Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TCP1P3
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:19941253-19943106  UCSC
Coordinates (T2T) chr12:19819565-19821418  UCSC
Coordinates (hg19) chr12:20094187-20096040  UCSC
Strand +
Parental Sequence NM_030752.3
Parental seq. overlap 1756 bp
Parental seq. overlap (%) 74.6%
Genomic Region Intergenic
Retrocopy Summary TCP1P3, located on chr12:19941253-19943106, is a retrocopy of the parental gene TCP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TCP1
Full Name t-complex 1
Also known as CCT-alpha|CCT1|CCTa|D6S230E|TCP-1-alpha
Coordinate chr6:159778498-159789602
Strand -
Gene summary The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TCP1P3
Bonobo Pan paniscus TCP1P3
Gorilla Gorilla gorilla TCP1P2
Orangutan Pongo abelii TCP1P3
Gibbon Nomascus leucogenys TCP1P2
Green monkey Chlorocebus sabaeus TCP1P2
Crab-eating macaque Macaca fascicularis TCP1P4
Rhesus Macaca mulatta TCP1P4
Baboon Papio anubis TCP1P4
Golden snub-nosed monkey Rhinopithecus roxellana TCP1P4
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TCP1P3
GCATCACTCGGGTCCGCTCCACACCGTCGCCACTGCTGTGGTAGCCGGTTGGCCGAGGGGCCACGATAACTGGTTGCCCGCAGTAGGAGCAGAATTCGGTATGTACCGCCGCCAGGAAGATGGAGGGGCCTTTGTCCGTGTTCGGAGACCGCAGCAGTGGGGAGGCGATCCGCTCCCAGAACATTATGGCTGCAGCTTCGATTGCCAATATTGTAAAAAGTGCTCTTGGTCCGTTGTCTTGGATAAAATGTTGGTGGATGATACTGGTGATGTAACCATTACTAATGATGGTGCAACCATCCTGAAGTTACTGGAGGTAGAACATCCTGCAGCTAATGTTCTTTGTGAGCTGGCTGATCTGCAAGACAAAGAAGTTAGAGATGGAACTACCTCAGTGGTTATTATTGCAGCAGAACTCCTAAAAAATGCAGATTAATTAGTTAAACAGAAAATTCATCCCACATCAGTTATTAGTGGCTAACGACTTGCTTGCAAGGAAGCAGTGCATTTTATCAATGAAAACCTAATTGTTAACAAAGATGAACTGGGAAGAGATTGCCTGATTAATGCTGCTAAGACAATCCATGTCTTCCAAAATCATTGGAATAAATGGTGATTTCTTTGCTAACATGGTAGTAGATGCTGTACTTGCTATTAAATACACAGATATAAGAGGCCAGCCACATTATCCAGTGAATTCTGTTAATATTTTGAAAGCCCGTGGGAGAAGTCAAACAGAGAGCATGCACGTCAGTGGCTGTGCACTCAACTGTGTGGTGGGATCCCACGGCATGCCCAAGAGAATCATAAATGCAAAAATTGCTTGCCTTGACTTTAGCCTGAAAAAAACATGAAGCTTGGTGTACAGTGGTCATTACAGATCATGAAAAACTGGACCAAATTAGACAAAGAGAATCAGATTATCACCAAGGAGAGAATTCAGAAGATCCTGGCAACTGGTGCCAACGTTATTCTAACCACTGGTGGAATTGATGATATGTGTCTGAAGTATTTTGTGGAGGCAGGTGCTATGGCAGTTAGAAGAGTTTTAAAGGCATTGCTAAAGCTTCTGGAGCAACTATTCTGTCAACCCTGGCCAATTCGGAAGGTGAAGAAACTTTTGAAGCTGCAATGTTGGGACAGGCAGAAGTGGTACGGGAGGGAATTTGTGATGATGAGCTGATCTTAAAAACACTAAGGCTCATACATCTGCATCGATTATCTTACGTGGGGCAAATGATATCATGTGTGGTGAGATGGAGCGCTCTTTACATGATGCACTTTGTGTAGTGAAGAGAGTTTTGGAGTCAAAATCCATGGTTCCAGGCGGGGGTGCTGTAGAAGCAGCCCTTTCCATATACCTTGAAAACTATGCAACCAGCATGGGGTCTCAGGAAGAGCTTGCTATTGCAGAGTTTGCAAGATCACTTCTTGTTATTCCTAATACACTGGCAGTTAATGCTGCCCAGGACTCCACAGATCTGGTCACAAAATTCAGAGCTTTTCATAATGAGGCTCAGGTTAACCCAGAACATAAAAATCTGAAATGGATTGGTCTTGATTTGAGCAATGGTGAACGTGGAGACAACAAACAAGCAGGGATGTTTGAACCAACCATAGTTAAAGTTAAGAGTTTGAAATTTGCAACAGAAGCTGCAATTACCATTCTTCGAATTGATGATCTTACTAAATTACATCCAGAAAGTAAAGATGATAAACATGGAGGTTATGAAGATGCTGTTCACTCTGGAGCCCTTAATGATTGATCTGATGTCTCTTTTATTTATAACAATGTGAAATGCAATTGTCTTGTACCTTGAGTTGAGTATTACACATTAAAGTACAACAAGCTGT
>NM_030752.3
AGTAGCTCCTGGGACATCGCTCGGGTACGCTCCACGCCGTCGCAGCCACTGCTGTGGTCGCCGGTCGGCCGAGGGGCCGCGATACTGGTTGCCCGCGGTGTAAGCAGAATTCGACGTGTATCGCTGCCGTCAAGATGGAGGGGCCTTTGTCCGTGTTCGGTGACCGCAGCACTGGGGAAACGATCCGCTCCCAAAACGTTATGGCTGCAGCTTCGATTGCCAATATTGTAAAAAGTTCTCTTGGTCCAGTTGGCTTGGATAAAATGTTGGTGGATGATATTGGTGATGTAACCATTACTAACGATGGTGCAACCATCCTGAAGTTACTGGAGGTAGAACATCCTGCAGCTAAAGTTCTTTGTGAGCTGGCTGATCTGCAAGACAAAGAAGTTGGAGATGGAACTACTTCAGTGGTTATTATTGCAGCAGAACTCCTAAAAAATGCAGATGAATTAGTCAAACAGAAAATTCATCCCACATCAGTTATTAGTGGCTATCGACTTGCTTGCAAGGAAGCAGTGCGTTATATCAATGAAAACCTAATTGTTAACACAGATGAACTGGGAAGAGATTGCCTGATTAATGCTGCTAAGACATCCATGTCTTCCAAAATCATTGGAATAAATGGTGATTTCTTTGCTAACATGGTAGTAGATGCTGTACTTGCTATTAAATACACAGACATAAGAGGCCAGCCACGCTATCCAGTCAACTCTGTTAATATTTTGAAAGCCCATGGGAGAAGTCAAATGGAGAGTATGCTCATCAGTGGCTATGCACTCAACTGTGTGGTGGGATCCCAGGGCATGCCCAAGAGAATCGTAAATGCAAAAATTGCTTGCCTTGACTTCAGCCTGCAAAAAACAAAAATGAAGCTTGGTGTACAGGTGGTCATTACAGACCCTGAAAAACTGGACCAAATTAGACAGAGAGAATCAGATATCACCAAGGAGAGAATTCAGAAGATCCTGGCAACTGGTGCCAATGTTATTCTAACCACTGGTGGAATTGATGATATGTGTCTGAAGTATTTTGTGGAGGCTGGTGCTATGGCAGTTAGAAGAGTTTTAAAAAGGGACCTTAAACGCATTGCCAAAGCTTCTGGAGCAACTATTCTGTCAACCCTGGCCAATTTGGAAGGTGAAGAAACTTTTGAAGCTGCAATGTTGGGACAGGCAGAAGAAGTGGTACAGGAGAGAATTTGTGATGATGAGCTGATCTTAATCAAAAATACTAAGGCTCGTACGTCTGCATCGATTATCTTACGTGGGGCAAATGATTTCATGTGTGATGAGATGGAGCGCTCTTTACATGATGCACTTTGTGTAGTGAAGAGAGTTTTGGAGTCAAAATCTGTGGTTCCCGGTGGGGGTGCTGTAGAAGCAGCCCTTTCCATATACCTTGAAAACTATGCAACCAGCATGGGGTCTCGGGAACAGCTTGCGATTGCAGAGTTTGCAAGATCACTTCTTGTTATTCCCAATACACTAGCAGTTAATGCTGCCCAGGACTCCACAGATCTGGTTGCAAAATTAAGAGCTTTTCATAATGAGGCCCAGGTTAACCCAGAACGTAAAAATCTAAAATGGATTGGTCTTGATTTGAGCAATGGTAAACCTCGAGACAACAAACAAGCAGGGGTGTTTGAACCAACCATAGTTAAAGTTAAGAGTTTGAAATTTGCAACAGAAGCTGCAATCACCATTCTTCGAATTGATGATCTTATTAAATTACATCCAGAAAGTAAAGATGATAAACATGGAAGTTATGAAGATGCTGTTCACTCTGGAGCCCTTAATGATTGATCTGATGTTCCTTTTATTTATAACAATGTTAAATGCAATTGTCTTGTACCTTGAGTTGAGTATTACACATTAAAGTAAAGTACAAGCTGTAAACTTGGGTTTTTGTGATGTAGGAAATGGTTTCCATCTGTACTTTGGTCCTCTGATTTCACATATTGCAACCTAGTACTTTATTAGTTTAAAAAGAAATTGAGGTTGTTCAAAGTTTAAGCAATTCATTCTCTCTGAACACACATTGCTATTCCCATCCCACCCCCAATGCACAGGGCTGCAACACCACGACTTCTGCCCATTCTCTCCAGTGTGTGTAACAGGGTCACAAGAATTCGACAGCCAGATGCTCCAAGAGGGTGGCCCAAGGCTATAGCCCCTCCTTCAATATTGACCTAACGGGGGAGAAAAGATTTAGATTGTTTATTCTTCTGTGGACACAGTTTAAAATCTTAAACTTGTCTTTTTCCTCTTAATGTATCAGCATGCTACCCTTTCAAACTCAAATTTTCATTTTAACTGCTTAGGAATAAATTTACACCTTTGTGAAAATTCA

Publications

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