGCCTGCTTGGCAAGTTTGAACTCACGGGCATACTTCCTGTGACAGTGCTCCTCACACTGAAGTCACTTGACACTGATGCTAGTGACATCCTCAGTGTCTCTGCTGTGGACAAAAGTA
>NM_006597.6
CTCATTGAACTCGCCTGCAGCTCTTGGGTTTTTTGTGGCTTCCTTCGTTATTGGAGCCAGGCCTACACCCCAGCAACCATGTCCAAGGGACCTGcagttggtattgatcttggcaccacctactcttgtgtgggtgttttccagcacggaaaagtcgagataattgccaatgatcagggaaaccgaaccactcCAAGCTATGTCGCCTTTACGGACACTGAACGGTTGATCGGTGATGCCGCAAAGAATCAAGTTGCAATGAACCCCACCAACACAGTTTTTGATGCCAAACGTCTGATTGGACGCAGATTTGATGATGCTGTTGTCCAGTCTGATATGAAACATTGGCCCTTTATGGTGGTGAATGATGCTGGCAGGCCCAAGGTCCAAGTAGAATACAAGGGAGAGACCAAAAGCTTCTATCCAGAGGAGGTGTCTTCTATGGTTCTGACAAAGATGAAGGAAATTGCAGAAGCCTACCTTGGGAAGACTGTTACCAATGCTGTGGTCACAGTGCCAGCTTACTTTAatgactctcagcgtcaggctaccaaagatgctggaactattgctggtctcaatgtacttagaattattaatgagccaactgctgctgctattgcttacggcttagacaaaaagGTTGGAGCAGAAAGAAACGTGCTCATCTTTGACCTGGGAGGTGGCACTTTTGATGTGTCAATCCTCACTATTGAGGATGGAATCTTTGAGGTCAAGTCTACAGCTGGAGACACCCACTTGGGTGGAGAAGATTTTGACAACCGAATGGTCAACCATTTTATTGCTGAGTTTAAGCGCAAGCATAAGAAGGACATCAGTGAGAACAAGAGAGCTGTAAGACGCCTCCGTACTGCTTGTGAACGTGCTAAGCGTACCCTCTCTTCCAGCACCCAGGCCAGTATTGAGATCGATTCTCTCTATGAAGGAATCGACTTCTATACCTCCATTACCCGTGCCCGATTTGAAGAACTGAATGCTGACCTGTTCCGTGGCACCCTGGACCCAGTAGAGAAAGCCCTTCGAGATGCCAAACTAGACAAGTCACAGATTCATGATATTGTCCTGGTTGGTGGTTCTACTCGTATCCCCAAGATTCAGAAGCTTCTCCAAGACTTCTTCAATGGAAAAGAACTGAATAAGAGCATCAACCCTGATGAAGCTGTTGCTTATGGTGCAGCTGTCCAGGCAGCCATCTTGTCTGGAGACAAGTCTGAGAATGTTCAAGATTTGCTGCTCTTGGATGTCACTCCTCTTTCCCTTGGTATTGAAACTGCTGGTGGAGTCATGACTGTCCTCATCAAGCGTAATACCACCATTCCTACCAAGCAGACACAGACCTTCACTACCTATTCTGACAACCAGCCTGGTGTGCTTATTCAGGTTTATGAAGGCGAGCGTGCCATGACAAAGGATAACAACCTGCTTGGCAAGTTTGAACTCACAGGCATACCTCCTGCACCCCGAGGTGTTCCTCAGATTGAAGTCACTTTTGACATTGATGCCAATGGTATACTCAATGTCTCTGCTGTGGACAAGAGTACGGGAAAAGAGAACAAGATTACTATCACTAATGACAAGGGCCGTTTGAGCAAGGAAGACATTGAACGTATGGTCCAGGAAGCTGAGAAGTACAAAGCTGAAGATGAGAAGCAGAGGGACAAGGTGTCATCCAAGAATTCACTTGAGTCCTATGCCTTCAACATGAAAGCAACTGTTGAAGATGAGAAACTTCAAGGCAAGATTAACGATGAGGACAAACAGAAGATTCTGGACAAGTGTAATGAAATTATCAACTGGCTTGATAAGAATCAGACTGCTGAGAAGGAAGAATTTGAACATCAACAGAAAGAGCTGGAGAAAGTTTGCAACCCCATCATCACCAAGCTGTACCAGAGTGCAGGAGGCATGCCAGGAGGAATGCCTGGGGGATTTCCTGGTGGTGGAGCTCCTCCCTCTGGTGGTGCTTCCTCAGGGCCCACCATTGAAGAGGTTGATTAAGCCAACCAAGTGTAGATGTAGCATTGTTCCACACATTTAAAACATTTGAAGGACCTAAATTCGTAGCAAATTCTGTGGCAGTTTTAAAAAGTTAAGCTGCTATAGTAAGTTACTGGGCATTCTCAATACTTGAATATGGAACATATGCACAGGGGAAGGAAATAACATTGCACTTTATAAACACTGTATTGTAAGTGGAAAATGCAATGTCTTAAATAAAACTATTTAAAATTGGCACCATACAA

Publications

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