Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name OSTF1P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:114588050-114588801  UCSC
Coordinates (T2T) chr12:114564998-114565749  UCSC
Coordinates (hg19) chr12:115025855-115026606  UCSC
Strand +
Parental Sequence NM_012383.5
Parental seq. overlap 645 bp
Parental seq. overlap (%) 47.7%
Genomic Region Intergenic
Retrocopy Summary OSTF1P1, located on chr12:114588050-114588801, is a retrocopy of the parental gene OSTF1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name OSTF1
Full Name osteoclast stimulating factor 1
Also known as OSF|SH3P2|bA235O14.1
Coordinate chr9:75088480-75147265
Strand +
Gene summary Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes OSTF1P1
Bonobo Pan paniscus OSTF1P1
Gorilla Gorilla gorilla OSTF1P1
Orangutan Pongo abelii OSTF1P1
Gibbon Nomascus leucogenys OSTF1P1
Green monkey Chlorocebus sabaeus OSTF1P1
Crab-eating macaque Macaca fascicularis OSTF1P1
Rhesus Macaca mulatta OSTF1P1
Baboon Papio anubis OSTF1P1
Golden snub-nosed monkey Rhinopithecus roxellana OSTF1P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>OSTF1P1
gACAGCAAACCAGACAAAAAGTAACTCTGAGGTGCTTGGAGTGCCAGGTAGCAGGCAAGCAGTGGGCTTTTCAGCGTCGTCTTTAGAATATGCAGCTCAAGGAAGTGAGATGTCAAAGCTGCCACCCAAACCGGTCAAACCAGCGTAAGATAAAGTCTTCAGAGCCCTCTATACTTTTGAACCCAGAACTCCAGATGAACTATGCTTTGAGAAAGGTGATATCATCTACGTTACTGACATGAATGATGCAAATTGGTGGAAAGGCACCTCCAAAGGCAGGACTGGACTAACTCCAAGCAACTATGTGGCCGAGCAGGCAGAATCCATTGACAATCTATTGCATGAAGTAGCAAAAAGAGGCAACTTGAGTTGGTTGCGAGAGTGTTTGGACAACCGAGTGGGTGTTAATGGCTTAGACAAGGCTGGAAGCACTGCCTTAGACTAGGCTTGTCATGGGGATCTCAGAGATATAGTGGAAATGCTATTTACTCAACGGAGTATTTAACTGAGCCAACAGAACAAGTTGGGAGACACAGCTTTACATGCTGCTGCCTGGAAGGGTTATGCAGATATTGTCCAGTTGCTTCTGGCAAAAGGTGCCAGAACAGACTGAAGAAACAATGAGAAGAAGCTGGCTTTGGGCATGGCTACCAATGCCCATGCGTCTCTCCTGAAAAAGAAACAGGAGACAGATGCAGTTCGAACATTAAGCAATGC
>NM_012383.5
ACTCGGCGGAGCCGCTCTGCCTGCGTCCGCTCTTCCCGCAGCCAAGGGTGGGCGCCGGTCCTAGGAGGCGCACGGTTGTAAGCCAGACAAAAAGAACTGGGGTGCCCGGAGTGCCAGGTGGCGGGCAAGCGGTGGGCTTTTCGGCGGGGTCTTTAGGATTTGCAGCTCCAGGAAGCGAGATGTCGAAGCCGCCACCCAAACCAGTCAAACCAGGGCAAGTTAAAGTCTTCAGAGCCCTGTATACGTTTGAACCCAGAACTCCAGATGAATTATACTTTGAGGAAGGTGATATTATCTACATTACTGACATGAGCGATACCAATTGGTGGAAAGGCACCTCCAAAGGCAGGACTGGACTAATTCCAAGCAACTATGTGGCTGAGCAGGCAGAATCCATTGACAATCCATTGCATGAAGCAGCAAAAAGAGGCAACTTGAGCTGGTTGAGAGAGTGTTTGGACAACAGAGTGGGTGTTAATGGCTTAGACAAAGCTGGAAGCACTGCCTTATACTGGGCTTGCCACGGGGGCCACAAAGATATAGTGGAAATGCTATTTACTCAACCAAATATTGAACTGAACCAGCAGAACAAGTTGGGAGATACAGCTTTGCATGCTGCTGCCTGGAAGGGTTATGCAGATATCGTCCAGTTGCTTCTGGCAAAAGGTGCTAGAACAGACTTAAGAAACATTGAGAAGAAGCTGGCCTTCGACATGGCTACCAATGCTGCCTGTGCATCTCTCCTGAAAAAGAAACAGGGAACAGATGCAGTTCGAACATTAAGCAATGCCGAGGACTATCTCGATGATGAAGACTCAGATTAATTCCTTTCTGGAGCTTTGAGATCTAAAACTTCTGTTGCTTTTGCCATTCCAAAACTTTGTCTTTGCCAGAAAAGTGTTGGTAACTATAAAGAAAATTATATATGAACACGGCAGTGTTGCACTGTGTTTGAGTAGAACGTGTAAATGAATTGTTCCCACCTTTGGTTTGCCAGTAAGTGACTGGATTCTTGGCACATTTATGTTCACCAAAGTAGAACAAGAAGATATTATTTCTATTTATCAAGCAAAAGGAATTTTAAGATTTTTTTTTTTCTTTAAAAACAAATTAGGAttttttttttttttttttttttAGTTAAAATGCTTTACCTCAATGGTTGAGATATTTTGAATGGATTTTTCAAGGGGGGGAAATGCTTATTATAATAATAAACCAAAATACTTAACAGAAAATTGTCAGCTATTCTGACAAAAATAAACATTTTGAGAGACTTTATTTCTTTTGTCCGTTTCTGTGGTATCACTCATTGTCGTTAAGTAAGTAAAGCTTTTTATATTTAGGT

Publications

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