Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name COPS5P2
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:123441523-123441853  UCSC
Coordinates (T2T) chr12:123438106-123438436  UCSC
Coordinates (hg19) chr12:123926070-123926400  UCSC
Strand -
Parental Sequence NM_006837.3
Parental seq. overlap 285 bp
Parental seq. overlap (%) 22%
Genomic Region Intergenic
Retrocopy Summary COPS5P2, located on chr12:123441523-123441853, is a retrocopy of the parental gene COPS5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name COPS5
Full Name COP9 signalosome subunit 5
Also known as CSN5|JAB1|MOV-34|SGN5
Coordinate chr8:67043079-67062133
Strand -
Gene summary The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes COPS5P3
Bonobo Pan paniscus COPS5P2
Orangutan Pongo abelii COPS5P2
Gibbon Nomascus leucogenys COPS5P2
Green monkey Chlorocebus sabaeus COPS5P1
Crab-eating macaque Macaca fascicularis COPS5P2
Rhesus Macaca mulatta COPS5P2
Baboon Papio anubis COPS5P2
Golden snub-nosed monkey Rhinopithecus roxellana COPS5P2
Marmoset Callithrix jacchus COPS5P3
Gorilla Gorilla gorilla Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>COPS5P2
TGATGCCTCAGAAGTCTCATATTTCAAATCTTCTTTGGATTGCAAATTGCTTGAGCGTTCGTGGACTAAATCCTGGGCGAATACACGGAGTTCCTCGAGCAGGCTTACCAATGCAGACTATAGCACTGGTTGGGTCTTTGATTTGTCTGAAAAGTTAGGGCAGTCAGAAGCGCAGCTGGGAAGAGGGAGTTTCATGTTGAGTTTAGAAGCACATGACTGAAAGTCAGAAGACAAACTCACCGAAGCTATGAGAGACACCTATGAAACCATAGAAGCCATCTGTGGACTCATGTCTAGGTTATTCAAGATAAACTGTTTAATCAAATTC
>NM_006837.3
AGGTGTCATGGCTGCCCCAAGAGTCTAGGTAAGAGTTTGTTCCCGTGGTGCGGAGGGTCAAGGCCCACACCCGGAAACCTAGCGAGGTAAAGTTGCGTCTTGGTTGTAGAGACGACAACTTCTCCGCTTCCTCGGCGATGGCGGCGTCCGGGAGCGGTATGGCCCAGAAAACCTGGGAACTGGCCAACAACATGCAGGAAGCTCAGAGTATCGATGAAATCTACAAATACGACAAGAAACAGCAGCAAGAAATCCTGGCGGCGAAGCCCTGGACTAAGGATCACCATTACTTTAAGTACTGCAAAATCTCAGCATTGGCTCTGCTGAAGATGGTGATGCATGCCAGATCGGGAGGCAACTTGGAAGTGATGGGTCTGATGCTAGGAAAGGTGGATGGTGAAACCATGATCATTATGGACAGTTTTGCTTTGCCTGTGGAGGGCACTGAAACCCGAGTAAATGCTCAGGCTGCTGCATATGAATACATGGCTGCATACATAGAAAATGCAAAACAGGTTGGCCGCCTTGAAAATGCAATCGGGTGGTATCATAGCCACCCTGGCTATGGCTGCTGGCTTTCTGGGATTGATGTTAGTACTCAGATGCTCAATCAGCAGTTCCAGGAACCATTTGTAGCAGTGGTGATTGATCCAACAAGAACAATATCCGCAGGGAAAGTGAATCTTGGCGCCTTTAGGACATACCCAAAGGGCTACAAACCTCCTGATGAAGGACCTTCTGAGTACCAGACTATTCCACTTAATAAAATAGAAGATTTTGGTGTACACTGCAAACAATATTATGCCTTAGAAGTCTCATATTTCAAATCCTCTTTGGATCGCAAATTGCTTGAGCTGTTGTGGAATAAATACTGGGTGAATACGTTGAGTTCTTCTAGCTTGCTTACTAATGCAGACTATACCACTGGTCAGGTCTTTGATTTGTCTGAAAAGTTAGAGCAGTCAGAAGCCCAGCTGGGACGAGGGAGTTTCATGTTGGGTTTAGAAACGCATGACCGAAAATCAGAAGACAAACTTGCCAAAGCTACAAGAGACAGCTGTAAAACTACCATAGAAGCTATCCATGGATTGATGTCTCAGGTTATTAAGGATAAACTGTTTAATCAAATTAACATCTCTTAAACAGTCTCTGAGAAGTACTTTACCTGAAAGACAGTATGAGAAAAATATTCAAGTAACACTTTAAAACCAGTTACCCAAAATCTGATTAGAAGTATAAGGTGCTCTGAAGTGTCCTAAATATTAATATCCTGTAATAAAGCTCTTTAAAATGAAA

Publications

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