Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TPD52L2P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr20). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:132745551-132745906  UCSC
Coordinates (T2T) chr12:132796172-132796527  UCSC
Coordinates (hg19) chr12:133322137-133322492  UCSC
Strand +
Parental Sequence NM_001243892.2
Parental seq. overlap 301 bp
Parental seq. overlap (%) 13.8%
Genomic Region Intragenic (ANKLE2)
Retrocopy Summary TPD52L2P1, located on chr12:132745551-132745906, is a retrocopy of the parental gene TPD52L2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TPD52L2
Full Name TPD52 like 2
Also known as D54|TPD54
Coordinate chr20:63865247-63891538
Strand +
Gene summary This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TPD52L2P2
Bonobo Pan paniscus TPD52L2P2
Gorilla Gorilla gorilla TPD52L2P1
Orangutan Pongo abelii TPD52L2P1
Gibbon Nomascus leucogenys TPD52L2P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TPD52L2P1
GAGACCTCAGCGGCCCTGTCCATGGTGGGCTCTGCCATCAGTAGGAAGCTCGGAGACGTAAGGAAATTTGCAACTTTCAAGTCGTTTGAAGACCAAGTTGGGCCCATGAAGTCTAAGGTCGTGGGTGACAGAGAACAGCAAGGACAATCTCCCTTCCTCAGCAGGGAGGGGCGACGAGCCCGTCGGATCCCGCACCTCTCTAAGCCTGTGGTCGCTTACGCTCAGCTGCAGAGCACACACACACACCCTCAGCATCACAGCCGGAGCTCTGAGCAACAAAGCGGCCAGCCAGGACGCACACGCAGAGCCGGCTTTGAGAATAGTCCTGCCCATCCACAAGGAGACGTGGCTACCGC
>NM_001243892.2
AGTTCCGCTGGCTAGTGTGTACGCGGCGAGCTTCTCCCGGCGCCGCCCGCTCGGCTCCCATAGCGCCCGCGACAGCGGTCCGGACGCCGCCCGAACATGGACTCCGCCGGCCAAGGTGTGGCTGCCCGGACTCCTGCTGTTGAGGGTCTGACAGAGGCTGAGGAGGAGGAGCTCAGGGCTGAGCTTACCAAGGTGGAAGAGGAAATTGTCACTCTGCGCCAGGTCCTGGCAGCCAAGGAGAGGCACTGTGGAGAGCTCAAGAGGAGGCTGGGCCTCTCCACCCTGGGGGAGCTGAAACAGAACCTGTCCAGGAGCTGGCATGACGTGCAGGTCTCTAGCGCCTACAAGAAGACTCAGGAAACTCTTTCACAGGCAGGACAGAAGACTTCAGCTGCCCTGTCCACAGTGGGCTCTGCCATCAGCAGGAAGCTTGGAGACATGAGGAACTCTGCGACCTTCAAGTCGTTTGAGGACCGAGTTGGGACCATAAAGTCTAAGGTTGTGGGTGACAGAGAGAACGGCAGTGACAACCTCCCTTCCTCAGCGGGGAGTGGTGACAAGCCCCTGTCGGATCCCGCACCTTTCTAAGCCTGTGGTTGCTTCACCCGCTGCAGAGCACACGCAACCCAGCCTCAGCATCACAGCCGCAGCTCTGTTCAGCGGAGCAGCCAGCCAGGGCGGATGAGCAGAGCCGGCCCTGAGGACAGTCCTGCCCATCCACGCGGAGATGTGGCTGCCGCGTTTGCATGAATTTGAAGAACACAGGCTTGTACACAGATGTTTTACACTCACGTTTGTAGATGAAACAGATCACTGTGCTGTCCTTCCTAGGGGTGCAGGAAGTGGACAGGGCGGAGGGTTTGAAAGAATATTGAGCCAAAGCCCAGGCTCCCTTTGGGAATCATGTTAGCCCATCAGAATGTTGAAGGATTGAAGAGTTCTAAGCATAAAATAAGTGGCATTTTCTGACTTCTTCCTCCTCCTCCTTCCCTGACTCACAGAAGGAATGCAATCACCCAGCAAGTCCTACCTGTTACGCAATTTTTTATCTCAAAATGCCGAACGAGAAAACTGTCCATTTTCTGAGACCCCCAGAAAGGAAACTGACCCTCAGCAGCTGCCTGATTGTTACGCGAATCTAGCTTTAACGGAAGCAAATTCATTATTTTTTAAATGCAGTGGACTTTTCAAAAAGTTTAAATTAGGCAAAGCAGCTTTAGCCTCATAGAATATTATTTCTTTGGACTCAAGCTGAAATACAAGCCTTACATTGCCTTATGCTTTATTTCTTTCTAATTTTTATATGTATATAGATGAGGGTTCCTTAATGGTTGTGAGCATTGTGTGGAATTTTACACCTGGCCTGCGTGGCAGCCTCTTCCAGTTGAGGTGTTTTATGTCACGCACACTCCATCCCAGTGTACAAAACCTGCTTCTCTTCTCAACCGTGGCAGCTCCCGCTGGCTCCTATGCCCTGCCCTAAAGGGCTCTTGAGCCTCTGGGAATGGGAGGGGCCAAGAGAAGGAAAACCCTGTCTTTAGCACCCTTTAAAAGAACTGTGCCCCCCTTCTCAGTGCTGCCTTTGCATGGGCCTGGCCCGGCTCACATTCGTCAGTGACTCCAACCCTCCTGCTTGCTGTACTTGGGATGAAACGACCCCACAGGTCAGGTGGAGGGTGGGGCGTGGGCATCAGCCAGGATTGCCGTTACAGTCTTTTTCTCAGGAGCTACAAAGATCTCTTCCTGTTACTAAATAGTCGCACCCCAGCAGCCTCTCTCGCACACCGGGGCCCTGCATGTCAGATGGCGTGGTCTGCAGGGGGAGCTCTGTGCCTTAGTGGCTCTTGGCAGGACACTGAGGGCCTGCCTGTGGTGTGCCCGGCTCTGCCACTCCCGGGAGGGGAAGGGCTGCTCAGCTCAAGGTGTCCTGTTCGGTAGAGCAAGTGTCCTCTGACAGCCGTGTCCCCGGACAGTTCAGACACCCTTGGGGATGGCACTCCACACACGACAGAGATGCAGGGGCCAGGGAAGCCCAGCGCTCGGTGCCCTTCGTCCAGGGTTAAAATCGGCCTGTGGGGTGTGGTGAGAAGGCAGGTTGTGCGGGTGTTGACCGATGTATCTTTTCCTTAAAGTTATTATAATAATGGGTAATTTGTCAATAAAGCATTCCTTTGGGGGAAA

Publications

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