Summary

Retrocopy Name	PRB3P1
Species	Homo sapiens
Coordinates (hg38)	chr12:11267174-11268161  UCSC
Coordinates (hg19)	chr12:11420107-11421095  UCSC
Strand	-
Parental Sequence	NM_006249.5
Parental seq. overlap	860 bp
Parental seq. overlap (%)	70%
Genomic Region	Intergenic
Retrocopy Summary	PRB3P1, located on chr12:11267174-11268161, is a retrocopy of the parental gene PRB3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	PRB3
Full Name	proline rich protein BstNI subfamily 3
Also known as	G1|PRG
Coordinate	chr12:11265914-11269707
Strand	-
Gene summary	This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Long" allele. The protein isoforms encoded by this gene are recognized as the "first line of oral defense" against the detrimental effects of polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015]

Homology

	Species	Scientific Name	Retrocopy
	Chimpanzee	Pan troglodytes	Without Homology
	Bonobo	Pan paniscus	Without Homology
	Gorilla	Gorilla gorilla	Without Homology
	Orangutan	Pongo abelii	Without Homology
	Gibbon	Nomascus leucogenys	Without Homology
	Green monkey	Chlorocebus sabaeus	Without Homology
	Crab-eating macaque	Macaca fascicularis	Without Homology
	Rhesus	Macaca mulatta	Without Homology
	Baboon	Papio anubis	Without Homology
	Golden snub-nosed monkey	Rhinopithecus roxellana	Without Homology
	Marmoset	Callithrix jacchus	Without Homology
	Mouse lemur	Microcebus murinus	Without Homology
	Mouse	Mus musculus	Without Homology
	Rat	Rattus norvegicus	Without Homology
	Chinese hamster	Cricetulus griseus	Without Homology
	Rabbit	Oryctolagus cuniculus	Without Homology
	Pig	Sus scrofa	Without Homology
	Cow	Bos taurus	Without Homology
	Sheep	Ovis aries	Without Homology
	Dolphin	Tursiops truncatus	Without Homology
	Horse	Equus caballus	Without Homology
	Dog	Canis familiaris	Without Homology
	Panda	Ailuropoda melanoleuca	Without Homology
	Cat	Felis catus	Without Homology
	Pale spear-nosed bat	Phyllostomus discolor	Without Homology
	Velvety free-tailed bat	Molossus molossus	Without Homology
	Greater mouse-eared bat	Myotis myotis	Without Homology
	Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
	Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
	Egyptian rousette	Rousettus aegyptiacus	Without Homology
	Sloth	Choloepus didactylus	Without Homology
	Tasmanian Devil	Sarcophilus harrisii	Without Homology
	Opossum	Monodelphis domestica	Without Homology
	Platypus	Ornithorhynchus anatinus	Without Homology
	Chicken	Gallus gallus	Without Homology
	Turkey	Meleagris gallopavo	Without Homology
	Zebra Finch	Taeniopygia guttata	Without Homology
	Budgerigar	Melopsittacus undulatus	Without Homology
	Painted Turtle	Chrysemys picta	Without Homology
	Lizard	Anolis Carolinensis	Without Homology
	Frog	Xenopus tropicalis	Without Homology
	Zebrafish	Danio rerio	Without Homology
	Drosophila	Drosophila melanogaster	Without Homology

Expression

This retrocopy transcript is not present in the ARCHS4 database for expression quantificationThis retrocopy transcript is not present in the GTEx database for expression quantification.

Related Sequence

>PRB3P1

CCACCTCCTCCAGGAAAGCCAGAAGGACGACGCCCACAAGGAGGAAACCAGCCCCAACGTACCCCACCTCCTCCAGGAAAGCCAGAAGGACGACCCCCACAAGGAGGCAACCAGTCCCAAGGTCCCCCACCTCGTCCAGGAAAGCCAGAAGGACCACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCACCTCGTCCGGGAAAGCCAGAAGGACAACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCACCTCGTCCGGGAAAGCCAGAAGGACCACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCGCCTCGTCCGGGAAAGCCAGAAGGACCACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCGCCTCGTCCGGGAAAGCCAGAAGGACCACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCGCCTCATCCGGGAAAGCCAGAAGGACCACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCACCTCGTCCGGGAAAGCCAGAAGGACCACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCACCTCGTCCGGGAAAGCCAGAAGGACCACCCCCACAAGGAGGCAACAAACCTCAAGGTCCCCCACCTCGTCCAGGAAAGCCAGAAGGACCACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCACCTCGTCCAGGAAAGCCAGAAGGACCACCTTCACAAGGAGGCAACAAACCTCAAGGTCCCCCACCTCATCCAGGAAAGCCACAAGGACCACCCCCACAAGAAGGTAACAAACCTCAACGTCCCCCTCCTCCAGGAAGGCCACAAGGACCACCCCCACCAGGAGGCAATCCCCAGCAGCCTCTGCCACCTCCCGCTGGAAAGCCCCAGGGACCACCTCCACCTCCTCAAGGGGGCAGACCACACAGACCTCCCCAGGGACAGCCTCCCCAGTAATCAAGGTTCAATGACAGGT

>NM_006249.5

AGCACAGAGTTGGGAGTGACTCCAGAGCCTCCAGCAAGATGCTACTGATTCTGCTGTCGGTGGCCCTGCTGGCCCTGAGCTCAGCTCAGAGCTTAAATGAAGATGTCAGCCAGGAAGAATCTCCCTCCGTAATATCAGGAAAGCCAGAAGGACGACGCCCACAAGGAGGAAACCAGCCCCAACGTACCCCACCTCCTCCAGGAAAGCCAGAAGGACGACCCCCACAAGGAGGCAACCAGTCCCAAGGTCCCCCACCTCGTCCAGGAAAGCCAGAAGGACCACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCACCTCGTCCGGGAAAGCCAGAAGGACAACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCACCTCGTCCGGGAAAGCCAGAAGGACCACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCGCCTCGTCCGGGAAAGCCAGAAGGACCACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCGCCTCGTCCGGGAAAGCCAGAAGGACCACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCGCCTCATCCGGGAAAGCCAGAAGGACCACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCACCTCGTCCGGGAAAGCCAGAAGGACCACCCCCACAAGGAGGAAACCAGTCCCAAGGTCCCCCACCTCGTCCAGGAAAGCCAGAAGGACCACCTTCACAAGGAGGCAACAAACCTCAAGGTCCCCCACCTCATCCAGGAAAGCCACAAGGACCACCCCCACAAGAAGGTAACAAACCTCAACGTCCCCCTCCTCCAGGAAGGCCACAAGGACCACCCCCACCAGGAGGCAATCCCCAGCAGCCTCTGCCACCTCCCGCTGGAAAGCCCCAGGGACCACCTCCACCTCCTCAAGGGGGCAGACCACACAGACCTCCCCAGGGACAGCCTCCCCAGTAATCAAGGTTCAATGACAGGAAGTGAACAAGAAGATGACAGTGATTCAAATGATTCAAATGCCATGACATTGGAAGAAGGTGGTCATAGCTCTACCTTTAATATACCAATAAAATAAACAGCTTACAATTTCTGA

Publications

PMID - Link	Title
No publications available for this retrocopy