Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FBXO3P1
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Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:18424565-18426409  UCSC
Coordinates (T2T) chr12:18300490-18302333  UCSC
Coordinates (hg19) chr12:18577499-18579343  UCSC
Strand +
Parental Sequence NM_012175.4
Parental seq. overlap 1325 bp
Parental seq. overlap (%) 54.1%
Genomic Region Intragenic (PIK3C2G)
Retrocopy Summary FBXO3P1, located on chr12:18424565-18426409, is a retrocopy of the parental gene FBXO3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FBXO3
Full Name F-box protein 3
Also known as FBA|FBX3
Coordinate chr11:33740944-33774520
Strand -
Gene summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FBXO3P1
Bonobo Pan paniscus FBXO3P1
Gorilla Gorilla gorilla FBXO3P1
Orangutan Pongo abelii FBXO3P1
Gibbon Nomascus leucogenys FBXO3P1
Green monkey Chlorocebus sabaeus FBXO3P1
Crab-eating macaque Macaca fascicularis FBXO3P1
Rhesus Macaca mulatta FBXO3P1
Baboon Papio anubis FBXO3P1
Golden snub-nosed monkey Rhinopithecus roxellana FBXO3P1
Marmoset Callithrix jacchus FBXO3P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

Related Sequence

>FBXO3P1
ATAGCAACACCTGAGGATATTAGCATTTCAGTTTCCCCATAGTTTCTGCCAGAACTTAGCTTCTGTACATCAACCCCACTATTCCTTCACACACCGAATTAAGATTGTCAAAAGATGCTATTCCTGAGAAGGCTTGTCAGTTGGACAGTTGCTAGTGGAGACTAACGAATGCTAAAGGTGAAGTAGAAGAAGTTCAAGGACCTGGATTAGCTTGTGAATTTCCAGTCATCAGCCCAGGCTGGGTATATGACTGGAGCAGCTGTACCACATTCTCTACAACACCACGATATATGGAAGGGTATTATACCTACCATTTCCTGTACTTTAAATATCTTTAATGTTGCCATTCTCCAATTCCATATGGCATGTCCAACGTTCAGGGTGTCTATAGTATGATTGGAAATGGGTCCTGATGAATATGAAGAGATGGAAGAGAAAGATGAGGGGGAGGAGAAAAAATGATAATGATGATGCTGATGATGATTCAGCAGATATGGATGAATCAGAAGAAGATGAGGAGAAAGAGAGAGTAGAGTCTTTGATGTTCCCATTTGTAGATGCCACTGCTCGTGCCTTTTTTAGCAAGCCTTCTGCTGATGGAAGCATTGGGATGATTCTAGTCTGCTAAATAGATTTCTCAATAATGTAAATAACTAAATTATTCTCAGCATATAGCAGGAAAACCAGAATGAAATATTGTTCCAGGCCCTGTGTTCTGTATGACATTACATTAGGAATTGGATTGTTTTGGTTTGTTTTGTGTTTTTGAAGTAAAGAAGGAAATGGGTTGCTTTTTTTCTCTAGCTAAAGGACAGACAcTGACATTTCTTCCTTTTAAAATATTTTATACTTAAAAACATAGAGAAATGGAGAGAGAATTGTTTTGAATAAGGATTTAAAGTGTAGCAGAAATACCTACACAAGGGTAGATAAATACCATGTGACTGAATGATTCTGTGAAAAGATTTCCTGAAGTTAAGAGTTATTTATAAATGAAATAAAATTTCTAATTAGGCCAATCCATGTAGTGATTTCTTATATTTTGTACTCACAGAGAACTAATTGGATAAATAACTTGAATGCTAGTGGTTTGTCCTTTCTTACACAATATATCCTTGGATTTAAAGTCTTTGTCATCAAGACCTTGACTTTGAATTTTTCATCACTACAACCTTGAATTTAATTTCAAGTCTTCAACATGATGACCTTGAATTTAAAGTCTTCAACACTATGACCTTTATCATATTATTCATAGATGCATCATTTTTGAAATGTAGTATGTAAAAGTATTTATGGGTTGTTTATTAACAAAAAAAATTCTTTGCGATGTCTCATGTGGTTTAAAATTACTATTTCTGTTTTGTTTCTCCTTTATACACTTGACTATCTAACTTTGTGATAAGTGACATGAATTTTATGTTAGGATTAAGTGTGTTTTCCTGAAACATTGATTTTTTTTTGTGATTATATAATTGAGAGTTAAGAATAAAATCCTTCTAATGTTAAAAACTCACTTATTAAAAACAAATTTTGGTTCCAA
>NM_012175.4
agacctgcaccgggccaggCAAGATGGCGGCCATGGAGACCGAGACGGCGCCGCTGACCCTAGAGTCGCTGCCCACCGATCCCCTGCTCCTCATCTTATCCTTTTTGGACTATCGGGATCTAATCAACTGTTGTTATGTCAGTCGAAGACTTAGCCAGCTATCAAGTCATGATCCGCTGTGGAGAAGACATTGCAAAAAATACTGGCTGATATCTGAGGAAGAGAAAACACAGAAGAATCAGTGTTGGAAATCTCTCTTCATAGATACTTACTCTGATGTAGGAAGATACATTGACCATTATGCTGCTATTAAAAAGGCCTGGGATGATCTCAAGAAATATTTGGAGCCCAGGTGTCCTCGGATGGTTTTATCTCTGAAAGAGGGTGCTCGAGAGGAAGACCTCGATGCTGTGGAAGCGCAGATTGGCTGCAAGCTTCCTGACGATTATCGATGTTCATACCGAATTCACAATGGACAGAAGTTAGTGGTTCCTGGGTTATTGGGAAGCATGGCACTGTCTAATCACTATCGTTCTGAAGATTTGTTAGACGTCGATACAGCTGCCGGAGGATTCCAGCAGAGACAGGGACTGAAATACTGTCTCCCTTTAACTTTTTGCATACATACTGGTTTGAGTCAGTACATAGCAGTGGAAGCTGCAGAGGGCCGAAACAAAAATGAAGTTTTCTACCAATGTCCAGACCAAATGGCTCGAAATCCAGCTGCTATTGACATGTTTATTATAGGTGCTACTTTTACTGACTGGTTTACCTCTTATGTCAAAAATGTTGTATCAGGTGGCTTCCCCATCATCAGAGACCAAATTTTCAGATATGTTCACGATCCAGAATGTGTAGCAACAACTGGGGATATTACTGTGTCAGTTTCCACATCGTTTCTGCCAGAACTTAGCTCTGTACATCCACCCCACTATTTCTTCACATACCGAATCAGGATTGAAATGTCAAAAGATGCACTTCCTGAGAAGGCCTGTCAGTTGGACAGTCGCTATTGGAGAATAACAAATGCTAAGGGTGACGTGGAAGAAGTTCAAGGACCTGGAGTAGTTGGTGAATTTCCAATCATCAGCCCAGGTCGGGTATATGAATACACAAGCTGTACCACATTCTCTACAACATCAGGATACATGGAAGGATATTATACCTTCCATTTTCTTTACTTTAAAGACAAGATCTTTAATGTTGCCATTCCCCGATTCCATATGGCATGTCCAACATTCAGGGTGTCTATAGCCCGATTGGAAATGGGTCCTGATGAATATgaagagatggaagaagaggaggaggaggaagaggaggaagacgaggatgatgattcagcagatatggatgaatcagatgaagatgatgaagaggagagacggaggagAGTCTTTGATGTTCCCATTCGCAGACGCCGCTGCTCACGCCTTTTTTAGCAAGCCTTCTGCTGATGGAAGCACTAGGATGATTCTAGGCTGTTAAATAGATTTCTCAATAATGTAAATAACTAAATTGTTCTCTGCATATAGCAGGAAAACTAGCATGAAATATTGTTTCAGGCCCTGGGTTCTATGTGACACTACATTAGGAATTGGATTGTTTGGGTTTGCTTTGTGTTTTTGAGGTAGAGGAAGAAATGGGAATCTTTTTTTTCTCTTCCAGGAGTCAGTGGAAGAATAGTTCTCTAGCTAAGGAATGGACATACCTTTGTTTTAAAATATTTTATACTTACAAAAATCTAGAAATGGAGAGGGAACTGTTTTGAATAAGGATTTAAAATACCTGCACAAGGATAGAGAGAAACTATGTGACTCATTCTGTGAAAAGACTTCTTGCAGTTGTGAGTTATTTAGAAATGATCAAAATTTGTAATTAGGCTAATCCATTTAGTGATTCCTAATATTTTGTACTCACAGAGAACTAATTGACTAAACAACTTGAACGCTAGTGGTTTGTCCTTAGACAATCTGTCTTTGAATTTAAAGTCTTTATCGCTAAGACCTTGACTTTAAATTTTTCATCACTACAACCTTGAATTTAATTTCAGGTCTTCAACATGATGACCTTGGATTTAATTTAAAGTCTTCAACACTATGCGCTTTATCATATTATTCACAGATGCATTTTTGAAATGTAGTATGTAAAAGTATGTAACGTGCTGTTTATTAACAAAAGATTGTTCACAACATCTCATGTAGTTTAAATTTGTAAATACTGCTTCTGTTTTGTTTCTCCTTTATACACTTGACTGTCTTTGTGATAAGTGACATGAATTTTATGTTAGGATTAAGTATGTTTTCCTGAAACTTGGATTTTTTTTGTAATTATATAATTGAGAGTTAAGAATGAAATCCTTCAAGTGTTAAAAACTCACATTTTAAAAGCAAATTTTGGTTCCAA

Publications

PMID - Link Title
No publications available for this retrocopy