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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DNAJC2P1
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Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:112322397-112323093  UCSC
Coordinates (T2T) chr12:112299305-112300001  UCSC
Coordinates (hg19) chr12:112760201-112760897  UCSC
Strand +
Parental Sequence NM_001362667.2
Parental seq. overlap 590 bp
Parental seq. overlap (%) 26.6%
Genomic Region Intragenic (HECTD4)
Retrocopy Summary DNAJC2P1, located on chr12:112322397-112323093, is a retrocopy of the parental gene DNAJC2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DNAJC2
Full Name DnaJ heat shock protein family (Hsp40) member C2
Also known as MPHOSPH11|MPP11|ZRF1|ZUO1
Coordinate chr7:103312289-103344790
Strand -
Gene summary This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DNAJC2P1
Bonobo Pan paniscus DNAJC2P1
Gorilla Gorilla gorilla DNAJC2P1
Orangutan Pongo abelii DNAJC2P1
Gibbon Nomascus leucogenys DNAJC2P1
Green monkey Chlorocebus sabaeus DNAJC2P1
Rhesus Macaca mulatta DNAJC2P1
Baboon Papio anubis DNAJC2P1
Golden snub-nosed monkey Rhinopithecus roxellana DNAJC2P1
Marmoset Callithrix jacchus DNAJC2P1
Mouse lemur Microcebus murinus DNAJC2P1
Crab-eating macaque Macaca fascicularis Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DNAJC2P1
CAAGTAGAAAAACTTTGTAATCAGCTTGAACTAGAAAGCTTACAGTAGTTGAATGAAACACATCATCTACAAAAGAAGTAGGAATGGCTGCTCTGGAAAAACAGAAGAAATAAATGAACAAATTACGAAGGAGAAACAGGAAGGTGGGGCTCGTATGTAATAAGCATCTAAGAATGCAGAGAAATAAACTGGCAGAGGTGGAAATGGCAGCAACAACTGGTAAGAAGATGATCTGCAGCTACAAGTTAAAGCTATGAATCTCTTCCCTGCTGGTATGAATTCAAGATGGGAAGTTGGTAAGTTATTGCTAATTACATCAACATACATTCTTCTACTGATGTCAAGACAACCACCAAAGGTGTTACTGGCAAAGCAAAGAGCCTCCAAAAATTGGACCCTCATCAAAAAGATGACAAACAAAAAAGGCTTTTGATAAACTTTAAAAAGAACATTGCCTCAAGCAGACAATGAAACACCTTCAGAATGATTTTACAGTCCATGCACCCACTTCACCCCTTGGAGAACGAACAGAAGCTTTTTGAACAAGCTTTGAAAACACACCCAGTCAACACACCTGAAAGATGAGAGAAAACAGCACAAACTGCCAGTACCTGGCAGGACAAAGAAAGGCTGCATGAAAAGATGCAAGGAACTTGCCAAGATGGTAAAAGCAAAGAAAGCTGCTCAAGAGCAAGTG
>NM_001362667.2
ACTGGTCGTCTCCATGCGCCGGTTCCTGGGCGTCTTAGAGCCAAGGCGCGAGGCTCGGAGTGAGAGGTAGAGCTGGAGGGGACCCTAAGCGCCCTCCGCCCGGGACGTGAGCCGCTGCGCCCACCGGGCTAGACCCGGCGCCATCATGCTGCTTCTGCCAAGCGCCGCGGACGGCCGGGGCACCGCCATCACCCACGCTCTGACCTCTGGAACTGGAGGATAAGAAAGAGTTATCCGAGGAATCAGAAGATGAAGAATTGCAGTTGGAAGAGTTTCCCATGCTGAAAACACTTGATCCCAAAGACTGGAAGAACCAAGATCATTATGCAGTTCTTGGACTTGGCCATGTGAGATACAAGGCTACACAGAGACAGATCAAAGCAGCTCATAAAGCAATGGTTTTAAAACATCACCCAGACAAACGGAAAGCAGCTGGTGAACCAATAAAAGAAGGAGATAATGACTACTTCACTTGCATAACTAAAGCTTATGAAATGTTATCTGATCCAGTGAAAAGACGAGCATTTAACAGTGTAGATCCTACTTTTGATAACTCAGTTCCTTCTAAAAGTGAAGCAAAGGATAATTTCTTCGAAGTGTTTACCCCAGTGTTTGAAAGGAATTCCAGATGGTCAAATAAAAAAAATGTTCCTAAACTTGGTGATATGAATTCATCATTTGAAGATGTAGATATATTTTATTCTTTCTGGTATAATTTTGATTCTTGGAGAGAATTTTCTTATTTAGATGAAGAAGAAAAAGAAAAAGCAGAATGTCGTGATGAGAGGAGATGGATTGAAAAGCAGAACAGAGCAACAAGAGCACAAAGAAAAAAAGAAGAAATGAACAGAATAAGAACATTAGTTGACAATGCATACAGCTGTGATCCAAGGATAAaaaagttcaaggaagaagaaaaagccaagaaagaagcagaaaagaaagcaaaagcagaagctaaacggaaggagcaagaagctaaagaaaaaCAAAGACAAGCTGAATTAGAAGCTGCTCGGTTAGCTAAGGAGAAAGAAGAGGAGGAAGTCAGACAGCAAGCATTGCTGGCAAAGAAGGAAAAAGATATCCAGAAAAAAGCCATTAAGAAGGAAAGGCAAAAACTTCGAAACTCATGCAAGACCTGGAATCATTTTTCTGATAATGAGGCAGAGCGGGTTAAAATGATGGAAGAAGTGGAAAAACTTTGTGATCGGCTTGAACTGGCAAGCTTACAGTGCTTGAATGAAACACTCACATCATGCACAAAAGAAGTAGGAAAGGCTGCTTTGGAAAAACAGATagaagaaataaatgagcaaatcagaaaagagaaagaggaaGCTGAGGCTCGTATGCGACAAGCATCTAAGAACACAGAGAAATCAACTGGTGGAGGTGGAAATGGAAGTAAAAATTGGTCAGAAGATGATCTACAATTACTAATTAAAGCTGTGAATCTGTTCCCTGCTGGAACAAATTCAAGATGGGAAGTTATTGCTAATTACATGAACATACATTCTTCCTCTGGAGTCAAAAGAACTGCCAAAGATGTTATTGGCAAAGCAAAGAGTCTCCAAAAACTTGACCCTCATCAAAAAGATGACATAAATAAAAAGGCATTTGATAAGTTCAAAAAAGAACATGGAGTGGTACCTCAAGCAGACAACGCAACGCCTTCAGAACGATTTGAAGGTCCATATACAGACTTCACCCCTTGGACAACAGAAGAACAGAAGCTTTTGGAACAAGCTTTGAAAACATACCCAGTAAATACACCTGAAAGATGGGAAAAAATAGCAGAAGCGGTGCCTGGCAGGACAAAGAAGGACTGCATGAAACGATACAAGGAACTTGTCGAGATGGTAAAAGCAAAGAAAGCTGCTCAAGAACAAGTGCTGAATGCAAGTAGAGCCAAGAAATGACAATCTTTGTTGTGTGTGCATTTTTATAATAAAACTGAAAATACTGTAAACATTTTCATTCTTAAAATTATACTCATGGTAATAATTTGAAAGTATGCTGCTTCCAACATAATTTCTCAGAGAACAAAGACTGACCATTAATACAAAACAACCTTCAGAGGGGTAGTCTTTTTATCCTTTGAAAGTATGATACAGTATTTAATTCAAATTTCCAAATGTATATACATGTTCATTTTTATTTTTCTCTAGCTCTGTTTTATAAATACATGTGTTCAAACAA

Publications

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