Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PEA15P1
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:19418958-19419262  UCSC
Coordinates (T2T) chr12:19295729-19296033  UCSC
Coordinates (hg19) chr12:19571892-19572196  UCSC
Strand -
Parental Sequence NM_003768.5
Parental seq. overlap 262 bp
Parental seq. overlap (%) 10.8%
Genomic Region Intragenic (AEBP2)
Retrocopy Summary PEA15P1, located on chr12:19418958-19419262, is a retrocopy of the parental gene PEA15. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PEA15
Full Name proliferation and apoptosis adaptor protein 15
Also known as HMAT1|HUMMAT1H|MAT1|MAT1H|PEA-15|PED|PED-PEA15|PED/PEA15
Coordinate chr1:160205384-160215376
Strand +
Gene summary This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PEA15P1
Bonobo Pan paniscus PEA15P1
Gorilla Gorilla gorilla PEA15P1
Orangutan Pongo abelii PEA15P1
Gibbon Nomascus leucogenys PEA15P1
Crab-eating macaque Macaca fascicularis PEA15P1
Rhesus Macaca mulatta PEA15P1
Baboon Papio anubis PEA15P1
Golden snub-nosed monkey Rhinopithecus roxellana PEA15P1
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PEA15P1
GCGGCGGCGCTGGGAGCCGAGGAGGAGGAGGCTCCGGGTGCTGCTCAGGAACTGGGGACCCACGAGTGCCTGCACCCTGAGTGTTCAGCTCCAGAGGCATGATGGCTGGGTATGGGACCCTCCTCCAGGATCTGACCAACAATATCACCCTTAAAGATCTGAAACAGCACAAGTCAACCTGTAAGAAGGACATCCCCAGTGAAAAGAGTGAGGAGATCACTACTGGCGATGTCTGGTTTAGCTTCCTGAAGAGCCACTAGCCGGACAAAGACAACCTCTCCTACACTAAGCACATCTTTGAGATA
>NM_003768.5
GGCTCCGCGggcggaagaggcggcggcggcggcagaagcggcggcggcggcggcggGAGCCGAGGAGGAGGTTCCGGACGCTGCTTAGGAACCGGGGACTCAGGAGTGCCCGCGCCCTGAGCGCTCAGCTCCAGAGGCGTCATGGCTGAGTACGGGACCCTCCTGCAAGACCTGACCAACAACATCACCCTTGAAGATCTAGAACAGCTCAAGTCGGCCTGCAAGGAAGACATCCCCAGCGAAAAGAGTGAGGAGATCACTACTGGCAGTGCCTGGTTTAGCTTCCTGGAGAGCCACAACAAGCTGGACAAAGACAACCTCTCCTACATTGAGCACATCTTTGAGATCTCCCGCCGTCCTGACCTACTCACTATGGTGGTTGACTACAGAACCCGTGTGCTGAAGATCTCTGAGGAGGATGAGCTGGACACCAAGCTAACCCGTATCCCCAGTGCCAAGAAGTACAAAGACATTATCCGGCAGCCCTCTGAGGAAGAGATCATCAAATTGGCTCCCCCACCGAAGAAGGCCTGAGCAAGGGGGAGGAAGAGGAGGAAGGTTGGACCTTCATCAGACCACTCCCTTCCCCCATCCTCCAGGAGAGGGGGCAAGGGCAACCCACCATCTACCCACTTACTAACCTGGTCCTAACCCCCTTACTGTGCGCGTGTGTGTGCGTGTGCGCACGCTCTGGCTGTTTGTCTATATGTCTAGCTCATCTAGTTCCTCTTCTTAAGGGGATGGGGGTCAGGGGCTAGGGGAGGGGGCTGAGTTTCCCCACTTTAGGAGGAGGTGGGGGCTATTTCTATGCAAATAGAAATCAGCACATTCCTCCTACTTCCCTTTCCTCCACTCCCCCCATATCTTTAAAGTGTGGAAGCAGAAAGGACCTGCATTTTCCTACATTGAGGAGCTGACATAGGGGTAAGGTATGGGAGAGGTAGGTGGATCCAGGGAAAAGCAGTGGGGACGGAAGGCAAAGAGACCACTCAACCCCCACCTGGAAGGGGCAAAGAAAAGCCAGAGTTCCATGTTTGTACTCCTGTGCTGGACTGTTTCCTGAGTACCAGCAGGTCCCTTTTTGTCTCTCATGGGCCTAGCATAGGTATGAGCCAGGGATCCTTTCCTGGTCCCTAAGATCAAACCCCATGGAGCAGCCAGCGTTAGATGCCCCCACCCACCTGTACTCTGGAGAGACTGTGCTGGGAACATGTACCACTGAGCCTGAGATGGGGATGAGGGCAGAGAGAGGGGAGCCCCCTCTTCCACTCAGTTGTTCCTACTCAGACTGTTGCACTCTAAACCTAGGGAGGTTGAAGAATGAGACCCTTAGGTTTTAACACGAATCCTGACACCACCATCTATAGGGTCCCAACTTGGTTATTGTAGGCAACCTTCCCTCTCTCCTTGGTGAAGAACATCCCAAGCCAGAAAGAAGTTAACTACAGTGTTTTCCTTTGCACCGATCCCCACCCCAATTCAATCCCGGAAGGGACTTACTTAGGAAACCCTTCTTTACTAGATATCCTGGCCCCCTGGGCTTGTGAACACCTCCTAGCCACATCACTACAGTACAGTGAGTGACCCCAGCCTCCTGCCTACCCCAAGATGCCCCTCCCCACCCTGACCGTGCTAACTGTGTGTACATATATATTCTACATATATGTATATTAAAACTGCACTGCCATGTCTGCCCTTTTTTGTGGTGTCTAGCATTAACTTATTGTCTAGGCCAGAGCGGGGGTGGGAGGGGAATGCCACAGTGAAGGGAGTGGCAGAATCAAATTGCTACATAGTCCAAACAAAAAAGAAGGCTTTTTCAAAAAACATTAAATTCACATGCAGTCTCAGAGACTATTTAGACAAAGTTCAAGTTAGGAGCTTTTAGGATGTGGGAGTAAAACTTTAATGGGAGGGGAGGGCTGGCTGCTGGAAGAAGGAAGAAGCCAGACTGGTTAGACAGTACTCTTAACTCCTAGCCCAGCCTAGCGTGCCCTGCCCCTCTGGCCACTGCTGCAGACACCTGCCTTAACACACACACCTCTAGGACTCCACAGTTTTGCCTTAAAGGACCTTCCCAAGTCTCCCTTTCCCTGTCTGGCTTCTCCCTTAAGAAGAGAGAGATACTTGTAGAATTGGGTGGGGGGAATGAGCATGAACTGTCCTTCCATTTGGGATATGTTACATTAGAGTGAGAGAGAGAATAAGGAGCCTTTCTTATGGAAGAAATGGGAGAAGAGAGACAGGGTTCTTTTCAGCAGAGTCTAGTAGTTTCTCTGTAAGGCAAAATAATCTAAAAAGACTAACCTGCCCACCCACTCCTTATATTGCTGTGAGATTGCCCCTATCTTGTGCTCTTCTGTCTGCAGTGTGCACGGCCTTGTTCTAACCCGGAATAAAGGTGATTGATTGTATTGCAA

Publications

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