Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name EGLN3P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:15970658-15972609  UCSC
Coordinates (T2T) chr12:15847923-15849868  UCSC
Coordinates (hg19) chr12:16123592-16125543  UCSC
Strand -
Parental Sequence NM_022073.4
Parental seq. overlap 1121 bp
Parental seq. overlap (%) 37.5%
Genomic Region Intragenic (DERA)
Retrocopy Summary EGLN3P1, located on chr12:15970658-15972609, is a retrocopy of the parental gene EGLN3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name EGLN3
Full Name egl-9 family hypoxia inducible factor 3
Also known as HIFP4H3|HIFPH3|PHD3
Coordinate chr14:33924227-33951074
Strand -
Gene summary Enables peptidyl-proline 4-dioxygenase activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and response to hypoxia. Located in cytosol and nucleus. Implicated in renal cell carcinoma. Biomarker of clear cell renal cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes EGLN3P1
Bonobo Pan paniscus EGLN3P1
Gorilla Gorilla gorilla EGLN3P1
Orangutan Pongo abelii EGLN3P1
Gibbon Nomascus leucogenys EGLN3P1
Green monkey Chlorocebus sabaeus EGLN3P1
Crab-eating macaque Macaca fascicularis EGLN3P1
Rhesus Macaca mulatta EGLN3P1
Baboon Papio anubis EGLN3P1
Golden snub-nosed monkey Rhinopithecus roxellana EGLN3P1
Marmoset Callithrix jacchus EGLN3P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>EGLN3P1
GAGTTGAGATATAAAGATGGCCTCTTCAGTGACGAAAAACTCCCCATCCCTGTCTTATGTGTGGGACTTAGTGTTTTCTTGCCAAGACTGCATGGACCTTCAGATGCTCTCTTTGCCAGATGAACTCATTTGCTATTCCACCTCCAGAAATTCCAGCAGACATACCAGTTGGCCAGCAGTTTACCTGATAGATTTGGTAACGCTGGCTATCAAGACAAGAGCCTAGGAGCACATGTGAGGAAAATAATCTTGTATTTTATGTATATTTCCTGATTTGAAAGGTTTGAAAAAGAAAAACAACGGCAGATGCCACAGAAAGGCACAATGGAAGCCTTAAAACAGAAAACAGAAATTTATGTCATCTGAACAATTTCCAGATGTTATTAATCCGGGGCTGTTGAAGTCTCTGGAGAATTGTCACAACCTAATGACAACATTATTACCTCTATAAAGGGCTGCTGTCATAGTGATCAATCTGTACATGTCCCATGGTGTGGACACTCCTTTTTCCAAATCTTACAACCTGGATTTTCTGCCTTGGCCCCATTTTGCTAAAAATAATGACTTTCTGAATAAAGATGGTAACACCATTTATTCTCTATTTTCACTTCTTACCTGAAGAATGTAATCCCCAGAAGCTAAAACTAGACATTAGGTTTTTTCATGTTGCTTTGGTGGAATGGAATCTGAATTTAAACCAAAGGATAAATATCTACTTGGTAGTTTGGTGTCAACCTCTGAAAACAACATGGAAAGAATCAGGTCTACAGATATACCAAGTACATGTGTACATCTTGAACAGTCTGAAAAGAGAGATGGAGTTGGAAATGTGGGTGTACCTGTTTTTTTTCATGCCCCTGGGACACATCATGAGGCAGGAATTGGAGAAAATTTCCCTAGAGTACATCATGCGCTGTCTGCGGGAAGTCAGCTTCTGCTACCCGCAAAACTTCCTGGGCAAGGAGGTGGTGGACAACTGCATCCAGGAGCACATTAAACAGCTGCATTGCAAGGGGGCCCTGCGGGACAGCCAGCTGGCTGGGATGTGTGCAGTGTCTCTAAAGGGTGAACTGTGGGGTGATCAGTTCACCCCACAGTTCTGGGAGCAACAAGAAGGGCCGCGAGGCCATTGGCTTCCTCCTGTCCCTCACTGACAGGCTAGTCCTCTAGTGCAGGAGCCACTGGGAAAATACTATGTCAAGGAGAGGTCCAAGGCAATGGTGGCTTGCTATCTTAAAAATGGAATAGGTTACATTCATCATGTGGACACCTCAACAACGATGGCTGCTGCACCACCTGCATCTACTATCTGAACAAGAACTGGGATACCAGGCTACACGGTGGGATCCTATGGCTATTTTCAGAGGAGAAATCATTCGTGGCAGATGTGGAGGCCAATTGTGAAAAAGTCCTGCTCTCCTGGTCAGATCGCAGGAAGCTACACGAGGTGCTGTCTTCCTATGAGACCAGATGTGCTATACTGTTTGGTACTTTGATAATGAAGAAAGGACAGAAGCCAAAAAGAAATTCAGGAATTTAATTAGGAAACATCTGCCCTCACTGAAGATTGACTGTGCTCCAAAATCTGCTGGCCTTGTTCACTTTAGCAATGGTTCCTGAATTATCTTTAAGAGTTGAGATCCg
>NM_022073.4
CTGGCCGCAGTCGCGGCAGTGGTGGCTTCCCATCCCCAAAAGGCGCCCTCCGACTCCTTGCGCCGCACTGCTCGCCGGGCCAGTCCGGAAACGGGTCGTGGAGCTCCGCACCACTCCCGCTGGTTCCCGAAGGCAGATCCCTTCTCCCGAGAGTTGCGAGAAACTTTCCCTTGTCCCCGACGCTGCAGCGGCTCGGGTACCGTGGCAGCCGCAGGTTTCTGAACCCCGGGCCACGCTCCCCGCGCCTCGGCTTCGCGCTCGTGTAGATCGTTCCCTCTCTGGTTGCACGCTGGGGATCCCGGACCTCGATTCTGCGGGCGAGATGCCCCTGGGACACATCATGAGGCTGGACCTGGAGAAAATTGCCCTGGAGTACATCGTGCCCTGTCTGCACGAGGTGGGCTTCTGCTACCTGGACAACTTCCTGGGCGAGGTGGTGGGCGACTGCGTCCTGGAGCGCGTCAAGCAGCTGCACTGCACCGGGGCCCTGCGGGACGGCCAGCTGGCGGGGCCGCGCGCCGGCGTCTCCAAGCGACACCTGCGGGGCGACCAGATCACGTGGATCGGGGGCAACGAGGAGGGCTGCGAGGCCATCAGCTTCCTCCTGTCCCTCATCGACAGGCTGGTCCTCTACTGCGGGAGCCGGCTGGGCAAATACTACGTCAAGGAGAGGTCTAAGGCAATGGTGGCTTGCTATCCGGGAAATGGAACAGGTTATGTTCGCCACGTGGACAACCCCAACGGTGATGGTCGCTGCATCACCTGCATCTACTATCTGAACAAGAATTGGGATGCCAAGCTACATGGTGGGATCCTGCGGATATTTCCAGAGGGGAAATCATTCATAGCAGATGTGGAGCCCATTTTTGACAGACTCCTGTTCTTCTGGTCAGATCGTAGGAACCCACACGAAGTGCAGCCCTCTTACGCAACCAGATATGCTATGACTGTCTGGTACTTTGATGCTGAAGAAAGGGCAGAAGCCAAAAAGAAATTCAGGAATTTAACTAGGAAAACTGAATCTGCCCTCACTGAAGACTGACCGTGCTCTGAAATCTGCTGGCCTTGTTCATTTTAGTAACGGTTCCTGAATTCTCTTAAATTCTTTGAGATCCAAAGATGGCCTCTTCAGTGACAACAATCTCCCTGCTACTTCTTGCATCCTTCACATCCCTGTCTTGTGTGTGGTACTTCATGTTTTCTTGCCAAGACTGTGTTGATCTTCAGATACTCTCTTTGCCAGATGAAGTTACTTGCTAACTCCAGAAATTCCTGCAGACATCCTACTCGGCCAGCGGTTTACCTGATAGATTCGGTAATACTATCAAGAGAAGAGCCTAGGAGCACAGCGAGGGAATGAACCTTACTTGCACTTTATGTATACTTCCTGATTTGAAAGGAGGAGGTTTGAAAAGAAAAAAATGGAGGTGGTAGATGCCACAGAGAGGCATCACGGAAGCCTTAACAGCAGGAAACAGAGAAATTTGTGTCATCTGAACAATTTCCAGATGTTCTTAATCCAGGGCTGTTGGGGTTTCTGGAGAATTATCACAACCTAATGACATTAATACCTCTAGAAAGGGCTGCTGTCATAGTGAACAATTTATAAGTGTCCCATGGGGCAGACACTCCTTTTTTCCCAGTCCTGCAACCTGGATTTTCTGCCTCAGCCCCATTTTGCTGAAAATAATGACTTTCTGAATAAAGATGGCAACACAATTTTTTCTCCATTTTCAGTTCTTACCTGGGAACCTAATTCCCCAGAAGCTAAAAAACTAGACATTAGTTGTTTTGGTTGCTTTGTTGGAATGGAATTTAAATTTAAATGAAAGGAAAAATATATCCCTGGTAGTTTTGTGTTAACCACTGATAACTGTGGAAAGAGCTAGGTCTACTGATATACAATAAACATGTGTGCATCTTGAACAATTTGAGAGGGGAGGTGGAGTTGGAAATGTGGGTGTTCCTGttttttttttttttttttttttagttttcctttttAATGAGCTCACCCTTTAACACAAAAAAAGCAAGGTGATGTATTTTAAAAAAGGAAGTGGAAATAAAAAAATCTCAAAGCTATTTGAGTTCTCGTCTGTCCCTAGCAGTCTTTCTTCAGCTCACTTGGCTCTCTAGATCCACTGTGGTTGGCAGTATGACCAGAATCATGGAATTTGCTAGAACTGTGGAAGCTTCTACTCCTGCAGTAAGCACAGATCGCACTGCCTCAATAACTTGGTATTGAGCACGTATTTTGCAAAAGCTACTTTTCCTAGTTTTCAGTATTACTTTCATGTTTTAAAAATCCCTTTAATTTCTTGCTTGAAAATCCCATGAACATTAAAGAGCCAGAAATATTTTCCTTTGTTATGTACGGATATATATATATATAGTCTTCCAAGATAGAAGTTTACTTTTTCCTCTTCTGGTTTTGGAAAATTTCCAGATAAGACATGTCACCATTAATTCTCAACGActgctctattttgttgtacggtaatagttatcaccttctaaattactatgtaatttattcacttattatgtttattgtcttgtatcctttctctggagtgtaagcacaatgaagacaggaattttgtatatttttaaccaatgcaacatactctcagcacctaaaatagtgccgggaacatagtaagggctcagtaaatacttgttgaataaaCTCAGTCTCCTACA

Publications

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