Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HIGD1AP8
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:11481346-11481675  UCSC
Coordinates (T2T) chr12:11350527-11350856  UCSC
Coordinates (hg19) chr12:11634280-11634609  UCSC
Strand +
Parental Sequence NM_014056.4
Parental seq. overlap 277 bp
Parental seq. overlap (%) 10.2%
Genomic Region Intergenic
Retrocopy Summary HIGD1AP8, located on chr12:11481346-11481675, is a retrocopy of the parental gene HIGD1A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HIGD1A
Full Name HIG1 hypoxia inducible domain family member 1A
Also known as HIG1|RCF1a
Coordinate chr3:42782908-42804490
Strand -
Gene summary Acts upstream of or within negative regulation of apoptotic process. Located in mitochondrion and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HIGD1AP14
Bonobo Pan paniscus HIGD1AP14
Gorilla Gorilla gorilla HIGD1AP14
Green monkey Chlorocebus sabaeus HIGD1AP10
Crab-eating macaque Macaca fascicularis HIGD1AP10
Rhesus Macaca mulatta HIGD1AP10
Baboon Papio anubis HIGD1AP9
Golden snub-nosed monkey Rhinopithecus roxellana HIGD1AP9
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HIGD1AP8
AGTTTTGTCACTCTTGGAAGATTCTCCAGGCAATCACTATTTCAGCCAGCACAGGTGTTGCTCTTTCTTCATATAAAAAAGATCAAGGATCCGAACTTATCTGAAAAGCTAAAGAGGTACCAAGTGTCCCCATTAGAATGGTGGGCTTTTCAGCAATTGTTGCATACGGATTACATGAGTTGAAGAGCAAGGGAAATACTAAAATGTCCATTCATGATCCACATGTGTGTAGCAGCCCAAGGCTTTGTTGTGGGAGCAGTGGCTCTTGTTGTGGGCTATTCCATGTTTCAGGAATTCTGGTTGAAACCTAAACCTTAGAAGAAGAGATGC
>NM_014056.4
GTGCGCCTGCAGGGATCGGAAGCCGGTTGGGGTGTGAGAGGTTTTCTCGCTCTAGGGAGATTCTTCAAGCAATCACTATGTCAACAGACACAGGTGTTTCCCTTCCTTCATATGAGGAAGATCAGGGATCAAAACTCATTCGAAAAGCTAAAGAGGCACCATTCGTACCCGTTGGAATAGCGGGTTTTGCAGCAATTGTTGCATATGGATTATATAAACTGAAGAGCAGGGGAAATACTAAAATGTCCATTCATCTGATCCACATGCGTGTGGCAGCCCAAGGCTTTGTTGTAGGAGCAATGACTGTTGGTATGGGCTATTCCATGTATCGGGAATTCTGGGCAAAACCTAAGCCTTAGAAGAAGAGATGCTGTCTTGGTCTTGTTGGAGGAGCTTGCTTTAGTTAGATGTCTTATTATTAAAGTTACCTATTATTGTTGGAAATAAACTAATTTGTATGGGTTTAGATGGTAACATGGCATTTTGAATATTGGCTTCCTTTCTTGCAGGCTTGATTTGCTTGGTGACCGAATTACTAGTGACTAGTTTACTAACTAGGTCATTCAAGGAAGTCAAGTTAACTTAAACATGTCACCTAAATGCACTTGATGGTGTTGAAATGTCCACCTTCTTAAATTTTTAAGATGAACTTAGTTCTAAAGAAGATAACAGGCCAATCCTGAAGGTACTCCCTGTTTGCTGCAGAATGTCAGATATTTTGGATGTTGCATAAGAGTCCTATTTGCCCCAGTTAATTCAACTTTTGTCTGCCTGTTTTGTGGACTGGCTGGCTCTGTTAGAACTCTGTCCAAAAAGTGCATGGAATATAACTTGTAAAGCTTCCCACAATTGACAATATATATGCATGTGTTTAAACCAAATCCAGAAAGCTTAAACAATAGAGCTGCATAATAGTATTTATTAAAGAATCACAACTGTAAACATGAGAATAATTTAAGGATTCTAGTTTAGTTTTTTGTAATTGCAAATTATATTTTTGCTGCTGATATATTAGAATAATTTTTAAATGTCATCTTGAAATAGAAATATGTATTTTAAGCACTCACGCAAAGGTAAATGAACACGTTTTAAATGTGTGTGTTGCTAATTTTTTCCATAAGAATTGTAAACATTGAACTGAACAAATTACCTATAATGGATTTGGTTAATGACTTATGAGCAAGCTGGTTTGGCCAGACAGTATACCCAAACTTTTATATAATATACAGAAGGCTATCACACTTGTGAAATTCTCTTGTCTAATCTGAATTTGCATTCCATGGTGTTAACATGGTATATGTATTGTTATTAAAGTAAGTGACCCATGTCAAATGTCTTTTATTTATTTCATGAGGAAAAGCTTTCTGTAGAGGAACAAATTTGAGAACAAGTTTCAGGAAATTGTCTTTTTTGTTGTTGTTCTCTAATCATGTTCTCCTTTCTGTTTCAACGATTTTAAAAATATTTTACTTTATGGTATGTTTTATTTTTTTTCCTTTTGTGGGTAATTTTTGTTCTATTGATTATCCATATAAAttttttttttttttttttgagacggagttattctctgtcatcttggctggcgtgcagtggcacgatcttggctcactgcaacttccatcccccaggttcaagtgattctcttgcctcagcctcctgagtagctgtgattacaggcatgcaccaacatgcctggctaatttttgtatatttagtagagacgaggtttcaccatgttggccaggctgatcttgaattcctgacctcaggttatccacctgcctcggcctcccaaagtgctaggattacaggcgtgagccaccacgcccagcTGATTATCCATATAATTATAACACTCTTCTATTTATTTTCAGTCACCAATAATTCCTTTTGAGCAATATTTAAGCCTAGCATATTTCTTCCTTCCCTCCTCCTCTACTAACCAGTTCTGGTCGATATATTATTGGATTTTACTCTTATACtgtttgtttgtttgtttgtttgtttAttttgagacagagtcttgctctgttgctgaggctggagtacagtggtgtgatctgagctcacggcaccctccacctcctagcttcgtgcgattctgatgcttcaaccttccgagtagctgggattacaggcatgcgccaccatgtcgggctaatttttgtgtttttagtaaaggcgaggtttcaccatgttggatgatcttgaactcctggcttcaagagatctatctgcctcagcctcccaaagtgctgggattacaagcataatccaccacacctgaccTACTTTTGTATGTTAAATGTGATTATACTTctctttgacttgtcagcttagctttagctgatacactctggtgcccaactattattgtatcagtgaacttccactttcttttccttttctctcaatttttgttgtatcattcctaccttgtgaggacatataatatttacattctgttgtcatcctcacatttcttagttccacagtttaaatgtatttgaaactcaaaacattcccattaatctcttggtcagctgaaattaatgatttaatagtttccttaaaaaagactcatggaacaatttccctaaatttttgccatgtcaaatatgtttatctgtagcctttacacagtaaaaacaatttggctagataatacaattctcagttcatatttttctttggaatattaaagtattgctatagagaa

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