Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name IER3IP1P2
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr18). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:112000665-112000986  UCSC
Coordinates (T2T) chr12:111977570-111977891  UCSC
Coordinates (hg19) chr12:112438469-112438790  UCSC
Strand -
Parental Sequence NM_016097.5
Parental seq. overlap 290 bp
Parental seq. overlap (%) 7.9%
Genomic Region Intragenic (TMEM116)
Retrocopy Summary IER3IP1P2, located on chr12:112000665-112000986, is a retrocopy of the parental gene IER3IP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name IER3IP1
Full Name immediate early response 3 interacting protein 1
Also known as HSPC039|MEDS|PRO2309
Coordinate chr18:47152834-47176364
Strand -
Gene summary This gene encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and apoptosis. Transcription of this gene is regulated by tumor necrosis factor alpha and specificity protein 1 (Sp1). Mutations in this gene may play a role in microcephaly, epilepsy, and diabetes syndrome (MEDS), and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Dec 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes IER3IP1P2
Bonobo Pan paniscus IER3IP1P2
Gorilla Gorilla gorilla IER3IP1P2
Orangutan Pongo abelii IER3IP1P3
Gibbon Nomascus leucogenys IER3IP1P1
Green monkey Chlorocebus sabaeus IER3IP1P1
Crab-eating macaque Macaca fascicularis LOC101866362P2
Rhesus Macaca mulatta IER3IP1P2
Baboon Papio anubis IER3IP1P2
Golden snub-nosed monkey Rhinopithecus roxellana IER3IP1P2
Marmoset Callithrix jacchus IER3IP1P3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>IER3IP1P2
CATGGCCTTTACCTTGTACTGACTGCTGCAGGCAGCCCTGCTCTGTGTCAGTGCCATCGCCATGCTGCACAAAGAGAAATTCCTCAAGAACATTGGCTGGAGAATAGACCAGAGAATTGGTGGATTCGGGGAGGAGCCAGGAATTAAATCTCAGCTAATGAACCGTATTCAATCTGTAACAACTGTGATGAGAATGCCATTGATAATAGTAAACTCAATTGCAATTGTGTTACTTTTATTATTTGGATGAATATCAGGAGAGGAAATGGAGACTCAGAAGAGATGCTAGCAGAAGTTATTATTTAGGTCATTATTGGAATAA
>NM_016097.5
GTAGGAAGGCGCCGGCCGTGGAGGCGCCACGTCCCTTGCGGCGGCGGGAGAGAAATCGCTTGGACTTCGGGGCGGCCTCGGACGGCCATGGCCTTTACCCTGTACTCACTGCTGCAGGCAGCCCTGCTCTGCGTCAACGCCATCGCAGTGCTGCACGAGGAGCGATTCCTCAAGAACATTGGCTGGGGAACAGACCAGGGAATTGGTGGATTTGGAGAAGAGCCGGGAATTAAATCACAGCTAATGAACCTTATTCGATCTGTAAGAACCGTGATGAGAGTGCCATTGATAATAGTAAACTCAATTGCAATTGTGTTACTTTTATTATTTGGATGAATATCAGTGGAGAAAATGGAGACTCAGAAGAGGACATGCCAGTAGAAGTTATTACTTTGGTCATTATTGGAATATTTATATCTTAGCTGGCTGACCTTGCACTTGTCAAAAATGTAAAGCTGAAAATAAAACCAGGGTTTCTATTTATCTGTTTTTTTTTTTAATGTTGCACTTGTAGTTTCATTACAAAAGATCAGATCATGAAAGGCAGTAACTCTCCAGGACTGGAATATCTGATTGCTCAGTGTTAATAGTAGTTCATGCTGTGGTGAGATTGTTAAAAGGGTGCAAGACTGTTGCTTCTCTTTTTTTAGATATTTTTCTATCTCTCACTTCTCAGGGATGAAATTCTTTTTCAAAGTTTTGAAGTTCCTTGCAACTTAGCCATGATGTGAGTGGTTATCCCTAGATAAAATTAAAAGGATTTTTAAAAAGTAATTACTGCACATAAAATGATAAATAGGTAATTTGAATAATTTTATTTTAAGCTCCTTGGTTAATTATTTTGTCTATTGTCTCAGCTATAAATTCAAATTTATACATACTATTGAGTATTAATATTCTCTGATTTCAGGGAGAATTCTGTCAGTCACATGATGATTATGTTTTTGTTTAACATTCTTTCCATGCACTTGTTATTTTATTAATTTGCCTGAATGATGAGACCAGACCAGTGTCTACAGATTTTCATTGTCAGAAAAATCTATAAGTCTGCCCTTTTTACAATGATGATTTAAAAAAAACAACAGCGTAAATATTAGCCCACAAGAGCAGTCCTAAACAATCACAATTACACTGTACTACCCAAGAAGACTGTTTATTGTGAAGCATTTACCTTTCAAAAAATCATTACATTTCTATTTCTTGGTGGAGCAGCACATTGTGGAGTGTGATTCTTAATTCTTCATTGAGTTTGTCAATAGGACATTGATGCTGGATAGGTTGTCTTTTGTTTTTATGTCTCAGACCATCTTGTGAGATTGTTTGCCTATCTCATAATACAGTTTTATGCAGAAAGGTTGAAACTATGTAAATGGTTTTTATGGAAATTATCAGTTACAATATTTTAAAGGTGTAGAATGGCATCTTTGTTTATAGGAGAACATTTGTAAATAAAGTTAAATTTCTAAGTCAAGCACTTGTTTTTGTACCTTAGTATAAACCTGTCAGTGTTAACTGCATTAATCTCCATTTTGGGTGAACACCTCTTATTATATGTTCTTTGCTGTAAAATTGCCGAGTATAGAGTTAATGAAAGTAAATATTTACATGTATTTTTTTTTCTTCAGTGAATTAACTGAATTGCTGACATACATCCAGAAGACTCATGAGCACCTTTTATTTCATGACTTCAGTTACTTCTAAAACTATGGAGCAGGTATTAAGTACCTTTTGGCCTTTCCTAAGTTAGAGATCAGTGATCTTTGGACTATAGGCTTGCAGCTAGTCCAAGGAAAGTACCAAGGATTCTTAGTTGATTACTTGGCTCATGTGAATGACTAATTTGGTACTTAGAGGCCGTGTTCTTTTAGCCTTACAAAGAACTGATGCCTGAGTTCAAGTTTGAGCTACTGAAAAGATTCAAAAGAAGCAGTTACTTGAGGGCAGGCCCATTTCCCCATATGGTATGAGCAGTACAAAATTTTTTAAAATGAAAGAAAAGAGAGACCTTGATCTGATGTTATTTTTCATATAAGACATTACAGCATACCTTCATCTTAATTCAGTGTTGGGATTTTGTCCAAATATTCCATCAGGGAGCAGTCACAGAAGGGCCAGGATCAAAGTATTCTGTAGCCAAGTAGTTCTGAGGAAAGTGAAGCACTGAACTGAACATCAAAATATGTCATATCTGGAGGCCACTTCATAATTCCAGTTTGTGGCTGAAGAGGGGTCTGTAAGCTTTCACTGGTCAGCCCTGGTTTCCCCAGAGCAGTTGTGATTCAGTAAACAGAGTGTGTTATTTTAGTAGACAGTAACTTAAGTGCCTGTTGGCCTGCCCATGTCCTCCCCTTTATCTATTACCAGGATTAACAATTTGTGATGATTCTGGACTCCAAATACCGATGATGTTTATAGTCCTTATGTATTCTGGCCCTGTGTTTGCATGTCTCTGAACTGTGCGAAGGTTCTTGGCTCTAGTCTGTAGATATTAACCAAATTCATCGCTAATCAAGTAcagtggttttcaaacttttatagttaacagcagaaccagattttcaaaggaattctgacacagaactgtaacattcccgtatctaaaccagatgagagtagGTCCATTTATTTGTTTTTAGTTGAAGTAGAGCTGGGATTCAAAGGCTCACTATTCAGCCTCCACTGCACTCTTGTCAGGCTTCCCAAGGCATTTCCATAAAACCCTAAATTTTCAAAAATATAGCTAAAAAGTATCTTATAAAAATCCCTGCTTTagccataaaaaagaattagataataccttctgtgggaacatggatggagctggaagccatcatccttaacaaactaatgtaggaacagaaaaccaaataccacatgttattacttataagtgggagctaaatgataagacctcatggacataaggagggggacaacagacactgggggctatttgagggtggagggtgagaaagagtgccagaaaaattactgggtactaggcttagcacctggataacgaaataatctgtgccaaacccccgtgacacaagtttacctatttaacaaatgtactgtacccctaaaagttaaaaaagtaaaaatataaaaaaaTAAAATCCCTGCTTTAgggagggtgggagggggtgagggaaacagaaactacatactgagtacaatgtacagtagtccagtgatgggtgcactaaaatttcagactttacaccactatacaattcatccatgtaaccagaaaccacttgtacccctaaagctattgaaataaaaaGCTAAATGAGTTCCCCCACCTTCCTCTCCCCATCAAAATCCTTGCTTTAGATACAATAAGAGTAGGCAATCTGTGTTCTATATGTGTTAGATGTGTATTACTGGTGAAATGACAAGAGAAAGCAAGATATTTGACTAGTAAAAAGACTAGGAGGCAAGATATTTCTAATATATCAAGCAAACCTTTTACCATGTGACTGAAAGCAAATAAACTTCCTAAGACCTCAGTAGTTTTTGGTTGTCCTATCTGTAAAATTGGTCAATAACCTTCAGAACAGAAGTCTGGTCCAGATATATATATATATCTTTTCCAGATCACTAATGTTTGTATCTAGATGTGCTTCAACCAAAGAGATGTTCTCCTTAAGTAAAATGTTTCTTATGAAGCAAA

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