Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AP3S1P4
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:12451178-12452579  UCSC
Coordinates (T2T) chr12:12320335-12321738  UCSC
Coordinates (hg19) chr12:12604112-12605513  UCSC
Strand -
Parental Sequence NM_001318090.2
Parental seq. overlap 583 bp
Parental seq. overlap (%) 38.8%
Genomic Region Intragenic (BORCS5)
Retrocopy Summary AP3S1P4, located on chr12:12451178-12452579, is a retrocopy of the parental gene AP3S1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AP3S1
Full Name adaptor related protein complex 3 subunit sigma 1
Also known as CLAPS3|Sigma3A
Coordinate chr5:115841606-115914081
Strand +
Gene summary This gene encodes a subunit of the AP3 adaptor complex. This complex functions in the formation of subcellular vesicles budded from the Golgi body. Several related pseudogenes of this gene have been found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AP3S1P4
Bonobo Pan paniscus AP3S1P3
Gorilla Gorilla gorilla AP3S1P2
Orangutan Pongo abelii AP3S1P3
Gibbon Nomascus leucogenys AP3S1P3
Green monkey Chlorocebus sabaeus AP3S1P1
Crab-eating macaque Macaca fascicularis AP3S1P2
Rhesus Macaca mulatta AP3S1P3
Baboon Papio anubis AP3S1P2
Golden snub-nosed monkey Rhinopithecus roxellana AP3S1P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AP3S1P4
AGTTCAATGTTGCTTTTCTTGCTCAGTGATTTTAAGGAAATTGAGTAGTTCCTATGTGATTTATTTATTTTTCTAAACTGCATTCCTGTGCCTACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAAGTGTTTGAGATATTTCTTTAATTATGTACAACCTAAAGTGTTGGTGTTTTGTATGGATCACAAGTGCGGCATTCCTTAATTCCTTCTGCTGTTTGTCACACAATTGTTAAAGAACCAGATATGTATCGCATGAAAACATTATGACGTTTTTCTCTTAGTTTAAATAAACTCCAAGGTAACTGGACTTCTAAAGCACCTTTCTGTTTGCCTGATACCTACTTTAGCAATAATTTTTTTTACAACCCTCTGACTCAACAAAGTAAAGTATATTTTATCACTGTTAAAGGGTGGGGAAGGATCGCCGGCAAGATCACGAGGCGAGGCTTGCGCGCCGGCCCGCACCCTGGCCCCCAGTGCCTACCCGGTGGGCCCGACCCAGCCACGATCAAGGCGATCCTAATCTTAACAATCATGGGAAACCGCGGCTCTCCAAGTTCTACCAGCCCTATGGATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTTTGTGAACTGGATTTGATTTTCCATGTAGACACGGTTCACAATATTCTTGCAGAAATGATGATGGGGGAATGGTATTGGAGACAAACATGAATGGGATTGTTACACAAATTGGTGCACAAAATAAGCTGGAAAAATCTGAGGCTGGCTGAGGGGGAGCTTCAGCCTGTGCTGAACCTGTATCAGCTGTAAAAAATGTGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATTACTATAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATTTAAAAAGGCTACTCCCAGGTAAAATCCAGGGGGGAAAGTCACGTAAGTTTACCAAAAATAGAGGAGGACAGTCAAGTTTTGCTCTTGGATTTAAGTCAAGGTACTGTATAAAAGCTGTGTAAAATCAATATGAAAGTTCAATGCTGCTTTCCt
>NM_001318090.2
AGGGGGCGGGTGGGGAAGGATCGCAGGCGAGATTACGAGGCGAGGCTCGCGCGCCCGCCCCCGCCCTGGCCCCCAGTGCCCACCCGGTCGGCCCGGCACAGCCATGATCAAGGCGATCCTAATCTTCAACAACCACGGGAAGCCGCGGCTCTCCAAGTTCTACCAGCCCTACGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGATTTGATTTTCCATGTAGACAAGGTTCACAATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTGTTACACAAATTGATGCACAAAATAAGCTGGAAAAATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAAATCCAGGGGGAAGAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGTCAAGGTACTGTATAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCCTATGTGATTTTTTTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAAGTGTTTCAGATATTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCATTCCTTAATTCCTTCTGCTATATGTCACACAGTTGTTATTTGGAGAACCAAGTATGTATTGCATGAAAACATTATGACTTTTTTCTCTTAGTTTAAATAAACTCCAAGGTAACTGGACTTCTAAAGCACCTTTCTGTTTGCCTGATATCTACTTTAGCAATAATTTTTTTTACAACCCTCTGACTCAACAAAGTAAATAAAAGTATATTTTATCACTATTAA

Publications

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