Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CLIC1P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:120914391-120915366  UCSC
Coordinates (T2T) chr12:120903485-120904460  UCSC
Coordinates (hg19) chr12:121352194-121353169  UCSC
Strand +
Parental Sequence NM_001287594.3
Parental seq. overlap 894 bp
Parental seq. overlap (%) 82.4%
Genomic Region Intergenic
Retrocopy Summary CLIC1P1, located on chr12:120914391-120915366, is a retrocopy of the parental gene CLIC1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CLIC1
Full Name chloride intracellular channel 1
Also known as CL1C1|CLCNL1|G6|NCC27
Coordinate chr6:31730581-31737318
Strand -
Gene summary Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CLIC1P1
Bonobo Pan paniscus CLIC1P1
Gorilla Gorilla gorilla CLIC1P2
Orangutan Pongo abelii CLIC1P1
Gibbon Nomascus leucogenys CLIC1P2
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CLIC1P1
GGACGCAACCACGGCGGAAGAACAACTGCCAGTCTAACTGTGCGTGAAGGCTGGCAGTGATGGGGCCGAGACTGGGAACCGCCCCTTCTCCCTGAGACTGTTCATAGTGCTGTGGGTCACAGGAGTCACCTTCAACGTTACCACCATTGACACCAAGAGACAGACTGAGAGAGTGCAGAAGCTGTGCCCAGGAGGGCAGCTCCCATTCCTGCTGCATGGCACTGAAGTGCACACAGACACCAACAAGATGGTGGAATTTCTGGAGGCAGTACTGTGCCCTCCGAGATACCCCAAGCTGGCAGCTCTGAACCCTGAGTCCAACACAGCTGGGCTGGACATATTTGCCAAATTTTCTGCCTACATCAAGAATTCAAACCCAGCACTCAATGATAATCTGCAGAAGGGACTCCTGGAAGCCCTGAAGGTTTTAGACAATTACTTAACATCCCCCCTCCCAAAAGAAGTAGATGAAACCAGTGCTGAAGATGAGGGCATCTCGCAGAGGAAGTTTCTGAATGGCAATGAGCTCACCCTGGCTGACTGCAACCTGTTGCCAAAGCTACACATAGTACAGGTGGTGTGTAAGAAGTACCGGGGATTTAACATCCCTGAGGCCTTCCCGGGAACGCGTCAGCACTTGAGCAATGCTTATGCATGGGAAGAACCCGTCTCCACCTGCCCAGATGATGAAGAGATCCAGCTCGCCTATGAGCAAGGGGCCAATGCCCTCAAATAAGCCCCTCCTGGGACTCCCTCAACCCCCTCCATTTTCTCCACAAAAGCCCTGGTGGTTTCCATATTGCAACCCAATGGACACACTCCAAAATGGCCAGTGGACAGGGAATCCTGGAAGACTTGTTCTGGGATGGTGTGGGGAAGAGGGGATGAGGGAAATAAATGGGGGGCTGGGTGAGATTTTTATTGTGGGGTGGGATGGGCAGGACAACATATTTCAGTAATAAAATAGAGAAAAAAA
>NM_001287594.3
CTCTGATCCAGCCCGGGAGAGGACCGAGCTGGAGGAGCTGGGTGTGGGCCCCTCCCAGTTCCCCCAGGGACGGCCACTTCCTGGTCCCCGACGCAACCATGGCTGAAGAACAACCGCAGGTCGAATTGTTCGTGAAGGCTGGCAGTGATGGGGCCAAGATTGGGAACTGCCCATTCTCCCAGAGACTGTTCATGGTACTGTGGCTCAAGGGAGTCACCTTCAATGTTACCACCGTTGACACCAAAAGGCGGACCGAGACAGTGCAGAAGCTGTGCCCAGGGGGGCAGCTCCCATTCCTGCTGTATGGCACTGAAGTGCACACAGACACCAACAAGATTGAGGAATTTCTGGAGGCAGTGCTGTGCCCTCCCAGGTACCCCAAGCTGGCAGCTCTGAACCCTGAGTCCAACACAGCTGGGCTGGACATATTTGCCAAATTTTCTGCCTACATCAAGAATTCAAACCCAGCACTCAATGACAATCTGGAGAAGGGACTCCTGAAAGCCCTGAAGGTTTTAGACAATTACTTAACATCCCCCCTCCCAGAAGAAGTGGATGAAACCAGTGCTGAAGATGAAGGTGTCTCTCAGAGGAAGTTTTTGGATGGCAACGAGCTCACCCTGGCTGACTGCAACCTGTTGCCAAAGTTACACATAGTACAGGTGGTGTGTAAGAAGTACCGGGGATTCACCATCCCCGAGGCCTTCCGGGGAGTGCATCGGTACTTGAGCAATGCCTACGCCCGGGAAGAATTCGCTTCCACCTGTCCAGATGATGAGGAGATCGAGCTCGCCTATGAGCAAGTGGCAAAGGCCCTCAAATAAGCCCCTCCTGGGACTCCCTCAACCCCCTCCATTTTCTCCACAAAGGCCCTGGTGGTTTCCACATTGCTACCCAATGGACACACTCCAAAATGGCCAGTGGGCAGGGAATCCTGGAGCACTTGTTCCGGGATGGTGTGGTGGAAGAGGGGATGAGGGAAAGAAATGGGGGGCCTGGGTCAGATTTTTATTGTGGGGTGGGATGAGTAGGACAACATATTTCAGTAATAAAATACAGAATAAAAATCAAGTGTTTTTACGCAA

Publications

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