Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name UBE2L2
Plot displaying the genomic locations of a retrocopy (in chr12) and its respective parental gene (in chr22). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr12:20449437-20450122  UCSC
Coordinates (T2T) chr12:20327891-20328576  UCSC
Coordinates (hg19) chr12:20602371-20603056  UCSC
Strand -
Parental Sequence NM_003347.4
Parental seq. overlap 632 bp
Parental seq. overlap (%) 22.1%
Genomic Region Intragenic (PDE3A)
Retrocopy Summary UBE2L2, located on chr12:20449437-20450122, is a retrocopy of the parental gene UBE2L3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name UBE2L3
Full Name ubiquitin conjugating enzyme E2 L3
Also known as E2-F1|L-UBC|UBCH7|UbcM4
Coordinate chr22:21549447-21624034
Strand +
Gene summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes UBE2L3P3
Bonobo Pan paniscus UBE2L3P3
Gorilla Gorilla gorilla UBE2L3P3
Orangutan Pongo abelii UBE2L3P2
Gibbon Nomascus leucogenys UBE2L3P6
Green monkey Chlorocebus sabaeus UBE2L3P3
Crab-eating macaque Macaca fascicularis UBE2L3P5
Rhesus Macaca mulatta UBE2L3P5
Baboon Papio anubis UBE2L3P4
Golden snub-nosed monkey Rhinopithecus roxellana UBE2L3P4
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>UBE2L2
ATTCTGGGAAAGGAGCAGCATCAAATCCAAGACGGCACCAGCAGAAGGCTGATGAAGGAGCTTGAAGAAATATGCAATTGTGGAATGAAAAACTTCCGTAACTTCCAGGTAGATGGAGCTAATTTATTGACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATAAGGGGGCCTTCAGAATCGAAATCAACTTTCCAGCAGAGTTCCCATTCAAACCACCGAAGAGCACACTTAAAGATCTGTCACCCAAATGTCCACTAAAAGGGGCAGGTCTCTCTGCCAGTAAATTAGTGCTGAAAACTGGAAGCCAGCAACCAAAACTGACCAAGTAATCCAGTCCCTCACAGCACTGGTGAATGACCCCCAGCCTGAGCATCCACTTCAGGCTGACCTAGCTGAATAATACTCTAAGGACTGTAAATATTTCTGTAAGAATGCTGAAGTTTACAGAGAAATAGGGGGAAAAGCGACTTGTAGACTAAAATCTGCCACAATTGGCTCCAGTAAGTGTGAGCAGAGACCCCGTGCAGTGCATTCAGATACCCCACATGGAAGGACTCTGTGGAAACTGACACGTGCCACCGCCTACCACTTTGGCAGTTACCAACTTTCTACAGTTTTCTTAATCAAAAGTCGTCTAGGCAACCTGTAAATAAAGGATTAAAAATTTAAGATGTTCTAA
>NM_003347.4
ATTCTGGGGAAGGAGCAGCACCAAATCCAAGATGGCGGCCAGCAGGAGGCTGATGAAGGAGCTTGAAGAAATCCGCAAATGTGGGATGAAAAACTTCCGTAACATCCAGGTTGATGAAGCTAATTTATTGACTTGGCAAGGGCTTATTGTTCCTGACAACCCTCCATATGATAAGGGAGCCTTCAGAATCGAAATCAACTTTCCAGCAGAGTACCCATTCAAACCACCGAAGATCACATTTAAAACAAAGATCTATCACCCAAACATCGACGAAAAGGGGCAGGTCTGTCTGCCAGTAATTAGTGCCGAAAACTGGAAGCCAGCAACCAAAACCGACCAAGTAATCCAGTCCCTCATAGCACTGGTGAATGACCCCCAGCCTGAGCACCCGCTTCGGGCTGACCTAGCTGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCTGAAGAGTTTACAAAGAAATATGGGGAAAAGCGACCTGTGGACTAAAATCTGCCACGATTGGTTCCAGCAAGTGTGAGCAGAGACCCCGTGCAGTGCATTCAGACACCCCGCAAAGCAGGACTCTGTGGAAATTGACACGTGCCACCGCCTGGCGTTCGCTTGTGGCAGTTACTAACTTTCTACAGTTTTCTTAATCAAAAGTGGTCTAGGTAACCTGTAAAGAAAGGATTAAAAATTTAAGATGTTCTAGTTCTGCTCTCTTTGTTTTAAAAATCACTGCTTCAATCTACTTCAAAAGAATGGTGTTTCTTTTCTTGTCCAATTTTATCCAAAATCTTCAAGTTACATTTAACCCATAAGGTTTAAAAAAAAGGAAAAAAAACGGTTGTGGTTCCCTTTCTTCCCTACCCTTGCCACTCCCACTTTCTGGCACCGAGTTTATTTTTCACTTACTTACTTCCCCAGACCCCGGGCTCGCCTCCACAAAGGAGAAGAGACTGCCCTGGCGGTCCTGGTGGCTTTTCTTAGCATGTGTGGCACTGTTGCCCAGTGTGGGAGTTGGTTTAAATTCTCCTGACTCCAGTTTATAACATCCTTTTAAAAAATTTAAAAACAAACAGCCACACCCCTCCTCCAGTCCTTCTCCTCAGTTCTTGTGTGAAACTCCAGCTGATGTTACCACAGTAACATCAGTTAATTGGGCAAGCCCTGATGTCAGTGTGTGTAACTGACCTCTGGCCTGGCCTGCACAGAGAAGCCCTATAATCACAGGTCTGTGGTGGCCCCGAAATGGGGGGCCTGCTAGTCAGGAGGATGCTGTGCACACTGTGTGTGATGAATCTCGCCAGAAAGGCTCCTGAGGTCCCAGGTTGGCACTTCTCCCTGCAGCCATTGTAGAAGATCTGCTGGTCCTTGCAGGCAAAGCTACAGCCAGAATGTCCGTTTGAAACTCCTAGCTCATCTGTCACCGAGCTTCATCCGAATGTGCCACGGAGCTTGCTCTCCACTTCCTCCGTGCAGTGGCCCTGCCACAGCCCTCCCTCGGCACACTTTGACCCTTTGTAGGATTGGAATTAGCAGGACTCGGCTATTTAAAGCACCAGTCTGGGGTCGCCTGGGCCCCTGCTGACCCCCTCCTCCAGAGCAGCCAGCCCAGCCCGGGAACAAGACGGACTTCCTCTCCCTTCGGACTCACAGCCTTTGCAGAGTCAAGCTCCACTTGAAGCTCACTCAGTAATATCCTTTCAATGTGTTTTATATTGTTTTGACTGCCTTTTTTTGTAGAAATAAAAATTGACCTTAGAATTTATCGTCAGATAAACTTGTAAAGATTTGAATATTAATGTCTTTTCAAGGCAAATGGGATTGTCCCCGCACTAGTAGAGAATCCATGTCGCTCTGACACCCCAAGGAAGCCGACGATCCAAATGCCGTGTGTCACCAACCCCGCTTCTGCCACTGGCGGCTTCCCTTCTTGGCTCTTGGGGGGGACTAGATCCTGTGGAGAAGATGACttaaactttgctttttgttttaattttaattctaTAACTTGAGATCTTTCCGGGGCCTACAGGCGTGTAAGACAGCTTGGTCTGGTCTGTGCAGAAGTGGGGAGTGATGGGCAGGTTCGGCAGCCTAACATTGTTCAGGCGCATGGCCCCTGCGGTGTGTACACGAACTCGGCTTCTTTTGTCCTAGGTACGCCAAGGGCAGGTTTCTGGAGACTCCCTTGTGCCCGGGATGGCAAGGGCACCGGGCTGGCGTTTCCACATCTGTCTTCATTAGCAGAAAAGTGATGATGGATTTTATTTCACTCACACTCCAGTTTGTAATAAAATGCCAAATTCTGTCAGCTATCCAAACAAGCCACCATTTGTTCTTGTTGCTTCTCTGGATCCAGAAATGTTGCCATTCTTGGAAACTGTCCCATTGCTTCGTATTTCTGCCAACGTAGCTCTGCCTGCCTGTCAACCCCTCACTGCACTCTGCTCATCACGGGAGGATACCTGTGTGCCGGCAGCCCCTCAGGGACTCTCAGCCCTGGCACTGGCACCCCAGGGTTGGCCCCGTCAGCAGAGGCTTGGCTTTCGAGCCAGTGGGTGTCTCTCCTTTGGGCCTGGGCGGCTTGCTCCTGCCAGCCATGCCTTCAGGGTAGGCTCTGAGCAAGCTGGCGAACAGCCCTGGCTGCTCCAAAACCAAAAAGCTGGGTCCTCTGGAGGAGGGGCGAGCTGTGGAGCAGCCACCCACTGCTGCCCCAAGCTCACTCAGGAATTCACACCCGCCTGGTTTCTTGAAGTGTGCTGGGTCCTTCCCTCTGCTCCCTACTCCCCACCACGGCAGAGAATAGGCTTTCTAAGATGCTGCGATCCCGTTCTGCTGCCCGTAATAAAAATGCTCTCAGACACTG

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